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3. BIN2 inhibition suppress ovarian cancer progression meanwhile protect ovarian function through downregulating HDAC1 and RPS6 phosphorylation respectively.

Author

Li, Cong‐Rong, Xie, Shi‐Ya, Zhang, Shu‐Ping, Yang, Yan‐Jie, Yang, Li‐Li, Cao, Ying, Wang, Li‐Li, Zhu, Feng‐Yu, Wang, Ruo‐Lei, Yang, Zhi‐Xia, Cui, Chen‐Chen, Li, Yan‐Ru, Xu, Jia‐Ning, Yue, Feng, Tian, Pei‐Zhe, Wang, Qian, Yao, Hong‐Jie, Guan, Yi‐Chun, Zhang, Shao‐Di, and Ying, Xiao‐Yan

Subjects
TUMOR suppressor genes, OVARIAN follicle, MEDICAL sciences, OVARIAN tumors, MERGERS & acquisitions
Abstract

The article explores the potential of BIN2 inhibition in suppressing ovarian cancer progression and protecting ovarian function. Through various experiments, it was found that BIN2 inhibition or knockout can suppress tumor growth, improve fertility, and protect ovarian health by targeting HDAC1 and RPS6. The study suggests a novel therapeutic strategy for young ovarian cancer patients by understanding the dual function of BIN2 in cancer progression and ovarian function. [Extracted from the article]

Published
2024
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7. Gm364 coordinates MIB2/DLL3/Notch2 to regulate female fertility through AKT activation

Author

Chen, Liang-Jian, primary, Zhang, Na-Na, additional, Zhou, Chun-Xiang, additional, Yang, Zhi-Xia, additional, Li, Yan-Ru, additional, Zhang, Teng, additional, Li, Cong-Rong, additional, Wang, Xin, additional, Wang, Yang, additional, Wang, Zi-Bin, additional, Xia, Zheng-Rong, additional, Wang, Zhen-Bo, additional, Zhang, Cui-Lian, additional, Guan, Yi-Chun, additional, Sun, Qing-Yuan, additional, and Zhang, Dong, additional

Published
2021
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