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Your search keyword '"KISSINGER, CHARLES R."' showing total 5 results
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2. Crystal structures of human calcineurin and the human FKBP12-FK506-calcineurin complex

Author

Kissinger, Charles R., Parge, Hans E., Knighton, Daniel R., Lewis, Cristina T., Pelletier, Laura A., Tempczyk, Anna, Kalish, Vincent J., Tucker, Kathleen D., Showalter, Richard E., Moomaw, Ellen W., Gastinel, Louis N., Habuka, Noriyuki, Chen, Xinghai, Maldonando, Fausto, Barker, John E., Bacquet, Russell, and Villafranca, J. Ernest

Subjects
Phosphatases -- Research, Carrier proteins -- Guadeloupe, Immunosuppression -- Research, Environmental issues, Science and technology, Zoology and wildlife conservation
Abstract

A study has been conducted to examine the crystal structures of human calcineurin, an important protein in T-cell activation, and the human binding protein complex, FKBP12-FK506, which inhibit calcineurin after association with cytoplasmic binding proteins. Electron microscopy showed that an autoinhibitory element binds calcineurin at the Zn/Fe-containing active site to induce nucleophilic attack on the substrate phosphate by a metal-activated water molecule. Since the auto-inhibitory element is displaced in the FK-506-calcineurin complex, the protein complex is forced to share a binding site with inhibitors of calcineurin.

Published
1995

3. Intrinsically disordered protein

Author

Dunker, A.Keith, Lawson, J.David, Brown, Celeste J, Williams, Ryan M, Romero, Pedro, Oh, Jeong S, Oldfield, Christopher J, Campen, Andrew M, Ratliff, Catherine M, Hipps, Kerry W, Ausio, Juan, Nissen, Mark S, Reeves, Raymond, Kang, ChulHee, Kissinger, Charles R, Bailey, Robert W, Griswold, Michael D, Chiu, Wah, Garner, Ethan C, and Obradovic, Zoran

Published
2001
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