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3. Chlamydial clinical isolates show subtle differences in persistence phenotypes and growth in vitro.

Author

Thomas, M, Lawrence, A, Kroon, S, Vodstrcil, LA, Phillips, S, Hocking, JS, Timms, P, Huston, WM, Thomas, M, Lawrence, A, Kroon, S, Vodstrcil, LA, Phillips, S, Hocking, JS, Timms, P, and Huston, WM

Abstract

Urogenital Chlamydia trachomatis infection is the most common sexually transmitted bacterial infection throughout the world. While progress has been made to better understand how type strains develop and respond to environmental stress in vitro, very few studies have examined how clinical isolates behave under similar conditions. Here, we examined the development and persistence phenotypes of several clinical isolates, to determine how similar they are to each other, and the type strain C. trachomatis D/UW-3/Cx. The type strain was shown to produce infectious progeny at a higher magnitude than each of the clinical isolates, in each of the six tested cell lines. All chlamydial strains produced the highest number of infectious progeny at 44 h post-infection in the McCoy B murine fibroblast cell line, yet showed higher levels of infectivity in the MCF-7 human epithelial cell line. The clinical isolates were shown to be more susceptible than the type strain to the effects of penicillin and iron deprivation persistence models in the MCF-7 cell line. While subtle differences between clinical isolates were observed throughout the experiments conducted, no significant differences were identified. This study reinforces the importance of examining clinical isolates when trying to relate in vitro data to clinical outcomes, as well as the importance of considering the adaptations many type strains have to being cultured in vitro.

Published
2021

4. Idiopathic and hereditary haemorrhagic telangiectasia associated pulmonary arteriovenous malformations: comparison of clinical and radiographic characteristics

Author

Externen Hematologie, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, Kroon, S., van den Heuvel, D. A.F., Vos, J. A., van Leersum, M., van Strijen, M. J.L., Post, M. C., Mager, J. J., Snijder, R. J., Externen Hematologie, Onderzoek Vrouw Hart & Vaatziekten, Team Medisch, Circulatory Health, Kroon, S., van den Heuvel, D. A.F., Vos, J. A., van Leersum, M., van Strijen, M. J.L., Post, M. C., Mager, J. J., and Snijder, R. J.

Published
2021

7. Learning Dynamics of Linear Denoising Autoencoders

Author

Pretorius, A., Kroon, S., and Herman Kamper

Subjects
FOS: Computer and information sciences, Computer Science::Machine Learning, Computer Science - Machine Learning, Statistics - Machine Learning, Machine Learning (stat.ML), Computer Science::Symbolic Computation, Machine Learning (cs.LG)
Abstract

Denoising autoencoders (DAEs) have proven useful for unsupervised representation learning, but a thorough theoretical understanding is still lacking of how the input noise influences learning. Here we develop theory for how noise influences learning in DAEs. By focusing on linear DAEs, we are able to derive analytic expressions that exactly describe their learning dynamics. We verify our theoretical predictions with simulations as well as experiments on MNIST and CIFAR-10. The theory illustrates how, when tuned correctly, noise allows DAEs to ignore low variance directions in the inputs while learning to reconstruct them. Furthermore, in a comparison of the learning dynamics of DAEs to standard regularised autoencoders, we show that noise has a similar regularisation effect to weight decay, but with faster training dynamics. We also show that our theoretical predictions approximate learning dynamics on real-world data and qualitatively match observed dynamics in nonlinear DAEs., 14 pages, 7 figures, accepted at the 35th International Conference on Machine Learning (ICML) 2018

Published
2018

18. Literacy use and acquisition in multilingual Eritrea

Author

Asfaha, Y.M., Kurvers, J.J.H., and Kroon, S.

Subjects
ComputingMilieux_COMPUTERSANDEDUCATION, Communicative Competences
Abstract

This study investigates literacy acquisition and use in different scripts in multilingual Eritrea, a Horn of Africa country. The research problem is approached from two major angles: the social use of literacy and the classroom acquisition of literacy which in turn includes assessment of literacy instructions, literacy skills and literacy learning processes. The social use of written language and the values attached to literacy and different scripts influence decisions in the acquisition of literacy and the functions assigned to it (Herbert and Robinson 2001). In smaller language communities, there is relatively lower motivation to learn to read and write in a language with limited reach and national status (Hailemariam 2002). Our research tries to compare social use and acquisition in multiple languages and scripts in the context of a complex language and script landscape in Eritrea., Language Documentation and Description, Vol. 4 (2007)

Published
2007

22. Phototherapy and exchange transfusion for neonatal hyperbilirubinaemia:Neonatal academic hospitals' consensus guidelines for South African hospitals and primary health care facilities

Author

Horn, A R, Kirsten, G F, Kroon, S M, Henning, P A, Möller, G, Pieper, C, Adhikari, M, Cooper, P, Hoek, B, Delport, S, Nazo, M, Mawela, B, Division of Neonatology, and Faculty of Health Sciences

Subjects
South Africa, Exchange transfusion, Neonatal hyperbilirubinaemia, Phototherapy, Management
Abstract

The purpose of this document is to address the current lack of consensus regarding the management of hyperbilirubinaemia in neonates in South Africa. If left untreated, severe neonatal hyperbilirubinaemia may cause kernicterus and ultimately death and the severity of neonatal jaundice is often underestimated clinically. However, if phototherapy is instituted timeously and at the correct intensity an exchange transfusion can usually be avoided. The literature describing intervention thresholds for phototherapy and exchange transfusion in both term and preterm infants is therefore reviewed and specific intervention thresholds that can be used throughout South Africa are proposed and presented graphically. A simplified version for use in a primary care setting is also presented. All academic heads of neonatology departments throughout South Africa were consulted in the process of drawing up this document and consensus was achieved.

Published
2006

24. Onderwijs in en van het Nederlands in Suriname

Author

Kroon, S.

Subjects
Structure and Variation, 12-14 januari 2005, Congres van de Nederlandse Taalunie, 12-14 januari 2005, Paramaribo, Paramaribo, Structuur en variatie, Congres van de Nederlandse Taalunie, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 42531.pdf (Publisher’s version ) (Open Access) 33 p.

Published
2005

26. IMEN Bibliography 1984-2004

Author

Kroon, S.

Subjects
Structure and Variation, Structuur en variatie, GeneralLiterature_REFERENCE(e.g.,dictionaries,encyclopedias,glossaries)
Abstract

Contains fulltext : 42794.pdf (Publisher’s version ) (Open Access) 20 p.

Published
2005

27. Bilder von Muttersprachenunterricht

Author

Kroon, S., Gogolin, I., Krüger-Potratz, M., Kuhs, K., Neumann, U., and Wittek, F.

Subjects
ComputingMilieux_LEGALASPECTSOFCOMPUTING
Published
2005

28. Dialect in Limburg

Author

Kroon, S. and Vallen, T.

Subjects
ComputingMilieux_LEGALASPECTSOFCOMPUTING
Published
2004

40. Teacher Education in the Netherlands

Author

Domovic, V, Gehrman, S, Helmchen, J, Krüger-Potratz, M, Petravic, A, Boon, D.A., Kroon, S., Ven, P.H.M. van de, Domovic, V, Gehrman, S, Helmchen, J, Krüger-Potratz, M, Petravic, A, Boon, D.A., Kroon, S., and Ven, P.H.M. van de

Abstract

Item does not contain fulltext

Published
2013

41. Globalization in the margins

Author

Wang, X., Spotti, M., Juffermans, K., Cornips, L., Kroon, S., Blommaert, J., Wang, X., Spotti, M., Juffermans, K., Cornips, L., Kroon, S., and Blommaert, J.

Abstract

http://www.tilburguniversity.edu/upload/39a4b586-f3ba-467a-a976-48e6eaf453f9_TPCS_73_Wang-etal.pdf, http://www.tilburguniversity.edu/upload/39a4b586-f3ba-467a-a976-48e6eaf453f9_TPCS_73_Wang-etal.pdf

Published
2013

50. Daylight-mediated photodynamic therapy of moderate to thick actinic keratoses of the face and scalp : a randomized multicentre study

Author

Wiegell, S. R., Fabricius, S., Gniadecka, M., Stender, I. M., Berne, Berit, Kroon, S., Andersen, B. L., Mork, C., Sandberg, C., Ibler, K. S., Jemec, G. B. E., Brocks, K. M., Philipsen, P. A., Heydenreich, J., Haedersdal, M., Wulf, H. C., Wiegell, S. R., Fabricius, S., Gniadecka, M., Stender, I. M., Berne, Berit, Kroon, S., Andersen, B. L., Mork, C., Sandberg, C., Ibler, K. S., Jemec, G. B. E., Brocks, K. M., Philipsen, P. A., Heydenreich, J., Haedersdal, M., and Wulf, H. C.

Abstract

Background Photodynamic therapy (PDT) is an attractive therapy for nonmelanoma skin cancers and actinic keratoses (AKs). Daylight-mediated PDT is a simple and tolerable treatment procedure for PDT. Methyl aminolaevulinate (MAL)-PDT is approved for the treatment of thin or nonhyperkeratotic AKs on the face and scalp. However, thick AK lesions are often treated as well when present in the field-cancerized treatment area. Objectives In a randomized multicentre study to evaluate efficacy of daylight-mediated PDT for different severity grades of AKs. Methods One hundred and forty-five patients with a total of 2768 AKs (severity grades I-III) of the face and scalp were randomized to either 1 1/2 or 2 1/2 h exposure groups. After application of a sunscreen (sun protection factor 20) and gentle lesion preparation, MAL was applied to the entire treatment area. Patients left the clinic immediately after application and exposed themselves to daylight according to randomization. Daylight exposure was monitored with a wrist-borne dosimeter. Results No difference in lesion response was found between the 1 1/2 and 2 1/2 h exposure group. The mean lesion response rate was significantly higher in grade I lesions (75.9%) than in grade II (61.2%) and grade III (49.1%) lesions (P < 0.0001). Most grade II (86%) and III AKs (94%) were in complete response or reduced to a lower lesion grade at follow-up. Large variations in response rate of grade II and III AKs were found between centres. No association was found between response rate and light dose in patients who received an effective light dose of > 3.5 J cm(-2). Conclusions Daylight-mediated PDT of moderate to thick AKs was less effective than daylight-mediated PDT of thin AKs especially in some centres. However, nearly all thicker lesions (grades II and III) were reduced to a lower lesion grade at 3 months after a single treatment of daylight-mediated PDT.

Published
2012
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