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3. Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

Author

Natunen, Teemu, Martiskainen, Henna, Marttinen, Mikael, Gabbouj, Sami, Koivisto, Hennariikka, Kemppainen, Susanna, Kaipainen, Satu, Takalo, Mari, Svobodová, Helena, Leppänen, Luukas, Kemiläinen, Benjam, Ryhänen, Simo, Kuulasmaa, Teemu, Rahunen, Eija, Juutinen, Sisko, Mäkinen, Petra, Miettinen, Pasi, Rauramaa, Tuomas, Pihlajamäki, Jussi, Haapasalo, Annakaisa, Leinonen, Ville, Tanila, Heikki, and Hiltunen, Mikko

Published
2020
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4. Additional file 1 of Diabetic phenotype in mouse and humans reduces the number of microglia around β-amyloid plaques

Author

Natunen, Teemu, Martiskainen, Henna, Marttinen, Mikael, Gabbouj, Sami, Hennariikka Koivisto, Kemppainen, Susanna, Kaipainen, Satu, Takalo, Mari, Svobodová, Helena, Luukas Leppänen, Kemiläinen, Benjam, Ryhänen, Simo, Kuulasmaa, Teemu, Rahunen, Eija, Juutinen, Sisko, Mäkinen, Petra, Miettinen, Pasi, Rauramaa, Tuomas, Pihlajamäki, Jussi, Annakaisa Haapasalo, Leinonen, Ville, Tanila, Heikki, and Hiltunen, Mikko

Abstract

Additional file 1: Supplementary Figure S1. a-c. Assessment of soluble Aβ42 and Aβ40 levels as well as Aβ42 and Aβ40 ratio of hippocampal samples from mice with A+ transgene (APPswe/PS1dE9) revealed no significant diet effect. Data are presented as mean + SEM, n = 5–6, Two-way ANOVA. d Representative immunofluorescence images of β-amyloid plaques stained with X-34 (blue) surrounded by 22C11-positive dystrophic neurites (red), and Iba1-positive microglia (green) from A+Tw and A+T+ mice from both STD and TWD groups. Scale bar 10 μm. e Counting of 22C11-positive neurites revealed no diet nor genotype effect. f Quantification of 22C11-positive area (pixels) around β-amyloid plaques revealed a statistically significant genotype x diet interaction (p 2.5 or 2.5 or 0.5) with Trem2”, “Genes correlated (r>0.3) with Trem2”, “Upregulated in AD-associated microglia (Keren-Shaul)”, and “Regulation of canonical Wnt signaling pathway”. Right heatmap: respective log2 fold change (log2(FC)) values from TWD vs. STD comparison. Highlighted are top significantly up- and down-regulated genes for TWD vs. STD comparison regarding each term (FDR

Published
2020
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