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1. What is the impact of one’s chronic illness on his or her spouse’s future chronic illness: a community-based prospective cohort study

Author

An, Hoyoung, Yang, Hee Won, Oh, Dae Jong, Lim, Eunji, Shin, Jin, Moon, Dong Gyu, Suh, Seung Wan, Byun, Seonjeong, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Bae, Jong Bin, Han, Ji Won, and Kim, Ki Woong

Published
2023
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2. Does parity matter in women’s risk of dementia? A COSMIC collaboration cohort study

Author

Bae, Jong Bin, Lipnicki, Darren M, Han, Ji Won, Sachdev, Perminder S, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Llibre-Rodriguez, Juan J, Llibre-Guerra, Jorge J, Valhuerdi-Cepero, Adolfo J, Ritchie, Karen, Ancelin, Marie-Laure, Carriere, Isabelle, Skoog, Ingmar, Najar, Jenna, Sterner, Therese Rydberg, Scarmeas, Nikolaos, Yannakoulia, Mary, Dardiotis, Efthimios, Meguro, Kenichi, Kasai, Mari, Nakamura, Kei, Riedel-Heller, Steffi, Roehr, Susanne, Pabst, Alexander, van Boxtel, Martin, Köhler, Sebastian, Ding, Ding, Zhao, Qianhua, Liang, Xiaoniu, Scazufca, Marcia, Lobo, Antonio, De-la-Cámara, Concepción, Lobo, Elena, and Kim, Ki Woong

Subjects
Alzheimer's Disease, Brain Disorders, Alzheimer's Disease including Alzheimer's Disease Related Dementias (AD/ADRD), Clinical Research, Neurodegenerative, Prevention, Neurosciences, Dementia, Aging, Acquired Cognitive Impairment, Neurological, Cohort Studies, Female, Humans, Middle Aged, Parity, Risk Factors, Alzheimer's disease, Risk factors, Women, for Cohort Studies of Memory in an International Consortium, Alzheimer’s disease, Medical and Health Sciences, General & Internal Medicine
Abstract

BackgroundDementia shows sex difference in its epidemiology. Childbirth, a distinctive experience of women, is associated with the risk for various diseases. However, its association with the risk of dementia in women has rarely been studied.MethodsWe harmonized and pooled baseline data from 11 population-based cohorts from 11 countries over 3 continents, including 14,792 women aged 60 years or older. We investigated the association between parity and the risk of dementia using logistic regression models that adjusted for age, educational level, hypertension, diabetes mellitus, and cohort, with additional analyses by region and dementia subtype.ResultsAcross all cohorts, grand multiparous (5 or more childbirths) women had a 47% greater risk of dementia than primiparous (1 childbirth) women (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.10-1.94), while nulliparous (no childbirth) women and women with 2 to 4 childbirths showed a comparable dementia risk to primiparous women. However, there were differences associated with region and dementia subtype. Compared to women with 1 to 4 childbirths, grand multiparous women showed a higher risk of dementia in Europe (OR = 2.99, 95% CI = 1.38-6.47) and Latin America (OR = 1.49, 95% CI = 1.04-2.12), while nulliparous women showed a higher dementia risk in Asia (OR = 2.15, 95% CI = 1.33-3.47). Grand multiparity was associated with 6.9-fold higher risk of vascular dementia in Europe (OR = 6.86, 95% CI = 1.81-26.08), whereas nulliparity was associated with a higher risk of Alzheimer disease (OR = 1.91, 95% CI 1.07-3.39) and non-Alzheimer non-vascular dementia (OR = 3.47, 95% CI = 1.44-8.35) in Asia.ConclusionParity is associated with women's risk of dementia, though this is not uniform across regions and dementia subtypes.

Published
2020

7. A Preliminary Study on the Potential Protective Role of the Antioxidative Stress Markers of Cognitive Impairment: Glutathione and Glutathione Reductase

Author

Park, Sang-a, primary, Byeon, Gihwan, additional, Jhoo, Jin Hyeong, additional, Kim, Hyung-Chun, additional, Lim, Myoung-Nam, additional, Jang, Jae-Won, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2023
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9. Shared Risk Factors for Depressive Disorder Among Older Adult Couples in Korea

Author

Han, Ji Won, primary, Yang, Hee Won, additional, Bae, Jong Bin, additional, Oh, Dae Jong, additional, Moon, Dong Gyu, additional, Lim, Eunji, additional, Shin, Jin, additional, Kim, Bong Jo, additional, Lee, Dong Woo, additional, Kim, Jeong Lan, additional, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Lee, Jung Jae, additional, Kwak, Kyung Phil, additional, Lee, Seok Bum, additional, Moon, Seok Woo, additional, Ryu, Seung-Ho, additional, Kim, Shin Gyeom, additional, and Kim, Ki Woong, additional

Published
2023
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10. Retraction to “Korean Version of Mini Mental Status Examination for Dementia Screening and Its Short Form”

Author

Kim, Tae Hui, primary, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Kim, Jeong Lan, additional, Ryu, Seung Ho, additional, Moon, Seok Woo, additional, Choo, Il Han, additional, Lee, Dong Woo, additional, Yoon, Jong Chul, additional, Do, Yeon Ja, additional, Lee, Seok Bum, additional, Kim, Moon Doo, additional, and Kim, Ki Woong, additional

Published
2023
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11. Parental history of dementia and the risk of dementia: A cross‐sectional analysis of a global collaborative study.

Author

Oh, Dae Jong, Bae, Jong Bin, Lipnicki, Darren M., Han, Ji Won, Sachdev, Perminder S., Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung‐Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, and Skoog, Ingmar

Subjects
DISEASE risk factors, ALZHEIMER'S disease, CROSS-sectional method, NEUROPSYCHOLOGICAL tests, OLDER people
Abstract

Background: Parental history of dementia appears to increase the risk of dementia, but there have been inconsistent results. We aimed to investigate whether the association between parental history of dementia and the risk of dementia are different by dementia subtypes and sex of parent and offspring. Methods: For this cross‐sectional study, we harmonized and pooled data for 17,194 older adults from nine population‐based cohorts of eight countries. These studies conducted face‐to‐face diagnostic interviews, physical and neurological examinations, and neuropsychological assessments to diagnose dementia. We investigated the associations of maternal and paternal history of dementia with the risk of dementia and its subtypes in offspring. Results: The mean age of the participants was 72.8 ± 7.9 years and 59.2% were female. Parental history of dementia was associated with higher risk of dementia (odds ratio [OR] = 1.47, 95% confidence interval [CI] = 1.15–1.86) and Alzheimer's disease (AD) (OR = 1.72, 95% CI = 1.31–2.26), but not with the risk of non‐AD. This was largely driven by maternal history of dementia, which was associated with the risk of dementia (OR = 1.51, 95% CI = 1.15–1.97) and AD (OR = 1.80, 95% CI = 1.33–2.43) whereas paternal history of dementia was not. These results remained significant when males and females were analyzed separately (OR = 2.14, 95% CI = 1.28–3.55 in males; OR = 1.68, 95% CI = 1.16–2.44 for females). Conclusions: Maternal history of dementia was associated with the risk of dementia and AD in both males and females. Maternal history of dementia may be a useful marker for identifying individuals at higher risk of AD and stratifying the risk for AD in clinical trials. [ABSTRACT FROM AUTHOR]

Published
2023
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13. Association of Low Emotional and Tangible Support With Risk of Dementia Among Adults 60 Years and Older in South Korea

Author

Oh, Dae Jong, primary, Yang, Hee Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Bae, Jong Bin, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2022
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14. Effects of lifetime cumulative ginseng intake on cognitive function in late life

Author

Lho, Silvia Kyungjin, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Kayoung, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Kim, Tae Hyun, Moon, Seok Woo, Park, Jae Young, Park, Joon Hyuk, Byun, Seonjeong, Suh, Seung Wan, Seo, Ji Young, So, Yoonseop, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Kyoung Hwan, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Lee, Ju Ri, Jeong, Hyeon, Jeong, Hyun-Ghang, Jhoo, Jin Hyeong, Han, Kyuhee, Hong, Jong Woo, Han, Ji Won, and Kim, Ki Woong

Published
2018
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15. Driving-Related Adverse Events in the Elderly Men: A Population-Based Prospective Cohort Study

Author

Kim, Jae Sung, Bae, Jong Bin, Han, Kyuhee, Hong, Jong Woo, Han, Ji Hyun, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Kayoung, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Kim, Tae Hyun, Moon, Seok Woo, Park, Jae Young, Park, Joon Hyuk, Byun, Seonjeong, Suh, Seung Wan, Seo, Ji Young, So, Yoonseop, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Kyoung Hwan, Lee, Dong Young, Lee, Dong-Woo, Lee, Seok Bum, Lee, Jung Jae, Lee, Ju Ri, Jeong, Hyeon, Jeong, Hyun-Ghang, Jhoo, Jin Hyeong, Han, Ji Won, and Kim, Ki Woong

Subjects
Longitudinal study, Violation, business.industry, Incidence, Incidence (epidemiology), Cognition, Population based, medicine.disease, 03 medical and health sciences, Psychiatry and Mental health, 0302 clinical medicine, Accident, Memory, medicine, Dementia, Original Article, 030212 general & internal medicine, Adverse effect, Prospective cohort study, Memory test, business, 030217 neurology & neurosurgery, Biological Psychiatry, Driving, Demography
Abstract

Objective This study estimated the incidence of driving-related adverse events and examined the association of cognitive function with the risk of future driving-related adverse events in the elderly Korean male population.Methods We analyzed 1,172 male drivers aged 60 years or older in the Korean Longitudinal Study on Cognitive Aging and Dementia (KLOSCAD). Using the data from Korean National Police Agency, we classified the participants into three groups: safe driving (drove for 2 years after baseline without a traffic accident or repeated violations), driving cessation (stopped driving), and risky driving (one or more traffic accidents or repeated violations). We estimated the incidences of driving cessation and risky driving, and examined the effect of cognitive function on their risks.Results The incidence of driving cessation and risky driving in the Korean male drivers aged 60 years or older was 19.3 and 69.9 per 1,000 person-years respectively and increased in the late 80s. Drivers with better baseline Word List Memory Test scores showed less risky driving (OR=0.94, p=0.039).Conclusion Driving-related adverse events increased in late 80s, and better memory function was protective against these events.

Published
2020

16. Exploration of Cognitive Outcomes and Risk Factors for Cognitive Decline Shared by Couples

Author

Yang, Hee Won, primary, Bae, Jong Bin, additional, Oh, Dae Jong, additional, Moon, Dong Gyu, additional, Lim, Eunji, additional, Shin, Jin, additional, Kim, Bong Jo, additional, Lee, Dong Woo, additional, Kim, Jeong Lan, additional, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Lee, Jung Jae, additional, Kwak, Kyung Phil, additional, Lee, Seok Bum, additional, Moon, Seok Woo, additional, Ryu, Seung-Ho, additional, Kim, Shin Gyeom, additional, Han, Ji Won, additional, and Kim, Ki Woong, additional

Published
2021
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19. Additional file 1 of Posttraumatic stress disorder and depression of survivors 12 months after the outbreak of Middle East respiratory syndrome in South Korea

Author

Park, Hye Yoon, Park, Wan Beom, Lee, So Hee, Kim, Jeong Lan, Lee, Jung Jae, Haewoo Lee, and Hyoung-Shik Shin

Subjects
mental disorders
Abstract

Additional file 1 Table S1. Comparisons of mental health status and related factors between survivors with and without PTSD/depression in South Korea. Table S2. Univariate analysis assessing PTSD and depression and related variables 12 months after the MERS outbreak, in South Korea.

Published
2020
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20. Sex differences in subjective age-associated changes in sleep: a prospective elderly cohort study

Author

Suh, Seung Wan, primary, Han, Ji Won, additional, Han, Ji Hyun, additional, Bae, Jong Bin, additional, Moon, Woori, additional, Kim, Hye Sung, additional, Oh, Dae Jong, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Seo, Jiyeong, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2020
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22. Low Diastolic Blood Pressure and Cognitive Decline in Korean Elderly People: The Korean Longitudinal Study on Cognitive Aging and Dementia

Author

Lee, Dongyun, primary, Kim, Bong-Jo, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Ji Young, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, Bae, Jong Bin, additional, and Kim, Ki Woong, additional

Published
2020
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24. Differential effects of completed and incomplete pregnancies on the risk of Alzheimer disease

Author

Jang, Hyesue, Bae, Jong Bin, Dardiotis, Efthimios, Scarmeas, Nikolaos, Sachdev, Perminder S., Lipnicki, Darren M., Han, Ji Won, Kim, Tae Hui, Kwak, Kyung Phil, Kim, Bong Jo, Kim, Shin Gyeom, Kim, Jeong Lan, Moon, Seok Woo, Park, Joon Hyuk, Ryu, Seung-Ho, Youn, Jong Chul, Lee, Dong Young, Lee, Dong Woo, Lee, Seok Bum, Lee, Jung Jae, Jhoo, Jin Hyeong, Yannakoulia, Mary, Kosmidis, Mary H., Hadjigeorgiou, Giorgos M., Sakka, Paraskevi, Kim, Ki Woong, Hadjigeorgiou, Giorgos M. [0000-0001-5386-4273], Dardiotis, Efthimios [0000-0003-2957-641X], Yannakoulia, Mary [0000-0003-2171-7337], Kosmidis, Mary H. [0000-0001-8790-1220], and Scarmeas, Nikolaos [0000-0001-6453-8908]

Subjects
0301 basic medicine, medicine.medical_specialty, International Cooperation, Population, Logistic regression, Community Health Planning, Article, Cohort Studies, 03 medical and health sciences, Age Distribution, 0302 clinical medicine, Alzheimer Disease, Pregnancy, Republic of Korea, medicine, Humans, Dementia, Childbirth, education, Reproductive History, Aged, Aged, 80 and over, Psychiatric Status Rating Scales, education.field_of_study, Obstetrics, business.industry, Odds ratio, Middle Aged, medicine.disease, Confidence interval, Pregnancy Complications, 030104 developmental biology, Female, Neurology (clinical), Cognition Disorders, business, 030217 neurology & neurosurgery, Cohort study
Abstract

ObjectiveTo investigate the effects of completed pregnancy with childbirth and incomplete pregnancy without childbirth on the late-life cognition and the risk of Alzheimer disease (AD) in women.MethodsUsing the pooled data of 3,549 women provided by 2 population-based cohort studies, we conducted logistic regression analyses to examine retrospectively the associations of completed and incomplete pregnancy with the risks of mild cognitive impairment and AD. For women without dementia, we also conducted analyses of covariance to examine the associations of completed and incomplete pregnancy with Mini-Mental State Examination (MMSE) score.ResultsGrand multiparous women who experienced ≥5 completed pregnancies showed an ≈1.7-fold higher risk of AD than those who experienced 1 to 4 completed pregnancies (odds ratio [OR] 1.68, 95% confidence interval [CI] 1.04–2.72), while those who had incomplete pregnancies showed half the level of AD risk compared with those who never experienced an incomplete pregnancy (OR 0.43, 95% CI 0.24–0.76 for 1 incomplete pregnancy; OR 0.56, 95% CI 0.34–0.92 for ≥2 incomplete pregnancies). In women without dementia, the grand multiparous had worse MMSE scores than those with 1 to 4 completed pregnancies (p < 0.001), while those who experienced ≥1 incomplete pregnancies had better MMSE scores than those who never experienced an incomplete pregnancy (p = 0.008).ConclusionsGrand multiparity was associated with high risk of AD, while incomplete pregnancy was associated with low risk of AD in late life.

Published
2018

25. Anhedonia and Dysphoria Are Differentially Associated with the Risk of Dementia in the Cognitively Normal Elderly Individuals: A Prospective Cohort Study

Author

Lee, Ju Ri, primary, Suh, Seung Wan, additional, Han, Ji Won, additional, Byun, Seonjeong, additional, Kwon, Soon Jai, additional, Lee, Kyoung Hwan, additional, Kwak, Kyung Phil, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Joon Hyuk, additional, Lee, Dong-Woo, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, and Kim, Ki Woong, additional

Published
2019
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26. Normal-But-Low Serum Folate Levels and the Risks for Cognitive Impairment

Author

Jang, Soomin, primary, Han, Ji Won, additional, Shin, Jiyoon, additional, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Jiyeong, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, and Kim, Ki Woong, additional

Published
2019
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30. Is Dementia More Fatal Than Previously Estimated? A Population-based Prospective Cohort Study

Author

Bae, Jong Bin, primary, Han, Ji Won, primary, Kwak, Kyung Phil, primary, Kim, Bong Jo, primary, Kim, Shin Gyeom, primary, Kim, Jeong Lan, primary, Kim, Tae Hui, primary, Ryu, Seung-Ho, primary, Moon, Seok Woo, primary, Park, Joon Hyuk, primary, Youn, Jong Chul, primary, Lee, Dong Young, primary, Lee, Dong Woo, primary, Lee, Seok Bum, primary, Lee, Jung Jae, primary, Jhoo, Jin Hyeong, primary, and Kim, Ki Woong, primary

Published
2019
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31. Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

Author

Sack Ragna, Hess Daniel, Chun Taehoon, Cho Jae Youl, Seok Jeong Ho, Hur Gang Min, Kweon Gi Ryang, Kim Jeong-Lan, Hong Janghee, Won Minho, Byun Hee Sun, Park Kyeong Ah, Yang Keum-Jin, Li Yuwen, Piao Longzhen, Maira Sauveur-Michel, Brazil Derek P, Hemmings Brian A, and Park Jongsun

Subjects
Cytology, QH573-671
Abstract

Abstract Background The serine/threonine protein kinase B (PKB/Akt) is involved in insulin signaling, cellular survival, and transformation. Carboxyl-terminal modulator protein (CTMP) has been identified as a novel PKB binding partner in a yeast two-hybrid screen, and appears to be a negative PKB regulator with tumor suppressor-like properties. In the present study we investigate novel mechanisms by which CTMP plays a role in apoptosis process. Results CTMP is localized to mitochondria. Furthermore, CTMP becomes phosphorylated following the treatment of cells with pervanadate, an insulin-mimetic. Two serine residues (Ser37 and Ser38) were identified as novel in vivo phosphorylation sites of CTMP. Association of CTMP and heat shock protein 70 (Hsp70) inhibits the formation of complexes containing apoptotic protease activating factor 1 and Hsp70. Overexpression of CTMP increased the sensitivity of cells to apoptosis, most likely due to the inhibition of Hsp70 function. Conclusion Our data suggest that phosphorylation on Ser37/Ser38 of CTMP is important for the prevention of mitochondrial localization of CTMP, eventually leading to cell death by binding to Hsp70. In addition to its role in PKB inhibition, CTMP may therefore play a key role in mitochondria-mediated apoptosis by localizing to mitochondria.

Published
2009
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32. Overview of the Korean Longitudinal Study on Cognitive Aging and Dementia

Author

Han, Ji Won, primary, Kim, Tae Hui, additional, Kwak, Kyung Phil, additional, Kim, Kayoung, additional, Kim, Bong Jo, additional, Kim, Shin Gyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hyun, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Byun, Seonjeong, additional, Suh, Seung Wan, additional, Seo, Ji Young, additional, So, Yoonseop, additional, Ryu, Seung-Ho, additional, Youn, Jong Chul, additional, Lee, Kyoung Hwan, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Lee, Ju Ri, additional, Jeong, Hyeon, additional, Jeong, Hyun-Ghang, additional, Jhoo, Jin Hyeong, additional, Han, Kyuhee, additional, Hong, Jong Woo, additional, and Kim, Ki Woong, additional

Published
2018
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33. Prevalence and Risk Factors of Abusive Behaviors in the Caregivers of People with Dementia in Korea

Author

Kim, Taehyun, primary, Jeong, Hyeon, additional, Han, Ji Won, additional, Kwak, Kyung Phil, additional, Kim, Bong-Jo, additional, Kim, Shin-Kyeom, additional, Kim, Jeong Lan, additional, Kim, Tae Hui, additional, Ryu, Seung-Ho, additional, Moon, Seok Woo, additional, Park, Jae Young, additional, Park, Joon Hyuk, additional, Bae, Jae Nam, additional, Youn, Jong Chul, additional, Lee, Dong Young, additional, Lee, Dong Woo, additional, Lee, Seok Bum, additional, Lee, Jung Jae, additional, Jhoo, Jin Hyeong, additional, Lee, Jungwon, additional, and Kim, Ki Woong, additional

Published
2018
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38. The Effect of Choline Acetyltransferase Genotype on Donepezil Treatment Response in Patients with Alzheimer’s Disease

Author

Lee, Kang Uk, primary, Lee, Jung Hie, additional, Lee, Dong Young, additional, Youn, Jong Chul, additional, Kim, Jeong Lan, additional, Moon, Seok Woo, additional, Kim, Bong-Jo, additional, Ryu, Seung-Ho, additional, Kim, Moon Doo, additional, Lee, Chang-Uk, additional, Lee, Nam-Jin, additional, Chang, Sung Man, additional, Kim, Young Hoon, additional, Kim, Do Hoon, additional, Lee, Hae-Kook, additional, Woo, Jong Inn, additional, Kim, Ki Woong, additional, and Jhoo, Jin Hyeong, additional

Published
2015
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41. Development of a Screening Algorithm for Alzheimer's Disease Using Categorical Verbal Fluency

Author

Chi, Yeon Kyung, primary, Han, Ji Won, additional, Jeong, Hyeon, additional, Park, Jae Young, additional, Kim, Tae Hui, additional, Lee, Jung Jae, additional, Lee, Seok Bum, additional, Park, Joon Hyuk, additional, Yoon, Jong Chul, additional, Kim, Jeong Lan, additional, Ryu, Seung-Ho, additional, Jhoo, Jin Hyeong, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2014
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42. A Normative Study of the Disability Assessment for Dementia in Community-Dwelling Elderly Koreans

Author

Jhoo, Jin Hyeong, primary, Chi, Yeon Kyung, additional, Choi, Hyo Jung, additional, Han, Ji Won, additional, Kim, Tae Hui, additional, Lee, Jung Jae, additional, Lee, Seok Bum, additional, Park, Joon Hyuk, additional, Youn, Jong Chul, additional, Kim, Jeong Lan, additional, Ryu, Seung-Ho, additional, Lee, Dong Young, additional, and Kim, Ki Woong, additional

Published
2014
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47. Korean Version of Mini Mental Status Examination for Dementia Screening and Its' Short Form

Author

Kim, Tae Hui, primary, Jhoo, Jin Hyeong, additional, Park, Joon Hyuk, additional, Kim, Jeong Lan, additional, Ryu, Seung Ho, additional, Moon, Seok Woo, additional, Choo, Il Han, additional, Lee, Dong Woo, additional, Yoon, Jong Chul, additional, Do, Yeon Ja, additional, Lee, Seok Bum, additional, Kim, Moon Doo, additional, and Kim, Ki Woong, additional

Published
2010
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48. Heat shock protein 70-mediated sensitization of cells to apoptosis by Carboxyl-Terminal Modulator Protein

Author

Piao, Longzhen, primary, Li, Yuwen, additional, Yang, Keum-Jin, additional, Park, Kyeong Ah, additional, Byun, Hee Sun, additional, Won, Minho, additional, Hong, Janghee, additional, Kim, Jeong-Lan, additional, Kweon, Gi Ryang, additional, Hur, Gang Min, additional, Seok, Jeong Ho, additional, Cho, Jae Youl, additional, Chun, Taehoon, additional, Hess, Daniel, additional, Sack, Ragna, additional, Maira, Sauveur-Michel, additional, Brazil, Derek P, additional, Hemmings, Brian A, additional, and Park, Jongsun, additional

Published
2009
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49. Masticatory Function, Sex, and Risk of Dementia Among Older Adults: A Population-Based Cohort Study.

Author

Oh DJ, Han JW, Kim JS, Kim TH, Kwak KP, Kim BJ, Kim SG, Kim JL, Moon SW, Park JH, Ryu SH, Youn JC, Lee DY, Lee DW, Lee SB, Lee JJ, Jhoo JH, and Kim KW

Subjects
Humans, Male, Female, Aged, Prospective Studies, Risk Factors, Middle Aged, Cohort Studies, Proportional Hazards Models, Sex Factors, Cognition physiology, Cognitive Dysfunction, Aged, 80 and over, Mastication, Magnetic Resonance Imaging, Dementia, Brain diagnostic imaging, Brain pathology, Alzheimer Disease
Abstract

Background: A decline in masticatory function may indicate brain dysfunction related to dementia, but the relationship between masticatory function and dementia risk remains unclear. This study aimed to investigate whether masticatory function is associated with the risk of cognitive decline and dementia., Methods: Data were obtained from the nationwide prospective cohort study of randomly sampled community-dwelling Koreans aged ≥ 60 years. The 5,064 non-demented participants, whose number of chewing cycles per bite was assessed by clinical interview, were followed for 8 years with biennial assessments of cognitive performance and clinical diagnoses of all-cause dementia and Alzheimer's disease (AD). Structural brain magnetic resonance imaging was collected from a subset of cohort participants and their spouses for imaging analyses., Results: Males who chewed ≥ 30 cycles/bite had faster decline in global cognition and memory function and were at higher risk for incident all-cause dementia (hazard ratio [HR], 2.91; 95% confidence interval [CI], 1.18-7.18) and AD (HR, 3.22; 95% CI, 1.14-9.11) compared to males with less than 10 cycles/bite. Additionally, increased chewing cycles in males were associated with reduced brain volume, particularly in regions involved in compensatory cognitive control of mastication. There was no significant association between chewing cycles and the risk of dementia or brain volume in females., Conclusion: Older men who frequently chew their meals could be considered a notable population at risk for dementia who should be carefully assessed for their cognitive trajectories., Competing Interests: The authors have no potential conflicts of interest to disclose., (© 2024 The Korean Academy of Medical Sciences.)

Published
2024
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