6 results on '"Hungerbühler S"'
Search Results
2. Ergebnis der selektiven Verpaarung beim Entlebucher Sennenhund zur Reduktion der ureteralen Ektopie
- Author
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Merz, Fiona, Gallana, M, Hartnack, Sonja; https://orcid.org/0000-0002-5757-5708, Del Chicca, Francesca; https://orcid.org/0000-0002-8996-1961, Dolf, G, Hungerbühler, S, Hittmair, K M, Dorsch, R, Zaal, M, Vink-Nooteboom, M, Hartmann, A, Pieńkowska-Schelling, A, Schelling, Claude; https://orcid.org/0000-0002-2283-1126, Reichler, Iris M; https://orcid.org/0000-0001-7762-1217, Merz, Fiona, Gallana, M, Hartnack, Sonja; https://orcid.org/0000-0002-5757-5708, Del Chicca, Francesca; https://orcid.org/0000-0002-8996-1961, Dolf, G, Hungerbühler, S, Hittmair, K M, Dorsch, R, Zaal, M, Vink-Nooteboom, M, Hartmann, A, Pieńkowska-Schelling, A, Schelling, Claude; https://orcid.org/0000-0002-2283-1126, and Reichler, Iris M; https://orcid.org/0000-0001-7762-1217
- Abstract
The Entlebucher Mountain Dog is predisposed to ureteral ectopia and associated diseases of the urinary tract as well as the kidneys, which can have severe to lethal consequences. Due to the clustered occurrence of clinical signs in 11 % of Entlebucher Mountain dogs in the absence of a genetic test for ureteral ectopia, screening was introduced in 2008 to allow phenotype-based breeding selection. The ureteral orifices of the dogs are visualized by ultrasound and existing urinary retention or urinary incontinence is documented. The diagnostic findings were evaluated centrally with assignment to one of five phenotypes depending on the localization of the ureteral orifices and the renal and ureteral shape. Breeding approval and mating restrictions are the responsibility of the respective breeding associations and predominantly Entlebucher Mountain Dogs with extravesical ectopic ureters and/or clinical signs were excluded from breeding. The effect of phenotype-based selective mating on the incidence of ureteral ectopia and its clinical signs, as well as possible factors influencing the expression of the phenotype, were determined in the birth cohorts after the introduction of screening. Analysis of the data set of 1456 phenotyped Entlebucher Mountain Dogs showed, that at 11 % versus 5 %, males were more frequently assigned to the extravesical phenotype than females. The effect of phenotype-based breeding selection was examined in a subpopulation consisting of phenotyped parents and their offspring (n = 876). The prevalence of the extravesical phenotype decreased from 24 % in the 2005 to 2007 birth cohorts to 1,4 % in the 2015 to 2017 birth cohorts. Since 2015 almost no Entlebucher Mountain Dogs with incontinence, hydroureter or hydronephrosis have been recorded. It was feared that the additional selection measures to control ureteral ectopia in the small Entlebucher Mountain Dog population would intensify the inbreeding increase. However, this has so far remained absent.
- Published
- 2022
3. Ergebnis der selektiven Verpaarung beim Entlebucher Sennenhund zur Reduktion der ureteralen Ektopie.
- Author
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Merz, F., Gallana, M., Hartnack, S., Del Chicca, F., Dolf, G., Hungerbühler, S., Hittmair, K. M., Dorsch, R., Zaal, M., Vink-Nooteboom, M., Hartmann, A., Pieńkowska-Schelling, A., Schelling, C., and Reichler, I. M.
- Published
- 2022
- Full Text
- View/download PDF
4. [Outcome of selective mating in the Entlebucher Mountain Dog for reduction of ureteral ectopia].
- Author
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Merz F, Gallana M, Hartnack S, Del Chicca F, Dolf G, Hungerbühler S, Hittmair KM, Dorsch R, Zaal M, Vink-Nooteboom M, Hartmann A, Pieńkowska-Schelling A, Schelling C, and Reichler IM
- Subjects
- Animals, Dogs, Female, Male, Choristoma veterinary, Dog Diseases epidemiology, Dog Diseases genetics, Hydronephrosis veterinary, Ureter diagnostic imaging, Urinary Incontinence veterinary
- Abstract
Introduction: The Entlebucher Mountain Dog is predisposed to ureteral ectopia and associated diseases of the urinary tract as well as the kidneys, which can have severe to lethal consequences. Due to the clustered occurrence of clinical signs in 11 % of Entlebucher Mountain dogs in the absence of a genetic test for ureteral ectopia, screening was introduced in 2008 to allow phenotype-based breeding selection. The ureteral orifices of the dogs are visualized by ultrasound and existing urinary retention or urinary incontinence is documented. The diagnostic findings were evaluated centrally with assignment to one of five phenotypes depending on the localization of the ureteral orifices and the renal and ureteral shape. Breeding approval and mating restrictions are the responsibility of the respective breeding associations and predominantly Entlebucher Mountain Dogs with extravesical ectopic ureters and/or clinical signs were excluded from breeding. The effect of phenotype-based selective mating on the incidence of ureteral ectopia and its clinical signs, as well as possible factors influencing the expression of the phenotype, were determined in the birth cohorts after the introduction of screening. Analysis of the data set of 1456 phenotyped Entlebucher Mountain Dogs showed, that at 11 % versus 5 %, males were more frequently assigned to the extravesical phenotype than females. The effect of phenotype-based breeding selection was examined in a subpopulation consisting of phenotyped parents and their offspring (n = 876). The prevalence of the extravesical phenotype decreased from 24 % in the 2005 to 2007 birth cohorts to 1,4 % in the 2015 to 2017 birth cohorts. Since 2015 almost no Entlebucher Mountain Dogs with incontinence, hydroureter or hydronephrosis have been recorded. It was feared that the additional selection measures to control ureteral ectopia in the small Entlebucher Mountain Dog population would intensify the inbreeding increase. However, this has so far remained absent. Therefore, as long as no genetic test is available, it is recommended to continue phenotype-based breeding selection with exclusion of dogs with extravesical ureteral ectopia and/or hydroureter/hydronephrosis/urinary incontinence, while keeping an eye on the development of the inbreeding coefficient.
- Published
- 2022
- Full Text
- View/download PDF
5. Comparison of multi-detector row computed tomography with echocardiography for assessment of left ventricular function in healthy dogs.
- Author
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Henjes CR, Hungerbühler S, Bojarski IB, Nolte I, and Wefstaedt P
- Subjects
- Animals, Echocardiography methods, Echocardiography veterinary, Female, Male, Multidetector Computed Tomography veterinary, Regression Analysis, Retrospective Studies, Statistics, Nonparametric, Dogs physiology, Multidetector Computed Tomography methods, Ventricular Function, Left
- Abstract
Objective: To evaluate the use of retrospectively ECG-gated, contrast-enhanced, multi-detector row computed tomography (MDCT) for assessment of left ventricular function in dogs and to compare the results with those obtained by use of 2-D and M-mode echocardiographc techniques., Animals: 10 healthy Beagles., Procedures: Dogs underwent MDCT (performed by use of a 64-detector row CT system) and echocardiography under general anesthesia. Left ventricular end-systolic volume (ESV), end-diastolic volume (EDV), and ejection fraction (EF) were determined in MDCT-generated multiplanar reformatted images by use of Simpson and biplane area-length calculation methods. Results were compared with left ventricular ESV, EDV, and EF determined in echocardiographc images by use of Teichholz and bullet method calculations. Results were evaluated via Deming regression analysis and Pearson correlation tests. Bland-Altman analysis was used to assess limits of agreement and systematic errors between the 2 methods., Results: Mean values for EDV and ESV determined by use of MDCT were highly correlated with those determined by use of echocardiography, regardless of the calculation methods compared (r = 0.91 to 0.96); volumes determined by use of MDCT appeared to be higher than those determined by use of echocardiography, although most differences were nonsignificant. Mean EF determined by use of MDCT with the Simpson calculation method was highly correlated with that determined by use of echocardiography with bullet method calculations (r = 0.90)., Conclusions and Clinical Relevance: Results suggested that assessment of left ventricular volume and function in dogs is feasible with MDCT. To estimate left ventricular EF with MDCT. use of the Simpson calculation method is advised.
- Published
- 2012
- Full Text
- View/download PDF
6. Evaluation of the association between plasma concentration of N-terminal proatrial natriuretic peptide and outcome in cats with cardiomyopathy.
- Author
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Zimmering TM, Hungerbühler S, Meneses F, Nolte I, and Simon D
- Subjects
- Animals, Biomarkers blood, Cardiomyopathies blood, Case-Control Studies, Cats, Female, Heart Failure blood, Male, Atrial Natriuretic Factor blood, Cardiomyopathies veterinary, Cat Diseases blood, Heart Failure veterinary, Protein Precursors blood
- Abstract
Objective: To determine whether plasma N-terminal proatrial natriuretic peptide (NT-proANP) concentration could predict the outcome (survival duration) of cats with cardiomyopathy (CM)., Design: Case-control study., Animals: 51 cats with CM (25 with and 26 without congestive heart failure [CHF]) and 17 healthy cats., Procedures: Cats were thoroughly examined and assigned to 1 of 3 groups (control, CM with CHF, and CM alone). Plasma NT-proANP concentrations were measured by use of a human proANP(1-98) ELISA. Survival durations were compared between CM groups., Results: Plasma NT-proANP concentrations differed significantly among the 3 groups, and survival durations differed significantly between the 2 CM groups. Median (range) NT-proANP concentration was 413 fmol/mL (52 to 940 fmol/mL) in the control group, 1,254 fmol/mL (167 to 2,818 fmol/mL) in the CM alone group, and 3,208 fmol/mL (1,189 to 15,462 fmol/mL) in the CM with CHF group. At a cutoff of 517 fmol/mL, NT-proANP concentration had a sensitivity of 90% and specificity of 82% for detecting CM. Multivariate analysis revealed that only the variable left atrium-to-aortic diameter ratio was a significant predictor of survival duration., Conclusions and Clinical Relevance: Plasma NT-proANP concentration may have potential as a testing marker for distinguishing healthy cats from cats with CM. It may also be useful for distinguishing CM cats with CHF from those without CHF The value of NT-proANP concentration as a predictor of survival duration was not supported in this study and requires further evaluation.
- Published
- 2010
- Full Text
- View/download PDF
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