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5 results on '"Kim, Sella"'

1. Antiviral Effects of Black Raspberry (Rubus coreanus) Seed and Its Gallic Acid against Influenza Virus Infection

Author

Lee, Ji-Hye, primary, Oh, Mi, additional, Seok, Jong, additional, Kim, Sella, additional, Lee, Dan, additional, Bae, Garam, additional, Bae, Hae-In, additional, Bae, Seon, additional, Hong, Young-Min, additional, Kwon, Sang-Oh, additional, Lee, Dong-Hun, additional, Song, Chang-Seon, additional, Mun, Ji, additional, Chung, Mi, additional, and Kim, Kyung, additional

Published
2016
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2. Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal Antibody

Author

Cho, Ki Joon, primary, Schepens, Bert, additional, Seok, Jong Hyeon, additional, Kim, Sella, additional, Roose, Kenny, additional, Lee, Ji-Hye, additional, Gallardo, Rodrigo, additional, Van Hamme, Evelien, additional, Schymkowitz, Joost, additional, Rousseau, Frederic, additional, Fiers, Walter, additional, Saelens, Xavier, additional, and Kim, Kyung Hyun, additional

Published
2015
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4. Insight into structural diversity of influenza virus haemagglutinin

Author

Cho, Ki Joon, primary, Lee, Ji-Hye, additional, Hong, Kwang W., additional, Kim, Se-Ho, additional, Park, Yiho, additional, Lee, Jun Young, additional, Kang, Seokha, additional, Kim, Sella, additional, Yang, Ji Hoon, additional, Kim, Eui-Ki, additional, Seok, Jong Hyeon, additional, Unzai, Satoru, additional, Park, Sam Yong, additional, Saelens, Xavier, additional, Kim, Chul-Joong, additional, Lee, Joo-Yeon, additional, Kang, Chun, additional, Oh, Hee-Bok, additional, Chung, Mi Sook, additional, and Kim, Kyung Hyun, additional

Published
2013
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5. Structure of the Extracellular Domain of Matrix Protein 2 of Influenza A Virus in Complex with a Protective Monoclonal Antibody.

Author

Ki Joon Cho, Schepens, Bert, Jong Hyeon Seok, Kim, Sella, Roose, Kenny, Ji-Hye Lee, Gallardo, Rodrigo, Van Hamme, Evelien, Schymkowiz, Joost, Rousseau, Frederic, Fiers, Walter, Saelens, Xavier, and Kyung Hyun Kim

Subjects
*INFLUENZA A virus, *VACCINE research, *IMMUNOGLOBULINS, *MONOCLONAL antibodies, *TRYPTOPHAN
Abstract

The extracellular domain of influenza A virus matrix protein 2 (M2e) is conserved and is being evaluated as a quasiuniversal influenza A vaccine candidate. We describe the crystal structure at 1.6 Å resolution of M2e in complex with the Fab fragment of an M2e-specific monoclonal antibody that protects against influenza A virus challenge. This antibody binds M2 expressed on the surfaces of cells infected with influenza A virus. Five out of six complementary determining regions interact with M2e, and three highly conserved M2e residues are critical for this interaction. In this complex, M2e adopts a compact U-shaped conformation stabilized in the center by the highly conserved tryptophan residue in M2e. This is the first description of the three-dimensional structure of M2e. [ABSTRACT FROM AUTHOR]

Published
2015
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