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2. The global impact of the COVID-19 pandemic on pediatric spinal care: A multi-centric study.

Author

Otremski, Hila, Dermott, Jennifer, Page, Kira, Ipp, Lisa S, Blanco, John S, Studer, Daniel, Sigal, Amit, Kim, Dorothy, Hasler, Carol C, Lebel, David E, Widmann, Roger F, and Ovadia, Dror

Subjects
COVID-19 pandemic, SPINAL surgery, ADOLESCENT idiopathic scoliosis, PEDIATRIC therapy, CHILD patients, PEDIATRIC clinics, SPINE abnormalities
Abstract

Background: The COVID-19 pandemic has affected healthcare worldwide since December 2019. We aimed to identify the effect of the COVID-19 pandemic on outpatient clinic and surgical volumes and peri-operative complications for pediatric spinal deformities patients. Methods: In this multi-center retrospective study, outpatient visits (in-person and virtual care) and pediatric spine surgeries volumes in four high-volume pediatric spine centers were compared between March and December 2019 and the same period in 2020. Peri-operative complications were collected and compared in the same periods. Descriptive statistics were calculated, and comparative analyses were performed. Results: During the 2020 study period, the outpatient visit (in-person and virtual care) volume decreased during local lockdown periods by 71% for new patients (p < 0.001) and 53% for returning patients (p = 0.03). Overall, for 2020, there was a 20% reduction in new patients (p = 0.001) and 21% decrease in returning patients (p < 0.001). During the pandemic, there was also 20% less overall surgical volume of adolescent idiopathic scoliosis (AIS) patients undergoing primary posterior spinal fusion, with a 70% reduction during lockdown times (p < 0.001). Complication rate and profile were similar between periods. Conclusion: There was a significant decrease in outpatient pediatric spine outpatient visits, particularly new patients, which may increase the proportion of pediatric patients with spinal deformities that present late, meeting surgical indication. This, in combination with the reduction in surgical volume of AIS over the first year of the pandemic, could result in an extended waitlist for surgeries during years to come. Complication rate was similar for both periods, suggesting it is safe to continue elective pediatric spine surgery even in a time of a pandemic. Level of evidence: level IV. [ABSTRACT FROM AUTHOR]

Published
2024
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5. IGHV-unmutated and IGHV-mutated chronic lymphocytic leukemia cells produce activation-induced deaminase protein with a full range of biologic functions

Author

Patten, Piers E.M., Chu, Charles C., Albesiano, Emilia, Damle, Rajendra N., Yan, Xiao-Jie, Kim, Dorothy, Zhang, Lu, Magli, Amanda R., Barrientos, Jacqueline, Kolitz, Jonathan E., Allen, Steven L., Rai, Kanti R., Roa, Sergio, Mongini, Patricia K., MacCarthy, Thomas, Scharff, Matthew D., and Chiorazzi, Nicholas

Published
2012
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7. Canadian Spine Society: 22nd Annual Virtual Scientific Conference, Apr. 11, 13, 20 and 27, 2022.

Author

Sidhu, Karamjot, Filezio, Marina, Singh, Vishwajeet, Ferri-de-Barros, Fabio, Kim, Dorothy, Dermott, Jennifer, Lebel, David, Machida, Masayoshi, Bath, Natasha, Levin, David, Campbell, Fiona, Koyle, Martin, Isaac, Lisa, Ruskin, Danielle, Brennenstuh, Sarah, Stinson, Jennifer, Alshammari, Abdullah, Navarro-Ramirez, Rodrigo, Rabau, Oded, and Ouellet, Jean A.

Subjects
ADOLESCENT idiopathic scoliosis, SPONDYLOLISTHESIS, CANADIAN history, SCHWANNOMAS
Abstract

The total sample included 43 487 patients undergoing ACDF, 6800 patients undergoing laminoplasty, 2075 patients undergoing CDA and 32 871 patients undergoing posterior laminectomy and fusion. Patient's expectations of surgery for degenerative spondylolisthesis: analysis b... Background Patients with lumbar degenerative spondylolisthesis have higher expectations of pain relief and functional well-being than patients with lumbar stenosis. At 1 year after surgery, mildly frail patients were 1.50 times (p = 0.002), moderately frail patients were 1.72 times (p < 0.001) and severely frail patients were 1.71 times (p < 0.001) more likely to achieve MCID. Results A total of 493 patients were included in this study, with 272 patients (55.2%) receiving their surgery less than 60 days after providing consent for surgery and 221 patients (44.8%) 60 days or more after providing consent for surgery. Results A total of 253 patients were included: 40 patients died within the first 3 months after surgery and 213 patients survived more than 3 months. [Extracted from the article]

Published
2022
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8. Multi-omic Analysis of the Interaction between Clostridioides difficile Infection and Pediatric Inflammatory Bowel Disease

Author

Bushman, Frederic D., primary, Conrad, Maire, additional, Ren, Yue, additional, Zhao, Chunyu, additional, Gu, Christopher, additional, Petucci, Christopher, additional, Kim, Min-Soo, additional, Abbas, Arwa, additional, Downes, Kevin J., additional, Devas, Nina, additional, Mattei, Lisa M., additional, Breton, Jessica, additional, Kelsen, Judith, additional, Marakos, Sarah, additional, Galgano, Alissa, additional, Kachelries, Kelly, additional, Erlichman, Jessi, additional, Hart, Jessica L., additional, Moraskie, Michael, additional, Kim, Dorothy, additional, Zhang, Huanjia, additional, Hofstaedter, Casey E., additional, Wu, Gary D., additional, Lewis, James D., additional, Zackular, Joseph P., additional, Li, Hongzhe, additional, Bittinger, Kyle, additional, and Baldassano, Robert, additional

Published
2020
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9. Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant Klebsiella pneumoniae Transmission within and between Regional Long-Term Acute-Care Hospitals

Author

Han, Jennifer H., primary, Lapp, Zena, additional, Bushman, Frederic, additional, Lautenbach, Ebbing, additional, Goldstein, Ellie J. C., additional, Mattei, Lisa, additional, Hofstaedter, Casey E., additional, Kim, Dorothy, additional, Nachamkin, Irving, additional, Garrigan, Charles, additional, Jain, Tanya, additional, Bilker, Warren, additional, Wolford, Hannah M., additional, Slayton, Rachel B., additional, Wise, Jacqueleen, additional, Tolomeo, Pam, additional, and Snitkin, Evan S., additional

Published
2019
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14. Evaluation of a therapy for Idiopathic Chronic Enterocolitis in rhesus macaques (Macaca mulatta) and linked microbial community correlates

Author

Taylor, Joshua M., primary, Clarke, Erik L., additional, Baker, Kate, additional, Lauder, Abigail, additional, Kim, Dorothy, additional, Bailey, Aubrey, additional, Wu, Gary D., additional, Collman, Ronald G., additional, Doyle-Meyers, Lara, additional, Russell-Lodrigue, Kasi, additional, Blanchard, James, additional, Bushman, Frederic D., additional, and Bohm, Rudolf, additional

Published
2018
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15. Optimizing methods and dodging pitfalls in microbiome research

Author

Kim, Dorothy, primary, Hofstaedter, Casey E., additional, Zhao, Chunyu, additional, Mattei, Lisa, additional, Tanes, Ceylan, additional, Clarke, Erik, additional, Lauder, Abigail, additional, Sherrill-Mix, Scott, additional, Chehoud, Christel, additional, Kelsen, Judith, additional, Conrad, Máire, additional, Collman, Ronald G., additional, Baldassano, Robert, additional, Bushman, Frederic D., additional, and Bittinger, Kyle, additional

Published
2017
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24. A KcsA/MloK1 Chimeric Ion Channel Has Lipid-dependent Ligand-binding Energetics

Author

McCoy, Jason G., primary, Rusinova, Radda, additional, Kim, Dorothy M., additional, Kowal, Julia, additional, Banerjee, Sourabh, additional, Jaramillo Cartagena, Alexis, additional, Thompson, Ameer N., additional, Kolmakova-Partensky, Ludmila, additional, Stahlberg, Henning, additional, Andersen, Olaf S., additional, and Nimigean, Crina M., additional

Published
2014
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30. Whole-Genome Sequencing To Identify Drivers of Carbapenem-Resistant Klebsiella pneumoniaeTransmission within and between Regional Long-Term Acute-Care Hospitals

Author

Han, Jennifer H., Lapp, Zena, Bushman, Frederic, Lautenbach, Ebbing, Goldstein, Ellie J. C., Mattei, Lisa, Hofstaedter, Casey E., Kim, Dorothy, Nachamkin, Irving, Garrigan, Charles, Jain, Tanya, Bilker, Warren, Wolford, Hannah M., Slayton, Rachel B., Wise, Jacqueleen, Tolomeo, Pam, and Snitkin, Evan S.

Abstract

Carbapenem-resistant Klebsiella pneumoniae(CRKP) is an antibiotic resistance threat of the highest priority. Given the limited treatment options for this multidrug-resistant organism (MDRO), there is an urgent need for targeted strategies to prevent transmission.

Published
2019
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