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Purpose:Myelodysplastic syndrome (MDS) is associated with a dysregulated innate immune system. The purpose of this study was to determine whether modulation of the innate immune system via high mobility group box-1 (HMGB1) could reduce cell viability in MDS.Experimental Design:We quantified HMGB1 in an MDS cell line MDS-L and in primary MDS cells compared with nonmalignant hematopoietic cells. We performed loss-of-function studies of HMGB1 using pooled siRNAs and a small-molecule inhibitor sivelestat compared with standard chemotherapy. We measured levels of engraftment of MDS-L cells in NOD-scidIL2Rgnull (NSG) mice following treatment with sivelestat. Mechanistically, we interrogated cell survival pathways and 45 targets within the NFκB pathway using both protein analysis and a proteome profiler array.Results:We discovered that HMGB1 had increased expression in both MDS-L cells and in primary CD34+ MDS cells compared with healthy CD34+ hematopoietic cells. Sivelestat impaired MDS cell expansion, increased cellular death, and spared healthy hematopoietic cells. MDS-L marrow engraftment is reduced significantly at 17 weeks following treatment with sivelestat compared with control mice. Treatment of CD34+ MDS cells with sivelestat and azacitidine or decitabine was additive to increase apoptotic cell death compared with chemotherapy alone. Sivelestat promoted apoptosis with increased expression of PUMA, activated caspase 3, and increased DNA double-strand breaks. Inhibition of HMGB1 reduced levels of Toll-like receptors (TLR) and suppressed activation of NFκB in MDS-L cells.Conclusions:Inhibition of HMGB1 could promote MDS cell death and alter innate immune responses via suppression of NFκB pathways.

Purpose: Myelodysplastic syndrome (MDS) is associated with a dysregulated innate immune system. The purpose of this study was to determine whether modulation of the innate immune system via high mobility group box-1 (HMGB1) could reduce cell viability in MDS. Experimental Design: We quantified HMGB1 in an MDS cell line MDS-L and in primary MDS cells compared with nonmalignant hematopoietic cells. We performed loss-of-function studies of HMGB1 using pooled siRNAs and a small-molecule inhibitor sivelestat compared with standard chemotherapy. We measured levels of engraftment of MDS-L cells in NOD-scidIL2Rgnull (NSG) mice following treatment with sivelestat. Mechanistically, we interrogated cell survival pathways and 45 targets within the NFκB pathway using both protein analysis and a proteome profiler array. Results: We discovered that HMGB1 had increased expression in both MDS-L cells and in primary CD34+ MDS cells compared with healthy CD34+ hematopoietic cells. Sivelestat impaired MDS cell expansion, increased cellular death, and spared healthy hematopoietic cells. MDS-L marrow engraftment is reduced significantly at 17 weeks following treatment with sivelestat compared with control mice. Treatment of CD34+ MDS cells with sivelestat and azacitidine or decitabine was additive to increase apoptotic cell death compared with chemotherapy alone. Sivelestat promoted apoptosis with increased expression of PUMA, activated caspase 3, and increased DNA double-strand breaks. Inhibition of HMGB1 reduced levels of Toll-like receptors (TLR) and suppressed activation of NFκB in MDS-L cells. Conclusions: Inhibition of HMGB1 could promote MDS cell death and alter innate immune responses via suppression of NFκB pathways.

A novel machine-learning algorithm based on single-shot measurements, named single-shot measurement learning, is demonstrated achieving the theoretical optimal accuracy. The method is at least as efficient as existing tomographic schemes and computationally much less demanding. The merits are attributed to the inclusion of weighted randomness in the learning rule governing the exploration of diverse learning routes. These advantages are explored experimentally by a linear-optical setup that is designed to draw the fullest potential of the proposed method. The experimental results show an unprecedented high level of accuracy for qubit-state learning and reproduction exhibiting (nearly) optimal infidelity scaling, O(N^{-0.983}), for the number N of unknown state copies, down to

Quantum teleportation allows to transfer unknown quantum states between distant parties. It is not only a primitive of quantum communications but also an essential task in realization of the quantum networks for promising applications such as quantum cryptography and distributed quantum computation. Despite recent substantial progresses in the realization of quantum communications, teleportation of shared quantum information between multiple senders and receivers is still missing. Here we propose and experimentally demonstrate quantum teleportation among spatially separate parties in a quantum network. The protocol can be jointly performed by distributed participants, while none of them can fully access the transferred information. It can be generally extended to quantum communications incorporating an arbitrary number of parties without a trusted central node. Our work opens a route to the realization of distributed quantum communications and computations in quantum networks

We experimentally demonstrate a time-multiplexing method for pulse-pumped heralded single-photon sources using switchable optical fiber delay lines. The optical fibers constitute a 32-channel binary-division photon buffer that can multiplex time slots into single temporal mode to enhance single-photon generation rate without increasing multi-photon noise. Relative time multiplexing using the same actively controlled variable delay realizes Hong-Ou-Mandel interferometry by two photons produced in arbitrary two time-bins. The interference dip depth in good agreement with theory verifies path length matching within the photonic coherence length and dispersion compensation of the optical fiber delay sections. We independently confirm by low-coherence interferometry that the internal optical path lengths of the optical switches are constant during the switching operations.

We propose a schematic setup of quantum key distribution (QKD) with an improved secret key rate based on high-dimensional quantum states. Two degrees-of-freedom of a single photon, orbital angular momentum modes, and multi-path modes, are used to encode secret key information. Its practical implementation consists of optical elements that are within the reach of current technologies such as a multiport interferometer. We show that the proposed feasible protocol has improved the secret key rate with much sophistication compared to the previous 2-dimensional protocol known as the detector-device-independent QKD., Comment: 10 pages, 6 figures

We calculate optical properties of guided modes of a hybrid-guiding photonic crystal fiber. The design and modeling of such hybrid-guiding PCF is made by replacing air holes with inserts of high refractive index material layer by layer in order. The optical properties such as mode intensity profile, mode dispersion, optical birefringence, confinement loss, and chromatic dispersion during transition of the guiding mechanism are analyzed and discussed. The guided modes in the hybrid-guiding region are also compared with those of reference index-guiding and bandgap-guiding photonic crystal fibers.

177 Copyrightc 2016 The Korean Association of Internal Medicine This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted noncommercial use, distribution, and reproduction in any medium, provided the original work is properly cited. Received: 2015. 8. 24 Revised: 2015. 9. 10 Accepted: 2015. 9. 16

In this paper, we propose a deterministic secure quantum communication (DSQC) protocol based on the BB84 system. We developed this protocol to include quantum entity authentication in the DSQC procedure. By first performing quantum entity authentication, it was possible to prevent third-party intervention. We demonstrate the security of the proposed protocol against the intercept-and-re-send attack and the entanglement-and-measure attack. Implementation of this protocol was demonstrated for quantum channels of various lengths. Especially, we propose the use of the multiple generation and shuffling method to prevent a loss of message in the experiment.

In this study, a cotton knit was dyed with elm bark extract; subsequently, the dyed fabric was measured according to the types of mordants and the preprocessing cationizers used. Additionally, antibiosis against super bacteria was examined. The results follow. First, the color of the dyed cotton knit appeared reddish and yellowish for fabrics treated with non-mordants and mordants. When preprocessing with a cationizer was conducted, the dyeing properties were the best. Second. even when mordants were not used for dyeing, color fastness after washing, sweating, and rubbing was generally good Grade 4 and 5. Color fastness after exposure to sunlight was the best Grade 4 for fabric prepared with ferrous sulfate as the mordant. Third. as for antimicrobial properties, or resistance to super bacteria, the growth of bacteria was suppressed in a meaningful way for fabrics treated with non-mordants and mordants, compared to the control group fabric. The dyeing methods with the most powerful antimicrobial effects were dyeing after preprocessing with a cationizer and preparing fabric with copper sulfate as the mordant. The results stated above show that in case of dyeing with elm bark extract, preprocessing of the cotton knit with a cationizer and dying with copper mordant displayed high levels of antimicrobial properties that were useful for resisting super bacteria. Of these the dyeing properties were the best when preprocessing with a cationizer.

[Purpose] The purpose of this study was to compare the strength and endurance of the orbicularis oris muscle in healthy Korean (young vs. elderly adults). [Participants and Methods] A total of 60 participants (30 young adults and 30 elderly adults) were recruited. The Iowa Oral Performance Instrument was used to measure orbicularis oris muscle maximal strength and endurance. [Results] Elderly adults showed significantly lower orbicularis oris muscle strength and endurance than younger adults. [Conclusion] This study confirmed a significant age-related decrease in orbicularis oris muscle strength and endurance. The data collected will be useful as a basis for future on speech and swallowing therapy.

[Purpose] We aimed to investigate the effect of resistance training of the orbicularis oris muscles on lip muscle strength and closure function in patients with swallowing disorder with facial palsy after stroke. [Participants and Methods] This study recruited 10 patients with swallowing disorder and facial palsy after stroke. All the participants received orbicularis oris muscle training at an intensity of 70% of 1 repetition maximum by using an Iowa oral performance instrument. Muscle strength and lip closure function were evaluated after orbicularis oris muscle training. [Results] After the intervention, the orbicularis oris muscle strength showed a statistically significant increase from 20.5 ± 5.15 to 25.3 ± 4.2 kilopascal. Lip closure function showed a statistically significant improvement from 2.6 ± 1.5 to 1.2 ± 1.0. [Conclusion] This study recommends to train at an intensity of 70% of 1 repetition maximum for 4 weeks to increase theorbicularis oris muscle strength and improve lip closure function.

A 48-year-old woman was referred to our clinic because she had been experiencing hemoptysis for 1 month. Chest computed tomography revealed a small portion of a thyroid mass was penetrating the trachea. Bronchoscopy revealed a blood vessel covered mass located in her trachea. The presence of a malignant tumor was confirmed by a biopsy. The patient was referred to the otolaryngology department for tumor resection and a pathological evaluation identified the thyroid angiosarcoma with tracheal invasion. Angiosarcomas have a poor prognosis, but the patient has not experienced any recurrence two years after surgery. A very rare case of primary thyroid angiosarcoma with tracheal invasion was cured successfully.

We propose a linear optical scheme that can conditionally generate high NOON states using polarization modes. This scheme provides advantages over the previous proposals on path-entangled NOON states in view of success probability or required resources of optical elements. We also investigate two experimental schemes feasible within existing technology that can produce the NOON-like or the NOON state for N = 4., Published version, 5 pages, 4 figures

[Purpose] This study investigated the effects of mirror therapy and neuromuscular electrical stimulation on upper extremity function in stroke patients. [Subjects and Methods] This study recruited 8 stroke patients. All patients were treated with mirror therapy and neuromuscular electrical stimulation five times per week for 4 weeks. Upper limb function evaluation was performed using upper extremity part of fugl meyer assessment. [Results] Before and after intervention, fugl meyer assessment showed significant improvement. [Conclusion] In this study, mirror therapy and neuromuscular electrical stimulation are effective methods for upper extremity function recovery in stroke patients.

High-dimensional entanglement is a valuable resource for secure and efficient quantum information processing. A major challenge for practical use of multidimensional quantum systems is the establishment of controls over arbitrary superposition states in realistic conditions. This work demonstrates spatially entangled photon pairs propagating through two separate four-core optical fibers with the amplitudes and phases of the superposition being independently controllable. Using quantum state analyzers that can detect arbitrary multicore superposition states, Bell-type CGLMP inequalities in two, three, and four dimensions are directly tested. Enhanced violation of the inequality by slight nonmaximality of entanglement is also demonstrated.

Myelodysplastic syndrome (MDS) is a heterogeneous and pre-leukemic clonal stem cell disorder characterized by aberrant hematopoiesis and bone marrow failure. Since MDS is associated with a dysregulated innate immune system, we performed a genetic screen of the human toll-like receptor (TLR) pathway and found that high mobility group box-1 (HMGB1) was abundantly expressed in MDS. HMGB1 is a ubiquitously expressed, non-histone chromatin-binding protein. In solid cancers, high expression of HMGB1 was associated with both shortened progression-free and overall survival, but its role in hematologic malignancies is not well defined. We hypothesized that targeting HMGB1 could be therapeutic in MDS. To study HMGB1 in human MDS, we utilized a cell line, MDS-L, derived from a patient with myelodysplastic syndrome with ring sideroblasts. Morphologically, the cells display dysplastic features, including cytoplasmic vacuolation and prominent, irregular nucleoli. We found that HMGB1 was detected at high levels in both MDS-L and in primary CD34+ MDS compared to CD34+ cord blood and healthy human marrow (*p Next, we sought to pharmacologically inhibit HMGB1 signaling with sivelestat, which is a small molecule inhibitor for neutrophil elastase and HMGB1. Since sivelestat has not been studied in either normal or malignant hematopoiesis, whether it or other HMGB1 inhibitors could impact MDS is not yet defined. Following 72 h culture, HMGB1 protein levels were decreased in both MDS-L cells and in primary CD34+ MDS cells treated with 300 mg/ml sivelestat compared to cultures with vehicle alone (*p Since treatment with sivelestat could decrease both MDS cell expansion and impair the ability to generate colonies in methylcellulose assays, we sought to determine whether blocking HMGB1 could decrease MDS engraftment in NOD-scid ILR2gnull (NSG) mice. At 17 weeks, irradiated NSG mice that were transplanted with MDS-L cells treated with sivelestat demonstrated a 3.2-fold decrease in human CD45 marrow engraftment with MDS-L compared to control cultures (*p Mechanistically, sivelestat increased cellular apoptosis in cultures of MDS cells compared to control cultures (*p=0.001). This was done in part by increasing levels of p53 upregulated modulator of apoptosis (PUMA, *p=0.0003), activated caspase 3 (*p Disclosures No relevant conflicts of interest to declare.

Photons have proven to be excellent carriers of quantum information and play essential roles in numerous quantum information processing (QIP) applications. In particular, heralded single-photon sources via spontaneous parametric-down conversion (SPDC) have been a key technology for demonstrating small-scale QIP, yet their low generation efficiency is a critical limitation to furthering the scale-up of optical QIP technology. In order to efficiently overcome the probabilistic nature of SPDC, here we demonstrate time multiplexing for up to 30 time slots of a periodically pumped heralded single-photon source using a switchable low-loss optical storage cavity. We observe a maximum single-photon probability of 38.6±0.4% in periodic output time windows, corresponding to ∼6 times enhancement over a nonmultiplexed source but with no increase in the contribution of unwanted multiphoton events. Combining this time-multiplexing technique with a heralded source producing pure single-photon states should enable larger-scale optical QIP systems than previously realized.

We demonstrate an experimental technique to generate and measure arbitrary superpositions of core modes in a multi-core fiber. Two spatial light modulators couple the fundamental mode of a single-mode fiber with multiple-core modes of the MCF to constitute a Mach-Zehnder-type multi-path interferometer. The phase tunability of each path is verified by comparing two-, three-, and four-path interference patterns with the theory. Interference fringes in the wavelength domain estimates the inter-core group index differences with a resolution of 10(-5) using a fiber length of 1 m.

A fiber-optic analogue to an externally driven three-level quantum state is demonstrated by acousto-optic coupling of the spatial modes in a few-mode fiber. Under the condition analogous to electromagnetically induced transparency, a narrow-bandwidth transmission within an absorption band for the fundamental mode is demonstrated. The presented structure is an efficient converter between the fundamental mode and the higher-order modes that cannot be easily addressed by previous techniques, therefore can play a significant role in the next-generation space-division multiplexing communications as an arbitrarily mode-selectable router. (C) 2014 Optical Society of America

Beam recombination characteristics were numerically investigated in array laser amplification using stimulated Brillouin scattering phase conjugation. To clarify the effect of piston errors due to imperfect phase locking, spatial intensity profiles of the beam recombination output were calculated in both the near and the far field on the basis of Rayleigh-Sommerfeld diffraction theory. The analyses indicate that piston errors are seriously detrimental to the quality of a beam recombination output and should be eliminated by a proper phase locking. It is also found that the gap between the beam splitting-combining wedges has a negligible effect.

We propose a multi-photon interferometer with a generalized C-SWAP operation that can estimate Tr[rho(1)rho(2)center dot center dot center dot rho(n)], a nonlinear functional of n photonic density matrices. The scheme is demonstrated for three single-photon states whose overlap is experimentally measured as the interference visibility of a control qubit encoded into photonic paths. The validity of this method is verified by comparing the visibility with the results of Hong-Ou-Mandel experiments. (C) 2013 Optical Society of America

We propose and demonstrate the scaling up of photonic graph state through path qubit fusion. Two path qubits from separate two-photon four-qubit states are fused to generate a two-dimensional seven-qubit graph state composed of polarization and path qubits. Genuine seven-qubit entanglement is verified by evaluating the witness operator. Six qubits from the graph state are used to execute the general two-qubit Deutsch-Jozsa algorithm with a success probability greater than 90%., Comment: 4 pages. Supplementary Material is included in the zip file

Whether entanglement in a state can be detected, distilled, and quantified without full state reconstruction is a fundamental open problem. We demonstrate a new scheme encompassing these three tasks for arbitrary two-qubit entanglement, by constructing the optimal entanglement witness for polarization-entangled mixed-state photon pairs without full state reconstruction. With better efficiency than quantum state tomography, the entanglement is maximally distilled by newly developed tunable polarization filters, and quantified by the expectation value of the witness, which equals the concurrence. This scheme is extendible to multiqubit Greenberger-Horne-Zeilinger entanglement., Comment: Phys. Rev. Lett. 105, 230404 (2010); supplementary information (OWitness_sup.pdf) is included in source zip file

Spatial interference of quantum mechanical particles exhibits a fundamental feature of quantum mechanics. A two-mode entangled state of N particles known as N00N state can give rise to non-classical interference. We report the first experimental observation of a three-photon N00N state exhibiting Young's double-slit type spatial quantum interference. Compared to a single-photon state, the three-photon entangled state generates interference fringes that are three times denser. Moreover, its interference visibility of $0.49 \pm 0.09$ is well above the limit of 0.1 for spatial super-resolution of classical origin. The demonstration of spatial quantum interference by a N00N state composed of more than two photons represents an important step towards applying quantum entanglement to technologies such as lithography and imaging.

We propose a novel approach to optical generation of superresolution atomic state density distribution based on interaction between Lambda- type atoms and temporally-cascaded driving fields. The scheme effectively inscribes multiplication of optical intensity profiles on atomic state density distribution, which can produce arbitrary patterns beyond the diffraction limit. The degree of resolution enhancement can be increased, not depending on the intrinsic nonlinearity of the photographic medium or the number of simultaneously interacting fields unlike the previous schemes. Procedures for drawing arbitrary two-dimensional patterns and effects of atomic state decoherence are described.

Hepatitis C virus (HCV) mainly affects the liver, but several tissues outside the liver have also been reported to be involved. It has been hypothesized that diabetes could be one of these extrahepatic conditions attributable to HCV infection. The specific mechanisms by which HCV leads to type 2 diabetes are not fully understood, but it seems that an increase in insulin resistance associated with both steatosis and overproduction of proinflammatory cytokines could play a crucial role. We report a patient whose type 2 diabetes that was resolved following interferon-α (IFN-α) therapy for HCV. A 57-year-old man presented with fatigue, polyuria, and polydipsia. He was newly diagnosed as type 2 diabetes and chronic hepatitis C. He was started on subcutaneous insulin and IFN-α. After 24 weeks of treatment with IFN-α, the results of HCV polymerase chain reaction were negative, and his diabetes had resolved. Our case shows a resolution of diabetes after IFN-α therapy for chronic hepatitis C. Although it is unclear whether the resolution of diabetes in this case occurred as an effect of IFN-α or as a result of becoming HCV RNA-negative, our finding suggest roles of IFN-α and HCV infection in the pathogenesis of diabetes.

Iatrogenic aortic dissection occurs in association with diverse invasive procedures. It occurs primarily as a complication of cardiac surgery or after catheterization procedure. We found a case of iatrogenic abdominal aortic dissection caused by traumatic needle injury. The patient complained of abdominal pain after balloon kyphoplasty. Abdominal computed tomography (CT) showed intramural hematoma with air density suggestive of an iatrogenic cause. The patient was managed conservatively, and no lesion progression was noted in the follow-up CT. To the best of our knowledge, this is the first case of iatrogenic aortic dissection associated with kyphoplasty.

Myocardial bridging (MB) occurs when the myocardium covers a segment of a major epicardial coronary artery, resulting in a tunneled arterial segment. Although MB is generally considered benign, it has been associated with myocardial ischemia. A 70-year-old man with MB (50% luminal narrowing during systole) at the mid-left anterior descending artery (LAD) on previous coronary angiography (CAG) visited our hospital with worsening chest pain. His blood pressure (BP) was not well controlled because of poor compliance. Follow-up CAG showed that MB at the mid-LAD progressed to severe stenosis (>90% luminal narrowing during systole) and the total length of tunneled artery extended from 22.5 to 23.9 mm. His chest pain was relieved by BP control. This is the first report of myocardial ischemia secondary to progression of MB demonstrated by CAG in Korea.

We describe a novel optical acoustic detector based on a bias-controlled fiber Fabry-Perot interferometer. The detector has a broad bandwidth from 10 Mhz to a few gigahertz and higher sensitivity than conventional systems, which are useful for noncontact characterization of microsamples based on laser ultrasound.

We propose and experimentally demonstrate a two-photon four-qubit cluster state generator using linear optics and a single polarization-entangled photon-pair source based on spontaneous parametric down-conversion (SPDC). Our novel scheme provides greater design flexibility compared to previous schemes that rely on hyperentanglement.