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15 results on '"Kayoko YAMASHITA"'

1. Effect of Shakuyaku-kanzo-to on muscle cramps in hemodialysis patients

Author

Ayako Yoshida, Yukihiro Matsuda, Takenori Ochiai, Tsunetoshi Shimada, Keiko Anzai, Kazushige Ito, Noriyoshi Murotani, Yasushi Ito, Kayoko Yamashita, and Mizue Miyamoto

Subjects
business.industry, medicine.medical_treatment, Anesthesia, Medicine, Hemodialysis, medicine.symptom, business, Muscle cramp
Published
2003

2. Three distinct anti-allergic drugs, amlexanox, cromolyn and tranilast, bind to S100A12 and S100A13 of the S100 protein family

Author

Hajime Maeta, Yuiro Hata, Yuhta Oyama, Ryoji Kobayashi, Osamu Matsushita, Akinobu Okabe, Kayoko Yamashita, Tsuyoshi Shishibori, and Hiromi Furuichi

Subjects
DNA, Complementary, Calmodulin, Tranilast, Molecular Sequence Data, Aminopyridines, Biology, Biochemistry, Chromatography, Affinity, law.invention, Affinity chromatography, law, Complementary DNA, Anti-Allergic Agents, Cromolyn Sodium, medicine, Animals, Humans, ortho-Aminobenzoates, Amino Acid Sequence, Molecular Biology, Peptide sequence, Chromatography, High Pressure Liquid, Base Sequence, Calcium-Binding Proteins, S100 Proteins, S100A12 Protein, Degranulation, Cell Biology, Molecular biology, Recombinant Proteins, Molecular Weight, Amlexanox, biology.protein, Recombinant DNA, Cattle, Protein Binding, Research Article, medicine.drug
Abstract

To investigate the roles of calcium-binding proteins in degranulation, we used three anti-allergic drugs, amlexanox, cromolyn and tranilast, which inhibit IgE-mediated degranulation of mast cells, as molecular probes in affinity chromatography. All of these drugs, which have different structures but similar function, scarcely bound to calmodulin in bovine lung extract, but bound to the same kinds of calcium-binding proteins, such as the 10-kDa proteins isolated in this study, calcyphosine and annexins I–V. The 10-kDa proteins obtained on three drug-coupled resins and on phenyl-Sepharose were analysed by reversed-phase HPLC. It was found that two characteristic 10-kDa proteins, one polar and one less polar, were bound with all three drugs, although S100A2 (S100L), of the S100 family, was bound with phenyl-Sepharose. The cDNA and deduced amino acid sequence proved our major polar protein to be identical with the calcium-binding protein in bovine amniotic fluid (CAAF1, S100A12). The cDNA and deduced amino acid sequence of the less-polar protein shared 95% homology with human and mouse S100A13. In addition, it was demonstrated that the native S100A12 and recombinant S100A12 and S100A13 bind to immobilized amlexanox. On the basis of these findings, we speculate that the three anti-allergic drugs might inhibit degranulation by binding with S100A12 and S100A13.

Published
1999

3. Abstracts

Author

Liliam Pineda, Takayuki Harada, Akinobu Nakano, Yoshitaka Ohsugi, Akira Matsuno, Tadashi Nagashima, Susumu Takekoshi, R.Yoshiyuki Osamura, Keiichi Watanabe, Hideki Mori, Takako Nomura, Junzo Sasaki, Naritaka HEIJI, Toru KAMEYA, Ikuo KOBAYASHI, Yuichi SATO, Takeshi KAWASE, Yasuko Kato, Takeshi Baba, Nobuo Terada, Hideho Ueda, Ichiro Takayama, Yasuhisa Fujii, Shinichi Ohno, Takumi Tamayama, Masahito Watanabe, Jun Watanabe, Yasuharu Takamori, Hiroko Mondo, Shinsuke Kanamura, Hirohiko IWATSUKI, Masumi SUDA, Ichiro KUMANO, Chizuru OGAWA, Satoko Inoue, Ichiro Naito, Toshiyuki MATSUZAKI, Takeshi SUZUKI, Kuniaki TAKATA, Motohiro TAKEYA, Ryu-ichiro TOMOKIYO, Katsunori JINNOUCHI, Kiyoshi TAKAHASHI, Naoko UDAKA, Takaaki ITO, Hitoshi KITAMURA, Ryoichiro KAGEYAMA, Norimichi Nemoto, Taku Honma, Hitohiko Murakami, Wei Lu, Hisashi Ushiyama, Yoshikatsu Kanai, Wei LU, Norimichi NEMOTO, Hisashi USHIYAMA, Naohiko KOSHIKAWA, Hiroto MIZUSHIMA, Kaoru MIYAZAKI, Makoto Sano, Akihiro Umezawa, Atsushi Suzuki, Takahiro Honda, Kouji Shimoda, Jun-ichi Hata, Hirotsugu IMAEDA, Atsushi TAKAKI, Hiroshi YAMAMOTO, Naoki HAYASHI, Takaaki NAKAMURA, Mineko FUJIMIYA, Runa MASAKI, Ritsuko OHTANI-KANEKO, Kayoko YAMASHITA, Tare SAITO, Kyoji YAMADA, Susumu YAMAGUCHI, Kazuaki HIRATA, Kensuke CHIKAMORI, Keiji Suzuki, Kyoumi Nakazato, Tomomi Yoshida, Katsuyuki Nakajima, Jun-ichi Kawano, Akira Sawaguchi, Ryoko Nagaike, Tsutomu Oinuma, Tatsuo Suganuma, Hideaki TAMAKI, Shohei YAMASHINA, Ayami NAKAZAWA, Nobuteru USUDA, Yuxiu SHI, Haiping LU, Cangxia XIE, Mitsuhiro KAWATA, Hiroshi OGAWA, Mayumi NISHI, Yimu Yang, Hitoshi Ozawa, Kazunari Yuri, Mituhiro Kawata, Hitoshi OZAWA, Yimu YANG, Kazunori Ishimura, Toshiko Suzuki-Yamamoto, Kazunori Toida, Yoshihiro Tsuruo, Kikuko Watanabe, Akiko SETO-OHSHIMA, Shuichi UEDA, Yuri HAGIWARA, Atsuko ISHIZUYA-OKA, Junichiro HAMADA, Ichiro YAMAZOE, Yoshihiro TAKEUCHI, Hiroko MATSUSHITA, Hisahiro SAKAI, Hisashi KAWANO, Tadashi SAWADA, Nobuyuki KARASAWA, Ryohachi ARAI, Ikuko NAGATSU, Keiko IKEMOTO, Hiroshi SHIMODA, Yoshiaki TAKAHASHI, Seiji KATO, Satoshi Iino, and Yoshiaki Nojyo

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1999

4. Ultrastructural distribution of 36-kD microfibril-associated glycoprotein (MAGP-36) in human and bovine tissues

Author

Tsuyoshi Shishibori, Tetsuhiko Toyoshima, Toshifumi Itano, Hiromi Furuichi, Kayoko Yamashita, and Ryoji Kobayashi

Subjects
0301 basic medicine, Histology, Cicatrix, Hypertrophic, Immunoelectron microscopy, Lysyl oxidase, Kidney, 03 medical and health sciences, Contractile Proteins, Antibody Specificity, Tropoelastin, Animals, Humans, Microscopy, Immunoelectron, Aorta, Glycoproteins, Skin, chemistry.chemical_classification, integumentary system, 030102 biochemistry & molecular biology, biology, Cell biology, 030104 developmental biology, chemistry, Biochemistry, Mesangium, biology.protein, Ultrastructure, Cattle, Microfibril, Anatomy, Glycoprotein, Elastin, Spleen
Abstract

We observed the ultrastructural distribution of MAGP-36 by immunoelectron microscopy in human and bovine tissues. MAGP-36 was present in microfibrils associated with tropoelastin in skin, aorta, and spleen. It was not detected in microfibrils from the ocular zonule and kidney mesangium that were not associated with tropoelastin. In skin, MAGP-36 was present in both early immature elastic fibers and mature elastic fibers. In mature elastic fibers, MAGP-36 was localized around amorphous elastic cores at the elastin-microfibril interface and in electron-dense bundles. Localization of MAGP-36 in elastic fibers coincided with the distribution of lysyl oxidase, an enzyme that plays a pivotal role in the deposition of tropoelastin. These findings suggest that MAGP-36 may be involved in elastogenesis. (J Histochem Cytochem 47:1049–1056, 1999)

Published
1999

8. Two distinct anti-allergic drugs, Amlexanox and Cromoglycic acid derivative, bind to the same calcium binding proteins except calmodulin in bovine lung extract

Author

Ryoji Kobayashi, Tsuyoshi Shishibori, Takayuki Naya, Yuhta Oyama, Shintaro Nakagiri, Junko Bandoh, and Kayoko Yamashita

Subjects
Pharmacology, Calmodulin, biology, Chemistry, Bovine lung, chemistry.chemical_compound, Biochemistry, Amlexanox, Calcium-binding protein, biology.protein, medicine, Anti allergy, Cromoglycic acid, Derivative (chemistry), medicine.drug
Published
1997

12. GENERAL SESSION

Author

Toshiko NAGASHIMA, Hitoshi TANABE, Kazuo NAGASHIMA, Makoto NAGATA, Michiaki HIROE, Motoyoshi TSUJINO, Motonari HASUMI, Kiyomi NIKI, Toshiro NISHIKAWA, Toshinobu HORIE, Minoru SHIBUYA, Saichi HOSODA, Yukio HIRATA, Fumiaki MARUMO, Morie SEKIGUCHI, Tetsuji NAGATA, Nobuteru USUDA, Hongjun MA, Yoshiko Nakae, J Stoward, Mitsuru NAKAJIMA, Nobuaki ITO, Katsuji NISHI, Yoshiro OKAMURA, Tadaomi HIROTA, Atsushi Nakamura, Yutaka Futaesaku, Kennichi Kakudo, Keiichi Watanabe, Susumu NAKASONE, Takeyuki OHSHITA, Yasufumi UTSUMI, Teruo IWAMASA, Noriko NISHIMURA, Hisao NISHIMURA, Minako KASUYA, Shizuko KOBAYASHI, Chiharu TOHYAMA, Sakon NORIKI, Yoshiaki IMAMURA, Takuo IKEDA, Norio MIYOSHI, Kazuo NAKANISHI, Masaru FUKUDA, Masami Oguni, Haruo SHINOHARA, Osamu TANAKA, Keiji OGURO, Toshio MASUZAWA, Akiko SETO-OHSHIMA, Hitoshi OKAMURA, Marc ABITBOL, Jean-Francois JULIEN, Pierre BOBILLIER, Leif WIKLUND, Jaques MALLET, Kunio KITAHAMA, Yoshitake MATSUMOTO, Yukio ICHITANI, Yasuhiko IBATA, T. OLEA, T. NAGATA, Hiroyoshi OTA, Keiko ISHII, Tsutomu KATSUYAMA, Yoshinori OTSUKI, Suniko MAGARI, Hiramichi KUBO, Yuko ITO, Ying Jie Piao, Men Hu, Zheng Jin, Noriyuki SAHARA, Kazuo SUZUKI, Naoaki SAITO, Akiko KOSE, Atsuko ITO, Midori HIRATA, Takeshi TSUJINO, Chika YOSHIHARA, Chikako TANAKA, Yasutaka SAKAI, Atsuhiko HATTORI, Kayoko YAMASHITA, Takuro SUZUKI, Noriko SAKAIDA, Hideto SENZAKI, Nobuaki SHIKATA, Sotokichi MORII, Hiroyuki SAKUMA, Takashi FUKUDA, Kazuhide HIGUCHI, Tetsuo ARAKAWA, Kenzo KOBAYASHI, Yasuo SARUHASHI, Mineko FUJIMIYA, Hiroshi KIMURA, Sinsuke HUKUDA, Toshihiro MAEDA, Junzo SASAKI, Sadahiro WATANABE, Nagayasu OTSUKA, T. SAWADA, T. YAMAMOTO, T. YANAGISAWA, S. TAKUMA, H. HASEGAWA, K. WATANABE, H. SEGUCHI, T. KOBAYASHI, X. ZHANG, T. OKADA, Yoshio IZUNO, Airo TSUBURA, Hisato SHIDA, Kazuto SHIGEMATSU, Takihiro KAMIO, Kioko KAWAI, Iezo NAKAO, Noboru SHINDO, Seiichi SHIBATA, Hiroyuki SHINOHARA, Yoshiaki TAKAI, Yukio OKADA, Masahiko MORI, H. Sugihara, K. Katsura, S. Fujita, Yawara SUMI, Masashi OKANO, Fumio Suzuki, Jyoji Handa, Hidenori SUZUKI, Tomoko TANAKA, Kenjiro TANOUE, Hiroh YAMAZAKI, Koichi SUZUKI, Hirotaka MATSUMOTO, Makio KOBAYASHI, Akira KAWAOI, Kohtaro ASAYAMA, Shin-ichi MORIYAMA, Atsushi TAIRA, Kumiko KIMURA, Mitsuhiro KUDOH, Zyunzo MURATA, and Goro ASANO

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1989

13. GENERAL SESSION

Author

Kazuya Abbey, Hayato Kawakami, Takeo Kobayashi, Hiroshi Hirano, Hiromichi ABE, Yasunobu TOMIDA, Junzo OCHI, Morimi SHIMADA, Kazuharu IENAGA, Hiroshi KIMURA, Junko Akiyama, Koh Kawagoe, Takashi Kawana, Masaya Araki, Kouichiro Umemoto, Nobukazu ARAKI, Masao LEE, Yoichiro TAKASHIMA, Kazuo OGAWA, Tsutomu Araki, Akira Yamamoto, Youko Asaka, Jun Watanabe, Kazuo Kanai, Shinsuke Kanamura, T. DAIMON, K. KAWAI, K. UCHIDA, Naoto Doi, Nobuo Moriyama, Eiji Higashihara, Isao Murahashi, Yoshio Aso, Osamu FUJIMORI, Azuma TSUKISE, Kazuyori YAMADA, Akimune FUKUSHIMA, Toshihiko IZUTSU, Morimasa MATSUDA, Teruo KAGABU, Iwao NISHIYA, Sadayuki FUNATSUMARU, Nobuhisa YONEMITSU, Hajime SUGIHARA, Yasushi Furuta, Toshiya Shinohara, Kimiaki Sano, Mizuho Meguro, Kazuo Nagashima, HAN Minghu, PIAO Yingjie, Makoto HARA, Yoshinobu HOSHINO, Nobuo MORIYAMA, Masayuki HARA, Kayoko YAMASHITA, Yumi ISHIGE, Takuro SUZUKI, Hideaki HASEGAWA, Hideo TSUKAMOTO, Keiichi WATANABE, Hiroshi HIKITA, Keizo KAGAWA, Takeshi DEGUCHI, Takayuki TAKEUCHI, Hisashi TADA, Kazuo SAKABE, Masayuki MIZUMO, Masafumi MATSUMOTO, Takeshi OKANOUE, Kei KASHIMA, Tsukasa ASHIHARA, Tomoko HIRABAYASHI, Kazunori ISHIMURA, Hideaki TSURI, Hisao FUJITA, Makoto HIRAKAWA, Mitsuhiro KAWATA, Yutaka SANO, Yoshiaki HIRAYAMA, Tsugio AMEMIYA, Tajimi HIROHATA, Tetsuzo KUMAMOTO, Yohei HOSOKAWA, Kazushi ISETANI, Kazuhiko TOKITA, Shoji MITSUFUJI, Toshio TANI, Kyohei MARUYAMA, Tadashi KODAMA, Yasunari TSUCHIHASHI, H. Ichimal, T. Makita, Yukio ICHTANI, Sadatsugu MURAKAMI, Hitoshi OKAMURA, Ikuko NAGATSU, Noboru YANAIHARA, Yasuhiko IBATA, Hiroaki IGARASHI, Kenichirou INOMATA, Kaori IHIDA, Shinichiro TSUYAMA, Fusayoshi MURATA, Takuo IKEDA, Sakon NORIKI, Norio MIYOSHI, Hisataka KATO, Yoshiaki IMAMURA, Kazuo NAKANISHI, Kazuo MIYAZAWA, Toru HIROSE, Shirou KIMURA, Masaru FUKUDA, Kikuko Imamoto, Hiroyuki SUGIHARA, Toshihiko INUI, Yuji NAKA, Tetsuji SHOJI, Yoshio IZUNO, Airo TSUBURA, Sotokichi MORII, Keiko ISHIII, Takayuki HONDA, Tsutomu KATSUYAMA, Atsuko ITO, Masamichi ITO, Nobuaki ITO, Katsuji NISHI, Mitsuru NAKAJIMA, Yoshiro OKAMURA, Tadaomi HIROTA, Masaki IWAI, Motomu KASHIWADANI, Megumi Iwano, E-iti Yokomura, Hirohiko IWATSUKI, Kazushige UEDA, Masayuki MIZUNO, and Yoko KAMEDA

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1989

14. GENERAL SESSION

Author

Katsuko KATAOKA, Yasuko TAKEOKA, Noboru YANAIHARA, T. MUKAI, R. KONEMORI, A. KAMBARA, K. OKAMOTO, S. SHIMIZU, S. KISHIMOTO, G. KAJIYAMA, Kenichi INADA, Takayuki HARADA, Tsutomu OHATA, Ikuko TORII, Shigeru MORIKAWA, Nobuteru USUDA, Tetsuji NAGATA, Hideaki HASEGAWA, Hiroshi NAGURA, Shinichi YOSHIMURA, Keiichi WATANABE, Yayoi KATAYAMA, Hiroshi KIYAMA, Reizo MANABE, Masaya TOHYAMA, Yahei SHIOTANI, Hiroshi YAMASAKI, Haruki HAYASHI, Sadao SHIOSAKA, Toshisaburo Nagai, Hisao Tago, Toshihiro Maeda, Tokuzo Harada, Tadashi Okada, Naoaki SAITO, Kazuo KUMOI, Hiroshi KIMURA, Chikako TANAKA, Hideo MORI, Masanuri TOMONAGA, Akira Mizutani, Yoshiro Yamazaki, Mamoru Sano, Tajimi HIROHATA, Tetsuzo KUMAMOTO, Shingo HIRUMA, Manabu TAKAHASHI, Takao SATOU, Shigeo HASHIMOTO, Fumiharu AKAI, Motohiro OGURA, Junko TOKI, Masayuki SHINTAKU, Ryuei MAEDA, Masaki UENO, Vinci MIZUHIRA, Kenichi TAKAYA, Takashi YAMOTO, Takashi MAKITA, Takao INOUE, Hirotami KOIKE, Kazuo OGAWA, Osamu FUKUSHIMA, Minoru KODA, Norihisa GOSHI, Hideyuki NAKAJIMA, Kazu Shige OGAWA, Kazushi FUJIMOTO, Tomoichi ISHIKAWA, Harumichi SEGUCHI, Takashi KOSHIKAWA, Hajime HAIMOTO, Junpei ASAI, Kanefusa KATO, Hiroshi HACHISUKA, Yoichiro SASAI, Yasuhiro NAKAMURA, Hisashi USHIYAMA, Norimichi NEMOTO, Tadao OKANO, Hideko SATO, Toshio SHIKATA, Noboru YAMAMOTO, Shigeyuki TAKAMA, Shunichi KITAJIMA, Yasuo KISHINO, Kinji Ito, Yoshiyuki KUBOTA, Hiroshi TAKAGI, Yumiko MORISHIMA, Sachiko HATAKENAKA, Naomasa MIKI, Yoshihisa OHTAWARA, Kazuo SUZUKI, Atsushi TAJIMA, Yoshio ASO, Toshiko NAGASHIMA, Masanori UONO, Kazuo NAGASHIMA, Yawara SUMI, Kayoko YAMASHITA, Takeshi MURAKI, Takuro SUZUKI, Shinichi OHNO, Yasuhisa FUJII, Naoto OHTAKE, Monique DUBOIS-DALCQ, Shigenori TANAKA, Chosei ZUKERAN, Shiro NAKAGAWA, Iezo NAKAO, Nobuaki SHIKATA, Nobutoshi KOTAHI, Toshio NISHIMURA, Sotokichi MORII, and Hisato SHIDA

Subjects
Histology, Physiology, Cell Biology, Biochemistry, Pathology and Forensic Medicine
Published
1984

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