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1. Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease

Author

Andoh, Akira, Ashida, Toshifumi, Endo, Katsuya, Endo, Yutaka, Esaki, Motohiro, Fujita, Hiroshi, Fujiya, Mikihiro, Haruma, Ken, Hibi, Toshifumi, Hiraoka, Sakiko, Hirata, Ichiro, Hisamatsu, Tadakazu, Honda, Yutaka, Iijima, Hideki, Iizuka, Bunei, Ikeya, Kentaro, Inoue, Takuya, Inoue, Syuji, Ishida, Tetsuya, Ishiguro, Yo, Ishihara, Shyunji, Ito, Hiroaki, Iwakiri, Ryuichi, Kagaya, Takashi, Kanai, Takanori, Kashida, Hiroshi, Kato, Shingo, Kato, Jun, Katsurada, Takehiko, Kinjyo, Fukunori, Kobayashi, Kiyonori, Kodama, Mayumi, Kunisaki, Reiko, Kurahara, Koichi, Kurokami, Takafumi, Kyouwon, Lee, Matsuda, Koichiro, Matsueda, Kazuhiro, Matsui, Toshiyuki, Matsumoto, Takayuki, Mitsuyama, Keiichi, Mizokami, Yuji, Motoya, Satoshi, Naito, Yuji, Nakagawa, Tomoo, Nakamura, Shiro, Nakase, Hiroshi, Nojima, Masanori, Nomura, Masafumi, Ogawa, Atsuhiro, Okazaki, Kazuichi, Otsuka, Kazuaki, Sakuraba, Hirotake, Saruta, Masayuki, Sasaki, Makoto, Shirai, Takayuki, Suga, Tomoaki, Sugimura, Kazuhito, Sugiyama, Toshiro, Suzuki, Yasuo, Takeshima, Fuminao, Tamaki, Hiroyuki, Tanaka, Shinji, Tanida, Satoshi, Tominaga, Keiichi, Tomizawa, Taku, Watababe, Kenji, Watanabe, Mamoru, Watanabe, Kenji, Yamamoto, Syojiro, Yamashita, Masaki, Yoshida, Atsushi, Yoshimura, Naoki, and Nagahori, Masakazu

Published
2018
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3. Comparison of Targeted vs Random Biopsies for Surveillance of Ulcerative Colitis-Associated Colorectal Cancer

Author

Watanabe, Toshiaki, Ajioka, Yoichi, Mitsuyama, Keiichi, Watanabe, Kenji, Hanai, Hiroyuki, Nakase, Hiroshi, Kunisaki, Reiko, Matsuda, Keiji, Iwakiri, Ryuichi, Hida, Nobuyuki, Tanaka, Shinji, Takeuchi, Yoshiaki, Ohtsuka, Kazuo, Murakami, Kazunari, Kobayashi, Kiyonori, Iwao, Yasushi, Nagahori, Masakazu, Iizuka, Bunei, Hata, Keisuke, Igarashi, Masahiro, Hirata, Ichiro, Kudo, Shin-ei, Matsumoto, Takayuki, Ueno, Fumiaki, Watanabe, Gen, Ikegami, Masahiro, Ito, Yoko, Oba, Koji, Inoue, Eisuke, Tomotsugu, Naoki, Takebayashi, Toru, Sugihara, Kenichi, Suzuki, Yasuo, Watanabe, Mamoru, and Hibi, Toshifumi

Published
2016
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6. TYK2 Promoter Variant and Diabetes Mellitus in the Japanese

Author

Nagafuchi, Seiho, Kamada-Hibio, Yumi, Hirakawa, Kanako, Tsutsu, Nobutaka, Minami, Masae, Okada, Akira, Kai, Katsuya, Teshima, Miho, Moroishi, Arisa, Murakami, Yoshikazu, Umeno, Yoshikazu, Yokogawa, Yasushi, Kogawa, Kazuhiko, Izumi, Kenichi, Anzai, Keizo, Iwakiri, Ryuichi, Hamaguchi, Kazuyuki, Sasaki, Nobuhiro, Nohara, Sakae, Yoshida, Eiko, Harada, Mine, Akashi, Koichi, Yanase, Toshihiko, Ono, Junko, Okeda, Toshimitsu, Fujimoto, Ryoji, Ihara, Kenji, Hara, Toshiro, Kikuchi, Yohei, Iwase, Masanori, Kitazono, Takanari, Kojima, Fumiko, Kono, Suminori, Kurisaki, Hironori, Kondo, Shiori, and Katsuta, Hitoshi

Published
2015
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7. Computational Simulation Model to Predict Behavior Changes in Inflammatory Bowel Disease Patients during the COVID-19 Pandemic: Analysis of Two Regional Japanese Populations

Author

Suzuki, Gen, primary, Iwakiri, Ryuichi, additional, Udagawa, Eri, additional, Ma, Sindy, additional, Takayama, Ryoko, additional, Nishiura, Hiroshi, additional, Nakamura, Koshi, additional, Burns, Samuel P., additional, D’Alessandro, Paul Michael, additional, and Fernandez, Jovelle, additional

Published
2023
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9. Significance of measurement of serum trough level and anti‐drug antibody of adalimumab as personalised pharmacokinetics in patients with Crohnʼs disease: a subanalysis of the DIAMOND trial

Author

Nakase, H., Motoya, S., Matsumoto, T., Watanabe, K., Hisamatsu, T., Yoshimura, N., Ishida, T., Kato, S., Nakagawa, T., Esaki, M., Nagahori, M., Matsui, T., Naito, Y., Kanai, T., Suzuki, Y., Nojima, M., Watanabe, M., Hibi, T., Andoh, Akira, Ashida, Toshifumi, Endo, Katsuya, Endo, Yutaka, Esaki, Motohiro, Fujita, Hiroshi, Fujiya, Mikihiro, Haruma, Ken, Hibi, Toshifumi, Hiraoka, Sakiko, Hirata, Ichiro, Hisamatsu, Tadakazu, Honda, Yutaka, Iijima, Hideki, Iizuka, Bunei, Ikeya, Kentaro, Inoue, Takuya, Inoue, Shuji, Ishida, Tetsuya, Ishiguro, Yo, Ishihara, Shunji, Ito, Hiroaki, Iwakiri, Ryuichi, Kagaya, Takashi, Kanai, Takanori, Kashida, Hiroshi, Kato, Shingo, Kato, Jun, Katsurada, Takehiko, Kinjyo, Fukunori, Kobayashi, Kiyonori, Kodama, Mayumi, Kunisaki, Reiko, Kurahara, Koichi, Kurokami, Takafumi, Kyouwon, Lee, Matsuda, Koichiro, Matsueda, Kazuhiro, Matsui, Toshiyuki, Matsumoto, Takayuki, Mitsuyama, Keiichi, Mizokami, Yuji, Motoya, Satoshi, Naito, Yuji, Nakagawa, Tomoo, Nakamura, Shiro, Nakase, Hiroshi, Nojima, Masanori, Nomura, Masafumi, Ogawa, Atsuhiro, Okazaki, Kazuichi, Otsuka, Kazuaki, Sakuraba, Hirotake, Saruta, Masayuki, Sasaki, Makoto, Shirai, Takayuki, Suga, Tomoaki, Sugimura, Kazuhito, Sugiyama, Toshiro, Suzuki, Yasuo, Takeshima, Fuminao, Tamaki, Hiroyuki, Tanaka, Shinji, Tanida, Satoshi, Tominaga, Keiichi, Tomizawa, Taku, Watanabe, Kenji, Watanabe, Mamoru, Yamamoto, Shojiro, Yamashita, Masaki, Yoshida, Atsushi, and Yoshimura, Naoki

Published
2017
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10. Efficacy of biologic therapies for biologic-naïve Japanese patients with moderately to severely active ulcerative colitis: a network meta-analysis

Author

Hibi, Toshifumi, Kamae, Isao, Pinton, Philippe, Ursos, Lyann, Iwakiri, Ryuichi, Hather, Greg, and Patel, Haridarshan

Subjects
medicine.medical_specialty, efficacy, lcsh:Medicine, Placebo, Vedolizumab, law.invention, Randomized controlled trial, law, Internal medicine, medicine, Adalimumab, biologics, lcsh:RC799-869, network meta-analysis, colitis, ulcerative, business.industry, lcsh:R, Gastroenterology, Odds ratio, Inflammatory Bowel Diseases, medicine.disease, Ulcerative colitis, Infliximab, Golimumab, Original Article, lcsh:Diseases of the digestive system. Gastroenterology, business, medicine.drug
Abstract

Background/Aims: Several biologic therapies are approved in Japan to treat moderately to severely active ulcerative colitis (UC), but there are no published comparative efficacy studies in a Japanese population. We compared the efficacy of biologics approved in Japan (adalimumab, infliximab, golimumab, and vedolizumab) for treating biologic-naive patients with UC at their approved doses. Methods: A targeted literature review identified 4 randomized controlled trials of biologics for UC in biologic-naive Japanese patients. For each study, efficacy outcome data from induction (weeks 6-12) and maintenance (weeks 30-60) treatment were extracted for analysis. Treatment effects on clinical response, clinical remission, and mucosal healing relative to the average placebo results across all trials were estimated using network meta-analyses followed by transformation into probabilities and odds ratios (OR). Results: At the end of induction, the likelihood of clinical response and clinical remission was highest with infliximab (OR: 2.12 and 2.35, respectively) and vedolizumab (OR: 2.10 and 2.32, respectively); the likelihood of mucosal healing was highest with infliximab (OR: 2.24) and adalimumab (OR: 1.86). During maintenance, the likelihood of clinical response and clinical remission was highest with vedolizumab (OR: 6.44 and 4.68, respectively) and golimumab (OR: 5.13 and 3.84, respectively); the likelihood of mucosal healing was significantly higher than placebo with all biologics. Conclu sions: All active treatments were efficacious compared with placebo. Infliximab and vedolizumab had the highest odds for induction of clinical response, remission, and mucosal healing. Golimumab and vedolizumab had numerically higher odds of achieving efficacy outcomes in the maintenance phase. (Intest Res 2021;19:53-61)

Published
2021
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12. Decline incidence in upper gastrointestinal bleeding in several recent years: data of the Japan claims database of 13 million accumulated patients

Author

Fujimoto, Shun, primary, Tsuruoka, Nanae, additional, Esaki, Motohiro, additional, Takamori, Ayako, additional, Sakata, Yasuhisa, additional, Shimoda, Ryo, additional, Akutagawa, Takashi, additional, Node, Koichi, additional, Anzai, Keizo, additional, Sugisaki, Nobuyuki, additional, Iwakiri, Ryuichi, additional, Takagi, Kuniaki, additional, Yamanouchi, Kohei, additional, and Fujimoto, Kazuma, additional

Published
2021
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13. Long-Term Follow-Up of Targeted Biopsy Yield (LOFTY Study) in Ulcerative Colitis Surveillance Colonoscopy

Author

Hata, Keisuke, primary, Ishihara, Soichiro, additional, Ajioka, Yoichi, additional, Mitsuyama, Keiichi, additional, Watanabe, Kenji, additional, Hanai, Hiroyuki, additional, Kunisaki, Reiko, additional, Nakase, Hiroshi, additional, Matsuda, Keiji, additional, Iwakiri, Ryuichi, additional, Hida, Nobuyuki, additional, Tanaka, Shinji, additional, Takeuchi, Yoshiaki, additional, Shinozaki, Masaru, additional, Ogata, Noriyuki, additional, Moriichi, Kentaro, additional, Hirai, Fumihito, additional, Sugihara, Kenichi, additional, Hisamatsu, Tadakazu, additional, Suzuki, Yasuo, additional, Watanabe, Mamoru, additional, and Hibi, Toshifumi, additional

Published
2020
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16. Risk Factors for Helicobacter pylori Infection and Endoscopic Reflux Esophagitis in Healthy Young Japanese Volunteers

Author

Tanaka, Yuichiro, Sakata, Yasuhisa, Hara, Megumi, Kawakubo, Hiroharu, Tsuruoka, Nanae, Yamamoto, Koji, Itoh, Yoichiro, Hidaka, Hidenori, Shimoda, Ryo, Iwakiri, Ryuichi, and Fujimoto, Kazuma

Subjects
Adult, Male, Volunteers, nodular gastritis, F scale, Helicobacter pylori, gastroesophageal reflux, dyspepsia, Antibodies, Bacterial, Endoscopy, Gastrointestinal, Body Mass Index, Helicobacter Infections, Young Adult, Sex Factors, Japan, Risk Factors, Duodenal Ulcer, Immunoglobulin G, Prevalence, Humans, Original Article, endoscopy
Abstract

Objective The aim of this study was to determine the prevalence and risk factors of reflux esophagitis and Helicobacter pylori (H.pylori) infection and their interrelationship in healthy young Japanese volunteers. Methods Between 2010 and 2016, 550 fifth-year medical students at Saga Medical School, aged 22 to 30 years, underwent upper gastrointestinal endoscopy and completed a questionnaire (frequency scale for symptoms of gastroesophageal reflux disease). H. pylori infection was determined by detecting urinary immunoglobulin G antibodies. Results H. pylori antibodies were detected in 45 of the 550 subjects (8.2%). Endoscopic reflux esophagitis was detected in 38 out of 550 (6.9%): grade A in 37 subjects (97.3%) and grade B in 1. Most subjects with reflux esophagitis were H. pylori-negative (35/37). Nodular gastritis was observed in 33.3% (15/45) of H. pylori-positive subjects. The risk factors for H. pylori infection were drinking well water in childhood, nodular gastritis, and duodenal ulcer scars. The risk factors for endoscopic reflux esophagitis were male gender and obesity (body mass index ≥25). Conclusion This study describes the risk factors for H. pylori infection and reflux esophagitis in healthy young Japanese subjects. The prevalence of reflux esophagitis was relatively high, and the infection rate of H. pylori was low compared with the aged Japanese population.

Published
2017

18. Perforation and Postoperative Bleeding Associated with Endoscopic Submucosal Dissection in Colorectal Tumors: An Analysis of 398 Lesions Treated in Saga, Japan

Author

Yamamoto, Koji, primary, Shimoda, Ryo, additional, Ogata, Shinichi, additional, Hara, Megumi, additional, Ito, Yoichiro, additional, Tominaga, Naoyuki, additional, Nakayama, Atsushi, additional, Sakata, Yasuhisa, additional, Tsuruoka, Nanae, additional, Iwakiri, Ryuichi, additional, and Fujimoto, Kazuma, additional

Published
2018
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19. Mo1174 - The Psychotropic Agent Was One of the Risk Factors for Developing Upper Gastrointestinal Mucosal Injuries: A Case-Control Study using the Large Organized Database of Claims in Japan (Apporoximately 3.7 Million Populations on the Accumulated Basis)

Author

Fujimoto, Shun, primary, Sugisaki, Nobuyuki, additional, Takara, Yoshimichi, additional, Tsuruoka, Nanae, additional, Sakata, Yasuhisa, additional, Iwakiri, Ryuichi, additional, and Fujimoto, Kazuma, additional

Published
2018
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20. Clinical and Pharmacokinetic Factors Associated With Adalimumab-Induced Mucosal Healing in Patients With Crohn’s Disease

Author

Watanabe, Kenji, primary, Matsumoto, Takayuki, additional, Hisamatsu, Tadakazu, additional, Nakase, Hiroshi, additional, Motoya, Satoshi, additional, Yoshimura, Naoki, additional, Ishida, Tetsuya, additional, Kato, Shingo, additional, Nakagawa, Tomoo, additional, Esaki, Motohiro, additional, Nagahori, Masakazu, additional, Matsui, Toshiyuki, additional, Naito, Yuji, additional, Kanai, Takanori, additional, Suzuki, Yasuo, additional, Nojima, Masanori, additional, Watanabe, Mamoru, additional, Hibi, Toshifumi, additional, Andoh, Akira, additional, Ashida, Toshifumi, additional, Endo, Katsuya, additional, Endo, Yutaka, additional, Fujita, Hiroshi, additional, Fujiya, Mikihiro, additional, Haruma, Ken, additional, Hiraoka, Sakiko, additional, Hirata, Ichiro, additional, Honda, Yutaka, additional, Iijima, Hideki, additional, Iizuka, Bunei, additional, Ikeya, Kentaro, additional, Inoue, Takuya, additional, Inoue, Syuji, additional, Ishiguro, Yo, additional, Ishihara, Shyunji, additional, Ito, Hiroaki, additional, Iwakiri, Ryuichi, additional, Kagaya, Takashi, additional, Kashida, Hiroshi, additional, Kato, Jun, additional, Katsurada, Takehiko, additional, Kinjyo, Fukunori, additional, Kobayashi, Kiyonori, additional, Kodama, Mayumi, additional, Kunisaki, Reiko, additional, Kurahara, Koichi, additional, Kurokami, Takafumi, additional, Kyouwon, Lee, additional, Matsuda, Koichiro, additional, Matsueda, Kazuhiro, additional, Mitsuyama, Keiichi, additional, Mizokami, Yuji, additional, Nakamura, Shiro, additional, Nomura, Masafumi, additional, Ogawa, Atsuhiro, additional, Okazaki, Kazuichi, additional, Otsuka, Kazuaki, additional, Sakuraba, Hirotake, additional, Saruta, Masayuki, additional, Sasaki, Makoto, additional, Shirai, Takayuki, additional, Suga, Tomoaki, additional, Sugimura, Kazuhito, additional, Sugiyama, Toshiro, additional, Takeshima, Fuminao, additional, Tamaki, Hiroyuki, additional, Tanaka, Shinji, additional, Tanida, Satoshi, additional, Tominaga, Keiichi, additional, Tomizawa, Taku, additional, Watababe, Kenji, additional, Watanabe, Kenji, additional, Yamamoto, Syojiro, additional, Yamashita, Masaki, additional, and Yoshida, Atsushi, additional

Published
2018
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21. A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of the Japanese Herbal Medicine Rikkunshito for Patients with Functional Dyspepsia: The Dream Study

Author

Sakata, Yasuhisa, primary, Tominaga, Kazunari, additional, Kusunoki, Hiroaki, additional, Odaka, Takeo, additional, Sakurai, Kouichi, additional, Kato, Mototsugu, additional, Furuta, Takahisa, additional, Murakami, Kazunari, additional, Chiba, Toshimi, additional, Watanabe, Sumio, additional, Kinoshita, Yoshikazu, additional, Miwa, Hiroto, additional, Higuchi, Kazuhide, additional, Kusano, Motoyasu, additional, Iwakiri, Ryuichi, additional, Fujimoto, Kazuma, additional, Tack, Jan F., additional, and Arakawa, Tetsuo, additional

Published
2017
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22. Additional file 1: of An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohnâ s disease

Author

Yoshimura, Naoki, Yokoyama, Yoko, Matsuoka, Katsuyoshi, Takahashi, Hiroki, Iwakiri, Ryuichi, Yamamoto, Takayuki, Nakagawa, Tomoo, Fukuchi, Takumi, Motoya, Satoshi, Kunisaki, Reiko, Kato, Shingo, Hirai, Fumihito, Yoh Ishiguro, Tanida, Satoshi, Hiraoka, Sakiko, Mitsuyama, Keiichi, Ishihara, Shunji, Tanaka, Shinji, Michiro Otaka, Osada, Taro, Kagaya, Takashi, Suzuki, Yasuo, Nakase, Hiroshi, Hanai, Hiroyuki, Watanabe, Kenji, Nobuhito Kashiwagi, and Hibi, Toshifumi

Abstract

CONSORT 2010 checklist. (DOC 217 kb)

Published
2015
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23. Persistent Gastrointestinal Angiodysplasia in Heyde's Syndrome after Aortic Valve Replacement

Author

Akutagawa, Takashi, primary, Shindo, Takero, additional, Yamanouchi, Kohei, additional, Hayakawa, Masaki, additional, Ureshino, Hiroshi, additional, Tsuruoka, Nanae, additional, Sakata, Yasuhisa, additional, Shimoda, Ryo, additional, Noguchi, Ryo, additional, Furukawa, Kojiro, additional, Morita, Shigeki, additional, Iwakiri, Ryuichi, additional, Kimura, Shinya, additional, Matsumoto, Masanori, additional, and Fujimoto, Kazuma, additional

Published
2017
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24. Upper Gastrointestinal Symptoms Are More Frequent in Female than Male Young Healthy Japanese Volunteers as Evaluated by Questionnaire

Author

Kawakubo, Hiroharu, primary, Tanaka, Yuichiro, additional, Tsuruoka, Nanae, additional, Hara, Megumi, additional, Yamamoto, Koji, additional, Hidaka, Hidenori, additional, Sakata, Yasuhisa, additional, Shimoda, Ryo, additional, Iwakiri, Ryuichi, additional, Kusano, Motoyasu, additional, and Fujimoto, Kazuma, additional

Published
2016
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25. Increase in Endoscopic and Laparoscopic Surgery Regarding the Therapeutic Approach of Gastric Cancer Detected by Cancer Screening in Saga Prefecture, Japan

Author

Yamaguchi, Shunsuke, primary, Sakata, Yasuhisa, additional, Iwakiri, Ryuichi, additional, Hara, Megumi, additional, Akutagawa, Kayo, additional, Shimoda, Ryo, additional, Yamaguchi, Daisuke, additional, Hidaka, Hidenori, additional, Sakata, Hiroyuki, additional, Fujimoto, Kazuma, additional, Mizuguchi, Masanobu, additional, Shimoda, Yuichiro, additional, Irie, Hiroyuki, additional, and Noshiro, Hirokazu, additional

Published
2016
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27. An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease

Author

Yoshimura, Naoki, Yokoyama, Yoko, Matsuoka, Katsuyoshi, Takahashi, Hiroki, Iwakiri, Ryuichi, Yamamoto, Takayuki, Nakagawa, Tomoo, Fukuchi, Takumi, Motoya, Satoshi, Kunisaki, Reiko, Kato, Shingo, Hirai, Fumihito, Ishiguro, Yoh, Tanida, Satoshi, Hiraoka, Sakiko, Mitsuyama, Keiichi, Ishihara, Shunji, Tanaka, Shinji, Otaka, Michiro, Osada, Taro, Kagaya, Takashi, Suzuki, Yasuo, Nakase, Hiroshi, Hanai, Hiroyuki, Watanabe, Kenji, Kashiwagi, Nobuhito, Hibi, Toshifumi, Yoshimura, Naoki, Yokoyama, Yoko, Matsuoka, Katsuyoshi, Takahashi, Hiroki, Iwakiri, Ryuichi, Yamamoto, Takayuki, Nakagawa, Tomoo, Fukuchi, Takumi, Motoya, Satoshi, Kunisaki, Reiko, Kato, Shingo, Hirai, Fumihito, Ishiguro, Yoh, Tanida, Satoshi, Hiraoka, Sakiko, Mitsuyama, Keiichi, Ishihara, Shunji, Tanaka, Shinji, Otaka, Michiro, Osada, Taro, Kagaya, Takashi, Suzuki, Yasuo, Nakase, Hiroshi, Hanai, Hiroyuki, Watanabe, Kenji, Kashiwagi, Nobuhito, and Hibi, Toshifumi

Published
2015

28. An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn's disease

Author

Yoshimura Naoki, Yokoyama Yoko, Matsuoka Katsuyoshi, Takahashi Hiroki, Iwakiri Ryuichi, Yamamoto Takayuki, Nakagawa Tomoo, Fukuchi Takumi, Motoya Satoshi, Kunisaki Reiko, Kato Shingo, Hirai Fumihito, Ishiguro Yoh, Tanida Satoshi, Hiraoka Sakiko, Mitsuyama Keiichi, ISHIHARA, Shunji, Tanaka Shinji, Otaka Michiro, Osada Taro, Kagaya Takashi, Suzuki Yasuo, Nakase Hiroshi, Hanai Hiroyuki, Watanabe Kenji, Kashiwagi Nobuhito, Hibi Toshifumi, Yoshimura Naoki, Yokoyama Yoko, Matsuoka Katsuyoshi, Takahashi Hiroki, Iwakiri Ryuichi, Yamamoto Takayuki, Nakagawa Tomoo, Fukuchi Takumi, Motoya Satoshi, Kunisaki Reiko, Kato Shingo, Hirai Fumihito, Ishiguro Yoh, Tanida Satoshi, Hiraoka Sakiko, Mitsuyama Keiichi, ISHIHARA, Shunji, Tanaka Shinji, Otaka Michiro, Osada Taro, Kagaya Takashi, Suzuki Yasuo, Nakase Hiroshi, Hanai Hiroyuki, Watanabe Kenji, Kashiwagi Nobuhito, and Hibi Toshifumi

Published
2015

29. Long-term efficacy and safety of rabeprazole in patients taking low-dose aspirin with a history of peptic ulcers: a phase 2/3, randomized, parallel group, multicenter, extension clinical trial

Author

Fujishiro Mitsuhiro, Higuchi Kazuhide, Kato Mototsugu, Kinoshita, Yoshikazu, Iwakiri Ryuichi, Watanabe Toshio, Takeuchi Toshihisa, Sugisaki Nobuyuki, Okada Yasushi, Ogawa Hisao, Arakawa Tetsuo, Fujimoto Kazuma, Fujishiro Mitsuhiro, Higuchi Kazuhide, Kato Mototsugu, Kinoshita, Yoshikazu, Iwakiri Ryuichi, Watanabe Toshio, Takeuchi Toshihisa, Sugisaki Nobuyuki, Okada Yasushi, Ogawa Hisao, Arakawa Tetsuo, and Fujimoto Kazuma

Published
2015

30. Effect of additional surgery after noncurative endoscopic submucosal dissection for early gastric cancer

Author

Yamanouchi, Kohei, additional, Ogata, Shinichi, additional, Sakata, Yasuhisa, additional, Tsuruoka, Nanae, additional, Shimoda, Ryo, additional, Nakayama, Atsushi, additional, Akutagawa, Takashi, additional, Shirai, Shimpei, additional, Takeshita, Eri, additional, Yamamoto, Koji, additional, Fujimoto, Kazuma, additional, and Iwakiri, Ryuichi, additional

Published
2015
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31. An open-label prospective randomized multicenter study of intensive versus weekly granulocyte and monocyte apheresis in active crohn’s disease

Author

Yoshimura, Naoki, primary, Yokoyama, Yoko, additional, Matsuoka, Katsuyoshi, additional, Takahashi, Hiroki, additional, Iwakiri, Ryuichi, additional, Yamamoto, Takayuki, additional, Nakagawa, Tomoo, additional, Fukuchi, Takumi, additional, Motoya, Satoshi, additional, Kunisaki, Reiko, additional, Kato, Shingo, additional, Hirai, Fumihito, additional, Ishiguro, Yoh, additional, Tanida, Satoshi, additional, Hiraoka, Sakiko, additional, Mitsuyama, Keiichi, additional, Ishihara, Shunji, additional, Tanaka, Shinji, additional, Otaka, Michiro, additional, Osada, Taro, additional, Kagaya, Takashi, additional, Suzuki, Yasuo, additional, Nakase, Hiroshi, additional, Hanai, Hiroyuki, additional, Watanabe, Kenji, additional, Kashiwagi, Nobuhito, additional, and Hibi, Toshifumi, additional

Published
2015
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34. Tu1205 Upper Gastrointestinal Symptoms Evaluated by Questionnaire Are Exaggerated in Females Compared to Males in Young Adults Healthy Volunteers

Author

Kawakubo, Hiroharu, primary, Tanaka, Yuichiro, additional, Tsuruoka, Nanae, additional, Okamoto, Norihiro, additional, Shirai, Shimpei, additional, Yamamoto, Koji, additional, Uchida, Masahiko, additional, Yamanouchi, Kohei, additional, Sakata, Yasuhisa, additional, Iwakiri, Ryuichi, additional, and Fujimoto, Kazuma, additional

Published
2015
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35. 523 - A Randomized, Placebo-Controlled, Double-Blind Clinical Trial of the Japanese Herbal Medicine Rikkunshito for Patients with Functional Dyspepsia: The Dream Study

Author

Sakata, Yasuhisa, Tominaga, Kazunari, Kusunoki, Hiroaki, Odaka, Takeo, Sakurai, Kouichi, Kato, Mototsugu, Furuta, Takahisa, Murakami, Kazunari, Chiba, Toshimi, Watanabe, Sumio, Kinoshita, Yoshikazu, Miwa, Hiroto, Higuchi, Kazuhide, Kusano, Motoyasu, Iwakiri, Ryuichi, Fujimoto, Kazuma, Tack, Jan F., and Arakawa, Tetsuo

Published
2017
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37. Clinical characteristics of elderly patients with proton pump inhibitor-refractory non-erosive reflux disease from the G-PRIDE study who responded to rikkunshito

Author

Sakata Yasuhisa, Tominaga Kazunari, Kato Mototsugu, Takeda Hiroshi, Shimoyama Yasuyuki, Takeuchi Toshihisa, Iwakiri Ryuichi, Furuta Kenji, Sakurai Kouichi, Odaka Takeo, Kusunoki Hiroaki, Nagahara Akihito, Iwakiri Katsuhiko, Furuta Takahisa, Murakami Kazunari, Miwa Hiroto, Kinoshita, Yoshikazu, Haruma Ken, Takahashi Shin'ichi, Watanabe Sumio, Higuchi Kazuhide, Fujimoto Kazuma, Kusano Motoyasu, Arakawa Tetsuo, Sakata Yasuhisa, Tominaga Kazunari, Kato Mototsugu, Takeda Hiroshi, Shimoyama Yasuyuki, Takeuchi Toshihisa, Iwakiri Ryuichi, Furuta Kenji, Sakurai Kouichi, Odaka Takeo, Kusunoki Hiroaki, Nagahara Akihito, Iwakiri Katsuhiko, Furuta Takahisa, Murakami Kazunari, Miwa Hiroto, Kinoshita, Yoshikazu, Haruma Ken, Takahashi Shin'ichi, Watanabe Sumio, Higuchi Kazuhide, Fujimoto Kazuma, Kusano Motoyasu, and Arakawa Tetsuo

Published
2014

38. Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison

Author

Furuta Kenji, Kohata Yukie, Fujiwara Yasuhiro, Sugimoto Mitsushige, Uotani Takahiro, Yamade Mihoko, Sahara Shu, Ichikawa Hitomi, Furuta Takahisa, Nio Kenta, Iwakiri Ryuichi, Inamori Masahiko, Kawamura Osamu, Kusano Motoyasu, Kato Mototsugu, Kawami Noriyuki, Iwakiri Katsuhiko, Takeuchi Toshihisa, Higuchi Kazuhide, Aimi Masahito, Naora, Kohji, Fujimoto Kazuma, Arakawa Tetsuo, Kinoshita, Yoshikazu, Furuta Kenji, Kohata Yukie, Fujiwara Yasuhiro, Sugimoto Mitsushige, Uotani Takahiro, Yamade Mihoko, Sahara Shu, Ichikawa Hitomi, Furuta Takahisa, Nio Kenta, Iwakiri Ryuichi, Inamori Masahiko, Kawamura Osamu, Kusano Motoyasu, Kato Mototsugu, Kawami Noriyuki, Iwakiri Katsuhiko, Takeuchi Toshihisa, Higuchi Kazuhide, Aimi Masahito, Naora, Kohji, Fujimoto Kazuma, Arakawa Tetsuo, and Kinoshita, Yoshikazu

Published
2014

41. 1032 Prevention of Recurrence of Gastric and Duodenal Ulcers by Rabeprazole in Patients Taking Low-Dose Aspirin -A Phase 2/3, Randomized, Parallel-Group, Double-Blind, Double-Dummy, Active-Controlled, Multicenter Study

Author

Watanabe, Toshio, primary, Higuchi, Kazuhide, additional, Kato, Mototsugu, additional, Fujishiro, Mitsuhiro, additional, Kinoshita, Yoshikazu, additional, Iwakiri, Ryuichi, additional, Umegaki, Eiji, additional, Sugisaki, Nobuyuki, additional, Okada, Yasushi, additional, Ogawa, Hisao, additional, Arakawa, Tetsuo, additional, and Fujimoto, Kazuma, additional

Published
2014
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43. Intra-gastric pH following single oral administrations of rabeprazole and esomeprazole: double-blind cross-over comparison

Author

Furuta, Kenji, primary, Kohata, Yukie, additional, Fujiwara, Yasuhiro, additional, Sugimoto, Mitsushige, additional, Uotani, Takahiro, additional, Yamade, Mihoko, additional, Sahara, Shu, additional, Ichikawa, Hitomi, additional, Furuta, Takahisa, additional, Nio, Kenta, additional, Iwakiri, Ryuichi, additional, Inamori, Masahiko, additional, Kawamura, Osamu, additional, Kusano, Motoyasu, additional, Kato, Mototsugu, additional, Kawami, Noriyuki, additional, Iwakiri, Katsuhiko, additional, Takeuchi, Toshihisa, additional, Higuchi, Kazuhide, additional, Aimi, Masahito, additional, Naora, Kohji, additional, Fujimoto, Kazuma, additional, Arakawa, Tetsuo, additional, and Kinoshita, Yoshikazu, additional

Published
2014
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44. Low-dose Aspirin and Comorbidities are Significantly Related to Bleeding Peptic Ulcers in Elderly Patients Compared with Nonelderly Patients in Japan

Author

Higuchi, Toru, primary, Iwakiri, Ryuichi, additional, Hara, Megumi, additional, Shimoda, Ryo, additional, Sakata, Yasuhisa, additional, Nakayama, Atsushi, additional, Nio, Kenta, additional, Yamaguchi, Shunsuke, additional, Yamaguchi, Daisuke, additional, Watanabe, Akira, additional, Akutagawa, Takashi, additional, Sakata, Hiroyuki, additional, and Fujimoto, Kazuma, additional

Published
2014
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46. Su1968 Gastric Endoscopic and Laparoscopic Surgery Instead of Open Laparotomy Have Been Main Therapeutic Procedures for Gastric Cancers Picked up in Xray Screening in Saga

Author

Yamaguchi, Shunsuke, primary, Iwakiri, Ryuichi, additional, Shimoda, Ryo, additional, Yamaguchi, Daisuke, additional, Higuchi, Toru, additional, Sakata, Yasuhisa, additional, Sakata, Hiroyuki, additional, Eujimoto, Kazuma, additional, Mizuguchi, Masanobu, additional, and Noshiro, Hirokazu, additional

Published
2013
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48. 1035 Subpopulation Analysis Based on Background Responds to Rabeprazole Dose in Patients With Functional Dyspepsia in a Multicenter, Double-Blind, Randomized, Placebo-Controlled Clinical Trial; the Samurai Study

Author

Tominaga, Kazunari, primary, Iwakiri, Ryuichi, additional, Kinoshita, Yoshikazu, additional, Kato, Mototsugu, additional, Haruma, Ken, additional, Miwa, Hiroto, additional, Higuchi, Kazuhide, additional, Takahashi, Shin'ichi, additional, Kusano, Motoyasu, additional, Fujimoto, Kazuma, additional, and Arakawa, Tetsuo, additional

Published
2013
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49. Arm span–height difference is correlated with gastroesophageal reflux symptoms in aged Japanese subjects

Author

Eguchi, Hitoshi, primary, Eguchi, Yuichiro, additional, Fujiwara, Motoshi, additional, Nishii, Midori, additional, Tokushima, Yoshinori, additional, Eguchi, Naoko, additional, Tago, Masaki, additional, Sakanishi, Yuta, additional, Tomonaga, Motosuke, additional, Yoshioka, Tsuneaki, additional, Hyakutake, Masaki, additional, Emura, Sei, additional, Koizumi, Shunzo, additional, Iwakiri, Ryuichi, additional, Edakuni, Genichiro, additional, Oda, Masamichi, additional, Hiramatsu, Katsuma, additional, Fujimoto, Kazuma, additional, Sugioka, Takashi, additional, and Yamashita, Shuichi, additional

Published
2013
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50. Mo1075 Clinical Characteristics of Responders for Rikkunshito and Rabeprazole in Patients With PPI-Refractory NERD From the GERD 4 Study (a Prospective Randomized Multicenter Trial in Japan)

Author

Tominaga, Kazunari, primary, Iwakiri, Ryuichi, additional, Fujimoto, Kazuma, additional, Fujiwara, Yasuhiro, additional, Shimoyama, Yasuyuki, additional, Umegaki, Eiji, additional, Higuchi, Kazuhide, additional, Kusano, Motoyasu, additional, and Arakawa, Tetsuo, additional

Published
2012
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