1. Evaluation of in vitro antiplasmodial effect of extracts from seven medicinal plants used to treat malaria in Côte d'Ivoire
- Author
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Trésor Marius Dable, Dominique Konan Tano, Kigbafori Dieudonné Silue, William Yavo, and Jeanne Akissi Koffi
- Subjects
biology ,Traditional medicine ,030231 tropical medicine ,Pharmaceutical Science ,Anthocleista ,General Medicine ,biology.organism_classification ,01 natural sciences ,General Biochemistry, Genetics and Molecular Biology ,Margaritaria discoidea ,0104 chemical sciences ,010404 medicinal & biomolecular chemistry ,03 medical and health sciences ,0302 clinical medicine ,Phytochemical ,visual_art ,visual_art.visual_art_medium ,Harungana ,medicine ,Bark ,Mangifera ,Artemisinin ,Medicinal plants ,medicine.drug - Abstract
Introduction: Plasmodium falciparum strains had been increasingly resistant to commonly used molecules including artemisinin. It is therefore urges to find new therapeutic alternatives. Methods: In this study, the antiplasmodial activity of 21 extracts obtained from seven plants of the Anthocleista djalonensis, Cochlospermum planchonii, Harungana madagascariensis, Hoslundia opposita, Mangifera indica, Margaritaria discoidea and Pericopsis laxiflora of the Ivorian pharmacopoeia was evaluated on the chloroquine sensitive (NF54) and multi-resistant (K1) reference strains and on clinical isolates as well. The technique used was the microtiter method based on fluorescence reading with SYBR Green. Results: The aqueous extract of the bark of H. madagascariensis and methanolic extracts of P. laxiflora showed the best antiplasmodial activity with IC50 values of 6.16 µg/mL and 7.44 µg/mL, respectively. On the other hand, extracts of M. indica showed a very moderate activity with IC50 values between 15 µg/mL and 50 µg/mL (550P. falciparum. Only the aqueous extract of A. djalonensis had IC50 values greater than 50 µg/mL. The phytochemical analysis showed a strong presence of polyphenols and alkaloids in extracts with a cumulative rate of 90.47% and 95.23%, respectively. Conclusion: The results obtained were also justified by the composition of these plants, which have several secondary metabolites involved in the treatment of malaria. The antiplasmodial properties of these plants could partially justify their use in malaria treatment. Further studies on these extracts are needed to manufacture a stable galenic formulation for the development of an improved traditional medicine.
- Published
- 2020