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11 results on '"Kuijper, Steven C."'

1. Survival scenarios of patients with localized and metastatic pancreatic adenocarcinoma:A population-based study

Author

Kuijper, Steven C., Gehrels, Anne M., van Der Geest, Lydia G., Verhoeven, Rob H. A., Koerkamp, Bas Groot, Molenaar, I. Quintus, Stommel, Martijn W. J., de Meijer, Vincent E., de Vos-Geelen, J., Wumkes, Miriam L., Besselink, Marc G., Wilmink, Johanna W., van Laarhoven, Hanneke W. M., Kuijper, Steven C., Gehrels, Anne M., van Der Geest, Lydia G., Verhoeven, Rob H. A., Koerkamp, Bas Groot, Molenaar, I. Quintus, Stommel, Martijn W. J., de Meijer, Vincent E., de Vos-Geelen, J., Wumkes, Miriam L., Besselink, Marc G., Wilmink, Johanna W., and van Laarhoven, Hanneke W. M.

Abstract

Pancreatic adenocarcinoma (PAC) is notorious for its poor survival. The provision of survival scenarios-that is, best-case, typical and worst-case scenarios-could prove valuable to patients and clinicians. This study investigated survival scenarios and how these have changed over a period of 16 years for patients with PAC. Data from the Netherlands Cancer Registry were used to identify patients with localized and metastatic PAC (2005-2021). Survival scenarios, including best-case, upper-typical, typical (median), lower-typical, and worst-case, were estimated based on survival curve percentiles (p10, p25, p50, p75, and p90). Annual differences were assessed for significance using weighted linear regression analyses. Factors associated with these scenarios were identified through univariable tests. Overall, 14,622 patients with localized and 20,199 with metastatic PAC were included. For patients with localized PAC, the best, upper-typical and typical survival scenarios improved statistically significant with average annual improvement of 1.54 (95%CI: 1.2-1.88), 0.67 (0.56-0.78), and 0.24 (0.19-0.29) months, respectively. For patients with metastatic PAC the best and upper-typical survival scenarios increased statically significantly with annual improvement of 0.28 (0.21-0.34) and 0.06 (0.02-0.09) months, respectively. The best-case and upper-typical scenarios were associated with younger patients, more aggressive disease-focused treatments, fewer comorbidities, and better overall performance status. Over the past 16 years, survival improvements in patients with PAC have been most notable in these scenarios. Although the absolute gains were modest, these results offer encouraging potential for advancements in life-prolonging care for this type of cancer.

Published
2024

2. Potential Adverse Outcomes of Shared Decision Making about Palliative Cancer Treatment: A Secondary Analysis of a Randomized Trial

Author

MS Medische Oncologie, Brain, Cancer, van de Water, Loïs F, Bos-van den Hoek, Danique W, Kuijper, Steven C, van Laarhoven, Hanneke W M, Creemers, Geert-Jan, Dohmen, Serge E, Fiebrich, Helle-Brit, Ottevanger, Petronella B, Sommeijer, Dirkje W, de Vos, Filip Y F, Smets, Ellen M A, Henselmans, Inge, MS Medische Oncologie, Brain, Cancer, van de Water, Loïs F, Bos-van den Hoek, Danique W, Kuijper, Steven C, van Laarhoven, Hanneke W M, Creemers, Geert-Jan, Dohmen, Serge E, Fiebrich, Helle-Brit, Ottevanger, Petronella B, Sommeijer, Dirkje W, de Vos, Filip Y F, Smets, Ellen M A, and Henselmans, Inge

Published
2024

3. Assessing real-world representativeness of prospective registry cohorts in oncology:insights from patients with esophagogastric cancer

Author

Kuijper, Steven C., Besseling, Joost, Klausch, Thomas, Slingerland, Marije, van der Zijden, Charlène J., Kouwenhoven, Ewout A., Beerepoot, Laurens V., Mohammad, Nadia Haj, Klarenbeek, Bastiaan R., Verhoeven, Rob H.A., van Laarhoven, Hanneke W.M., Kuijper, Steven C., Besseling, Joost, Klausch, Thomas, Slingerland, Marije, van der Zijden, Charlène J., Kouwenhoven, Ewout A., Beerepoot, Laurens V., Mohammad, Nadia Haj, Klarenbeek, Bastiaan R., Verhoeven, Rob H.A., and van Laarhoven, Hanneke W.M.

Abstract

Objectives: This study aimed to explore the real-world representativeness of a prospective registry cohort with active accrual in oncology, applying a representativeness metric that is novel to health care. Study Design and Setting: We used data from the Prospective Observational Cohort Study of Esophageal-Gastric Cancer Patients (POCOP) registry and from the population-based Netherlands Cancer Registry (NCR). We used Representativeness-indicators (R-indicators) and overall survival to investigate the degree to which the POCOP cohort and clinically relevant subgroups were a representative sample compared to the NCR database. Calibration using inverse propensity score weighting was applied to correct differences between POCOP and NCR. Results: The R-indicator of the entire POCOP registry was 0.72 95% confidence interval [0.71, 0.73]. Representativeness of palliative patients was higher than that of potentially curable patients (R-indicator 0.88 [0.85, 0.90] and 0.70 [0.68, 0.71], respectively). Stratification to clinically relevant subgroups based on treatment resulted in higher R-indicators of the respective subgroups. Both after stratification and calibration weighting survival estimates in the POCOP registry were more similar to that in the NCR population. Conclusion: This study demonstrated the assessment of real-world representativeness of patients who participated in a prospective registry cohort and showed that real-world representativeness improved when the variability in treatment was accounted for.

Published
2023

4. Assessing real-world representativeness of prospective registry cohorts in oncology: insights from patients with esophagogastric cancer

Author

MS Medische Oncologie, Cancer, Kuijper, Steven C, Besseling, Joost, Klausch, Thomas, Slingerland, Marije, van der Zijden, Charlène J, Kouwenhoven, Ewout A, Beerepoot, Laurens V, Mohammad, Nadia Haj, Klarenbeek, Bastiaan R, Verhoeven, Rob H A, van Laarhoven, Hanneke W M, MS Medische Oncologie, Cancer, Kuijper, Steven C, Besseling, Joost, Klausch, Thomas, Slingerland, Marije, van der Zijden, Charlène J, Kouwenhoven, Ewout A, Beerepoot, Laurens V, Mohammad, Nadia Haj, Klarenbeek, Bastiaan R, Verhoeven, Rob H A, and van Laarhoven, Hanneke W M

Published
2023

6. Trends in best-case, typical and worst-case survival scenarios of patients with non-metastatic esophagogastric cancer between 2006 and 2020: a population-based study

Author

MS Medische Oncologie, Cancer, MS CGO, Kuijper, Steven C, Pape, Marieke, Vissers, Pauline A J, Jeene, Paul M, Kouwenhoven, Ewout A, Haj Mohammad, Nadia, Ruurda, Jelle P, Sosef, Meindert N, Verhoeven, Rob H A, van Laarhoven, Hanneke W M, MS Medische Oncologie, Cancer, MS CGO, Kuijper, Steven C, Pape, Marieke, Vissers, Pauline A J, Jeene, Paul M, Kouwenhoven, Ewout A, Haj Mohammad, Nadia, Ruurda, Jelle P, Sosef, Meindert N, Verhoeven, Rob H A, and van Laarhoven, Hanneke W M

Published
2023

7. SOURCE beyond first-line: A survival prediction model for patients with metastatic esophagogastric adenocarcinoma after failure of first-line palliative systemic therapy

Author

MS Medische Oncologie, Cancer, Kuijper, Steven C, Pape, Marieke, Haj Mohammad, Nadia, van Voorthuizen, Theo, Verhoeven, Rob H A, van Laarhoven, Hanneke W M, MS Medische Oncologie, Cancer, Kuijper, Steven C, Pape, Marieke, Haj Mohammad, Nadia, van Voorthuizen, Theo, Verhoeven, Rob H A, and van Laarhoven, Hanneke W M

Published
2023

9. What Works for Whom in School-Based Anti-bullying Interventions? An Individual Participant Data Meta-analysis

Author

Hensums, Maud, de Mooij, Brechtje, Kuijper, Steven C., Fekkes, Minne, Overbeek, Geertjan, DeSmet, Ann, BIRC: the anti-Bullying Interventions Research Consortium, and BIRC: the anti-Bullying Interventions Research Consortium

Subjects
Educational sciences, Public Health, Environmental and Occupational Health, Human medicine
Abstract

The prevalence of bullying worldwide is high (UNESCO, 2018). Over the past decades, many anti-bullying interventions have been developed to remediate this problem. However, we lack insight into for whom these interventions work and what individual intervention components drive the total intervention effects. We conducted a large-scale individual participant data (IPD) meta-analysis using data from 39,793 children and adolescents aged five to 20 years (Mage = 12.58, SD = 2.34) who had participated in quasi-experimental or randomized controlled trials of school-based anti-bullying interventions (i.e., 10 studies testing nine interventions). Multilevel logistic regression analyses showed that anti-bullying interventions significantly reduced self-reported victimization (d = − 0.14) and bullying perpetration (d = − 0.07). Anti-bullying interventions more strongly reduced bullying perpetration in younger participants (i.e., under age 12) and victimization for youth who were more heavily victimized before the intervention. We did not find evidence to show that the inclusion of specific intervention components was related to higher overall intervention effects, except for an iatrogenic effect of non-punitive disciplinary methods–which was strongest for girls. Exploratory analyses suggested that school assemblies and playground supervision may have harmful effects for some, increasing bullying perpetration in youth who already bullied frequently at baseline. In conclusion, school-based anti-bullying interventions are generally effective and work especially well for younger children and youth who are most heavily victimized. Further tailoring of interventions may be necessary to more effectively meet the needs and strengths of specific subgroups of children and adolescents.

Published
2022
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10. Improving survival prediction of oesophageal cancer patients treated with external beam radiotherapy for dysphagia

Author

MS Radiotherapie, Cancer, Jeene, Paul M., Kuijper, Steven C., van den Boorn, Héctor G., El Sharouni, Sherif Y., Braam, Pètra M., Oppedijk, Vera, Verhoeven, Rob H.A., Hulshof, Maarten C.C.M., van Laarhoven, Hanneke W.M., MS Radiotherapie, Cancer, Jeene, Paul M., Kuijper, Steven C., van den Boorn, Héctor G., El Sharouni, Sherif Y., Braam, Pètra M., Oppedijk, Vera, Verhoeven, Rob H.A., Hulshof, Maarten C.C.M., and van Laarhoven, Hanneke W.M.

Published
2022

11. Attitudes Toward Striving for Quality and Length of Life Among Patients With Advanced Cancer and a Poor Prognosis

Author

MS Medische Oncologie, Cancer, van der Velden, Naomi C A, van Laarhoven, Hanneke W M, Nieuwkerk, Pythia T, Kuijper, Steven C, Sommeijer, Dirkje W, Ottevanger, Petronella B, Fiebrich, Helle-Brit, Dohmen, Serge E, Creemers, Geert-Jan, de Vos, Filip Y F L, Smets, Ellen M A, Henselmans, Inge, MS Medische Oncologie, Cancer, van der Velden, Naomi C A, van Laarhoven, Hanneke W M, Nieuwkerk, Pythia T, Kuijper, Steven C, Sommeijer, Dirkje W, Ottevanger, Petronella B, Fiebrich, Helle-Brit, Dohmen, Serge E, Creemers, Geert-Jan, de Vos, Filip Y F L, Smets, Ellen M A, and Henselmans, Inge

Published
2022

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