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37 results on '"Greenstein, Vivienne"'

6. Quantitative Fundus Autofluorescence in HCQ Retinopathy

Author

Greenstein, Vivienne C., primary, Lima de Carvalho, Jose Ronaldo, additional, Parmann, Rait, additional, Amaro-Quireza, Luz, additional, Lee, Winston, additional, Hood, Donald C., additional, Tsang, Stephen H., additional, and Sparrow, Janet R., additional

Published
2020
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9. Multimodal analysis of the Preferred Retinal Location and the Transition Zone with macular atrophy in Patients with Stargardt Disease

Author

Verdina, Tommaso, Greenstein, Vivienne C., Sodi, Andrea, Tsang, Stephen H., Burke, Tomas R., Passerini, Ilaria, Allikmets, Rando, Virgili, Gianni, Cavallini, Gian Maria, and Rizzo, Stanislao

Subjects
Adult, Male, Fundus Oculi, Visual Acuity, Reproducibility of Results, Retinal Pigment Epithelium, Middle Aged, Multimodal Imaging, Article, Ophthalmoscopy, Macular Degeneration, Young Adult, Humans, Stargardt Disease, Female, Macula Lutea, Fluorescein Angiography, Visual Fields, Tomography, Optical Coherence, Aged, Retrospective Studies
Abstract

The purpose of our study was to investigate morpho-functional features of the preferred retinal location (PRL) and the transition zone (TZ) in a series of patients with recessive Stargardt disease (STGD1).Fifty-two STGD1 patients with at least one ABCA4 mutation, atrophy of the central macula (MA) and an eccentric PRL were recruited for the study. Microperimetry, fundus autofluorescence (FAF), spectral-domain optical coherence tomography (SD-OCT) were performed. The location and stability of the PRL along with the associated FAF pattern and visual sensitivities were determined and compared to the underlying retinal structure.The mean visual sensitivity of the PRLs for the 52 eyes was 10.76 +/- 3.70 dB. For the majority of eyes, PRLs were associated with intact ellipsoid zone (EZ) bands and qualitatively normal FAF patterns. In 17 eyes (32.7%) the eccentric PRL was located at the edge of the MA. In 35 eyes (67.3%) it was located at varying distances from the border of the MA with a TZ between the PRL and the MA. The TZ was associated with decreased sensitivity values (5.92 +/- 4.69 dB) compared to PRLs (p0.05), with absence/disruption of the EZ band and abnormal FAF patterns (hyper or hypo-autofluorescence).In STGD1 eccentric PRLs are located away from the border of MA and associated with intact EZ bands and normal FAF. The TZ is characterized by structural and functional abnormalities. The results of multimodal imaging of the PRL and TZ suggest a possible sequence of retinal and functional changes with disease progression that may help in the planning of future therapies; RPE dysfunction appears to be the primary event leading to photoreceptor degeneration and then to RPE loss.

Published
2017

34. Blue (S) cone pathway vulnerability: a test of a fragile receptor hypothesis

Author

Hood, Donald C. and Greenstein, Vivienne C.

Abstract

The vulnerability of the blue (S) cone pathways to retinal disease has been attributed by some to S (blue) receptors, which are said to be more susceptible to metabolic damage (the fragile receptor hypothesis). Other investigators have suggested postreceptoral causes. To test the fragile receptor hypothesis, a two-site model of the S cone system is presented, and a psychophysical procedure is described. Data from a patient with congenital stationary night blindness (CSNB) and a patient with retinitis pigmentosa (RP) demonstrate the feasibility of this approach. As expected from previous work, the data reinforce the conclusion that the primary defect in CSNB is at the level of the receptors. The data from the patient with RP are consistent with the fragile receptor hypothesis.

Published
1988

35. Foveal sensitivity changes in retinitis pigmentosa

Author

Greenstein, Vivienne, Hood, Donald C., and Carr, Ronald E.

Abstract

Loss in foveal sensitivity in retinitis pigmentosa (RP) has been attributed to a decrease in quantal catching ability. Using a psychophysical technique (the probe–flash paradigm), we previously found that the results obtained for six RP patients under light adapted conditions were not consistent with a quantal catch hypothesis. To test further this hypothesis twelve RP patients were examined in dark adapted conditions. Probe thresholds were normal for five patients and increased for seven patients. The decreased quantal catching hypothesis was rejected for six of the seven patients.

Published
1987

36. Correlations among near-infrared and short-wavelength autofluorescence and spectral-domain optical coherence tomography in recessive Stargardt disease.

Author

Duncker T, Marsiglia M, Lee W, Zernant J, Tsang SH, Allikmets R, Greenstein VC, and Sparrow JR

Subjects
Adolescent, Adult, Case-Control Studies, Child, Fovea Centralis pathology, Fundus Oculi, Humans, Macular Degeneration genetics, Macular Degeneration pathology, Male, Middle Aged, Optical Imaging methods, Phenotype, Prospective Studies, Spectroscopy, Near-Infrared methods, Stargardt Disease, Tomography, Optical Coherence, Young Adult, Fluorescein Angiography methods
Abstract

Purpose: Short-wavelength (SW) fundus autofluorescence (AF) is considered to originate from lipofuscin in retinal pigment epithelium (RPE) and near-infrared (NIR) AF from melanin. In patients with recessive Stargardt disease (STGD1), we correlated SW-AF and NIR-AF with structural information obtained by spectral-domain optical coherence tomography (SD-OCT)., Methods: Twenty-four STGD1 patients (45 eyes; age 8 to 61 years) carrying confirmed disease-associated ABCA4 mutations were studied prospectively. Short-wavelength AF, NIR-AF, and SD-OCT images were acquired., Results: Five phenotypes were identified according to features of the central lesion and extent of fundus change. Central zones of reduced NIR-AF were typically larger than areas of diminished SW-AF and reduced NIR-AF usually approximated areas of ellipsoid zone (EZ) loss identified by SD-OCT (group 1; r, 0.93, P < 0.0001). In patients having a central lesion with overlapping parafoveal rings of increased NIR-AF and SW-AF (group 3), the extent of EZ loss was strongly correlated with the inner diameter of the NIR-AF ring (r, 0.89, P < 0.0001) and the eccentricity of the outer border of the NIR-AF ring was greater than that of the SW-AF ring., Conclusions: Lesion areas were more completely delineated in NIR-AF images than with SW-AF. In most cases, EZ loss was observed only at locations where NIR-AF was reduced or absent, indicating that RPE cell atrophy occurs in advance of photoreceptor cell degeneration. Because SW-AF was often increased within the central area of EZ disruption, degenerating photoreceptor cells may produce lipofuscin at accelerated levels. Consideration is given to mechanisms underlying hyper-NIR-AF in conjunction with increased SW-AF., (Copyright 2014 The Association for Research in Vision and Ophthalmology, Inc.)

Published
2014
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37. Local cone and rod system function in progressive cone dystrophy.

Author

Holopigian K, Seiple W, Greenstein VC, Hood DC, and Carr RE

Subjects
Adolescent, Adult, Electroretinography, Female, Humans, Male, Middle Aged, Visual Fields, Retinal Cone Photoreceptor Cells physiopathology, Retinal Degeneration physiopathology, Retinal Rod Photoreceptor Cells physiopathology
Abstract

Purpose: To compare the patterns of local cone and rod system impairment in patients with progressive cone dystrophy (CD) using psychophysical and electrophysiological techniques., Methods: Local cone system function was assessed by measuring cone system thresholds (visual fields) and cone-mediated multifocal electroretinograms (mfERGs). Rod system function was assessed by measuring rod system thresholds (visual fields) and rod-mediated mfERGs. The results in a group of eight patients with CD were compared with those in an age-similar control group., Results: All the patients had abnormal cone system visual field thresholds and cone-mediated mfERGs. Cone system psychophysical thresholds were elevated for targets presented within the central 10 degrees, but were within normal limits for targets at peripheral locations. Cone-mediated mfERG measures of amplitude scale and time scale were abnormal for most of the hexagons tested. Most of the rod-mediated psychophysical thresholds and mfERGs were within normal limits. Rod system losses tended to be patchy and scattered throughout the area tested., Conclusions: There was poor correspondence among local measures of cone and rod system losses in these patients with CD. The results suggest that the spatial pattern of cone system losses in this disease differs from the spatial pattern of rod system losses.

Published
2002

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