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148 results on '"Ikeda, Yuko"'

5. The Report on 'Study Skill'2019

Author

Fukuzawa, Takeshi, Otonari, Yoko, Ikeda, Yuko, Katayama, Tomihiro, Kikkawa, Takuya, Pak, Sung-Jae, Maeda, Takao, and Myoujin, Mie

Subjects
Study Skill, プレイスメントテスト, スタディスキル, placement test, Academic literacy, アカデミックリテラシー
Published
2020

8. Utilization of Libraries as Learning Centers to Support Foreign Language Learning

Author

Caton, Thomas.H, McInnes, Scott, Ikeda, Yuko, Tsuda, Akiko, and Takata, Kazunori

Subjects
教育改革支援制度報告, Educational Reform Support System Report, Utilizing the Library, 外国語学習支援, Foreign Language Learning Support, ラーニング・コモンズ, Learning Commons, 平成29年度, 図書館の活用
Published
2019

17. The Report on 'Academic Literacy' 2016

Author

Fukuzawa, Takeshi, Otonari, Yoko, Kinoshita, Kazuya, Ikeda, Yuko, Shin, Shigenori, Teshima, Emi, Nakagawa, Takashi, and Nakagawa, Hiromichi

Subjects
授業報告, テーマ授業, 図書館ツアー, Report, Academic Literacy, 必修科目, アカデミックリテラシー, グループ授業
Published
2017

18. Phase resetting of circadian peripheral clocks using human and rodent diets in mouse models of type 2 diabetes and chronic kidney disease

Author

Yasuda, Shinnosuke, Iwami, Shiho, Konomi Tamura, Ikeda, Yuko, Kamagata, Mayo, Sasaki, Hiroyuki, Haraguchi, Atsushi, Miyamatsu, Masako, Hanashi, Shizuka, Takato, Yoshiyuki, and Shibata, Shigenobu

Abstract

The expression rhythms of clock genes, such as Per1, Per2, Bmal1, and Rev-erb α, in mouse peripheral clocks, are entrained by a scheduled feeding paradigm. In terms of food composition, a carbohydrate-containing diet is reported to cause strong entrainment through insulin secretion. However, it is unknown whether human diets entrain peripheral circadian clocks. In this study, we used freeze-dried diets for type 2 diabetes (DB) and chronic kidney disease (CKD), as well as low-carbohydrate diets. After 24 h of fasting, PER2::LUC knock-in mice were given access to food for 2 days during inactive periods, and bioluminescence rhythm was then measured using an in vivo imaging system. AIN-93M, the control mouse diet with a protein:fat:carbohydrate (PFC) ratio of 14.7:9.5:75.8, caused a significant phase advance (7.3 h) in the liver clock compared with that in 24 h fasted mice, whereas human diets caused significant but smaller phase advances (4.7–6.2 h). Compared with healthy and high fat/sucrose-induced DB mice, adenine-induced CKD mice showed attenuation of a phase-advance with a normal diet. There were no significant differences in phase-advance values between human diets (normal, DB, and CKD). In addition, a normal-carbohydrate diet (PFC ratio of 20.3:23.3:56.4) and a low-carbohydrate diet (PFC ratio of 36.4:42.9:20.7) caused similar phase advances in peripheral clocks. The present results strongly suggest that scheduled feeding with human diets can cause phase advances in the peripheral clocks of not only healthy, but also DB and CKD mice. This discovery provides support to the food-induced entrainment of peripheral clocks in human clinical trials.

Published
2019
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22. Association between changes in the mRNA expression of platelet-activating factor receptor in peripheral blood mononuclear cells and progression of diabetic nephropathy

Author

Ghavidel Darestani, Sahar, primary, Kurano, Mihoko, additional, Shinnakasu, Atsushi, additional, Yamamoto, Kiyoaki, additional, Dochi, Yukari, additional, Uemura, Kayo, additional, Ikeda, Yuko, additional, Arimura, Aiko, additional, Arimura, Hiroshi, additional, Kikuchi, Akira, additional, Hashiguchi, Hiroshi, additional, Deguchi, Takahisa, additional, and Nishio, Yoshihiko, additional

Published
2019
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24. Potent synchronization of peripheral circadian clocks by glucocorticoid injections in PER2::LUC-Clock/Clock mice

Author

Kamagata, Mayo, Ikeda, Yuko, Sasaki, Hiroyuki, Hattori, Yuta, Yasuda, Shinnosuke, Iwami, Shiho, Tsubosaka, Miku, Ishikawa, Ryosuke, Todoh, Ai, Konomi Tamura, Tahara, Yu, and Shibata, Shigenobu

Abstract

In mammals, the central clock (the suprachiasmatic nuclei, SCN) is entrained mainly by the light-dark cycle, whereas peripheral clocks in the peripheral tissues are entrained/synchronized by multiple factors, including feeding patterns and endocrine hormones such as glucocorticoids. Clock-mutant mice (Clock/Clock), which have a mutation in a core clock gene, show potent phase resetting in response to light pulses compared with wild-type (WT) mice, owing to the damped and flexible oscillator in the SCN. However, the phase resetting of the peripheral clocks in Clock/Clock mice has not been elucidated. Here, we characterized the peripheral clock gene synchronization in Clock/Clock mice by daily injections of a synthetic glucocorticoid (dexamethasone, DEX) by monitoring in vivo PER2::LUCIFERASE bioluminescence. Compared with WT mice, the Clock/Clock mice showed significantly decreased bioluminescence and peripheral clock rhythms with decreased amplitudes and delayed phases. In addition, the DEX injections increased the amplitudes and advanced the phases. In order to examine the robustness of the internal oscillator, T-cycle experiments involving DEX stimulations with 24- or 30-h intervals were performed. The Clock/Clock mice synchronized to the 30-h T-cycle stimulation, which suggested that the peripheral clocks in the Clock/Clock mice had increased synchronizing ability upon DEX stimulation, to that of circadian and hour-glass type oscillations, because of weak internal clock oscillators.

Published
2017
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26. Glucagon and/or IGF-1 Production Regulates Resetting of the Liver Circadian Clock in Response to a Protein or Amino Acid-only Diet

Author

Ikeda, Yuko, primary, Kamagata, Mayo, additional, Hirao, Mizuho, additional, Yasuda, Shinnosuke, additional, Iwami, Shiho, additional, Sasaki, Hiroyuki, additional, Tsubosaka, Miku, additional, Hattori, Yuta, additional, Todoh, Ai, additional, Tamura, Konomi, additional, Shiga, Kazuto, additional, Ohtsu, Teiji, additional, and Shibata, Shigenobu, additional

Published
2018
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35. γ-oryzanol ameliorates the acute stress induced by behavioral anxiety testing in mice

Author

Akter, Salina, Sasaki, Hiroyuki, Ikeda, Yuko, Miyakawa, Hiroki, and Shibata, Shigenobu

Abstract

We evaluated the anxiolytic effect of γ-oryzanol (GORZ) and elucidated the molecular mechanisms involved in its inhibition of behavioral test-induced anxiety. Behavioral tests were conducted on day 13, and mice were subjected to 30 min of acute restraint stress treatment (ARST) before sacrifice on day 16. In other group, behavioral tests were conducted on day 13 and 14 after ARST. 0.5% GORZ significantly weakened the effect of behavioral stress, but not the effect of strong ARST. GORZ downregulated ARST-induced cFoslevels in the cerebral cortex. In conclusion, GORZ has potential ant-anxiety effect in the treatment of weak behavioral test-induced stress.

Published
2024
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36. l-Ornithine affects peripheral clock gene expression in mice

Author

Fukuda, Takafumi, primary, Haraguchi, Atsushi, additional, Kuwahara, Mari, additional, Nakamura, Kaai, additional, Hamaguchi, Yutaro, additional, Ikeda, Yuko, additional, Ishida, Yuko, additional, Wang, Guanying, additional, Shirakawa, Chise, additional, Tanihata, Yoko, additional, Ohara, Kazuaki, additional, and Shibata, Shigenobu, additional

Published
2016
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