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7. Anoctamin 5 regulates the cell cycle and affects prognosis in gastric cancer

Author

Fukami, Tomoyuki, primary, Shiozaki, Atsushi, additional, Kosuga, Toshiyuki, additional, Kudou, Michihiro, additional, Shimizu, Hiroki, additional, Ohashi, Takuma, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Morinaga, Yukiko, additional, Konishi, Eiichi, additional, and Otsuji, Eigo, additional

Published
2022
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9. The Effect of Preoperative Oral Antibiotics in the Prevention of Surgical Site Infection after Laparoscopic Colorectal Cancer Surgery: A Propensity Score Matching Study

Author

Kudou, Michihiro, primary, Nakanishi, Masayoshi, additional, Kuriu, Yoshiaki, additional, Arita, Tomohiro, additional, Shimizu, Hiroki, additional, Kiuchi, Jun, additional, Katsurahara, Keita, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, and Otsuji, Eigo, additional

Published
2021
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10. Impact of Inferior Mesenteric Artery Lymph Node Metastasis on the Prognosis of Left-sided Colorectal Cancer

Author

TAKABATAKE, KAZUYA, primary, ARITA, TOMOHIRO, additional, NAKANISHI, MASAYOSHI, additional, KURIU, YOSHIAKI, additional, MURAYAMA, YASUTOSHI, additional, SHIMIZU, HIROKI, additional, KUDOU, MICHIHIRO, additional, KIUCHI, JUN, additional, KOSUGA, TOSHIYUKI, additional, KONISHI, HIROTAKA, additional, MORIMURA, RYO, additional, SHIOZAKI, ATSUSHI, additional, IKOMA, HISASHI, additional, KUBOTA, TAKESHI, additional, FUJIWARA, HITOSHI, additional, OKAMOTO, KAZUMA, additional, and OTSUJI, EIGO, additional

Published
2021
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11. ANO9 regulates PD‐L2 expression and binding ability to PD‐1 in gastric cancer

Author

Katsurahara, Keita, primary, Shiozaki, Atsushi, additional, Kosuga, Toshiyuki, additional, Shimizu, Hiroki, additional, Kudou, Michihiro, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, and Otsuji, Eigo, additional

Published
2021
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12. Clinical significance of the distance between the cricoid cartilage and upper edge of the tumor using PET‑CT in cervical esophageal cancer

Author

Katsurahara, Keita, primary, Shiozaki, Atsushi, additional, Fujiwara, Hitoshi, additional, Konishi, Hirotaka, additional, Kudou, Michihiro, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Kosuga, Toshiyuki, additional, Morimura, Ryo, additional, Murayama, Yasutoshi, additional, Kuriu, Yoshiaki, additional, Ikoma, Hisashi, additional, Kubota, Takeshi, additional, Nakanishi, Masayoshi, additional, Okamoto, Kazuma, additional, and Otsuji, Eigo, additional

Published
2020
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13. Value of intra-tumor heterogeneity evaluated by diffusion-weighted MRI for predicting pathological stages and therapeutic responses to chemoradiotherapy in lower rectal cancer

Author

Kudou, Michihiro, primary, Nakanishi, Masayoshi, additional, Kuriu, Yoshiaki, additional, Murayama, Yasutoshi, additional, Arita, Tomohiro, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Goto, Mariko, additional, Yamada, Kei, additional, and Otsuji, Eigo, additional

Published
2020
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14. Value of Prognostic Nutritional Index as a Predictor of Lymph Node Metastasis in Gastric Cancer

Author

KOSUGA, TOSHIYUKI, primary, KONISHI, TOMOKI, additional, KUBOTA, TAKESHI, additional, SHODA, KATSUTOSHI, additional, KONISHI, HIROTAKA, additional, SHIOZAKI, ATSUSHI, additional, OKAMOTO, KAZUMA, additional, FUJIWARA, HITOSHI, additional, KUDOU, MICHIHIRO, additional, ARITA, TOMOHIRO, additional, MORIMURA, RYO, additional, MURAYAMA, YASUTOSHI, additional, KURIU, YOSHIAKI, additional, IKOMA, HISASHI, additional, NAKANISHI, MASAYOSHI, additional, and OTSUJI, EIGO, additional

Published
2019
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15. MOESM1 of Clinical significance of neutrophil-to-lymphocyte ratio as a predictor of lymph node metastasis in gastric cancer

Author

Kosuga, Toshiyuki, Konishi, Tomoki, Kubota, Takeshi, Shoda, Katsutoshi, Konishi, Hirotaka, Shiozaki, Atsushi, Okamoto, Kazuma, Fujiwara, Hitoshi, Kudou, Michihiro, Arita, Tomohiro, Morimura, Ryo, Murayama, Yasutoshi, Kuriu, Yoshiaki, Ikoma, Hisashi, Nakanishi, Masayoshi, and Otsuji, Eigo

Subjects
urologic and male genital diseases
Abstract

Additional file 1: Table S1. Diagnostic accuracy for pT2/T3/T4 in patients with gastric cancer.

Published
2019
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16. The expression of the alpha1 subunit of Na+/K+-ATPase is related to tumor development and clinical outcomes in gastric cancer.

Author

Nakamura, Kei, Shiozaki, Atsushi, Kosuga, Toshiyuki, Shimizu, Hiroki, Kudou, Michihiro, Ohashi, Takuma, Arita, Tomohiro, Konishi, Hirotaka, Komatsu, Shuhei, Kubota, Takeshi, Fujiwara, Hitoshi, Okamoto, Kazuma, Kishimoto, Mitsuo, Konishi, Eiichi, and Otsuji, Eigo

Subjects
STOMACH cancer, CANCER prognosis, TREATMENT effectiveness, IMMUNOHISTOCHEMISTRY, CELLULAR signal transduction, DNA microarrays, MICROARRAY technology
Abstract

Background: The Na+/K+-ATPase alpha1 subunit (ATP1A1) is a critical component of Na+/K+-ATPase (NKA), a membrane pump that maintains a low intracellular Na+/K+ ratio and retains cellular volume and osmolarity. ATP1A1 was recently implicated in tumor behavior. Therefore, the present study investigated the role of ATP1A1 in patients with gastric cancer (GC). Methods: Knockdown experiments were conducted on human GC cell lines using ATP1A1 siRNA, and its effects on proliferation, the cell cycle, apoptosis, and cellular movement were examined. Gene expression profiling was performed by a microarray analysis. Primary tumor samples from 192 GC patients who underwent gastrectomy were subjected to an immunohistochemical analysis. Results: High ATP1A1 expression levels were observed in NUGC4 and MKN74 cells. Cell proliferation was suppressed and apoptosis was induced by the siRNA-induced knockdown of ATP1A1. The microarray analysis showed that knockdown of ATP1A1 leads to the up-regulated expression of genes involved in the interferon (IFN) signaling pathway, such as STAT1, STAT2, IRF1, and IRF9. Furthermore, the depletion of ATP1A1 altered the phosphorylation of the MAPK pathway. The immunohistochemical analysis revealed that the expression of ATP1A1 was associated with the histological type, venous invasion, and the pathological T stage. Furthermore, the prognostic analysis showed a relationship between high ATP1A1 expression levels and poor postoperative survival. Conclusions: ATP1A1 appears to regulate tumor progression by altering IFN signaling, and high ATP1A1 expression levels were associated with poor postoperative survival in GC patients. The present results provide novel insights into the function of ATP1A1 as a mediator and/or biomarker of GC. [ABSTRACT FROM AUTHOR]

Published
2021
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17. Anatomical liver segmentectomy 2 for combined hepatocellular carcinoma and cholangiocarcinoma with tumor thrombus in segment 2 portal branch

Author

Ishii Hiromichi, Kobayashi Takuma, Kudou Michihiro, Nishimura Masumi, Toma Atsushi, Nakamura Kenji, Mazaki Takeshi, and Itoh Tsuyoshi

Subjects
anatomical segmentectomy 2, portal vein tumor thrombus, combined hepatocellular carcinoma and cholangiocarcinoma, modified selective hepatic vascular exclusion, Surgery, RD1-811, Neoplasms. Tumors. Oncology. Including cancer and carcinogens, RC254-282
Abstract

Abstract Background Hepatic resection is the only effective treatment for combined hepatocellular carcinoma and cholangiocarcinoma. Case presentation A 52-year-old man was preoperatively diagnosed with hepatocellular carcinoma in segment 2 with tumor thrombus in the segment 2 portal branch. Anatomical liver segmentectomy 2, including separation of the hepatic arteries, portal veins, and bile duct, enabled us to remove the tumor and portal thrombus completely. Modified selective hepatic vascular exclusion, which combines extrahepatic control of the left and middle hepatic veins with occlusion of left hemihepatic inflow, was used to reduce blood loss. A pathological examination revealed combined hepatocellular carcinoma and cholangiocarcinoma with tumor thrombus in the segment 2 portal branch. No postoperative liver failure occurred, and remnant liver function was adequate. Conclusion The separation method of the hepatic arteries, portal veins, and bile duct is safe and feasible for a liver cancer patient with portal vein tumor thrombus. Modified selective hepatic vascular exclusion was useful to control bleeding during liver transection. Anatomical liver segmentectomy 2 using these procedures should be considered for a patient with a liver tumor located at segment 2 arising from a damaged liver.

Published
2012
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18. The expression and role of TRPV2 in esophageal squamous cell carcinoma

Author

Kudou, Michihiro, primary, Shiozaki, Atsushi, additional, Yamazato, Yuzo, additional, Katsurahara, Keita, additional, Kosuga, Toshiyuki, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2019
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19. Functional Outcomes of Billroth I Gastroduodenostomy Using Linear Staplers in Totally Laparoscopic Distal Gastrectomy

Author

KATSURAHARA, KEITA, primary, KOSUGA, TOSHIYUKI, additional, KUBOTA, TAKESHI, additional, SHIOZAKI, ATSUSHI, additional, OKAMOTO, KAZUMA, additional, SHODA, KATSUTOSHI, additional, KONISHI, HIROTAKA, additional, FUJIWARA, HITOSHI, additional, KUDOU, MICHIHIRO, additional, ARITA, TOMOHIRO, additional, MORIMURA, RYO, additional, MURAYAMA, YASUTOSHI, additional, KURIU, YOSHIAKI, additional, IKOMA, HISASHI, additional, NAKANISHI, MASAYOSHI, additional, KOMATSU, SHUHEI, additional, and OTSUJI, EIGO, additional

Published
2019
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20. Essentiality of Imaging Diagnostic Criteria Specific to Rectal Neuroendocrine Tumors for Detecting Metastatic Lymph Nodes

Author

KUDOU, MICHIHIRO, primary, ARITA, TOMOHIRO, additional, NAKANISHI, MASAYOSHI, additional, KURIU, YOSHIAKI, additional, MURAYAMA, YASUTOSHI, additional, SHODA, KATSUTOSHI, additional, KOSUGA, TOSHIYUKI, additional, KONISHI, HIROTAKA, additional, MORIMURA, RYO, additional, SHIOZAKI, ATSUSHI, additional, IKOMA, HISASHI, additional, KUBOTA, TAKESHI, additional, FUJIWARA, HITOSHI, additional, OKAMOTO, KAZUMA, additional, and OTSUJI, EIGO, additional

Published
2018
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21. Clinical safety and efficacy of neoadjuvant combination chemotherapy of tranilast in advanced esophageal squamous cell carcinoma: Phase I/II study (TNAC).

Author

Atsushi Shiozaki, Michihiro Kudou, Hitoshi Fujiwara, Hirotaka Konishi, Hiroki Shimizu, Tomohiro Arita, Toshiyuki Kosuga, Yusuke Yamamoto, Ryo Morimura, Hisashi Ikoma, Yoshiaki Kuriu, Takeshi Kubota, Kazuma Okamoto, Eigo Otsuji, Shiozaki, Atsushi, Kudou, Michihiro, Fujiwara, Hitoshi, Konishi, Hirotaka, Shimizu, Hiroki, and Arita, Tomohiro

Published
2020
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22. Relationship Between Postoperative CRP and Prognosis in Thoracic Esophageal Squamous Cell Carcinoma

Author

KATSURAHARA, KEITA, primary, SHIOZAKI, ATSUSHI, additional, FUJIWARA, HITOSHI, additional, KONISHI, HIROTAKA, additional, KUDOU, MICHIHIRO, additional, SHODA, KATSUTOSHI, additional, ARITA, TOMOHIRO, additional, KOSUGA, TOSHIYUKI, additional, MORIMURA, RYO, additional, MURAYAMA, YASUTOSHI, additional, KURIU, YOSHIAKI, additional, IKOMA, HISASHI, additional, KUBOTA, TAKESHI, additional, NAKANISHI, MASAYOSHI, additional, OKAMOTO, KAZUMA, additional, and OTSUJI, EIGO, additional

Published
2018
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23. Functional analysis and clinical significance of sodium iodide symporter expression in gastric cancer

Author

Shiozaki, Atsushi, primary, Ariyoshi, Yosuke, additional, Iitaka, Daisuke, additional, Kosuga, Toshiyuki, additional, Shimizu, Hiroki, additional, Kudou, Michihiro, additional, Konishi, Tomoki, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Marunaka, Yoshinori, additional, Ichikawa, Daisuke, additional, and Otsuji, Eigo, additional

Published
2018
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24. Comparison of Feeding Jejunostomy via Gastric Tube Versus Jejunum After Esophageal Cancer Surgery

Author

KONISHI, TOMOKI, primary, SHIOZAKI, ATSUSHI, additional, FUJIWARA, HITOSHI, additional, KONISHI, HIROTAKA, additional, TAKEMOTO, KENICHI, additional, KUDOU, MICHIHIRO, additional, SHODA, KATSUTOSHI, additional, ARITA, TOMOHIRO, additional, KOSUGA, TOSHIYUKI, additional, MORIMURA, RYO, additional, MURAYAMA, YASUTOSHI, additional, KURIU, YOSHIAKI, additional, IKOMA, HISASHI, additional, KUBOTA, TAKESHI, additional, NAKANISHI, MASAYOSHI, additional, OKAMOTO, KAZUMA, additional, and OTSUJI, EIGO, additional

Published
2018
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25. Anion exchanger 2 suppresses cellular movement and has prognostic significance in esophageal squamous cell carcinoma

Author

Shiozaki, Atsushi, primary, Hikami, Shoichiro, additional, Ichikawa, Daisuke, additional, Kosuga, Toshiyuki, additional, Shimizu, Hiroki, additional, Kudou, Michihiro, additional, Yamazato, Yuzo, additional, Kobayashi, Toshiyuki, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Kubota, Takeshi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Konishi, Eiichi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2018
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26. Blockade of potassium ion transports enhances hypotonicity-induced cytocidal effects in gastric cancer

Author

Kosuga, Toshiyuki, primary, Shiozaki, Atsushi, additional, Kudou, Michihiro, additional, Yamazato, Yuzo, additional, Ichikawa, Daisuke, additional, Komatsu, Shuhei, additional, Konishi, Hirotaka, additional, Okamoto, Kazuma, additional, Shoda, Katsutoshi, additional, Arita, Tomohiro, additional, Morimura, Ryo, additional, Murayama, Yasutoshi, additional, Kuriu, Yoshiaki, additional, Ikoma, Hisashi, additional, Nakanishi, Masayoshi, additional, Fujiwara, Hitoshi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2017
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27. Expression and role of anion exchanger 1 in esophageal squamous cell carcinoma

Author

Shiozaki, Atsushi, primary, Kudou, Michihiro, additional, Ichikawa, Daisuke, additional, Shimizu, Hiroki, additional, Arita, Tomohiro, additional, Kosuga, Toshiyuki, additional, Konishi, Hirotaka, additional, Komatsu, Shuhei, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Kishimoto, Mitsuo, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2017
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28. Efficacy of PET-CT in the Diagnosis and Treatment of Recurrence After Esophageal Cancer Surgery

Author

KUDOU, MICHIHIRO, primary, SHIOZAKI, KUDOU,, additional, FUJIWARA, HITOSHI, additional, KONISHI, HIROTAKA, additional, ARITA, TOMOHIRO, additional, KOSUGA, TOSHIYUKI, additional, MORIMURA, RYO, additional, MURAYAMA, YASUTOSHI, additional, KOMATSU, SHUHEI, additional, KURIU, YOSHIAKI, additional, IKOMA, HISASHI, additional, NAKANISHI, MASAYOSHI, additional, ICHIKAWA, DAISUKE, additional, OKAMOTO, KAZUMA, additional, and OTSUJI, EIGO, additional

Published
2016
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29. Inhibition of Regulatory Volume Decrease Enhances the Cytocidal Effect of Hypotonic Shock in Hepatocellular Carcinoma

Author

Kudou, Michihiro, primary, Shiozaki, Atsushi, additional, Kosuga, Toshiyuki, additional, Ichikawa, Daisuke, additional, Konishi, Hirotaka, additional, Morimura, Ryo, additional, Komatsu, Shuhei, additional, Ikoma, Hisashi, additional, Fujiwara, Hitoshi, additional, Okamoto, Kazuma, additional, Hosogi, Shigekuni, additional, Nakahari, Takashi, additional, Marunaka, Yoshinori, additional, and Otsuji, Eigo, additional

Published
2016
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30. Essentiality of Imaging Diagnostic Criteria Specific to Rectal Neuroendocrine Tumors for Detecting Metastatic Lymph Nodes.

Author

Kudou M, Arita T, Nakanishi M, Kuriu Y, Murayama Y, Shoda K, Kosuga T, Konishi H, Morimura R, Shiozaki A, Ikoma H, Kubota T, Fujiwara H, Okamoto K, and Otsuji E

Subjects
Adenocarcinoma pathology, Adenocarcinoma surgery, Adult, Aged, Female, Humans, Lymph Nodes pathology, Lymph Nodes surgery, Lymphatic Metastasis, Male, Middle Aged, Neuroendocrine Tumors pathology, Neuroendocrine Tumors surgery, Rectal Neoplasms pathology, Rectal Neoplasms surgery, Retrospective Studies, Adenocarcinoma diagnostic imaging, Lymph Nodes diagnostic imaging, Neuroendocrine Tumors diagnostic imaging, Rectal Neoplasms diagnostic imaging
Abstract

Background/aim: The present study aimed to clarify an accurate diagnostic method for lymph node metastasis (LN+) in rectal neuroendocrine tumors (rNETs)., Patients and Methods: This was a retrospective study of 14 rNETs and 45 rectal adenocarcinoma patients undergoing rectal resection. The short axis of LNs was measured using CT and pathological findings (43 paraffin-fixed LNs in rNETs and 786 LNs in adenocarcinoma)., Results: The size of LN+ in CT and pathological findings was smaller in rNETs than adenocarcinoma (p=0.082 and p<0.001, respectively). The AUC values of ROC curves for detecting LN+ using LN sizes on CT were 0.837 for rNETs and 0.885 for adenocarcinoma (Cut-off values: 5 mm for rNETs, 7 mm for adenocarcinoma). rNETs were diagnosed with high accuracy using the cut-off value of rNETs (5 mm) (sensitivity: 80.0%, and specificity: 87.5%)., Conclusion: The size of LN+ was smaller in rNETs than in adenocarcinoma, suggesting the essentiality of diagnostic criteria specific for rNETs., (Copyright© 2019, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2019
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31. Efficacy of Additional Surgical Resection After Endoscopic Submucosal Dissection for Superficial Esophageal Cancer.

Author

Kudou M, Shiozaki A, Fujiwara H, Konishi H, Shoda K, Arita T, Kosuga T, Morimura R, Murayama Y, Kuriu Y, Ikoma H, Kubota T, Nakanishi M, Okamoto K, Dohi O, Konishi H, Naito Y, and Otsuji E

Subjects
Aged, Disease-Free Survival, Esophageal Neoplasms pathology, Female, Humans, Male, Middle Aged, Survival Analysis, Treatment Outcome, Endoscopic Mucosal Resection, Esophageal Neoplasms surgery
Abstract

Background/aim: This study aimed to investigate the efficacy of additional surgical resection (ASR) after endoscopic submucosal dissection (ESD) for superficial esophageal cancer (SEC)., Patients and Methods: Clinicopathological features and prognoses were analyzed in esophageal cancer (EC) cases with the indication for additional treatments (AT) after ESD (37 cases) and in cases that underwent primary resection (13 cases)., Results: Sixteen out of 37 cases underwent ASR. The remaining 21 cases underwent other treatments or observation. Although all ASR cases are alive without recurrence, recurrence developed in 2 non-ASR cases. Residual tumors were detected in 2 ASR cases. All 4 cases were T1b and positive for lymph vessel invasion (ly+). No significant difference was observed in surgical outcomes between ASR and primary surgical resection (PSR) cases., Conclusion: AT need to be considered for T1b and ly+ cases, and ASR is one of the effective AT. The safety of ASR was similar to PSR for SEC., (Copyright© 2017, International Institute of Anticancer Research (Dr. George J. Delinasios), All rights reserved.)

Published
2017
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