1. High expression of Kruppel-like factor 4 as a predictor of poor prognosis for cervical cancer patient response to radiotherapy.
- Author
-
Liu HX, Li N, Wei L, Zhou FX, Ma R, Xiao F, Zhang W, Zhang Y, Hui YP, Song H, and Chen BL
- Subjects
- Adult, Aged, Biomarkers, Tumor genetics, Carcinoma, Squamous Cell pathology, Carcinoma, Squamous Cell radiotherapy, Disease-Free Survival, Female, Gene Expression Regulation, Neoplastic, Humans, Kaplan-Meier Estimate, Kruppel-Like Factor 4, Kruppel-Like Transcription Factors genetics, Lymphatic Metastasis, Middle Aged, Prognosis, Uterine Cervical Neoplasms pathology, Uterine Cervical Neoplasms radiotherapy, Biomarkers, Tumor biosynthesis, Carcinoma, Squamous Cell genetics, Kruppel-Like Transcription Factors biosynthesis, Uterine Cervical Neoplasms genetics
- Abstract
Purpose: The aim of this study was to explore the associations of Kruppel-like factor 4 expression with sensitivity to radiation therapy in locally advanced cervical squamous cell carcinoma patients., Methods: The records of 117 locally advanced cervical squamous cell carcinoma patients were retrospectively reviewed, and Kruppel-like factor 4 expression in cervical carcinoma tissues was examined by immunohistochemical staining. The associations of Kruppel-like factor 4 expression with clinicopathological parameters were analyzed. Survival time was analyzed using Kaplan-Meier analysis and a Cox regression model., Results: Patients being resistant to radiation therapy were associated with advanced International Federation of Gynecology and Obstetrics stage, tumor diameter (>4 cm), and poor differentiation grade. The high Kruppel-like factor 4 expression level was significantly related to resistance to radiation therapy, including radiation therapy non-response, local recurrence, and distant metastasis. The high Kruppel-like factor 4 expression level was also significantly related to the advanced International Federation of Gynecology and Obstetrics stage and poor differentiation grade. Kaplan-Meier analysis indicates that locally advanced cervical squamous cell carcinoma patients with high Kruppel-like factor 4 expression showed worse progression-free survival and overall survival. Univariate and multivariate Cox regression model analyses suggest that the high Kruppel-like factor 4 expression was one of the high-risk factors associated with poor prognosis in locally advanced cervical squamous cell carcinoma patients after radiation therapy., Conclusion: Our results suggest that the high Kruppel-like factor 4 expression can be used as a novel biomarker to predict radiation therapy resistance and poor prognosis for locally advanced cervical squamous cell carcinoma.
- Published
- 2017
- Full Text
- View/download PDF