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Background: High psychological resilience (HR) could protect individuals from psychosocial stress and thereby make individuals less vulnerable to depression and anxiety; however, the underlying neural mechanism remains to be investigated. Methods: The Montreal Imaging Stress Task (MIST) was administered to participants of 59 healthy individuals with HR and 56 individuals with low psychological resilience (LR) during functional magnetic resonance imaging (fMRI) scanning. Cortisol concentrations and subjective stress levels were collected across the MIST. Repeated measures analyses of variance were conducted to measure the group differences in subjective and cortisol stress responses. Two‐sample t‐tests were conducted to detect the group differences in stress‐related brain activation and functional connectivity (FC). Results: The LR group exhibited an increase in cortisol concentration after the MIST, whereas the HR group exhibited a decrease in cortisol concentration after the MIST. The LR group exhibited higher activation in the left anterior insula and lower FC between the left orbitofrontal cortex (OFC) and the right temporal pole (TP) (all pFWE < 0.05). Mediation analyses revealed that the left anterior insula mediates the relationship between psychological resilience and depression and the left OFC–right TP FC mediates the relationship between psychological resilience and anxiety. Conclusions: Findings highlight that the anterior insula and OFC–TP FC could be the critical neural mechanism underlying the interaction between psychological resilience and psychosocial stress. Moreover, higher anterior insula activation and lower OFC–TP FC could be the crucial neural mechanism of individuals with low psychological resilience developing into depression/anxiety when experiencing daily psychosocial stressors. [ABSTRACT FROM AUTHOR]

Background and Purpose: This study explores the relationship between serum 25-hydroxyvitamin D [25(OH)D] levels and mortality among Parkinson's disease (PD) patients, providing evidence for the potential benefits of vitamin D (VD) supplementation., Methods: PD patients were collected from the National Health and Nutrition Examination Survey (NHANES) database from 1999 to 2020. These patients were categorized based on their serum 25(OH)D levels: deficiency, insufficiency, and sufficiency. We compared demographic information and analyzed mortality data from the National Death Index. A restricted cubic spline model assessed the nonlinear association between 25(OH)D levels and mortality, complemented by multivariable Cox regression analysis. Consistency of results was checked through subgroup analysis., Results: The study included 364 PD patients: 87 (23.9%) with VD deficiency, 121 (33.2%) with insufficiency, and 156 (42.9%) with sufficiency. Demographically, 46.4% were male, and 56% were over 65 years. The deficiency group predominantly consisted of Mexican Americans (53.1%), had lower income levels, a higher unmarried rate, and increased liver disease incidence. The analysis showed a U-shaped curve between 25(OH)D levels and mortality risk, with the lowest risk at 78.68 nmol/L ( p -non-linear = 0.007, p -overall = 0.008). Kaplan-Meier analysis found the highest survival rates in patients with 25(OH)D levels between 75-100 nmol/L ( p  = 0.039). Compared to this group, patients with levels below 50 nmol/L had a 3.52-fold increased mortality risk (95% CI = 1.58-7.86, p  = 0.002), and those above 100 nmol/L had a 2.92-fold increase (95% CI = 1.06-8.05, p  = 0.038). Age-specific subgroup analysis ( p  = 0.009) revealed that both very low (<50 nmol/L) and high (>100 nmol/L) levels increased mortality risk in patients under 65, while levels below 75 nmol/L raised mortality risk in older patients., Conclusion: Serum 25(OH)D levels are nonlinearly linked to mortality in PD patients, with optimal survival rates occurring at 75-100 nmol/L. Deviations from this range increase the risk of death., Competing Interests: The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest., (Copyright © 2024 Yong, Dong, Zhou, Zhu, Gu and Li.)