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Summary: Changes in taste have been perceived as a common side effect of different cancers and may lead to malnutrition. Hence, the importance of understanding cancer patients' sensory taste perceptions and its impact on nutritional status, quality of life (QoL), and oral nutrition supplements (ONS) compliance becomes crucial. This qualitative study involved semi-structured, in-depth interviews with 24 adults (15 with multiple myeloma and 9 with head & neck cancer). The interviews were transcribed and the data analysis was conducted using reflexive thematic analysis and template analysis. This guided the development of four themes: 1. Taste and smell changes, 2. Impact on nutritional status and quality of life, 3. Information and help available for people experiencing changes in their taste, and 4. ONS and its compliance. Our findings show significant negative impact of chemosensory changes on nutritional status, quality of life and ONS compliance. Patient's experience with the level of support received for the management of taste changes during cancer treatment varied widely. Providing adequate information and support in a timely manner about changes in taste during treatment can improve patients' coping strategies and maintain their nutritional status. Overall, the findings highlight the importance of addressing taste changes and ONS compliance for people with multiple myeloma and head and neck cancer undergoing treatment. Specifically, the taste changes and its impact experienced by people with head and neck cancer were found to be more severe than those experienced by multiple myeloma patients. This study provides an understanding of changes in sensory taste perception experienced by cancer patients and its impact on nutritional status and QoL. This understanding can provide insight into ways to improve ONS consumption and compliance for preventing malnutrition. It is crucial to further conduct ONS sensory evaluations that cater to the specific needs of this cohort to help prevent malnutrition among cancer patients.

This auto-ethnographic essay draws upon Foucault's Archaeology of Knowledge to discuss the condition of Indian women in the Humanities in academia today. While acknowledging the encouragingly gender-inclusive projections in India's National Education Policy vision statement from 2020, I argue for more probing engagement with the concrete reality of being a woman teacher and researcher in the increasingly competitive and corporatized milieu of higher education. My methodology has been a close reading of the NEP's vision statement to analyze recurrences of terms and concepts as pointers to its discursive field. I argue that this policy statement implicitly envisions an empowered new-age Indian woman teacher, notionally mother to all her pupils, aiding their awakening intuitively from the very heart of her experiences, skills, and memories. Against this somewhat idealized feminine ecology of the NEP in principle and spirit, I juxtapose the actual everyday choices and struggles of women in academic positions. Does the decolonization of education in spirit also impart actual transformative agency to women academics? Will women be listened to? Not one essential woman, but heterogeneous women--women across different strata, identities, professional spaces, and ideologies? Above all, my essay probes the challenges and dividends of transitioning to a more home-grown teaching and research methodology derived from current Western academic models. For instance, what forms and lines of interdisciplinarity could best serve the interest of quality control in research and teaching? In the third and last section, I argue that women are equal contributors in the discourse of academics in the future. We are committed stakeholders that can help enhance collective performance and efficiency in ways that are commensurate and compatible with our particular needs, contexts, restraints, aptitudes, and encumbrances. I conclude my essay by urging colleagues in academia, women and men, to recognize that we can truly deliver on this challenge only in a spirit of intellectual, ethical, and interpersonal collaboration and collegiality. Keywords: Higher education, Women workers, India, Collegiality, Gender, Michel Foucault, Auto-ethnography, National Education Policy, Introduction In this informally longitudinal study, I shall be mining my own personal two-decades-long journey as teacher of literature and culture for share-worthy insights about the condition of women in [...]

The ADP ribosyltransferases (PARPs 1-17) regulate diverse cellular processes, including DNA damage repair. PARPs are classified on the basis of their ability to catalyze poly-ADP-ribosylation (PARylation) or mono-ADP-ribosylation (MARylation). Although PARP9 mRNA expression is significantly increased in progressive tuberculosis (TB) in humans, its participation in host immunity to TB is unknown. Here, we show that PARP9 mRNA encoding the MARylating PARP9 enzyme was upregulated during TB in humans and mice and provide evidence of a critical modulatory role for PARP9 in DNA damage, cyclic GMP-AMP synthase (cGAS) expression, and type I IFN production during TB. Thus, Parp9-deficient mice were susceptible to Mycobacterium tuberculosis infection and exhibited increased TB disease, cGAS and 2'3'-cyclic GMP-AMP (cGAMP) expression, and type I IFN production, along with upregulation of complement and coagulation pathways. Enhanced M. tuberculosis susceptibility is type I IFN dependent, as blockade of IFN a receptor (IFNAR) signaling reversed the enhanced susceptibility of [Parp9.sup.-/-] mice. Thus, in sharp contrast to PARP9 enhancement of type I IFN production in viral infections, this member of the MAR family plays a protective role by limiting type I IFN responses during TB., Introduction Mycobacterium tuberculosis infects approximately 25% of the world's population and causes tuberculosis (TB), a leading infectious disease that results in approximately 1.3 million deaths annually. Although a majority of [...]

X-box binding protein 1 (XBP1) is a transcription factor that plays a crucial role in the unfolded protein response (UPR), a cellular stress response pathway involved in maintaining protein homeostasis in the endoplasmic reticulum (EnR). While the role of XBP1 in UPR is well-characterised, emerging evidence suggests its involvement in endocrine resistance in breast cancer. The transcriptional activity of spliced XBP1 (XBP1s) is a major component of its biological effects, but the targets of XBP1s in estrogen receptor (ER)-positive breast cancer are not well understood. Here, we show that the expression of miR-378 and PPARGC1B (host gene of miR-378) is downregulated during UPR. Using chemical and genetic methods, we show that XBP1s is necessary and sufficient for the downregulation of miR-378 and PPARGC1B. Our results show that overexpression of miR-378 significantly suppressed cell growth, colony formation, and migration of ER-positive breast cancer cells. Further, we found that expression of miR-378 sensitised the cells to UPR-induced cell death and anti-estrogens. The expression of miR-378 and PPARGC1B was downregulated in breast cancer, and higher expression of miR-378 is associated with better outcomes in ER-positive breast cancer. We found that miR-378 upregulates the expression of several genes that regulate type I interferon signalling. Analysis of separate cohorts of breast cancer patients showed that a gene signature derived from miR-378 upregulated genes showed a strong association with improved overall and recurrence-free survival in breast cancer. Our results suggest a growth-suppressive role for miR-378 in ER-positive breast cancer where downregulation of miR-378 by XBP1 contributes to endocrine resistance in ER-positive breast cancer. [ABSTRACT FROM AUTHOR]

This auto-ethnographic essay draws upon Foucault's Archaeology of Knowledge to discuss the condition of Indian women in the Humanities in academia today. While acknowledging the encouragingly gender-inclusive projections in India's National Education Policy vision statement from 2020, I argue for more probing engagement with the concrete reality of being a woman teacher and researcher in the increasingly competitive and corporatized milieu of higher education. My methodology has been a close reading of the NEP's vision statement to analyze recurrences of terms and concepts as pointers to its discursive field. I argue that this policy statement implicitly envisions an empowered new-age Indian woman teacher, notionally mother to all her pupils, aiding their awakening intuitively from the very heart of her experiences, skills, and memories. Against this somewhat idealized feminine ecology of the NEP in principle and spirit, I juxtapose the actual everyday choices and struggles of women in academic positions. Does the decolonization of education in spirit also impart actual transformative agency to women academics? Will women be listened to? Not one essential woman, but heterogeneous women--women across different strata, identities, professional spaces, and ideologies? Above all, my essay probes the challenges and dividends of transitioning to a more home-grown teaching and research methodology derived from current Western academic models. For instance, what forms and lines of interdisciplinarity could best serve the interest of quality control in research and teaching? In the third and last section, I argue that women are equal contributors in the discourse of academics in the future. We are committed stakeholders that can help enhance collective performance and efficiency in ways that are commensurate and compatible with our particular needs, contexts, restraints, aptitudes, and encumbrances. I conclude my essay by urging colleagues in academia, women and men, to recognize that we can truly deliver on this challenge only in a spirit of intellectual, ethical, and interpersonal collaboration and collegiality. [ABSTRACT FROM AUTHOR]