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The lung airways exhibit distinct features with long, wide proximal branches and short, thin distal branches, crucial for optimal respiratory function. In this study, we investigated the mechanism behind this hierarchical structure through experiments and modeling, focusing on the regulation of branch length and width during the pseudoglandular stage. To evaluate the response of mouse lung epithelium to fibroblast growth factor 10 (FGF10), we monitored the activity of extracellular signal-regulated kinase (ERK). ERK activity exhibited an increase dependent on the curvature of the epithelial tissue, which gradually decreased with the progression of development. We then constructed a computational model that incorporates curvature-dependent growth to predict its impact on branch formation. It was demonstrated that branch length is determined by the curvature dependence of growth. Next, in exploring branch width regulation, we considered the effect of apical constriction, a mechanism we had previously proposed to be regulated by Wnt signaling. Analysis of a mathematical model representing apical constriction showed that branch width is determined by cell shape. Finally, we constructed an integrated computational model that includes curvature-dependent growth and cell shape controls, confirming their coordination in regulating branch formation. This study proposed that changes in the autonomous property of the epithelium may be responsible for the progressive branch morphology., Competing Interests: The authors have declared that no competing interests exist., (Copyright: © 2024 Takigawa-Imamura et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.)

In human celiac disease (CeD) HLA-DQ2.5 presents gluten peptides to antigen-specific CD4 + T cells, thereby instigating immune activation and enteropathy. Targeting HLA-DQ2.5 with neutralizing antibody for treating CeD may be plausible, yet using pan-HLA-DQ antibody risks affecting systemic immunity, while targeting selected gluten peptide:HLA-DQ2.5 complex (pHLA-DQ2.5) may be insufficient. Here we generate a TCR-like, neutralizing antibody (DONQ52) that broadly recognizes more than twenty-five distinct gluten pHLA-DQ2.5 through rabbit immunization with multi-epitope gluten pHLA-DQ2.5 and multidimensional optimization. Structural analyses show that the proline-rich and glutamine-rich motif of gluten epitopes critical for pathogenesis is flexibly recognized by multiple tyrosine residues present in the antibody paratope, implicating the mechanisms for the broad reactivity. In HLA-DQ2.5 transgenic mice, DONQ52 demonstrates favorable pharmacokinetics with high subcutaneous bioavailability, and blocks immunity to gluten while not affecting systemic immunity. Our results thus provide a rationale for clinical testing of DONQ52 in CeD., (© 2023. The Author(s).)

Computers based on physical systems are increasingly anticipated to overcome the impending limitations on digital computer performance. One such computer is a coherent Ising machine (CIM) for solving combinatorial optimization problems. Here, we report a CIM with 100,512 degenerate optical parametric oscillator pulses working as the Ising spins. We show that the CIM delivers fine solutions to maximum cut problems of 100,000-node graphs drastically faster than standard simulated annealing. Moreover, the CIM, when operated near the phase transition point, provides some extremely good solutions and a very broad distribution. This characteristic will be useful for applications that require fast random sampling such as machine learning.

Nonlinear dynamics of spiking neural networks have recently attracted much interest as an approach to understand possible information processing in the brain and apply it to artificial intelligence. Since information can be processed by collective spiking dynamics of neurons, the fine control of spiking dynamics is desirable for neuromorphic devices. Here we show that photonic spiking neurons implemented with paired nonlinear optical oscillators can be controlled to generate two modes of bio-realistic spiking dynamics by changing optical-pump amplitude. When the photonic neurons are coupled in a network, the interaction between them induces an effective change in the pump amplitude depending on the order parameter that characterizes synchronization. The experimental results show that the effective change causes spontaneous modification of the spiking modes and firing rates of clustered neurons, and such collective dynamics can be utilized to realize efficient heuristics for solving NP-hard combinatorial optimization problems.

Evaluation of the binding and uptake of an antibody in liver non-parenchymal cells (NPC), including liver sinusoidal endothelial cells, is important for revealing its pharmacokinetic (PK) behavior, since NPC has important roles in eliminating an antibody from the blood via the Fc fragment of IgG receptor IIB (FcγRIIB). However, there is currently no in vitro quantitative assay using NPC. This study reports on the development of a cell-based assay for evaluating the binding and uptake of such an antibody using liver NPC of mice and monkeys. In mice, the FcγRIIB-expressing cells were identified in the CD146-positive and CD45-negative fraction by flow cytometry. A titration assay was performed to determine the PK parameters, and the obtained parameter was comparable to that determined by the fitting of the in vivo PK. This approach was also extended to NPC from monkeys. The concentration-dependent binding and uptake was measured to determine the PK parameters using monkey NPC, the FcγRIIB-expressing fraction of which was identified by CD31 and CD45. The findings presented herein demonstrate that the in vitro liver NPC assay using flow cytometry is a useful tool to determine the binding and uptake of biologics and to predict the PK.

Quantum random numbers distinguish themselves from others by their intrinsic unpredictability arising from the principles of quantum mechanics. As such they are extremely useful in many scientific and real-world applications with considerable efforts going into their realizations. Most demonstrations focus on high asymptotic generation rates. For this goal, a large number of repeated trials are required to accumulate a significant store of certifiable randomness, resulting in a high latency between the initial request and the delivery of the requested random bits. Here we demonstrate low-latency real-time certifiable randomness generation from measurements on photonic time-bin states. For this, we develop methods to certify randomness taking into account adversarial imperfections in both the state preparation and the measurement apparatus. Every 0.12 s we generate a block of 8192 random bits which are certifiable against all quantum adversaries with an error bounded by 2 -64 . Our quantum random number generator is thus well suited for realizing a continuously-operating, high-security and high-speed quantum randomness beacon.

Human pharmacokinetics (PK) profiles of monoclonal antibodies (mAbs) are usually predicted using non-human primates (NHP), but this comes with drawbacks in terms of cost and throughput. Therefore, we established a human PK profile prediction method using human neonatal Fc receptor (hFcRn) transgenic mice (TgM). We administered launched 13 mAbs to hFcRn TgM and measured the concentration in plasma using electro-chemiluminescence immunoassay. This was then used to calculate PK parameters and predict human PK profiles. The mAbs showed a bi-phased elimination pattern, and clearance (CL) (mL/d/kg) and distribution volume at steady state (V dss ) (mL/kg) ranges were 11.0 to 131 and 110 to 285, respectively. There was a correlation in half-life at elimination phase (t 1/2β ) between hFcRn TgM and humans for 10 mAbs showing CL of more than 80% in the elimination phase (R 2  = 0.714). Human t 1/2β was predicted using hFcRn TgM t 1/2β ; 9 out of 10 mAbs were within 2-fold the actual values, and all mAbs were within 3-fold. Regarding the predicted CL values, 7 out of 10 mAbs were within 2-fold the human values and all mAbs were within 3-fold. Furthermore, even on day 7 the predicted CL values of 8 out of 10 mAbs were within 2-fold the observed value, with all mAbs within 3-fold. These results suggest human PK profiles can be predicted using hFcRn TgM data. These methods can accelerate the development of antibody drugs while also reducing cost and improving throughput.

The minimum requirements for an optical reservoir computer, a recent paradigm for computation using simple algorithms, are nonlinearity and internal interactions. A promising optical system satisfying these requirements is a platform based on coupled degenerate optical parametric oscillators (DOPOs) in a fiber ring cavity. We can expect advantages using DOPOs for reservoir computing with respect to scalability and reduction of excess noise; however, the continuous stabilization required for reservoir computing has not yet been demonstrated. Here, we report the continuous and long-term stabilization of an optical system by introducing periodical phase modulation patterns for DOPOs and a local oscillator. We observed that the Allan variance of the optical phase up to 100 ms was suppressed and that the homodyne measurement signal had a relative standard deviation of 1.4% over 62,500 round trips. The proposed methods represent important technical bases for realizing stable computation on large-scale optical hybrid computers.

Physical annealing systems provide heuristic approaches to solving combinatorial optimization problems. Here, we benchmark two types of annealing machines-a quantum annealer built by D-Wave Systems and measurement-feedback coherent Ising machines (CIMs) based on optical parametric oscillators-on two problem classes, the Sherrington-Kirkpatrick (SK) model and MAX-CUT. The D-Wave quantum annealer outperforms the CIMs on MAX-CUT on cubic graphs. On denser problems, however, we observe an exponential penalty for the quantum annealer [exp(-α DW N 2 )] relative to CIMs [exp(-α CIM N )] for fixed anneal times, both on the SK model and on 50% edge density MAX-CUT. This leads to a several orders of magnitude time-to-solution difference for instances with over 50 vertices. An optimal-annealing time analysis is also consistent with a substantial projected performance difference. The difference in performance between the sparsely connected D-Wave machine and the fully-connected CIMs provides strong experimental support for efforts to increase the connectivity of quantum annealers.

Many problems in mathematics, statistical mechanics, and computer science are computationally hard but can often be mapped onto a ground-state-search problem of the Ising model and approximately solved by artificial spin-networks of coupled degenerate optical parametric oscillators (DOPOs) in coherent Ising machines. To better understand their working principle and optimize their performance, we analyze the dynamics during the ground state search of 2D Ising models with up to 1936 mutually coupled DOPOs. For regular as well as frustrated and disordered 2D lattices, the machine finds the correct solution within just a few milliseconds. We determine that calculation performance is limited by freeze-out effects and can be improved by controlling the DOPO dynamics, which allows to optimize performance of coherent Ising machines in various tasks. Comparisons with Monte Carlo simulations reveal that coherent Ising machines behave like low temperature spin systems, thus making them suitable for optimization tasks.

Sudden death associated with patients with severe motor and intellectual disabilities (SMID) have been thought to be caused in part by venous thromboembolism (VTE), but actual situation of VTE in SMID is not clear. We examined the prevalence and location of deep venous thrombosis (DVT), and the relation of the development of crural veins in 16 patients with SMID, using ultrasonography. The maximum diameter of soleal vein was 1.6±0.5 mm. In most cases, DVT was found in the femoral veins. We could not detect thrombus in the soleal veins. In the present study, the detection ratio of DVT was high in patients with SMID who had restricted mobility capability and were bedridden, and we found the veins centrally from popliteal veins in DVT in SMID, not soleal veins, as the initial sites of the DVT. In the literature, the mean diameter of soleal veins, in healthy adults is 6.7±1.8 mm, that in contrast in SMID being smaller. Underdevelopment of intramuscular veins is possibly related to the mechanism of DVT in SMID. In the current guidelines for the management of VTE, there is limited in scope of ambulatory adults and no application cases who exhibit to SMID restricted mobility of the lower extremities and are bedridden associated with cerebral palsy and developmental motor disabilities, and such patients have associated high risk of the complications of DVT. According to our present study, it is necessary to provide appropriate guidelines for DVT in SMID considering characteristic features. (This is a translation of Jpn J Phlebol 2017; 28: 29-34.).

Coupled cavities have been used previously to realize on-chip low-dispersion slow-light waveguides, but the bandwidth was usually narrower than 10 nm and the total length was much shorter than 1 mm. Here we report long (0.05-2.5 mm) slow-light coupled cavity waveguides formed by using 50, 200, and 1,000 L3 photonic crystal nanocavities with an optical volume smaller than (λ/n) 3 , slanted from Γ-K orientation. We demonstrate experimentally the formation of a single-mode wideband coupled cavity mode with a bandwidth of up to 32nm (4THz) in telecom C-band, generated from the ultra-narrow-band (~300 MHz) fundamental mode of each L3 nanocavity, by controlling the cavity array orientation. Thanks to the ultrahigh-Q nanocavity design, coupled cavity waveguides longer than 1 mm exhibited low loss and allowed time-of-flight dispersion measurement over a bandwidth up to 22 nm by propagating a short pulse over 1,000 coupled L3 nanocavities. The highly-dense slanted array of L3 nanocavity demonstrated unprecedentedly high cavity coupling among the nanocavities. The scheme we describe provides controllable planar dispersion-managed waveguides as an alternative to W1-based waveguides on a photonic crystal chip.

High-dimensional quantum entanglement can enrich the functionality of quantum information processing. For example, it can enhance the channel capacity for linear optic superdense coding and decrease the error rate threshold of quantum key distribution. Long-distance distribution of a high-dimensional entanglement is essential for such advanced quantum communications over a communications network. Here, we show a long-distance distribution of a four-dimensional entanglement. We employ time-bin entanglement, which is suitable for a fibre transmission, and implement scalable measurements for the high-dimensional entanglement using cascaded Mach-Zehnder interferometers. We observe that a pair of time-bin entangled photons has more than 1 bit of secure information capacity over 100 km. Our work constitutes an important step towards secure and dense quantum communications in a large Hilbert space.

In the pursuance of equality, behavioural scientists disagree about distinct motivators, that is, consideration of others and prospective calculation for oneself. However, accumulating data suggest that these motivators may share a common process in the brain whereby perspectives and events that did not arise in the immediate environment are conceived. To examine this, we devised a game imitating a real decision-making situation regarding redistribution among income classes in a welfare state. The neural correlates of redistributive decisions were examined under contrasting conditions, with and without uncertainty, which affects support for equality in society. The dorsal anterior cingulate cortex (dACC) and the caudate nucleus were activated by equality decisions with uncertainty but by selfless decisions without uncertainty. Activation was also correlated with subjective values. Activation in both the dACC and the caudate nucleus was associated with the attitude to prefer accordance with others, whereas activation in the caudate nucleus reflected that the expected reward involved the prospective calculation of relative income. The neural correlates suggest that consideration of others and prospective calculation for oneself may underlie the support for equality. Projecting oneself into the perspective of others and into prospective future situations may underpin the pursuance of equality.

Most patients with severe motor and intellectual disabilities (SMID) have restricted mobility capability and have been bedridden for long periods because of paralysis of the extremities caused by abnormal muscular tonicity due to cerebral palsy and developmental disabilities. Such patients are associated with a high risk of complications like deep vein thrombosis (DVT). Here, we report twelve patients (42.9%) with DVT among 28 patients with SMID during prolonged bed rest. However, we did not detect thrombosis in the soleal veins, finding it mostly in the femoral and common femoral veins. We applied anticoagulant therapy (warfarin), and carefully followed up the cases with DVT, regulating the warfarin dosage at prothrombin time-international normalized ratio (PT-INR) values around two to prevent recurrence of chronic thrombosis. Regarding laboratory data for the coagulation system, there were no cases above 5 µg/ml for the D-dimer and there were significant differences between the DVT and non-DVT groups in the D-dimer levels. The plasma levels of D-dimer in patients with DVT diminished to less than 1.0 µg/ml after warfarin treatment. Concerning sudden death (4.2%) in patients with SMID, we have to be very careful of the possibility of pulmonary thromboembolism due to DVT. Therefore, we should consider the particularity of the underdeveloped vascular system from underlying diseases for the evaluation of DVT. A detailed study of DVT as a vascular complication is very important for the smooth medical care of SMID, and serial assessment of compression Doppler ultrasonography of the lower extremities, as a noninvasive examination and measurement of D-dimer, is very helpful. (This article is a translation of Jpn J Phlebol 2014; 25: 34-42.).

We demonstrate the generation and demultiplexing of quantum correlated photons on a monolithic photonic chip composed of silicon and silica-based waveguides. Photon pairs generated in a nonlinear silicon waveguide are successfully separated into two optical channels of an arrayed-waveguide grating fabricated on a silica-based waveguide platform.

We report the first entanglement generation experiment using an on-chip slow light device. With highly efficient spontaneous four-wave mixing enhanced by the slow light effect in a coupled resonator optical waveguide based on a silicon photonic crystal, we generated 1.5-μm-band high-dimensional time-bin entangled photon pairs. We undertook two-photon interference experiments and observed the coincidence fringes with visibilities >74%. The present result enables us to realize an on-chip entanglement source with a very small footprint, which is an essential function for quantum information processing based on integrated quantum photonics.

We report the distribution of time-bin entangled photon pairs over 300 km of optical fiber. We realized this by using a high-speed and high signal-to-noise ratio entanglement generation/evaluation setup that consists of periodically poled lithium niobate waveguides and superconducting single photon detectors. The observed two-photon interference fringes exhibited a visibility of 84%. We confirmed the violation of Bell's inequality by 2.9 standard deviations.

We demonstrate the generation of quantum-correlated photon pairs from a Si photonic-crystal coupled-resonator optical waveguide. A slow-light supermode realized by the collective resonance of high-Q and small-mode-volume photonic-crystal cavities successfully enhanced the efficiency of the spontaneous four-wave mixing process. The generation rate of photon pairs was improved by two orders of magnitude compared with that of a photonic-crystal line defect waveguide without a slow-light effect.

Integrated quantum optical circuits are now seen as one of the most promising approaches with which to realize single-photon quantum information processing. Many of the core elements for such circuits have been realized, including sources, gates and detectors. However, a significant missing function necessary for photonic quantum information processing on-chip is a buffer, where single photons are stored for a short period of time to facilitate circuit synchronization. Here we report an on-chip single-photon buffer based on coupled resonator optical waveguides (CROW) consisting of 400 high-Q photonic crystal line-defect nanocavities. By using the CROW, a pulsed single photon is successfully buffered for 150 ps with 50-ps tunability while maintaining its non-classical properties. Furthermore, we show that our buffer preserves entanglement by storing and retrieving one photon from a time-bin entangled state. This is a significant step towards an all-optical integrated quantum information processor.

Most patients with severe motor and intellectual disabilities (SMID) have restricted mobility capability and have been bedridden for long periods because of paralysis of the extremities caused by abnormal muscular tonicity due to cerebral palsy and developmental disabilities, and such patients are associated with a high risk for the complications of deep vein thrombosis (DVT). Here, we report 8 patients (34.8%) with DVT among 23 patients with SMID during prolonged bed rest. However, we did not detect thrombosis in the soleal veins, finding it mostly in the superficial femoral and common femoral veins. Regarding laboratory data for the coagulation system, there were no cases with D-dimer above 5 µg/ml. Concerning sudden death in patients with SMID, we have to be very careful of the possibility of pulmonary thromboembolism due to DVT. Therefore, we should consider the particularities of an underdeveloped vascular system from underlying diseases for the evaluation of DVT in patients with SMID. A detailed study of DVT as a vascular complication is very important for smooth medical care of SMID and compression Doppler ultrasonography of the lower extremities, as noninvasive examination, is very helpful. (English translation of Jpn J Phlebol 2012; 23: 17-24).

Integrated photonic circuits are one of the most promising platforms for large-scale photonic quantum information systems due to their small physical size and stable interferometers with near-perfect lateral-mode overlaps. Since many quantum information protocols are based on qubits defined by the polarization of photons, we must develop integrated building blocks to generate, manipulate, and measure the polarization-encoded quantum state on a chip. The generation unit is particularly important. Here we show the first integrated polarization-entangled photon pair source on a chip. We have implemented the source as a simple and stable silicon-on-insulator photonic circuit that generates an entangled state with 91 ± 2% fidelity. The source is equipped with versatile interfaces for silica-on-silicon or other types of waveguide platforms that accommodate the polarization manipulation and projection devices as well as pump light sources. Therefore, we are ready for the full-scale implementation of photonic quantum information systems on a chip.

We demonstrate highly enhanced optical nonlinearity in a coupled-resonator optical waveguide (CROW) in a four-wave mixing experiment. Using a CROW consisting of 200 coupled resonators based on width-modulated photonic crystal nanocavities in a line defect, we obtained an effective nonlinear constant exceeding 10,000 /W/m, thanks to slow light propagation combined with a strong spatial confinement of light achieved by the wavelength-sized cavities.

We have demonstrated quantum key distribution (QKD) over 100 km using single-photon detectors based on InGaAs/InP avalanche photodiodes (APDs). We implemented the differential phase shift QKD (DPS-QKD) protocol with electrically cooled and 2-GHz sinusoidally gated APDs. The single-photon detector has a dark count probability of 2.8 × 10(-8) (55 counts per second) with a detection efficiency of 6 %, which enabled us to achieve 24 kbit/s secure key rate over 100 km of optical fiber. The DPS-QKD system offers better performances in a practical way than those achieved using superconducting single-photon detectors. Moreover, the distance that secure keys against the general individual attacks can be distributed has been extended to 160 km.

We report an entanglement-based quantum key distribution experiment that we performed over 100 km of optical fiber using a practical source and detectors. We used a silicon-based photon-pair source that generated high-purity time-bin entangled photons, and high-speed single photon detectors based on InGaAs/InP avalanche photodiodes with the sinusoidal gating technique. To calculate the secure key rate, we employed a security proof that validated the use of practical detectors. As a result, we confirmed the successful generation of sifted keys over 100 km of optical fiber with a key rate of 4.8 bit/s and an error rate of 9.1%, with which we can distill secure keys with a key rate of 0.15 bit/s.

Here we report the first demonstration of entanglement distribution over a record distance of 200 km which is of sufficient fidelity to realize secure communication. In contrast to previous entanglement distribution schemes, we use detection elements based on practical avalanche photodiodes (APDs) operating in a self-differencing mode. These APDs are low-cost, compact and easy to operate requiring only electrical cooling to achieve high single photon detection efficiency. The self-differencing APDs in combination with a reliable parametric down-conversion source demonstrate that entanglement distribution over ultra-long distances has become both possible and practical. Consequently the outlook is extremely promising for real world entanglement-based communication between distantly separated parties.

Quantum state tomography (QST) is an important method for evaluating the quality of entangled photon pairs, and has been widely used to measure polarization entanglement. However, QST has not been applied to time-bin entanglement, which is a type of entanglement suitable for fiber transmission. In this paper, we clarify the way to implement QST on time-bin entangled photon pairs using a 1-bit delayed interferometer. We also provide experimental results for a demonstration of QST for time-bin entangled photon pairs generated using spontaneous four-wave mixing in a dispersion shifted fiber.

We report the first entanglement swapping experiment using entangled photon-pair sources based on spontaneous four-wave mixing (SFWM). The 1.5-microm band entangled photon pairs generated by SFWM in two independent 500-m dispersion shifted fibers exhibited quantum interference, thanks to the negligible walk-off between the pump and photon pairs. The use of 500-MHz gated-mode InGaAs/InP avalanche photodiodes based on the sine-wave gating technique increased the fourfold coincidence rate. As a result, the formation of an entanglement between photons from independent sources was successfully observed.

We observed high-purity correlated and entangled photon pairs generated through spontaneous four-wave mixing (SFWM) in a silicon wire waveguide (SWW). Employing a nano-scale silicon waveguide with a low loss mode size converter, we obtained a high coincidence to accidental coincidence ratio (CAR) of around 200 that was larger than that of cooled dispersion shifted fiber (DSF) by a factor 3.2, and observed the two-photon interference fringe of time-bin entangled photons with > 95% visibility without subtracting the accidental coincidences.

We report the first entanglement-based quantum key distribution (QKD) experiment over a 100-km optical fiber. We used superconducting single photon detectors based on NbN nanowires that provide high-speed single photon detection for the 1.5-mum telecom band, an efficient entangled photon pair source that consists of a fiber coupled periodically poled lithium niobate waveguide and ultra low loss filters, and planar lightwave circuit Mach-Zehnder interferometers (MZIs) with ultra stable operation. These characteristics enabled us to perform an entanglement-based QKD experiment over a 100-km optical fiber. In the experiment, which lasted approximately 8 hours, we successfully generated a 16 kbit sifted key with a quantum bit error rate of 6.9 % at a rate of 0.59 bits per second, from which we were able to distill a 3.9 kbit secure key.

A quantum secret sharing (QSS) protocol based on a differential-phase-shift scheme is proposed, which quantum mechanically provides a full secret key to one party and partial keys to two other parties. A weak coherent pulse train is utilized instead of individual photons as in conventional schemes. Compared with previous QSS protocols, the present one features a simple setup, is suitable for fiber transmission, and offers the possibility for a high key creation rate. An experiment is also carried out to demonstrate the operation.

In this letter, we report an experimental realization of distributing entangled photon pairs over 100 km of dispersion-shifted fiber. In the experiment, we used a periodically poled lithium niobate waveguide to generate the time-energy entanglement and superconducting single-photon detectors to detect the photon pairs after 100 km. We also demonstrate that the distributed photon pairs can still be useful for quantum key distribution and other quantum communication tasks.

We report the experimental generation of polarization entangled photon pairs based on spontaneous four-wave mixing in a silicon waveguide. Using a nano-scale silicon wire waveguide placed in a fiber loop, we obtained 1.5-microm band polarization entanglement with two-photon interference visibilities of >83%.

This letter reports telecom-band sequential time-bin entangled photon-pair generation at a repetition rate of 10 GHz in periodically poled reverse-proton-exchange lithium niobate waveguides based on mode demultiplexing. With up-conversion single-photon detectors, we observed an entangled-photon-pair flux of 313 Hz and a two-photon-interference-fringe visibility of 85.32% without subtraction of accidental noise contributions.

We report an experimental demonstration of the distribution of time-bin entangled photon pairs over 100 km of optical fiber. In our experiment, 1.5-mum non-degenerated time-bin entangled photon pairs were generated with a periodically poled lithium niobate (PPLN) waveguide by using the parametric down conversion process. Combining this approach with ultra-low-loss filters to eliminate the pump light and separate signal and idler photons, we obtained an efficient entangled photon pair source. To detect the photons, we used single-photon detectors based on frequency up-conversion. These detectors operated in a non-gated mode so that we could use a pulse stream of time correlated entangled photon pairs at a high repetition frequency (1 GHz). Using these elements, we distributed time-bin entangled photon pairs over 100 km of dispersion shifted fiber and performed a two-photon interference experiment. We obtained a coincidence fringe of 81.6% visibility without subtracting any background noise, such as accidental coincidence or dark count, which was good enough to violate Bell's inequality. Thus, we successfully distributed time-bin entangled photon pairs over 100 km.

We report 10-ps correlated photon pair generation in periodically-poled reverse-proton-exchange lithium niobate waveguides with integrated mode demultiplexer at a wavelength of 1.5-mum and a clock of 10 GHz. Using superconducting single photon detectors, we observed a coincidence to accidental count ratio (CAR) as high as 4000. The developed photon-pair source may find broad application in quantum information systems as well as quantum entanglement experiments.

We report the generation of 1.5-mm-band energy-time entangled photon pairs using a periodically poled lithium niobate (PPLN) waveguide. We performed a two-photon interference experiment and obtained coincidence fringes with 77.3% visibilities without subtracting accidental coincidences.

We present a quantum key distribution experiment in which keys that were secure against all individual eavesdropping attacks allowed by quantum mechanics were distributed over 100 km of optical fiber. We implemented the differential phase shift quantum key distribution protocol and used low timing jitter 1.55 microm single-photon detectors based on frequency up-conversion in periodically poled lithium niobate waveguides and silicon avalanche photodiodes. Based on the security analysis of the protocol against general individual attacks, we generated secure keys at a practical rate of 166 bit/s over 100 km of fiber. The use of the low jitter detectors also increased the sifted key generation rate to 2 Mbit/s over 10 km of fiber.

We report a 1.5- mum band polarization independent single photon detector based on frequency up-conversion in periodically poled lithium niobate (PPLN) waveguides. To overcome the polarization dependence of the PPLN waveguides, we employed a polarization diversity configuration composed of two up-conversion detectors connected with a polarization beam splitter. We experimentally confirmed polarization independent single photon counting using our detector. We undertook a proof-of-principle differential phase shift quantum key distribution experiment using the detector, and confirmed that the sifted key rate and error rate remained stable when the polarization state was changed during single photon transmission.

This paper reports the first quantum key distribution experiment implemented with a 10-GHz clock frequency. We used a 10-GHz actively mode-locked fiber laser as a source of short coherent pulses and single photon detectors based on frequency up-conversion in periodically poled lithium niobate waveguides. The use of short pulses and low-jitter upconversion detectors significantly reduced the bit errors caused by detector dark counts even after long-distance transmission of a weak coherent state pulse. We employed the differential phase shift quantum key distribution protocol, and generated sifted keys at a rate of 3.7 kbit/s over a 105 km fiber with a bit error rate of 9.7%.

This paper reports the first demonstration of the generation and distribution of time-bin entangled photon pairs in the 1.5-microm band using spontaneous four-wave mixing in a cooled fiber. Noise photons induced by spontaneous Raman scattering were suppressed by cooling a dispersion shifted fiber with liquid nitrogen, which resulted in a significant improvement in the visibility of two-photon interference. By using this scheme, time-bin entangled qubits were successfully distributed over 60 km of optical fiber with a visibility of 76%, which was obtained without removing accidental coincidences.

Spontaneous four-wave mixing in a dispersion-shifted fiber (DSF) is a promising approach for generating quantum-correlated photon pairs in the 1.5 microm band. However, it has been reported that noise photons generated by the spontaneous Raman scattering process degrade the quantum correlation of the generated photons. This paper describes the characteristics of quantum-correlated photon pair generation in a DSF cooled by liquid nitrogen. With this technique, the number of noise photons was sufficiently suppressed and the ratio of true coincidence to accidental coincidence was increased to ~30.