11 results on '"Janssen, T. L."'
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2. Additional file 1 of Caregiver strain on informal caregivers when providing care for older patients undergoing major abdominal surgery: a longitudinal prospective cohort study
- Author
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Janssen, T. L., P. Lodder, J. De Vries, C. C. H. A. Van Hoof – De Lepper, P. D. Gobardhan, G. H. Ho, and L. Van Der Laan
- Subjects
surgical procedures, operative ,bacterial infections and mycoses ,neoplasms ,digestive system ,digestive system diseases - Abstract
Additional file 1: Appendix A. Caregiver strain index in relation to patients’ age. Appendix B. Caregiver strain index in relation to patients’ dependency in ADL. Appendix C. Caregiver strain index in relation to type of surgery. Appendix D. Caregiver strain index in relation to patients’ burden of comorbidity. Appendix E. Caregiver strain index in relation to patients ‘cognitive status. Appendix F. Caregiver strain index in relation to development of delirium during admission.
- Published
- 2020
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3. Caregiver strain on informal caregivers when providing care for older patients undergoing major abdominal surgery: A longitudinal prospective cohort study
- Author
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Janssen, T L, Lodder, P, de Vries, J, van Hoof-de Lepper, C C H A, Gobardhan, P D, Ho, G H, van der Laan, L, Janssen, T L, Lodder, P, de Vries, J, van Hoof-de Lepper, C C H A, Gobardhan, P D, Ho, G H, and van der Laan, L
- Abstract
Background: Health-care systems nowadays rely on complementary patient care by informal caregivers. The need for, and burden on, informal caregivers will likely increase in the upcoming years. This study aimed to examine the burden on caregivers when providing care for elderly patients undergoing major abdominal surgery.Methods: A single-centre longitudinal cohort study was conducted between November 2015 and June 2018 in the Amphia hospital in Breda, the Netherlands. Patients aged 70+ undergoing elective surgery for colorectal carcinoma (CRC) or an abdominal aortic aneurysm (AAA) were included in this study. Informal caregiver burden was assessed and compared over time using the Caregiver Strain Index (CSI) at the outpatient clinic visit, at discharge, 2 weeks post-discharge and after 6 and 12 months. The effects of patient- and caregiver-related factors on the experienced caregiver strain were examined.Results:CSI scores of 248 caregivers were significantly increased at discharge (3.5 vs 2.6; p < 0.001) and 2 weeks post-discharge (3.3 vs 2.6; p < 0.001). After 12 months, scores dropped below baseline scores (1.8 vs 2.6; p = 0.012). The highest strain was observed 2 weeks post-discharge for AAA patients and at discharge for CRC patients. Older age, physical or cognitive impairment and burden of comorbidity were associated with an increased caregiver strain at baseline. Type of surgery was independently associated with the change in mean CSI scores over time; a bigger change in caregiver burden is observed after open surgery.Conclusion: In the early postoperative period, perceived caregiver strain was significantly increased. Psychological support for caregivers may be advisable, with timing of this support depending on diagnosis and patient-related factors.Trial registration: This manuscript was retrospectively registered on 05-04-2016 in the Netherlands Trial Register (NTR5932). http://www.trialregis
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- 2020
4. Prevention of postoperative delirium in elderly patients planned for elective surgery : systematic review and meta-analysis
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Janssen, T L, Alberts, A R, Hooft, L, Mattace-Raso, Fus, Mosk, C A, van der Laan, L, Janssen, T L, Alberts, A R, Hooft, L, Mattace-Raso, Fus, Mosk, C A, and van der Laan, L
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- 2019
5. Prevention of postoperative delirium in elderly patients planned for elective surgery: systematic review and meta-analysis
- Author
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Epi Methoden Team 5, Other research (not in main researchprogram), JC onderzoeksprogramma Methodologie, Brain, Janssen, T L, Alberts, A R, Hooft, L, Mattace-Raso, Fus, Mosk, C A, van der Laan, L, Epi Methoden Team 5, Other research (not in main researchprogram), JC onderzoeksprogramma Methodologie, Brain, Janssen, T L, Alberts, A R, Hooft, L, Mattace-Raso, Fus, Mosk, C A, and van der Laan, L
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- 2019
6. Multimodal prehabilitation to reduce the incidence of delirium and other adverse events in elderly patients undergoing elective major abdominal surgery: An uncontrolled before-and-after study
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Janssen, T. L., primary, Steyerberg, E. W., additional, Langenberg, J. C. M., additional, de Lepper, C. C. H. A. van Hoof-, additional, Wielders, D., additional, Seerden, T. C. J., additional, de Lange, D. C., additional, Wijsman, J. H., additional, Ho, G. H., additional, Gobardhan, P. D., additional, van Alphen, R., additional, and van der Laan, L., additional
- Published
- 2019
- Full Text
- View/download PDF
7. Body mass index and complications following major gastrointestinal surgery: A prospective, international cohort study and meta-analysis
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Blanco-Colino, R., Lee, S., Kamarajah, S. K., Vasko, P., Kuiper, S. Z., Farina, V., Chapman, S. J., Drake, T. M., Gavagna, L., Pasquali, S., Pata, F., Pellino, G., de la Rosa-Estadella, M., Stellingwerf, M. E., Stijns, R. C. H., Borrellas, A., Golding, D., Ngaage, M., Van Tol, R. R., de Groof, J., de Wilt, H., Bemelman, W. A., Mcnamee, L., Espin-Basany, E., Emre Baki, B., Gecim, I. E., Can Tatar, O., Bach, S., Bhangu, A., Bresges, K., Burke, J., Claireaux, H. A., Fearnhead, N., Fitzgerald, J. E., Gallagher, S., Glasbey, J. C., Gundogan, B., Harrison, E. M., Hernon, J., Khatri, C., Kong, C. Y., Lyons, A., Mohan, M., Morton, D., Pinkney, T. D., Arezzo, A., Foppa, C., Morino, M., Rubbini, M., Selvaggi, F., Sensi, B., Sica, G., Orhalmi, J., Naccari, P., Sgro, A., Burger, B. H. C. M., Fares, D. A., Spijkerman, R., van Elst, T. R., Wiersema, R., Stassen, L. P. S., Rodriguez Garcia, R., Ozkan, B. B., Tavuz, A. I., Demirci, Z. S., Baki, B. E., Choi, P. J., O'Sullivan, H., Salman, M., Simioni, A., Colombo, F., Turati, L., Cazzola, F. E., Gallo, G., Perrotta, G., Papandrea, M., Naccari, P. M., Menduni, N., Rossi, E., Chetta, N., Romeo, F., Giordano, F., Randisi, B., Curletti, G., Kuiper, J., Costa, A., Marcos Rodrigo, A., Sanchez, A., Varo Munoz, A., Martinez Rios, C. E., Aliseda-Jover, D., Fernandez Nieto, D., Alvarez Reyes, I., Dominguez Rodriguez, L. M., Hernandez Ros, M. I., Esteban Sinovas, O., Bartrina Soler, P., Villarejo Campos, P., Laguna Roman, S., Fontanet-Soler, S., Raurich-Leandro, J., Dominguez-Prieto, V., Segura-Sampedro, J. J., Alconchel-Gago, F., Salazar-Garcia, C., Gezen, A. E., Sahin, A., Atasoy, H., Yuksek, B., Arslan, E., Ozmen, B. B., Sen, A. Y., Erol, H. I., Ucar, E., Aktas, M. K., Yurdaor, S. S., Mermer, S., Seyhan, U., Tosun, V., Gunaydin, Y., Ekinci, Z. B., Yazkan, Z., Choi, J., Yeoh, T. S. L., Jones, C. S., Venturini, S., Saat, M. I., Loo, J., Pike, G., Davies, S. C., Kabariti, R., Olivier, J., Hurny, M., Zebrak, R., Machacova, A., Schulzova, M., Smolak, P., Siroka, M., Palyzova, H., Jaros, J., Dusek, T., Simackova, B., Bartos, M., Sotona, O., Pos, M., Karasek, D., Higgins, P., Hacking, S., Arora, E., Coughlan, G., Palanivail, N., Quill, S., Zhang, A. A., Malak, M., Maan, D. S., Cheema, J., Goh, A. W. J., Shamsul Badrin, A. K., Guinness, F., Howard James, N., Neary, A., Sebaoui, S., Gilroy, D., Petrov, G., Craven, K., Macdonald, A., Redmond, A., Brennan, D., Roche, D., O'Dwyer, M., Collins, P., Edwards, S., Doyle, J., Tiedt, L., Arthurs, B., O'Byrne, L., Kiely, A., Glynn, M., Sproule, L., Heaney, A., Li Hi Shing, S., Goh, W., Al-Nasser, Z., Al-Nasser, A., Teh, J. W., De Boni, D., Goldin, E., Ciccioli, E., Vendramin, E., Marchese, N., Bruno, M., Vinci, A., Harder, G., Morandi, V., Magnoli, M., Suppa, A., Palmieri, A., Martorana, M., Sette, M., Balagna, P., Cruciani, C., Corte, M., Ciano, P., Bagaglini, G., Montuori, M., Di Benedetto, L., Arcudi, C., Pezzuto, R., Saraceno, F., Milana, F., Franceschilli, M., Rizzi, A., Sampietro, G., Rampulla, V., Bianco, F., Boschetti, M. E., Ghignone, F., Bianchini, S., Esposto, R., Riva, L., Riva, M., Cannavo, M., Arrigo, A., Giavarini, L., Colombo, E. M., Trompetto, M., Clerico, G., Catalano, M., Dosa, T., El Mabruk, M., Barone, V., Pallara, E., Pasqualoni, M., Caudullo, G., Mastandrea Bonaviri, G. N., Muro, M., Pistola, I., Verardi, L., Ferrara, D., Gerardi, S., Remore, L. M., Belia, F., Del Coco, F., Larotonda, C., Botrugno, E. M., Cammarota, A., Di Girolami, L., Laterza, V., Laurino, A., Paolo, G., Santocchi, P., Puccioni, C., Truma, A., Giardino, F. R., Giuffrida, A., Ripa, M., Cautiero, R., Patturelli, M., Capozzolo, A., Selvaggi, L., Facchiano, A., Milazzo, L. F., Papazachariou, S. K., Pattapola, V., Anania, G., Feo, C., Bellinato, M., Priani, P., Zigiotto, D., Troia, A., Vable, T., Piran, G., Targa, S., Pulpito, S., Tagariello, F., Fasano, A., Anconelli, D., Castiglione, F., Tognolo, L., Lopez, G., Campion, A., Tarantino, M., Sacco, R., Sammarco, G., Palmisano, S., Giacca, M., Rocco, I., Bellio, G., Favero, A., Raimondi, P., Pantalone, M. R., De Nardi, P., Notarnicola, M., Picciariello, A., Licari, L., Parinisi, Z., Fazzotta, S., Ciciliot, M., Reggiani, L., Mariani, F., Aonzo, P., Checcacci, P., Montanelli, P., Guerra, F., Skalamera, I., Staderini, F., Grandi, S., Nelli, T., de Boer, D. V., van der Pool, A. E. M., Janssen, T. L., El-Atmani, S., van Verschuer, V. M. T., Poelman, M., Dronkers, W. J., van Steensel, L., Toorenvliet, B. R., Duinhouwer, L. E., Vermaas, M., Ter Bruggen, F. F. J. A., Hogendoorn, W., van der Harst, E., van Rijckevorsel, V. A. J. I. M., Bayoumy, A. B., Lap, C. R., Gooszen, J. A. H., Abdulrahman, N., de Roy van Zuidewijn, D., de Groof, E. J., Zijlmans, J. L., van Dalen, A. S. H. M., Bos, K., Musters, G. D., Looijen, R. C., Fliers, J. M., Oostendorp, S. E., Mosterd, C. M., Blonk, L., Jurgens, J., Ribbink, M. E., Boom, M. S., Boersma, A. M., Hidding, E., Schmidt, P. A., Mensink, G., Graus, S. A., Gastel, M. D. A., Veenker, C. G. H., Van Heumen, T. M., Slieker, F. J. B., Sedee, W. J. A., Lowensteyn, Y. N., Amelung, F. J., de Guerre, L. E. V. M., Nota, C. L. M. A., Van Dijck, W. P. M., van Wijnbergen, J. W. M., Pronk, A., Kip, M., van der Zee, C., Heiloo, S., Muller, S., Verboeket, B., Oudman, T. S., Zope, S., Gilissen, V., Gommers, J., Cremers, D., Van der Lubbe, M., Smet, M., Ter Weele, K., de Bruin, M., Geerlings, M., Ter Horst, L., Kerimova, N., Pesser, N., Heesakkers, H., de Mees, T., de Gooyer, J. M., Willems, L., Gawria, L., Bonouvrie, D., Harms, J., Eggen, Y., Hengeveld, E., Smeets, H. J., Hoffman, R. P. C., Detmers Blom, F. P. N., Van Bruggen, D., Steup, W. H., Gooiker, G. A., Willems, Y. R., van der Hoeven, A. C., Vallve-Bernal, M., Perez-Gandara, B., Perez, J. L., Caballero Rodriguez, E., Perez Febles, M., Protti Ruiz, G. P., Hidalgo Pujol, M., Alberti Delgado, P., Gil Barrionuevo, E., Anabitarte, O., Caballero, L., Poyato Nunez, F. J., Prado Perez, R., de la Portilla de Juan, F., Fulgencio Barbarin, J., Elorza Echaniz, G., Mitxelena Elosegi, L., Delgado, A. T., Marti Gelonch, L., Gonzalez Arribas, M., De Serra Tejada, I., Alberdi San Roman, I., de Andres Olabarria, U., Fernandez-Domper, L., Perez Costoya, C., Perez Arias, H., Fa Binefa, M., Becerra Nieves, M., Escalona Canal, M. G., Aldrey, I., Vazquez-Gonzalez, I., Falcon Cazas, A., Amarelo Garcia, M., Gonzalez Ruiz, A. A., Garcia Garrido, M., Simon Frapolli, V., Martinez Diaz, J. M., De la Torre Conde, C., Rodrigues Silva, K., Hernandez Kakauridze, S., Lopez Garcia, M. C., Flores Funes, D., Gomez-Lopez de San Roman, C., San Martin Bragado, M., Tejero Pintor, F. J., Pando Ruiz, B., Sanchez Estebanez, E., Roquet Puignero, E., Pla Sero, S., Vela Polanco, F. F., Mirallas Vinas, O., Caro Gonzalez, M. P., Bertelli Puche, J. L., Gonzalez-Martinez, A., Sanchez Cambronero, M., Garcia Torres, A., Dominguez Jimenez, M., de Jesus Rodriguez Perdomo, M., Echazarreta-Gallego, E., Sanchez-Blasco, L., Del Mar Lopez-Cuevas, M., Latras-Cortes, I., Lopez-Vendrell, L., Diaz Padillo, A., Mestres Petit, N., Cruz Reyes, J. A., Fernandez, C., Posada, M., Moratilla Lapena, L., Martin Morales, E., Mate-Mate, P., Garcia Cruz, G., Gorini, L., Rubio-Perez, I., Soldevila-Verdeguer, C., Jimenez-Vinas, C., Luehrman, A., Sena-Ruiz, F., Garcia-Perez, J. M., Plomer-Sanchez, M., Pujol-Cano, N., Jimenez-Segovia, M., Diaz-Jover, P., Pineno-Flores, C., Ambrona-Zafra, D., Gonzalez-Argente, X. F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, R., Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. J., Alonso Goncalves, S., Parajo, A., Sanchez-Guillen, L., Lujan Mompean, J. A., Soria Aledo, V., Arenal, J. J., Blanco Antona, F., Badia, J. M., Roura, J., Garcia Garcia, J., Elia-Guedea, M., Millan, M., Vinas-Salas, J., Garcia-Olmo, D., Prieto-Nieto, M. I., Medina-Fernandez, F. J., Romero-Simo, M., Frasson, M., Espi Macias, A., Tirnaksiz, M. B., Leventoglu, S., Kara, E., Tasci, Y., Pehlivan, M., Guner, A., Ozben, V., Agalar, C., Albayrak, D., Ertekin, C., Oncel, M., Sakman, G., Guler, S. A., Firat, O., Akkucuk, S., Ozbalci, G. S., Sozuer, E. M., Sengul, N., Schizas, A., Horgan, P. G., Singh, B., Harikrishnan, A., Stechman, M., Hayat, J., Coyne, P., Wilson, T., Arun, C., Manvydas, V., Moroni, P., Lo Secco, G., Argenti, F., Romano, F., Calcagno, P., Steccanella, F., Cisternino, G., Bottini, C., Realis Luc, A., Apicella, M., Candilio, G., Gubbiotti, F., De Luca, E., Casagranda, B., Decorato, A., Aquilino, F., Badii, B., Rahmee, C. N. S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. 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W., De Boni, D., Goldin, E., Ciccioli, E., Vendramin, E., Marchese, N., Bruno, M., Vinci, A., Harder, G., Morandi, V., Magnoli, M., Suppa, A., Palmieri, A., Martorana, M., Sette, M., Balagna, P., Cruciani, C., Corte, M., Ciano, P., Bagaglini, G., Montuori, M., Di Benedetto, L., Arcudi, C., Pezzuto, R., Saraceno, F., Milana, F., Franceschilli, M., Rizzi, A., Sampietro, G., Rampulla, V., Bianco, F., Boschetti, M. E., Ghignone, F., Bianchini, S., Esposto, R., Riva, L., Riva, M., Cannavo, M., Arrigo, A., Giavarini, L., Colombo, E. M., Trompetto, M., Clerico, G., Catalano, M., Dosa, T., El Mabruk, M., Barone, V., Pallara, E., Pasqualoni, M., Caudullo, G., Mastandrea Bonaviri, G. N., Muro, M., Pistola, I., Verardi, L., Ferrara, D., Gerardi, S., Remore, L. M., Belia, F., Del Coco, F., Larotonda, C., Botrugno, E. M., Cammarota, A., Di Girolami, L., Laterza, V., Laurino, A., Paolo, G., Santocchi, P., Puccioni, C., Truma, A., Giardino, F. R., Giuffrida, A., Ripa, M., Cautiero, R., Patturelli, M., Capozzolo, A., Selvaggi, L., Facchiano, A., Milazzo, L. F., Papazachariou, S. K., Pattapola, V., Anania, G., Feo, C., Bellinato, M., Priani, P., Zigiotto, D., Troia, A., Vable, T., Piran, G., Targa, S., Pulpito, S., Tagariello, F., Fasano, A., Anconelli, D., Castiglione, F., Tognolo, L., Lopez, G., Campion, A., Tarantino, M., Sacco, R., Sammarco, G., Palmisano, S., Giacca, M., Rocco, I., Bellio, G., Favero, A., Raimondi, P., Pantalone, M. R., De Nardi, P., Notarnicola, M., Picciariello, A., Licari, L., Parinisi, Z., Fazzotta, S., Ciciliot, M., Reggiani, L., Mariani, F., Aonzo, P., Checcacci, P., Montanelli, P., Guerra, F., Skalamera, I., Staderini, F., Grandi, S., Nelli, T., de Boer, D. V., van der Pool, A. E. M., Janssen, T. L., El-Atmani, S., van Verschuer, V. M. T., Poelman, M., Dronkers, W. J., van Steensel, L., Toorenvliet, B. R., Duinhouwer, L. E., Vermaas, M., Ter Bruggen, F. F. J. A., Hogendoorn, W., van der Harst, E., van Rijckevorsel, V. A. J. I. M., Bayoumy, A. B., Lap, C. R., Gooszen, J. A. H., Abdulrahman, N., de Roy van Zuidewijn, D., de Groof, E. J., Zijlmans, J. L., van Dalen, A. S. H. M., Bos, K., Musters, G. D., Looijen, R. C., Fliers, J. M., Oostendorp, S. E., Mosterd, C. M., Blonk, L., Jurgens, J., Ribbink, M. E., Boom, M. S., Boersma, A. M., Hidding, E., Schmidt, P. A., Mensink, G., Graus, S. A., Gastel, M. D. A., Veenker, C. G. H., Van Heumen, T. M., Slieker, F. J. B., Sedee, W. J. A., Lowensteyn, Y. N., Amelung, F. J., de Guerre, L. E. V. M., Nota, C. L. M. A., Van Dijck, W. P. M., van Wijnbergen, J. W. M., Pronk, A., Kip, M., van der Zee, C., Heiloo, S., Muller, S., Verboeket, B., Oudman, T. S., Zope, S., Gilissen, V., Gommers, J., Cremers, D., Van der Lubbe, M., Smet, M., Ter Weele, K., de Bruin, M., Geerlings, M., Ter Horst, L., Kerimova, N., Pesser, N., Heesakkers, H., de Mees, T., de Gooyer, J. M., Willems, L., Gawria, L., Bonouvrie, D., Harms, J., Eggen, Y., Hengeveld, E., Smeets, H. J., Hoffman, R. P. C., Detmers Blom, F. P. N., Van Bruggen, D., Steup, W. H., Gooiker, G. A., Willems, Y. R., van der Hoeven, A. C., Vallve-Bernal, M., Perez-Gandara, B., Perez, J. L., Caballero Rodriguez, E., Perez Febles, M., Protti Ruiz, G. P., Hidalgo Pujol, M., Alberti Delgado, P., Gil Barrionuevo, E., Anabitarte, O., Caballero, L., Poyato Nunez, F. J., Prado Perez, R., de la Portilla de Juan, F., Fulgencio Barbarin, J., Elorza Echaniz, G., Mitxelena Elosegi, L., Delgado, A. T., Marti Gelonch, L., Gonzalez Arribas, M., De Serra Tejada, I., Alberdi San Roman, I., de Andres Olabarria, U., Fernandez-Domper, L., Perez Costoya, C., Perez Arias, H., Fa Binefa, M., Becerra Nieves, M., Escalona Canal, M. G., Aldrey, I., Vazquez-Gonzalez, I., Falcon Cazas, A., Amarelo Garcia, M., Gonzalez Ruiz, A. A., Garcia Garrido, M., Simon Frapolli, V., Martinez Diaz, J. M., De la Torre Conde, C., Rodrigues Silva, K., Hernandez Kakauridze, S., Lopez Garcia, M. C., Flores Funes, D., Gomez-Lopez de San Roman, C., San Martin Bragado, M., Tejero Pintor, F. J., Pando Ruiz, B., Sanchez Estebanez, E., Roquet Puignero, E., Pla Sero, S., Vela Polanco, F. F., Mirallas Vinas, O., Caro Gonzalez, M. P., Bertelli Puche, J. L., Gonzalez-Martinez, A., Sanchez Cambronero, M., Garcia Torres, A., Dominguez Jimenez, M., de Jesus Rodriguez Perdomo, M., Echazarreta-Gallego, E., Sanchez-Blasco, L., Del Mar Lopez-Cuevas, M., Latras-Cortes, I., Lopez-Vendrell, L., Diaz Padillo, A., Mestres Petit, N., Cruz Reyes, J. A., Fernandez, C., Posada, M., Moratilla Lapena, L., Martin Morales, E., Mate-Mate, P., Garcia Cruz, G., Gorini, L., Rubio-Perez, I., Soldevila-Verdeguer, C., Jimenez-Vinas, C., Luehrman, A., Sena-Ruiz, F., Garcia-Perez, J. M., Plomer-Sanchez, M., Pujol-Cano, N., Jimenez-Segovia, M., Diaz-Jover, P., Pineno-Flores, C., Ambrona-Zafra, D., Gonzalez-Argente, X. F., Jimenez-Morillas, P., Lopez-Marmol, R., Duran-Martinez, M., Gonzalez-Crespo, A., Checa Guillen, M., Valderrama Perez, A., Claramonte Bellmunt, O., Marti Fernandez, R. M., Kasap, S., Soylemez, Z. O. B. B., Bolat, A. B., Aydar, S. E. Y. I., Birgin, B. Z., Coskun, O., Cakir, S. G., Belibagli, Z. O., Herken, M., Erdem, S., Kayacan, S., Kelesoglu, Y., Moran, D., Atalay, H., Kucukdiler, E., Demirci, A., Buyukkasap, C., Kuzey, A., Emral, C., Dogan, H., Cok, H., Durmaz, H., Asma, A., Ergul, B., Kaya, A., Bilicen, G., Gunay, M., Senturk, E., Baskoy, L., Besisik, H. M., Topalan, K., Piraliyev, E., Danalioglu, A. N., Ilbak, A., Yigman, S., Kara, C., Guzel, M., Inci, E. T., Onsal, U., Erel, T., Cetin, S. K., Yekenkurul, E., Kasar, P., Saglam, Z. A., Gursoy, F., Cetinkaya, M., Aktekin, H., Bober, D. N., Mugurtay, Y. S., Koksal, G., Celik, S., Bektur, G., Yildirim, R., Ankarali, T., Guven, H., Yuksel, A., Semiz, A., Cise, S., Tomas, K., Ulusahin, M., Akbulut, F., Tulum, H., Bodur, S., Isler, V. C., Pektas, A. M., Mutlu, D., Mericliler, M., Tansoker, I., Polat, Z. P., Seyrek, N., Beyatli, S., Toto, O. F., Cakaloglu, H. C., Sapci, I., Akpunarli, B., Adiyaman, C., Kobal, B. B., Gok, Z., Benli, S., Turpan, M., Kocapinar, S., Parimli, H., Acar, S., Eger, M., Yilmaz, I., Cengiz, U., Yoruk, I., Mutlu, B., Ulkucu, A., Arukan, C., Kara, B., Gokce, K., Calisgan, B., Demirci, K., Elkatroushi, T., Ayaz, B., Uzun, B., Sivrikaya, T., Goksoy, B., Eroz, E., Celik, B., Canbay Torun, B., Ekin, B., Senay, B. B., Temiz, C., Yilmaz, M., Yasar, C., Cakir, E., Subasi, A., Celik, K., Aksoy, K., Karabulut, E., Altintas, O., Bali, A. N., Ciftci, E., Babaoglu, H., Aljbour, A., Aljbour, I., Akcaoglu, T., Kakil, E., Taskin, O., Taskin, R. B., Topal, U., Huzmeli, E., Caliskan, T., Unal, A. G., Yurekli, A. M., Sari, V., Tutam, D. N., Celen, D., Posteki, G., Demirtas, B., Yildiz, S., Kilic, E., Yalcin, Y., Kurt, A., Gozubuyuk, Y., Huseynova, S., Cinar, S., Calar, S. N., Kurklu, O., Binbuga, M., Ceylan, C., Yavuz, G., Alim, Y. E., Yildirim, N., Yilmaz, S., Onar, D., Aray, E., Ozsipahi, A. C., Koc, G. E., Yetiskin, E., Kocer, M. D., Ozgencil, B., Bahcecioglu, B., Hacioglu, A. D., Bilici, O., Cin, S., Uzunoglu, E. C., Cumen, E. C., Aslan, L., Erozgur, B., Yildiz, S. S., Zengin, T., Kullac, S., Mizan, S. R., Baykan, B., Kopac, O., Karabacak, U., Aytekin, A., Deliktas, T. S., Buyukkarabacak, Y., Uzun, O., Karahan, B., Turkmen, M., Akdogan, A., Uctepe, F., Bandirmali, O., Erdogan, P., Demir, F., Bozkurt, G. K., Yilmaz, T., Sheikh, I. M. I., Orhan, K., Balci, B., Keyif, M. F., Bilgin, S., Cantimer, E., Yaman, S., Akkaya, E., Atesavci, S. N., Arslan, U., Asik, M., Koksal, S., Murtaza, M. I., Mustafa, S., Oun, H., Sam, Z. H., Brogan, A., Zaidi, R., Quinn, K., Taylor, F., Pang, G., Heath, H., Smart, N. J., Home, J., Mauro, D., Noone, T. M., Fenn, J., Sinha, A., Lowe, R., Hutchings, I., Longstaff, L., Smith, A. G., Edwards, J. A., Alcocer, B. P., Oakley, T., Thomas-Davies, M., Hourston, G. J. M., Kankam, H. K. N., Ramana, A., Baker, C., Endo, Y., Wong, C., Anderson, R. G. J., Badran, A., Ali, A., Myers, L., Tippins, F., Stanley, S., Sandison, L., Schofield, E., Delf, J., Rees, S., Anyan-Brown, J., Long, K., Archer, M., Anakwenze, V., Goel, S., Sharma Khatiwada, A., Khan, S., Leafe, O., Lee, J., Embury-Young, Y., Edwards, L., Hazenberg, P., Agrawal, M., Guerero, D., Britton, F., Rejayee, M., Mahesh, S., Khaing, P. H., Baldwin, A., Iyer, S., Gaskell, P., Adlan, A., Cuckow, L., Barmayehvar, B., Rob, T., Ciurleo, C., Mural-Krishnan, S., Jong, N., Carlson, S., Abdelgalil, R., Goble, M., Doshi, A., Ogunleye, O., Marsh, L., Bagley, J., Poacher, A., Cantelo, J., Wylie, J., Govil, S., Hill, F., Beaver, D., Urquhart, A., Rakhimov, I., Raina, V., Clifford, T., Iorga, R., Cartwright, E., Harris, A. J., Shurovi, B., Wadanamby, S., Brown, E., Bradley, C., Ahmad, A., Jeyabraba, S., Hardaman, B., Truss, A., Mohamed, U. S., Kerin, M. J., Reynolds, J., Ridgway, P., Pietrabissa, A., Foschi, D., Sgroi, G., Rosati, G., Benevento, A., Coco, Claudio, Persiani, R., Vasquez, G., Messina, F., De Manzini, N., Innocenti, P., Rosati, R., Altomare, D. F., Sartori, A., Salamone, G., Galleano, R., Cianchi, F., Wijnhoven, B. P. L., van de Ven, A. W. H., de Vos Tot Nederveen Cappel, R. J., de Castro, S. M. M., Meijerink, W. J. H. J., Mulder, I. M., Acherman, Y. I. Z., van Leeuwen, B. L., Schasfoort, R. A., Kloppenberg, F. W. H., Wiezer, R., Consten, E. C. J., Van Grevenstein, W. M. U., Schiphorst, A., Wijffels, N., Uittenbogaart, M., Klinkert, M., Koppe, M., de Hingh, I., Konsten, J., Polat, F., Berends, F., Langenhoff, B., Zimmerman, D., van Engelenburg, T., Vries, J. J. M., Baeten, C. I. M., Bastiaansen, A. J. N. M., van Geloven, A., Khan, I., Girones, J., Barrera Gomez, M., Sanz Ortega, G., Duran Munoz-Cruzado, V. M., Ruiz Montesinos, I., Enriquez-Navascues, J. M., Portugal Porras, V., Baixauli, J., Garcia Florez, L. J., Alonso Goncalves, S., Parajo, A., Sanchez-Guillen, L., Lujan Mompean, J. A., Soria Aledo, V., Arenal, J. J., Blanco Antona, F., Badia, J. M., Roura, J., Garcia Garcia, J., Elia-Guedea, M., Millan, M., Vinas-Salas, J., Garcia-Olmo, D., Prieto-Nieto, M. I., Medina-Fernandez, F. J., Romero-Simo, M., Frasson, M., Espi Macias, A., Tirnaksiz, M. B., Leventoglu, S., Kara, E., Tasci, Y., Pehlivan, M., Guner, A., Ozben, V., Agalar, C., Albayrak, D., Ertekin, C., Oncel, M., Sakman, G., Guler, S. A., Firat, O., Akkucuk, S., Ozbalci, G. S., Sozuer, E. M., Sengul, N., Schizas, A., Horgan, P. G., Singh, B., Harikrishnan, A., Stechman, M., Hayat, J., Coyne, P., Wilson, T., Arun, C., Manvydas, V., Moroni, P., Lo Secco, G., Argenti, F., Romano, F., Calcagno, P., Steccanella, F., Cisternino, G., Bottini, C., Realis Luc, A., Apicella, M., Candilio, G., Gubbiotti, F., De Luca, E., Casagranda, B., Decorato, A., Aquilino, F., Badii, B., Rahmee, C. N. S., Kleine, E., Yauw, S., de Zeeuw, S., Aarts, E., Teixeira da Silva, M., Brueren, L., Bokkerink, G., Schok, T., Graafland, M., Gonzalez de Chaves, P. E., Jimenez-Gomez, L. M., Garcia Galocha, J. L., Palos Campos, M. C., Jimenez Escovar, F., Hernandez-Lizoain, J. L., Monzonis Hernandez, X., Dominguez Sanchez, J. M., Vives-Rodriguez, E., Abrisqueta Carrion, J., Beltran de Heredia, J., Padilla Valverde, D., Alcazar Montero, J. A., Cordoba-Diaz de Laspra, E., Franco Chacon, M., Muriel, P., Pastor-Riquelme, P., Peinado Iribar, B., Alonso Hernandez, N., Costa-Navarro, D., Martinez Chillaron, E., Secilmis, E., Bamac, E., Koc, F., Kayaci Durak, M., Bayram, S., Ekrem, M., Uzun, S., Gok, A. F. K., Gorguner, F., Yildiz, T., Dalci, K., Kilinc, C., Koc, M., Yuksek, M. A., Ersoy, T., Celik, E., Parmar, E., Abuhussein, N., Metcalf, P., Atif, M., Heywood, E., Mayes, J. W., Kelly, M., Mitchell, H., Antoniou, I., Dean, R., Davies, N., Trecarten, S., Henderson, I., Holmes, C., Shuttleworth, R. H., Jindal, A., Hughes, F., Gouda, P., Fleck, R., Hanrahan, M., Karunakaran, P., Chen, J. H., Sykes, M. C., Sethi, R. K., Suresh, S., Patel, P., Patel, M., Varma, R. K., Mushtaq, J., Bolton, W., Khan, T., Morley, R., Favero, N., Adams, R., Thirumal, V., Kennedy, E. D., Ong, K. K., Tan, Y. H., Gabriel, J., Bakhsh, A., Low, J. Y. L., Yener, A., Paraoan, V., Preece, R., Tilston, T. W., Cumber, E., Dean, S., Ross, T., Mccance, E., Amin, H., Satterthwaite, L., Clement, K. D., Gratton, R., Mills, E. D., Chiu, S. M., Hung, G., Rafiq, N. M., Hayes, J. D. B., Robertson, K. L., Dynes, K., Huang, H. C., Assadullah, S., Duncumb, J. W., Moon, R. D. C., Poo, S. X., Mehta, J. K., Joshi, K. R., Callan, R., Norris, J. M., Chilvers, N. J., Keevil, H., Jull, P., Mallick, S., Elf, D., Carr, L., Player, C., Barton, E. C., Martin, A. L., Ratu, S. G., Roberts, E. J., Phan, P. N., Dyal, A. R., Rogers, J. E., Henson, A. D., Reid, N. B., Burke, D., Culleton, G., Lynne, S., Mansoor, S., Brennan, C., Blessed, R., Holloway, C., Hill, A., Goldsmith, T., Mackin, S., Kim, S., Woin, E., Brent, G., Coffin, J., Ziff, O., Momoh, Z., Debenham, R., Ahmed, M., Yong, C. S., Wan, J. C., Copley, H. C., Raut, P., Chaudhry, F. I., Nixon, G., Dorman, C., Tan, R., Kanabar, S., Canning, N., Dolaghan, M., Bell, N., Mcmenamin, M., Chhabra, A., Duke, K., Turner, L., Patel, T., Chew, L. S., Mirza, M., Lunawat, S., Oremule, B., Ward, N., Khan, M., Tan, E. T., Maclennan, D., Mcgregor, R. J., Chisholm, E. G., Griffin, E. J., Bell, L., Hughes, B. A., Davies, J., Haq, H., Ahmed, H., Ungcharoen, N., Whacha, C., Thethi, R., Markham, R. M., Lee, A. H. Y., Batt, E., Bullock, N. P., Francescon, C. T., Davies, J. E., Shafiq, N. M., Zhao, J., Vivekanantham, S., Barai, I., Allen, J. L. Y., Marshall, D. C., Mcintyre, C. J., Wilson, H. C. P., Ashton, A. 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F., Lim, K., Ho, S., Crewdson, J. A., Singagireson, S., Kalra, N., Koumpa, F., Jhala, H., Soon, W. C., Karia, M., Rasiah, M. G., Xylas, D., Gilbert, H., Sundar-Singh, M., Wills, J., Akhtar, S., Patel, S., Hu, L., Brathwaite-Shirley, C., Nayee, H., Amin, O., Rangan, T., Turner, E. J. H., Mccrann, C., Shepherd, R., Patel, N., Prest-Smith, J., Auyoung, E., Murtaza, A., Coates, A., Prys-Jones, O., King, M., Gaffney, S., Dewdney, C. J., Nehikhare, I., Lavery, J., Bassett, J., Davies, K., Ahmad, K., Collins, A., Acres, M., Egerton, C., Cheng, K., Chen, X., Chan, N., Sheldon, A., Empey, J., Ingram, E., Malik, A., Johnstone, M., Goodier, R., Shah, J. P., Giles, J. E., Sanders, J. A., Mclure, S. W., Pal, S., Rangedara, A., Baker, A. N., Asbjoernsen, C. A., Girling, C., Gray, L., Gauntlett, L., Joyner, C., Qureshi, S., Mogan, Y. P., Ng, J. C. K., Kumar, A. N., Park, J. H., Tan, D., Choo, K. P., Raman, K. P., Buakuma, P., Xiao, C., Govinden, S., Thompson, O. D., Charalambos, M. A., Karsan, R. 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M., Sait, M. S., Mitha, N., de Bernier, G. L., Siddiqui, M., Shaunak, R., Wali, A., Cuthbert, G., Bhudia, R., Webb, E., Shah, S., Ansari, N., Perera, M., Kelly, N., Mcallister, R., Stanley, G. H., Keane, C. P., Shatkar, V., Maxwell-Armstrong, C., Henderson, L. A., Maple, N., Manson, R., Adams, R. D., Semple, E., Mills, M., Daoub, A., Marsh, A., Ramnarine, A., Hartley, J., Malaj, M., Jewell, P. D., Whatling, E. A., Hitchen, N., Chen, M., Goh, B., Fern, J., Rogers, S., Derbyshire, L., Robertson, D. T., Deekonda, P., Abid, A., Harrison, P. L. M., Aildasani, L., Turley, H., Sherif, M. A., Pandey, G., Filby, J. J., Johnston, A., Burke, E., Mohamud, M., Gohil, K., Tsui, A. Y., Singh, R., Lim, S. J., O'Sullivan, K., Mckelvey, L. L., O'Neill, S., Roberts, H. F., Brown, F. S., Cao, Y., Buckle, R. T., Liew, Y., Sii, S., Ventre, C. M., Graham, C. J., Filipescu, T., Yousif, A., Dawar, R., Wright, A., Peters, M., Varley, R., Owczarek, S., Hartley, S., Khattak, M., Iqbal, A., Ali, M., Durrani, B., Narang, Y., Bethell, G. S., Horne, L., Pinto, R., Nicholls, K., Kisyov, I., Torrance, H. D., English, W., Lakhani, S. M., Ashraf, S. F., Venn, M., Elangovan, V., Kazmi, Z., Brecher, J., Sukumar, S., Mastan, A., Mortimer, A., Parker, J., Boyle, J., Elkawafi, M., Beckett, J., Mohite, A., Narain, A., Mazumdar, E., Sreh, A., Hague, A., Weinberg, D., Fletcher, L., Steel, M., Shufflebotham, H., Masood, M., Sinha, Y., Jenvey, C., Kitt, H., Slade, R., Craig, A. R., Deall, C., Reakes, T., Chervenkoff, J., Strange, E., O'Bryan, M., Murkin, C., Joshi, D., Bergara, T., Naqib, S., Wylam, D., Scotcher, S. E., Hewitt, C. M., Stoddart, M. T., Kerai, A., Trist, A. J., Cole, S. J., Knight, C. L., Stevens, S., Cooper, G. E., Ingham, R., Dobson, J., O'Kane, A., Moradzadeh, J., Duffy, A., Henderson, C., Ashraf, S., Mclaughin, C., Hoskins, T. C., Reehal, R. S., Bookless, L. R., Mclean, R. C., Stone, E. J., Wright, E. V., Abdikadir, H. R., Roberts, C., Spence, O., Srikantharajah, M., Ruiz, E. M., Matthews, J. H., Gardner, E., Hester, E., Naran, P., Simpson, R., Minhas, M., Cornish, E., Semnani, S. A., Rojoa, D., Radotra, A., Eraifej, J., Eparh, K., Smith, D. N. E., Mistry, B. D., Hickling, S. L., Din, W., Liu, C., Mithrakumar, P., Mirdavoudi, V., Rashid, M., Mcgenity, C., Hussain, O., Kadicheeni, M., Gardner, H., Anim-Addo, N., Pearce, J., Aslanyan, A., Ntala, C., Sorah, T., Parkin, J., Alizadeh, M., White, A., Edozie, F., Johnston, J., Kahar, A., Navayogaarajah, V., Carter, D., Khonsari, P., Burgess, A., Patel, B., Kong, C., Ponweera, A., Cody, A., Tan, Y., Ng, A. Y. L., Croall, A., Allan, C., Ng, S., Raghuvir, V., Telfer, R., Greenhalgh, A. D., Mckerr, C. N., Edison, M. A., Patel, B. A., Dear, K., Hardy, M. R., Williams, P., Hassan, S., Sajjad, U., O'Neill, E. M., Lopes, S., Healy, L., Jamal, N., Tan, S., Lazenby, D., Husnoo, S. B., Beecroft, S., Sarvanandan, T., Weston, C., Bassam, N., Rabinthiran, S., Hayat, U., Ng, L., Varma, D., Sukkari, M., Mian, A., Omar, A., Kim, J. W., Sellathurai, J., Mahmood, J., O'Connell, C., Bose, R., Heneghan, H., Lalor, P., Matheson, J., Doherty, C., Cullen, C., Cooper, D., Angelov, S., Drislane, C., Smith, A. C. D., Kreibich, A., Palkhi, E., Durr, A., Lotfallah, A., Gold, D., Mckean, E., Dhanji, A., Anilkumar, A., Thacoor, A., Siddiqui, Z. H., Lim, S., Piquet, A., Anderson, S. M., Mccormack, D. R., Gulati, J., Ibrahim, A., Murray, S. E., Walsh, S. L., Mcgrath, A., Ziprin, P., Chua, E. Y., Lou, C. N., Bloomer, J., Paine, H. R., Osei-Kuffour, D., White, C. J., Szczap, A., Gokani, S., Patel, K., Malys, M. K., Reed, A., Torlot, G. E., Cumber, E. M., Charania, A., Ahmad, S., Varma, N., Cheema, H., Austreng, L., Petra, H., Chaudhary, M., Zegeye, M. I., Cheung, F., Coffey, D., Heer, R. S., Singh, S., Seager, E., Cumming, S., Suresh, R. S., Verma, S., Ptacek, I. B., Gwozdz, A. M., Yang, T., Khetarpal, A. A., Shumon, S., Fung, T. M. P., Leung, W., Kwang, P., Chew, L., Loke, W., Curran, A., Chan, C., Mcgarrigle, C., Mohan, K., Cullen, S., Wong, E., Toale, C., Collins, D., Keane, N., Traynor, B. P., Shanahan, D., Yan, A., Jafree, D. J., Topham, C., Mitrasinovic, S., Omara, S., Bingham, G., Lykoudis, P. M., Miranda, B. H., Whitehurst, K., Kumaran, G., Devabalan, Y., Aziz, H., Shoa, M., Dindyal, S., Yates, J. A., Bernstein, I., Rattan, G., Coulson, R., Stezaker, S., Isaac, A., Salem, M., Mcbride, A., Mcfarlane, H., Yow, L., Macdonald, J., Bartlett, R. D., Turaga, S., White, U., Liew, W., Yim, N., Ang, A., Simpson, A., Mcauley, D., Craig, E., Murphy, L., Shepherd, P., Kee, J. Y., Abdulmajid, A., Chung, A., Warwick, H. L., Livesey, A., Holton, P., Theodoreson, M. D., Jenkin, S. L., Turner, J., Entwisle, J. H., Marchal, S. T., O'Connor, S., Blege, H. K., Aithie, J. M., Sabine, L. M., Stewart, G. E., Jackson, S., Kishore, A., Lankage, C. M., Acquaah, F., Joyce, H. L., Mckevitt, K. L., Coffey, C. J., Fawaz, A. S., Dolbec, K. S., O'Sullivan, D. A., Geraghty, J. M., Lim, E., Bolton, L., Fitzpatrick, D., Robinson, C., Ramtoola, T., Collinson, S., Grundy, L., Mcenhill, P. M., Harbhajan Singh, G. S., Loughran, D., Golding, D. M., Keeling, R. E., Williams, R. P., Whitham, R. D. J., Yoganathan, S., Nachiappan, R., Egan, R. J., Owasil, R., Kwan, M. L., He, A., Goh, R. W., Bhome, R., Wilson, H., Teoh, P. J., Raji, K., Jayakody, N., Matthams, J., Chong, J., Luk, C. Y., Greig, R. J., Trail, M., Charalambous, G., Rocke, A. S., Gardiner, N., Bulley, F., Warren, N., Brennan, E., Fergurson, P., Wilson, R., Whittingham, H., Brown, E. J., Khanijau, R., Gandhi, K., Morris, S., Boulton, A. J., Chandan, N., Barthorpe, A. E., Maamari, R., Sandhu, S., Mccann, M., Higgs, L., Balian, V., Reeder, C., Diaper, C., Sale, T., Ali, H., Archer, C. H., Clarke, A. K., Heskin, J., Hurst, P. C., Farmer, J. D., O'Flynn, L. D., Doan, L., Shuker, B. A., Stott, G. D., Vithanage, N. A., Hoban, K. A., Nesargikar, P. N., Kennedy, H. R., Grossart, C. M., Tan, E. S. M., Roy, C. S. D., Sim, P., Leslie, K. E., Sim, D., Abul, M. H., Cody, N., Tay, A. Y., Woon, E., Sng, S., Mah, J., Robson, J., Shakweh, E., Wing, V. C., Mills, H., Li, M. M., Barrow, T. R., Balaji, S., Jordan, H. E. M., Phillips, C., Naveed, H., Hirani, S., Tai, A., Ratnakumaran, R., Sahathevan, A., Shafi, A. M. A., Seedat, M., Weaver, R., Batho, A., Punj, R., Selvachandran, H., Bhatt, N., Botchey, S., Khonat, Z., Brennan, K., Morrison, C. J., Devlin, E., Linton, A., Galloway, E., Mcgarvie, S., Ramsay, N., Mcrobbie, H. D., Whewell, H., Dean, W., Nelaj, S., Eragat, M., Mishra, A., Kane, T., Zuhair, M., Wells, M., Wilkinson, D., Woodcock, N., Sun, E., Aziz, N., Abd Ghaffar, M. K., Bath, M. F., Nepogodiev, D., and Coco C. (ORCID:0000-0002-4713-7093)
- Abstract
Aim Previous studies reported conflicting evidence on the effects of obesity on outcomes after gastrointestinal surgery. The aims of this study were to explore the relationship of obesity with major postoperative complications in an international cohort and to present a metaanalysis of all available prospective data. Methods This prospective, multicentre study included adults undergoing both elective and emergency gastrointestinal resection, reversal of stoma or formation of stoma. The primary end-point was 30-day major complications (Clavien–Dindo Grades III–V). A systematic search was undertaken for studies assessing the relationship between obesity and major complications after gastrointestinal surgery. Individual patient meta-analysis was used to analyse pooled results. Results This study included 2519 patients across 127 centres, of whom 560 (22.2%) were obese. Unadjusted major complication rates were lower in obese vs normal weight patients (13.0% vs 16.2%, respectively), but this did not reach statistical significance (P = 0.863) on multivariate analysis for patients having surgery for either malignant or benign conditions. Individual patient meta-analysis demonstrated that obese patients undergoing surgery formalignancy were at increased risk of major complications (OR 2.10, 95% CI 1.49–2.96, P < 0.001), whereas obese patients undergoing surgery for benign indications were at decreased risk (OR 0.59, 95% CI 0.46–0.75, P < 0.001) compared to normal weight patients. Conclusions In our international data, obesity was not found to be associated with major complications following gastrointestinal surgery. Meta-analysis of available prospective data made a novel finding of obesity being associated with different outcomes depending on whether patients were undergoing surgery for benign or malignant disease.
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- 2018
8. Risk factors for postoperative delirium after elective major abdominal surgery in elderly patients: A cohort study.
- Author
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Janssen TL, Steyerberg EW, Faes MC, Wijsman JH, Gobardhan PD, Ho GH, and van der Laan L
- Subjects
- Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Male, Postoperative Complications psychology, Risk Factors, Abdomen surgery, Aortic Aneurysm, Abdominal surgery, Colorectal Neoplasms surgery, Delirium etiology, Elective Surgical Procedures adverse effects, Postoperative Complications etiology
- Abstract
Background: Prehabilitation programs have recently been suggested as potentially able to lower the incidence of delirium in elderly patients undergoing major abdominal surgery. For these prehabilitation programs to become successful, it is essential to identify those patients who are most likely to develop a delirium., Material and Methods: A single-centre cohort study was conducted. Inclusion criteria were: age ≥70 years and scheduled for abdominal surgery for colorectal cancer or an abdominal aortic aneurysm between January 2013 and June 2018. Baseline patient, surgical, anaesthesiologic and haematological characteristics were collected. A risk factor analysis was conducted, with postoperative delirium as primary outcome, by performing a multivariable logistic regression analysis., Results: In this study, 627 patients were included, of whom 64 (10%) developed a delirium. Variables that differed significantly between delirious and non-delirious patients were age, burden of comorbidity, renal impairment, hypertension, cognitive impairment, history of delirium, physical and nutritional impairment, open surgery, preoperative anaemia and erythrocyte transfusion. After multivariable logistic regression analysis, risk factors for postoperative delirium after major abdominal surgery were renal impairment (OR 2.2; 95%CI 1.2-4.3), cognitive impairment (OR 4.1; 95%CI 1.8-9.2), an ASA score ≥ 3 (OR 2.0; 95% CI 1.0-3.9), being an active smoker (OR 2.7; 95%CI 1.3-5.8), ICU admission (OR 7.1; 95%CI 3.5-14.3), erythrocyte transfusion (OR 2.4; 95%CI 1.2-4.9) and a diagnosis of colorectal cancer (CRC); (OR 4.0; 95% CI 1.7-9.6). Prehabilitation had a protective effect (OR 0.5; 95% CI 0.3-0.9)., Conclusion: Postoperative delirium is a frequent complication after major abdominal surgery in the elderly, especially in octogenarians and after open procedures. Renal impairment, cognitive impairment, being an active smoker, ICU admission, erythrocyte transfusion and a diagnosis of CRC are important risk factors for the development of delirium. Prehabilitation lowers the risk of developing a delirium., (Copyright © 2019 IJS Publishing Group Ltd. Published by Elsevier Ltd. All rights reserved.)
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- 2019
- Full Text
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9. Prevention of postoperative delirium in elderly patients planned for elective surgery: systematic review and meta-analysis.
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Janssen TL, Alberts AR, Hooft L, Mattace-Raso F, Mosk CA, and van der Laan L
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- Aged, Antipsychotic Agents therapeutic use, Delirium therapy, Hospitalization, Humans, Incidence, Randomized Controlled Trials as Topic, Delirium etiology, Elective Surgical Procedures adverse effects, Postoperative Complications etiology
- Abstract
Introduction: Vulnerable or "frail" patients are susceptible to the development of delirium when exposed to triggers such as surgical procedures. Once delirium occurs, interventions have little effect on severity or duration, emphasizing the importance of primary prevention. This review provides an overview of interventions to prevent postoperative delirium in elderly patients undergoing elective surgery. Methods: A literature search was conducted in March 2018. Randomized controlled trials (RCTs) and before-and-after studies on interventions with potential effects on postoperative delirium in elderly surgical patients were included. Acute admission, planned ICU admission, and cardiac patients were excluded. Full texts were reviewed, and quality was assessed by two independent reviewers. Primary outcome was the incidence of delirium. Secondary outcomes were severity and duration of delirium. Pooled risk ratios (RRs) were calculated for incidences of delirium where similar intervention techniques were used. Results: Thirty-one RCTs and four before-and-after studies were included for analysis. In 19 studies, intervention decreased the incidences of postoperative delirium. Severity was reduced in three out of nine studies which reported severity of delirium. Duration was reduced in three out of six studies. Pooled analysis showed a significant reduction in delirium incidence for dexmedetomidine treatment, and bispectral index (BIS)-guided anaesthesia. Based on sensitivity analyses, by leaving out studies with a high risk of bias, multicomponent interventions and antipsychotics can also significantly reduce the incidence of delirium. Conclusion: Multicomponent interventions, the use of antipsychotics, BIS-guidance, and dexmedetomidine treatment can successfully reduce the incidence of postoperative delirium in elderly patients undergoing elective, non-cardiac surgery. However, present studies are heterogeneous, and high-quality studies are scarce. Future studies should add these preventive methods to already existing multimodal and multidisciplinary interventions to tackle as many precipitating factors as possible, starting in the pre-admission period., Competing Interests: The Ph.D. program of the corresponding author (T.L. Janssen) is funded by an “unrestricted grant” by Amphia Fund for innovation. The authors report no other conflicts of interest in this work.
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- 2019
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10. Controlled trial of pelvic floor exercises in the treatment of urinary stress incontinence in general practice.
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Lagro-Janssen TL, Debruyne FM, Smits AJ, and van Weel C
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- Adult, Aged, Family Practice, Female, Humans, Middle Aged, Pelvis, Exercise Therapy methods, Muscle Contraction physiology, Urinary Incontinence, Stress therapy
- Abstract
The aim of this study was to assess the usefulness of pelvic floor exercises in the treatment of urinary incontinence in women and to analyse the factors which determine a successful outcome. The study involved 66 women who had reported 'genuine stress incontinence' to their general practitioner. They were assigned at random to the treatment or control group. The treatment group received instructions in pelvic floor exercises from a general practitioner. The control group received no therapy. At the start of the trial the severity of the patients' incontinence was assessed objectively. This assessment was repeated after three months and patients were also asked for their own perception of whether their incontinence had improved. After the three months' evaluation the patients in the control group were also given instructions in pelvic floor exercises. After another three months they were assessed in the same way. About 60% of the patients in the treatment group were dry or mildly incontinent after three months compared with only one patient in the control group; the mean weekly frequency of incontinence episodes fell from 17 to five in the treatment group but remained virtually unchanged in the control group; and about 85% of the women in the treatment group felt that their incontinence had improved or was cured compared with no one in the control group. These results were later corroborated by those for the control group. The most important factor in the success of the treatment was the patients' motivation, as demonstrated by their adherence to the daily exercises.(ABSTRACT TRUNCATED AT 250 WORDS)
- Published
- 1991
11. Women with urinary incontinence: self-perceived worries and general practitioners' knowledge of problem.
- Author
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Lagro-Janssen TL, Smits AJ, and Van Weel C
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- Aged, Anxiety, Family Practice, Female, Humans, Middle Aged, Self Disclosure, Urinary Incontinence diagnosis, Quality of Life, Urinary Incontinence psychology
- Abstract
In the context of a large scale survey of health problems in women aged 50 to 65 years, a study was undertaken on the effects of incontinence on daily life. For this purpose 1442 women randomly selected from the practice files of 75 general practitioners in the eastern part of the Netherlands were interviewed at home (response rate 60%). In cases of moderate or severe incontinence the general practitioner of the woman concerned was asked whether this problem had been diagnosed in general practice. Incontinence was reported in 22.5% of the women. Overall, 77.8% of the women did not feel worried about it and 75.4% did not feel restricted in their activities; even for women with severe incontinence (daily frequency and needing protective pads) only 15.6% experienced much worry and 15.7% much restriction. About a third of the women with incontinence (32.0%) had been identified by their general practitioner. The greater the worries and restrictions owing to incontinence, the greater the chance that the incontinence was known to the general practitioner concerned. Only a small minority of the women who felt severely restricted were not identified by their general practitioner. There was a positive relation between recognized incontinence and a history of hysterectomy. This study contradicts the image of the incontinent woman as isolated and helpless; most women in this study seemed able to cope.
- Published
- 1990
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