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Your search keyword '"Jiao, Xiuxiu"' showing total 6 results
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6 results on '"Jiao, Xiuxiu"'

1. A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma

Author

Zhang, Shuyue, Jiao, Xiuxiu, Heger, Michal, Gao, Shen, He, Mei, Xu, Nan, Zhang, Jigang, Zhang, Mingjian, Yu, Yuan, Ding, Baoyue, Ding, Xueying, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, and Pharmaceutics

Subjects
Radiation-Sensitizing Agents, mic-roenvironment-responsive, Brain Neoplasms, Pharmaceutical Science, General Medicine, Chemoradiotherapy, chemo-radiotherapy, Mice, targeted nanotherapeutics, Doxorubicin, Cell Line, Tumor, Tumor Microenvironment, Animals, Humans, radiosensitization, Glioblastoma, Micelles
Abstract

Glioblastoma is rather recalcitrant to existing therapies and effective interventions are needed. Here we report a novel microenvironment-responsive micellar system (ch-K5(s-s)R8-An) for the co-delivery of the radiosensitizer Dbait and the chemotherapeutic doxorubicin (DOX) to glioblastoma. Accordingly, the ch-K5(s-s)R8-An/(Dbait-DOX) micelles plus radiotherapy (RT) treatment resulted in a high degree of apoptosis and DNA damage, which significantly reduced cell viability and proliferation capacity of U251 cells to 64.0% and 16.3%, respectively. The angiopep-2-modified micelles exhibited substantial accumulation in brain-localized U251 glioblastoma xenografts in mice compared to angiopep-2-lacking micelles. The ch-K5(s-s)R8-An/(Dbait-DOX) + RT treatment group exhibited the smallest tumor size and most profound tumor tissue injury in orthotopic U251 tumors, leading to an increase in median survival time of U251 tumor-bearing mice from 26 days to 56 days. The ch-K5(s-s)R8-An/(Dbait-DOX) micelles can be targeted to brain-localized U251 tumor xenografts and sensitize the tumor to chemotherapy and radiotherapy, thereby overcoming the inherent therapeutic challenges associated with malignant glioblastoma.

Published
2022

2. A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma

Author

Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics, Zhang, Shuyue, Jiao, Xiuxiu, Heger, Michal, Gao, Shen, He, Mei, Xu, Nan, Zhang, Jigang, Zhang, Mingjian, Yu, Yuan, Ding, Baoyue, Ding, Xueying, Afd Pharmaceutics, Sub Membrane Biochemistry & Biophysics, Pharmaceutics, Zhang, Shuyue, Jiao, Xiuxiu, Heger, Michal, Gao, Shen, He, Mei, Xu, Nan, Zhang, Jigang, Zhang, Mingjian, Yu, Yuan, Ding, Baoyue, and Ding, Xueying

Published
2022

6. A tumor microenvironment-responsive micelle co-delivered radiosensitizer Dbait and doxorubicin for the collaborative chemo-radiotherapy of glioblastoma.

Author

Zhang S, Jiao X, Heger M, Gao S, He M, Xu N, Zhang J, Zhang M, Yu Y, Ding B, and Ding X

Subjects
Animals, Cell Line, Tumor, Chemoradiotherapy methods, Doxorubicin, Humans, Mice, Micelles, Tumor Microenvironment, Brain Neoplasms drug therapy, Brain Neoplasms radiotherapy, Glioblastoma drug therapy, Glioblastoma radiotherapy, Radiation-Sensitizing Agents pharmacology
Abstract

Glioblastoma is rather recalcitrant to existing therapies and effective interventions are needed. Here we report a novel microenvironment-responsive micellar system (ch-K5(s-s)R8-An) for the co-delivery of the radiosensitizer Dbait and the chemotherapeutic doxorubicin (DOX) to glioblastoma. Accordingly, the ch-K5(s-s)R8-An/(Dbait-DOX) micelles plus radiotherapy (RT) treatment resulted in a high degree of apoptosis and DNA damage, which significantly reduced cell viability and proliferation capacity of U251 cells to 64.0% and 16.3%, respectively. The angiopep-2-modified micelles exhibited substantial accumulation in brain-localized U251 glioblastoma xenografts in mice compared to angiopep-2-lacking micelles. The ch-K5(s-s)R8-An/(Dbait-DOX) + RT treatment group exhibited the smallest tumor size and most profound tumor tissue injury in orthotopic U251 tumors, leading to an increase in median survival time of U251 tumor-bearing mice from 26 days to 56 days. The ch-K5(s-s)R8-An/(Dbait-DOX) micelles can be targeted to brain-localized U251 tumor xenografts and sensitize the tumor to chemotherapy and radiotherapy, thereby overcoming the inherent therapeutic challenges associated with malignant glioblastoma.

Published
2022
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