1. Oral fungal profiling and risk of nasopharyngeal carcinoma: a population-based case-control study.
- Author
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Chen, Yufeng, Li, Wanxin, Chang, Ellen, Debelius, Justine, Manoharan, Lokeshwaran, Zheng, Yuming, Li, Yancheng, Huang, Guangwu, Adami, Hans-Olov, Cai, Yonglin, Zhang, Zhe, Ye, Weimin, and Knight, Robin
- Subjects
Case–control study ,Fungi ,ITS sequencing ,Microbiome ,Nasopharyngeal carcinoma ,Oral mycobiome - Abstract
BACKGROUND: Dysbiosis of the oral mycobiome has been linked to some diseases, including cancers. However, the role of oral fungal communities in nasopharyngeal carcinoma (NPC) carcinogenesis has not previously been investigated. METHODS: We characterized the oral salivary fungal mycobiome in 476 untreated incident NPC patients and 537 population-based controls using fungal internal transcribed spacer (ITS)-2 sequencing. The relationship between oral fungal mycobiome and the risk of NPC was assessed through bioinformatic and biostatistical analyses. FINDINGS: We found that lower fungal alpha diversity was associated with an increased odds of NPC [lower vs. higher: observed features (adjusted odds ratio [OR] = 5.81, 95% confidence interval [CI] = 3.60-9.38); Simpson diversity (1.53, 1.03-2.29); Shannon diversity (2.03, 1.35-3.04)]. We also observed a significant difference in global fungal community patterns between cases and controls based on Bray-Curtis dissimilarity (P
- Published
- 2023