3 results on '"Juan Olazagasti"'
Search Results
2. Long-Term Treatment of Eosinophilic Esophagitis With Budesonide Oral Suspension
- Author
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Evan S. Dellon, Margaret H. Collins, David A. Katzka, Vincent A. Mukkada, Gary W. Falk, Robin Morey, Bridgett Goodwin, Jessica D. Eisner, Lan Lan, Nirav K. Desai, James Williams, Ikuo Hirano, Curtis Baum, Pradeep Bekal, David Chaletsky, Mirna Chehade, Larry Clark, Evan Dellon, Reed Dimmitt, David Dulitz, Gary Falk, Ronald Fogel, Keith Friedenberg, Scott Gabbard, Andrew Gentry, Benjamin Gold, Michael Goldstein, Sandeep Gupta, Karen Hsu-Blatman, Vikram Jayanty, David Katzka, Vidhya Kunnathur, John Lee, John Leung, Jonathan Markowitz, Calies Menard-Katcher, Benjamin Mitlyng, Sam E. Moussa, Vincent Mukkada, Molly O’Gorman, Juan Olazagasti, Timothy Ritter, Wael Sayej, Shauna Schroeder, Yamen Smadi, Daniel Soteres, Theodore Stathos, Michael F. Vaezi, Tom Whitlock, John Wo, Ziad Younes, and Salam Zakko
- Subjects
Budesonide ,medicine.medical_specialty ,Long term treatment ,Anti-Inflammatory Agents ,Administration, Oral ,Placebo ,Gastroenterology ,Double-Blind Method ,Suspensions ,Maintenance therapy ,Internal medicine ,Eosinophilia ,medicine ,Clinical endpoint ,Humans ,Therapy duration ,Eosinophilic esophagitis ,Hepatology ,business.industry ,Eosinophilic Esophagitis ,medicine.disease ,Dysphagia ,Enteritis ,humanities ,Treatment Outcome ,Gastritis ,medicine.symptom ,Deglutition Disorders ,business ,medicine.drug - Abstract
BACKGROUND & AIMS We evaluated treatment withdrawal, long-term outcomes, and safety of budesonide oral suspension (BOS) 2.0 mg twice daily in patients with eosinophilic esophagitis who completed a 12-week induction study. METHODS Induction full responders (≤6 eosinophils per high-power field [eos/hpf] and ≥30% reduction in the Dysphagia Symptom Questionnaire score) to BOS 2.0 mg twice daily (ORBIT1/SHP621-301/NCT02605837) were randomized to continue BOS (BOS-BOS) or withdraw to placebo (BOS-PBO) for 36 weeks (ORBIT2/SHP621-302/NCT02736409). Induction partial responders and nonresponders, and patients who received induction placebo, received BOS for 36 weeks. The primary end point was the proportion of BOS-BOS and BOS-PBO patients who relapsed (≥15 eos/hpf and ≥4 days of dysphagia [Dysphagia Symptom Questionnaire] over 2 weeks) by week 36. The key secondary end point was the proportion of induction partial responders and nonresponders who fully responded after 52 weeks of total BOS therapy. Other secondary end points included the proportion of induction full responders with histologic responses (≤1, ≤6
- Published
- 2022
3. Clinical Experience With Radiotracer-Guided Thoracoscopic Biopsy of Small, Indeterminate Lung Nodules
- Author
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Brendon M. Stiles, Talissa A. Altes, David R. Jones, K. Robert Shen, Gorav Ailawadi, Spencer B. Gay, Juan Olazagasti, Patrice K. Rehm, and Thomas M. Daniel
- Subjects
Male ,Pulmonary and Respiratory Medicine ,Thorax ,medicine.medical_specialty ,Lung Neoplasms ,Percutaneous ,Biopsy ,medicine ,Thoracoscopy ,Humans ,Stage (cooking) ,Pneumonectomy ,Lung cancer ,Technetium Tc 99m Aggregated Albumin ,Neoplasm Staging ,medicine.diagnostic_test ,business.industry ,Nodule (medicine) ,Middle Aged ,medicine.disease ,Gamma Rays ,Female ,Surgery ,Radiology ,Radiopharmaceuticals ,medicine.symptom ,Tomography, X-Ray Computed ,Cardiology and Cardiovascular Medicine ,business ,Gamma probe - Abstract
Background Although computed tomography lung-screening programs report a 31% to 51% incidence of subcentimeter pulmonary nodules, 85% are too small to biopsy or interrogate with positron emission spectroscopy scans. We developed a technique using transthoracic percutaneous radiotracer injection with thoracoscopic radioprobe localization and excision for small pulmonary nodules. This report describes our series of the first 46 patients evaluated with this technique. Methods Forty-six patients (79% smokers; 52% males; median age, 64 years) were evaluated. Patient selection was based on the surgeon's anticipated difficulty in thoracoscopically locating small nodules because of lesion size or location. Computed tomographic-guided injection of radiotracer solution was made into or adjacent to the nodule the day of surgery. Intraoperative gamma probe localization, followed by thoracoscopic excision of the lesion, was subsequently performed. Results Median nodule size was 9 mm (range, 3 to 22 mm), and median depth was 5 mm (range, 0 to 50 mm). Forty-four (96%) of the lesions were successfully localized and excised. Median time from injection to surgery was 270 minutes. Failures were the result of inadvertent pleural or chest wall radiotracer placement. Forty-six percent (21 of 46) of the lesions were malignant, of which 71% (15 of 21) were primary lung cancers. Patients with lung cancer underwent lobectomy or segmentectomy. Fourteen of 15 were stage IA, whereas 1 was stage IIIB (6 mm primary with 4 mm intralobar metastasis). Complications were three pneumothoraces at the time of radiotracer injection. Conclusions Computed tomography-guided radiotracer localization of small pulmonary nodules combined with thoracoscopic excisional biopsy is feasible and safe. This technique successfully localized and excised the nodule in 96% of cases.
- Published
- 2006
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