Ullah H, Huma S, Naeem L, Yasin G, Ashraf M, Tahir N, Yunus M, Shabana H, Shalaby AH, Hassan Ali AA, Mohamed Mahmoud ME, Elsayed Tayee EM, Elbwab AFAE, Alhawy AME, Abotaha AAM, Abdelraouf ME, Imam MS, Aladl HAA, Shawky TA, Said AM, Saeed Mahmoud M, Tayee KM, Mohamed RF, Farahat AH, Alsayyad MMAA, Lashin HES, Hamed HI, Ayoub HSAS, and Ahmed Nafie AMS
Himayat Ullah,1 Sarwat Huma,2,3 Lubna Naeem,4 Ghulam Yasin,1 Muhammad Ashraf,1 Nafisa Tahir,5 Mohammed Yunus,6 Hossam Shabana,1,7 Abdulrahman H Shalaby,7 Ahmed Ali Hassan Ali,7 Mohamed Elwan Mohamed Mahmoud,7 Elsayed Mohamed Elsayed Tayee,8 Ahmed Farag Abd Elkader Elbwab,7 Ahmed Mohamed Ewis Alhawy,7 Ahmed Ahmed Mohamed Abotaha,7 Mahmoud Ezzat Abdelraouf,7 Mohammed S Imam,7 Hossam Aladl Aladl Aladl,7 Taiseer Ahmed Shawky,7 Ashraf Mohammed Said,7 Mahmoud Saeed Mahmoud,9 Kazem Mohamed Tayee,7 Reda Fakhry Mohamed,7 Ali Hosni Farahat,7 Mohammad Mossaad Abd Allah Alsayyad,9 Hesham El Sayed Lashin,7 Hani Ismail Hamed,7 Hazem Sayed Ahmed Sayed Ayoub,7 Ayman Mohamed Salem Ahmed Nafie7 1Department of Medicine, Shaqra College of Medicine, Shaqra University, Shaqra, Saudi Arabia; 2Department of Health Professions Education, Health Services Academy, Islamabad, Pakistan; 3Department of Cardiology, Hayatabad Medical Complex, Peshawar, Pakistan; 4Department of Oral Biology, Riphah International University, Islamabad, Pakistan; 5Department of Medicine, NSHS, National University of Science and Technology, Islamabad, Pakistan; 6Department of Pathology, Maiwand Teaching Hospital, Kabul University of Medical Sciences (KUMS), Kabul, Afghanistan; 7Internal Medicine Department, Al-Azhar University, Cairo, Egypt; 8Faculty of Medicine, Helwan University, Cairo, Egypt; 9Faculty of Medicine for Boys, Al-Azhar University, New Damietta, EgyptCorrespondence: Mohammed Yunus, Department of Pathology, Maiwand Teaching Hospital, Kabul University of Medical Sciences (KUMS), Kabul, Afghanistan, Email m_yunus6061@yahoo.comPurpose: Coronary artery disease (CAD), clinically manifested as coronary syndrome (CS), is the leading cause of death and a significant contributor to morbidity worldwide. Elevated serum homocysteine levels have been associated with an increased risk of cardiovascular diseases, including CAD. Despite extensive research, the relationship between serum homocysteine and coronary syndromes with related short-term mortality is still under-studied. The main objective of this study is to evaluate the correlation between serum homocysteine levels and various types of CS, as well as in-hospital mortality in these patients.Patients and Methods: This multicenter study included 381 CS patients from Afghanistan, Egypt, and Pakistan tertiary care hospitals. The relation of serum homocysteine levels with different types of CS as well as with in-hospital mortality was measured and analyzed using inferential statistics (ANOVA, Kruskal–Wallis test, Tukey’s post-hoc, Pearson correlation, etc.) and regression analysis (Binary regression).Results: Among 381 patients from both genders, 160 were from Pakistan, 130 from Egypt, and 91 from Afghanistan. There was no significant difference in baseline characteristics, like age, gender, homocysteine level, CS type, and mortality, among the three countries (p > 0.05). The one-way ANOVA, the Kruskal Wallis Test, and Tukey’s post hoc test showed a significant difference among different CS groups based on serum homocysteine levels, and Pearson correlation showed a strong correlation between serum homocysteine and CS (r = 0.4). Binary regression analysis showed a 10.5% increase in in-hospital mortality for each 1 μmol/L increase in homocysteine levels.Conclusion: Serum homocysteine could serve as a valuable biomarker and mortality predictor in CS patients.Keywords: serum homocysteine, coronary artery disease (CAD), coronary syndromes (CS), cardiac biomarkers, risk factors of CAD