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39 results on '"Gu, Yixin"'

5. Potential Targets and Signaling Mechanisms of Cinnamaldehyde Enhancing Intestinal Function and Nutritional Regulation in Fat Greenling (Hexagrammos otakii).

Author

Gu, Yixin, Zhan, Yu, Guo, Yafeng, Hua, Wenyuan, Qi, Xin, Gu, Zhizhi, Cao, Shengnan, Chen, Yan, Xue, Zhuang, and Wang, Wei

Subjects
*HEREDITY, *PROSTAGLANDIN receptors, *TRANSCRIPTION factors, *CHINESE medicine, *FAT, *MOLECULAR docking
Abstract

Cinnamaldehyde is an ideal feed additive with good immune enhancement and anti-inflammatory regulation effects. However, the anti-inflammatory regulation mechanism in fat greenling (Hexagrammos otakii, H. otakii) remains unclear. The nine targets of cinnamaldehyde were gathered in identified by the Traditional Chinese Medicine Systems Pharmacology database and Uniprot database, and 1,320 intestinal inflammation disease (IIF)-related proteins were screened from DrugBank, Online Mendelian Inheritance in Man (OMIM), Genecards, and Pharmacogenetics and Pharmacogenomics Knowledge Base (PHARMGKB) Databases. According to the Gene Ontology enrichment results and Kyoto Encyclopedia of Genes and Genomes pathway results, cinnamaldehyde may regulated the responses to bacteria, lipopolysaccharide, an inflammatory cytokine, and external stimuli via the nuclear factor kappa-B (NFκB) signaling pathway within on inflammatory network. In addition, the protein–protein interaction analysis assisted in obtaining the closely related inflammatory regulatory proteins, including the C5a anaphylatoxin chemotactic receptor 1 (C5aR1), transcription factor p65 (RELA), prostaglandin G/H synthase 2 (PTGS2), and toll-like receptor 4 (TLR4), which were confirmed as the bottleneck nodes of the network to be more deeply verified via the molecular docking. Moreover, a cinnamaldehyde feeding model was established for evaluating the anti-inflammatory effect of cinnamaldehyde in vivo. According to the current findings implied that cinnamaldehyde may play a protective role against IIF H. otakii by reducing inflammation through the C5 complement (C5)/C5aR1/interleukin-6 (IL-6) and TLR4/NFκB/PTGS2 pathway. The study focused on investigating the action mechanism of cinnamaldehyde on IIF through combining pharmacology and experimental verification in vivo, which provided a fresh perspective on the promoting effect of cinnamaldehyde on IIF in fish. [ABSTRACT FROM AUTHOR]

Published
2024
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27. A Tunable Transmission Line With Controllable Phase Shifting and Characteristic Impedance.

Author

Ren, Han, Zhou, Mi, Gu, Yixin, and Arigong, Bayaner

Abstract

Tunable transmission lines have a high demand in the 5G wireless communication applications. In this brief, a novel transmission line is presented to control both electrical length and characteristic impedance individually, creating flexible functions. For the first function, the proposed transmission line can perform as a tunable phase shifter with 90° phase tuning range and a low insertion loss variation. For the second function, the proposed transmission line can tune the characteristic impedance from 23 Ω to 145 Ω with a fixed phase delay. The ABCD-matrix method is applied to derive the design equations. For the practical implementation, the varactor equivalent parasitic resistances are considered, and the even-odd mode is applied to re-optimize the proposed two tuning functions. To verify the design theory, an experimental prototype is simulated, fabricated, and measured. Both simulation and measurement results match well with the design theory. [ABSTRACT FROM AUTHOR]

Published
2020
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35. 1001 Questions & Answers

Author

Gu, Yixin

Subjects
Questions and answers, Science and technology
Abstract

1001 Questions & Answers. Helena Spiteri and David Pickering. Dorling Kindersley, 1995. $16.95. (12-18) Basically this is a perfect book for kids at different levels. Although using the simplest way--question [...]

Published
1996

36. The Visual Dictionary of Physics

Author

Gu, Yixin

Subjects
Science and technology
Abstract

The Visual Dictionary of Physics. Jack Challoner. Dorling Kindersley, 1995. $16.95. (14-18) I can't believe this! A colorful photograph book is actually a dictionary with thousands of physics terms. As [...]

Published
1996

37. Prehistoric Journey

Author

Gu, Yixin

Subjects
Prehistoric Journey: A History of Life on Earth (Nonfiction work) -- Michaels, Greg -- Wicker, Rich -- Johnson, Kirk R. -- Stucky, Richard K., Books -- Book reviews, Science and technology
Abstract

Prehistoric Journey. Kirk R. Johnson and Richard K. Stucky. Greg Michaels, illus., Rich Wicker, photography. Roberts Rinehart, 1995. paper $19.95 (12-18) This is a terrific book on the prehistory of [...]

Published
1996

38. Multiple-Locus Variable-Number Tandem-Repeat Analysis of 201 Mycoplasma pneumoniaeIsolates from Beijing, China, from 2008 to 2011

Author

Zhao, Fei, Liu, Gang, Cao, Bin, Wu, Jiang, Gu, Yixin, He, Lihua, Meng, Fanliang, Zhu, Liang, Yin, Yudong, Lv, Min, and Zhang, Jianzhong

Abstract

ABSTRACTA total of 201 Mycoplasma pneumoniaeclinical isolates from Beijing, China, isolated from 2008 to 2011, were clustered into 16 multiple-locus variable-number tandem-repeat analysis (MLVA) types, of which 6 new MLVA types have never been reported previously. Type 1 isolates based on p1 gene genotyping were mainly MLVA types E, J, P, U, and X. There was no correlation between macrolide-resistant Mycoplasma pneumoniaeand their MLVA type.

Published
2013
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39. Gastroenteritis Outbreak Caused by Campylobacter jejuni - Beijing, China, August, 2019.

Author

Li Y, Zhou G, Gao P, Gu Y, Wang H, Zhang S, Zhang Y, Wang Y, Jing H, He C, Zhen G, Ma H, Li Y, Zhang J, and Zhang M

Abstract

What is already known about this topic?, Campylobacter genus bacteria are recognized as some of the leading causes of the bacterial diarrheal illness in both developing and developed countries. Recent pilot surveillance study revealed Campylobacter is the most common pathogen in the diarrheal cases using the enhanced filtration methods in Beijing. One outbreak caused by multi-drug resistant Campylobacter coli ( C. coli ) was identified in 2018., What is added by this report?, This is the first identified gastroenteritis outbreak caused by local Campylobacter jejuni ( C . jejuni ) infection in Beijing. A total of 14 patients were identified from August 23 to 26, 2019. The epidemiological investigation indicated that all of the patients worked at the same factory and the diarrhea happened after the same meal supplied from one company which service the meal delivery. Fourteen C. jejuni isolates were obtained from 12 patients and 2 food workers. Whole Genome Sequencing (WGS) analysis indicated this outbreak was caused by one highly clonal C. jejuni ., What are the implications for public health practice?, Campylobacter is the major foodborne pathogen in the world. Surveillance and risk assessment for Campylobacter infection particularly for Guillain-Barré Syndrome (GBS) associated C. jejuni infection in China should closely monitored., (Copyright and License information: Editorial Office of CCDCW, Chinese Center for Disease Control and Prevention 2020.)

Published
2020
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