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In this high-tech era, the targeted drug delivery system has various progressions in the delivery of cancerous drugs. In the current review, the main purpose is to address the valuable needs of a targeted drug delivery system in all aspects of the safety and therapeutic delivery of drugs. The main objective is to introduce the drug carriers with their benefits. The targeted drug delivery system is superior to the traditional drug delivery system because they overcome the pros and cons and deliver the dosage form at the targeted site without exhibiting any side effects. The positive benefit of this system is that they reduce the dose dumping and provides the optimized delivery of drugs. The current review article elaborates on the different drug carriers used in the targeted drug delivery system such as liposomes, microspheres, and nanoparticles with their importance, merits, and demerits. This article mainly concentrates on the applications and some other important facts related to the targeted drug delivery carriers.