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3. Endovascular Versus Medical Management of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study

Author

Nguyen, Thanh N., Qureshi, Muhammad M., Strambo, Davide, Strbian, Daniel, Räty, Silja, Herweh, Christian, Abdalkader, Mohamad, Olive-Gadea, Marta, Ribo, Marc, Psychogios, Marios, Fischer, Urs, Nguyen, Anh, Kuramatsu, Joji B., Haupenthal, David, Köhrmann, Martin, Deuschl, Cornelius, Kühne Escola, Jordi, Yaghi, Shadi, Shu, Liqi, Puetz, Volker, Kaiser, Daniel P.O., Kaesmacher, Johannes, Mujanovic, Adnan, Marterstock, Dominique Cornelius, Engelhorn, Tobias, Klein, Piers, Haussen, Diogo C., Mohammaden, Mahmoud H., Abdelhamid, Hend, Souza Viana, Lorena, Cunha, Bruno, Fragata, Isabel, Romoli, Michele, Diana, Francesco, Virtanen, Pekka, Lappalainen, Kimmo, Clark, Judith, Matsoukas, Stavros, Fifi, Johanna T., Sheth, Sunil A., Salazar-Marioni, Sergio, Marto, João Pedro, Ramos, João Nuno, Miszczuk, Milena, Riegler, Christoph, Jadhav, Ashutosh P., Desai, Shashvat M., Maus, Volker, Kaeder, Maximilian, Siddiqui, Adnan H., Monteiro, Andre, Masoud, Hesham E., Suryadevara, Neil, Mokin, Maxim, Thanki, Shail, Siegler, James E., Khalife, Jane, Linfante, Italo, Dabus, Guilherme, Asdaghi, Negar, Saini, Vasu, Nolte, Christian H., Siebert, Eberhard, Meinel, Thomas R., Finitsis, Stefanos, Möhlenbruch, Markus A., Ringleb, Peter A., Berberich, Anne, Nogueira, Raul G., Hanning, Uta, Meyer, Lukas, Michel, Patrik, and Nagel, Simon

Published
2023
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5. Influence of bundled care treatment on functional outcome in patients with intracerebral hemorrhage.

Author

Mrochen, Anne, Yu Song, Harders, Verena, Sembill, Jochen A., Sprügel, Maximilian I., Hock, Stefan, Lang, Stefan, Engelhorn, Tobias, Kallmünzer, Bernd, Volbers, Bastian, and Kuramatsu, Joji B.

Subjects
SYSTOLIC blood pressure, BLOOD pressure, CEREBRAL hemorrhage, GLYCEMIC control, BODY temperature
Abstract

Background and aims: General guideline recommendations in patients with intracerebral hemorrhage (ICH) include blood pressure-, temperature- and glucose management. The therapeutic effect of such a "care bundle" (blood pressure lowering, glycemic control, and treatment of pyrexia) on clinical outcomes becomes increasingly established. For the present study, we aimed to investigate associations of strict bundled care treatment (BCT) with clinical outcomes and characterize associations with key outcome effectors such as hematoma enlargement (HE) and peak perihemorrhagic edema (PHE). Methods: We screened consecutive ICH patients (n = 1,322) from the prospective UKER-ICH cohort study. BCT was defined as achieving and maintaining therapeutic ranges for systolic blood pressure (110-160 mmHg), glucose (80-180 mg/dL), and body temperature (35.5-37.5°C) over the first 72 h. The primary outcome was the functional outcome at 12 months (modified Rankin Scale (mRS) 0-3). Secondary outcomes included mortality at 12 months, the occurrence of hematoma enlargement, and the development of peak perihemorrhagic edema. Confounding was addressed by a doubly robust methodology to calculate the absolute treatment effect (ATE) and by calculating e-values. Results: A total of 681 patients remained for analysis, and 182 patients fulfilled all three BCT criteria and were compared to 499 controls. The ATE of BCT to achieve the primary outcome was 9.3%, 95% CI (1.7 to 16.9), p < 0.001; e-value: 3.1, CI (1.8). Mortality at 12 months was significantly reduced by BCT [ATE: -12.8%, 95% CI (-19.8 to -5.7), p < 0.001; e-value: 3.8, CI (2.2)], and no association was observed for HE or peak PHE. Significant drivers of BCT effect on the primary outcome were systolic blood pressure control (ATE: 15.9%) and maintenance of normothermia (ATE: 10.9%). Conclusion: Strict adherence to this "care bundle" over the first 72 h during acute hospital care in patients with ICH was independently associated with improved functional long-term outcome, driven by systolic blood pressure control and maintenance of normothermia. Our findings strongly warrant prospective validation to determine the generalizability especially in Western countries. [ABSTRACT FROM AUTHOR]

Published
2024
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6. First‐Line Stent Retriever Versus Contact Aspiration or Combined Technique for Endovascular Therapy of Posterior Cerebral Artery Occlusion Stroke: The PLATO Study

Author

Nguyen, Thanh N., primary, Abdalkader, Mohamad, additional, Qureshi, Muhammad M., additional, Michel, Patrik, additional, Strambo, Davide, additional, Strbian, Daniel, additional, Herweh, Christian, additional, Möhlenbruch, Markus A., additional, Räty, Silja, additional, Olive‐Gadea, Marta, additional, Ribo, Marc, additional, Psychogios, Marios, additional, Fischer, Urs, additional, Nguyen, Anh, additional, Kuramatsu, Joji B., additional, Haupenthal, David, additional, Köhrmann, Martin, additional, Deuschl, Cornelius, additional, Escolà, Jordi Kühne, additional, Demeestere, Jelle, additional, Vandewalle, Lieselotte, additional, Yaghi, Shadi, additional, Shu, Liqi, additional, Puetz, Volker, additional, Kaiser, Daniel P.O., additional, Kaesmacher, Johannes, additional, Mujanovic, Adnan, additional, Marterstock, Dominique Cornelius, additional, Engelhorn, Tobias, additional, Klein, Piers, additional, Haussen, Diogo C., additional, Mohammaden, Mahmoud H., additional, Fragata, Isabel, additional, Cunha, Bruno, additional, Abdelhamid, Hend, additional, Romoli, Michele, additional, Diana, Francesco, additional, Virtanen, Pekka, additional, Lappalainen, Kimmo, additional, Jesser, Jessica, additional, Clark, Judith, additional, Matsoukas, Stavros, additional, Fifi, Johanna T., additional, Sheth, Sunil A., additional, Salazar‐Marioni, Sergio, additional, Marto, João Pedro, additional, Ramos, João Nuno, additional, Miszczuk, Milena, additional, Riegler, Christoph, additional, Poli, Sven, additional, Poli, Khouloud, additional, Jadhav, Ashutosh P., additional, Desai, Shashvat M., additional, Maus, Volker, additional, Kaeder, Maximilian, additional, Masoud, Hesham E., additional, Suryadareva, Neil, additional, Mokin, Maxim, additional, Siegler, James E., additional, Linfante, Italo, additional, Dabus, Guilherme, additional, Asdaghi, Negar, additional, Saini, Vasu, additional, Nolte, Christian H., additional, Siebert, Eberhard, additional, Meinel, Thomas R., additional, Weyland, Charlotte S., additional, Hanning, Uta, additional, Meyer, Lukas, additional, Nogueira, Raul G., additional, Ringleb, Peter A., additional, and Nagel, Simon, additional

Published
2024
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8. Hematoma Expansion and Clinical Outcomes in Patients With Factor-Xa Inhibitor–Related Atraumatic Intracerebral Hemorrhage Treated Within the ANNEXA-4 Trial Versus Real-World Usual Care

Author

Huttner, Hagen B., Gerner, Stefan T., Kuramatsu, Joji B., Connolly, Stuart J., Beyer-Westendorf, Jan, Demchuk, Andrew M., Middeldorp, Saskia, Zotova, Elena, Altevers, Julia, Andersohn, Frank, Christoph, Mary J., Yue, Patrick, Stross, Leonhard, and Schwab, Stefan

Published
2021
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9. Association of non-contrast CT markers with long-term functional outcome in deep intracerebral hemorrhage.

Author

Kölbl, Kathrin, Hock, Stefan W., Mingming Xu, Sembill, Jochen A., Mrochen, Anne, Balk, Stefanie, Lang, Stefan, Volbers, Bastian, Engelhorn, Tobias, Kallmünzer, Bernd, and Kuramatsu, Joji B.

Subjects
CEREBRAL hemorrhage, CLINICAL deterioration, BASAL ganglia, BLACK holes, DATABASES
Abstract

Objective: Hematoma expansion (HE) is the most important therapeutic target during acute care of patients with intracerebral hemorrhage (ICH). Imaging biomarkers such as non-contrast CT (NCCT) markers have been associated with increasing risk for HE. The aim of the present study was to evaluate the influence of NCCT markers with functional long-term outcome and with HE in patients with deep (basal ganglia and thalamus) ICH who represent an important subgroup of patients at the highest risk for functional deterioration with HE due to the eloquence of the affected brain region. Methods: From our prospective institutional database, all patients maximally treated with deep ICH were included and retrospectively analyzed. NCCT markers were recorded at diagnostic imaging, ICH volume characteristics were volumetrically evaluated, and all patients received follow-up imaging within 0-48 h. We explored associations of NCCT makers with unfavorable functional outcome, defined as modified Rankin scale 4-6, after 12 months and with HE. Bias and confounding were addressed by multivariable regression modeling. Results: In 322 patients with deep ICH, NCCT markers were distributed as follows: irregular shape: 69.6%, heterogenous density: 55.9%, hypodensities: 52.5%, island sign: 19.3%, black hole sign: 11.5%, and blend sign: 4.7%. Upon multivariable regression analyses, independent associations were documented with the functional outcome for irregular shape (aOR: 2.73, 95%CI: 1.42-5.22, p = 0.002), heterogenous density (aOR: 2.62, 95%CI: 1.40-4.90, p = 0.003) and island sign (aOR: 2.54, 95%CI: 1.05-6.14, p = 0.038), and with HE for heterogenous density (aOR: 5.01, 95%CI: 1.93-13.05, p = 0.001) and hypodensities (aOR: 3.75, 95%CI: 1.63-8.62, p = 0.002). Conclusion: NCCT markers are frequent in deep ICH patients and provide important clinical implications. Specifically, markers defined by diverging intrahematomal densities provided associations with a 5-times higher risk for HE and a 2.5-times higher likelihood for unfavorable functional long-term outcome. Hence, these markers allow the identification of patients with deep ICH at high risk for clinical deterioration due to HE. [ABSTRACT FROM AUTHOR]

Published
2024
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11. Cerebrospinal fluid biomarkers for cerebral amyloid angiopathy

Author

Sembill, Jochen A, primary, Lusse, Christoph, additional, Linnerbauer, Mathias, additional, Sprügel, Maximilian I, additional, Mrochen, Anne, additional, Knott, Michael, additional, Engelhorn, Tobias, additional, Schmidt, Manuel Alexander, additional, Doerfler, Arnd, additional, Oberstein, Timo Jan, additional, Maler, Juan Manuel, additional, Kornhuber, Johannes, additional, Lewczuk, Piotr, additional, Rothhammer, Veit, additional, Schwab, Stefan, additional, and Kuramatsu, Joji B, additional

Published
2023
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12. Why Does It Shine?—A Prognostic Analysis about Predisposing Factors for Blood–Brain Barrier Damage after Revascularisation of Cerebral Large-Vessel Occlusion

Author

Knott, Michael, primary, Hock, Stefan, additional, Soder, Liam, additional, Mühlen, Iris, additional, Kremer, Svenja, additional, Sprügel, Maximilian I., additional, Sembill, Jochen A., additional, Kuramatsu, Joji B., additional, Schwab, Stefan, additional, Engelhorn, Tobias, additional, and Doerfler, Arnd, additional

Published
2023
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14. Characteristics in Non–Vitamin K Antagonist Oral Anticoagulant–Related Intracerebral Hemorrhage

Author

Gerner, Stefan T., Kuramatsu, Joji B., Sembill, Jochen A., Sprügel, Maximilian I., Hagen, Manuel, Knappe, Ruben U., Endres, Matthias, Haeusler, Karl Georg, Sobesky, Jan, Schurig, Johannes, Zweynert, Sarah, Bauer, Miriam, Vajkoczy, Peter, Ringleb, Peter A., Purrucker, Jan C., Rizos, Timolaos, Volkmann, Jens, Müllges, Wolfgang, Kraft, Peter, Schubert, Anna-Lena, Erbguth, Frank, Nueckel, Martin, Schellinger, Peter D., Glahn, Jörg, Knappe, Ulrich J., Fink, Gereon R., Dohmen, Christian, Stetefeld, Henning, Fisse, Anna Lena, Minnerup, Jens, Hagemann, Georg, Rakers, Florian, Reichmann, Heinz, Schneider, Hauke, Rahmig, Jan, Ludolph, Albert Christian, Stösser, Sebastian, Neugebauer, Hermann, Röther, Joachim, Michels, Peter, Schwarz, Michael, Reimann, Gernot, Bäzner, Hansjörg, Schwert, Henning, Claßen, Joseph, Michalski, Dominik, Grau, Armin, Palm, Frederick, Urbanek, Christian, Wöhrle, Johannes C., Alshammari, Fahid, Horn, Markus, Bahner, Dirk, Witte, Otto W., Günther, Albrecht, Hamann, Gerhard F., Engelhorn, Tobias, Lücking, Hannes, Dörfler, Arnd, Schwab, Stefan, and Huttner, Hagen B.

Published
2019
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20. Association of Intraventricular Fibrinolysis With Clinical Outcomes in Intracerebral Hemorrhage: An Individual Participant Data Meta-Analysis

Author

Kuramatsu, Joji B., primary, Gerner, Stefan T., additional, Ziai, Wendy, additional, Bardutzky, Jürgen, additional, Sembill, Jochen A., additional, Sprügel, Maximilian I., additional, Mrochen, Anne, additional, Kölbl, Kathrin, additional, Ram, Malathi, additional, Avadhani, Radhika, additional, Falcone, Guido J., additional, Selim, Magdy H., additional, Lioutas, Vasileios-Arsenios, additional, Endres, Matthias, additional, Zweynert, Sarah, additional, Vajkoczy, Peter, additional, Ringleb, Peter A., additional, Purrucker, Jan C., additional, Volkmann, Jens, additional, Neugebauer, Hermann, additional, Erbguth, Frank, additional, Schellinger, Peter D., additional, Knappe, Ulrich J., additional, Fink, Gereon R., additional, Dohmen, Christian, additional, Minnerup, Jens, additional, Reichmann, Heinz, additional, Schneider, Hauke, additional, Röther, Joachim, additional, Reimann, Gernot, additional, Schwarz, Michael, additional, Bäzner, Hansjörg, additional, Claßen, Joseph, additional, Michalski, Dominik, additional, Witte, Otto W., additional, Günther, Albrecht, additional, Hamann, Gerhard F., additional, Lücking, Hannes, additional, Dörfler, Arnd, additional, Ishfaq, Muhammad Fawad, additional, Chang, Jason J., additional, Testai, Fernando D., additional, Woo, Daniel, additional, Alexandrov, Andrei V., additional, Staykov, Dimitre, additional, Goyal, Nitin, additional, Tsivgoulis, Georgios, additional, Sheth, Kevin N., additional, Awad, Issam A., additional, Schwab, Stefan, additional, Hanley, Daniel F., additional, Huttner, Hagen B., additional, Sansing, Lauren, additional, Matouk, Charles C., additional, Leasure, Audrey, additional, Sobesky, Jan, additional, Bauer, Miriam, additional, Schurig, Johannes, additional, Rizos, Timolaos, additional, Haeusler, Karl Georg, additional, Müllges, Wolfgang, additional, Kraft, Peter, additional, Schubert, Anna-Lena, additional, Stösser, Sebastian, additional, Ludolph, Albert Christian, additional, Nueckel, Martin, additional, Glahn, Jörg, additional, Stetefeld, Henning, additional, Rahmig, Jan, additional, Fisse, Anna Lena, additional, Michels, Peter, additional, Schwert, Henning, additional, Hagemann, Georg, additional, Rakers, Florian, additional, Wöhrle, Johannes C., additional, Alshammari, Fahid, additional, Horn, Markus, additional, Bahner, Dirk, additional, Urbanek, Christian, additional, Palm, Frederick, additional, and Grau, Armin, additional

Published
2022
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21. Intranasal delivery of a small-molecule ErbB inhibitor promotes recovery from acute and late-stage CNS inflammation

Author

Linnerbauer, Mathias, primary, Lößlein, Lena, additional, Vandrey, Oliver, additional, Tsaktanis, Thanos, additional, Beer, Alexander, additional, Naumann, Ulrike J., additional, Panier, Franziska, additional, Beyer, Tobias, additional, Nirschl, Lucy, additional, Kuramatsu, Joji B., additional, Winkler, Jürgen, additional, Quintana, Francisco J., additional, and Rothhammer, Veit, additional

Published
2022
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22. Association of intraventricular fibrinolysis with clinical outcomes in intracerebral hemorrhage: an individual participant data meta-analysis

Author

Kuramatsu, Joji B, Gerner, Stefan T, Falcone, Guido J, Selim, Magdy H, Lioutas, Vasileios-Arsenios, Endres, Matthias, Zweynert, Sarah, Vajkoczy, Peter, Ringleb, Peter A, Purrucker, Jan C, Volkmann, Jens, Neugebauer, Hermann, Ziai, Wendy, Erbguth, Frank, Schellinger, Peter D, Knappe, Ulrich J, Fink, Gereon R, Dohmen, Christian, Minnerup, Jens, Reichmann, Heinz, Schneider, Hauke, Röther, Joachim, Reimann, Gernot, Bardutzky, Jürgen, Schwarz, Michael, Bäzner, Hansjörg, Claßen, Joseph, Michalski, Dominik, Witte, Otto W, Günther, Albrecht, Hamann, Gerhard F, Lücking, Hannes, Dörfler, Arnd, Ishfaq, Muhammad Fawad, Sembill, Jochen A, Chang, Jason J, Testai, Fernando D, Woo, Daniel, Alexandrov, Andrei V, Staykov, Dimitre, Goyal, Nitin, Tsivgoulis, Georgios, Sheth, Kevin N, Awad, Issam A, Schwab, Stefan, Sprügel, Maximilian I, Hanley, Daniel F, Huttner, Hagen B, Collaborators, Sansing, Lauren, Matouk, Charles C, Leasure, Audrey, Sobesky, Jan, Bauer, Miriam, Schurig, Johannes, Rizos, Timolaos, Mrochen, Anne, Haeusler, Karl Georg, Müllges, Wolfgang, Kraft, Peter, Schubert, Anna-Lena, Stösser, Sebastian, Ludolph, Albert, Nueckel, Martin, Glahn, Jörg, Stetefeld, Henning, Rahmig, Jan, Kölbl, Kathrin, Fisse, Anna Lena, Michels, Peter, Schwert, Henning, Hagemann, Georg, Rakers, Florian, Wöhrle, Johannes C, Alshammari, Fahid, Horn, Markus, Bahner, Dirk, Urbanek, Christian, Ram, Malathi, Palm, Frederick, Grau, Armin, and Avadhani, Radhika

Subjects
Advanced and Specialized Nursing, drug therapy [Cerebral Hemorrhage], Fibrinolysis, diagnostic imaging [Cerebral Hemorrhage], intracerebral hemorrhage, mortality, Observational Studies as Topic, Treatment Outcome, Fibrinolytic Agents, standard of care, Drainage, Humans, Neurology (clinical), methods [Drainage], ddc:610, Cardiology and Cardiovascular Medicine, hydrocephalus, Cerebral Hemorrhage, Hydrocephalus
Abstract

Background: In patients with intracerebral hemorrhage (ICH), the presence of intraventricular hemorrhage constitutes a promising therapeutic target. Intraventricular fibrinolysis (IVF) reduces mortality, yet impact on functional disability remains unclear. Thus, we aimed to determine the influence of IVF on functional outcomes. Methods: This individual participant data meta-analysis pooled 1501 patients from 2 randomized trials and 7 observational studies enrolled during 2004 to 2015. We compared IVF versus standard of care (including placebo) in patients treated with external ventricular drainage due to acute hydrocephalus caused by ICH with intraventricular hemorrhage. The primary outcome was functional disability evaluated by the modified Rankin Scale (mRS; range: 0–6, lower scores indicating less disability) at 6 months, dichotomized into mRS score: 0 to 3 versus mRS: 4 to 6. Secondary outcomes included ordinal-shift analysis, all-cause mortality, and intracranial adverse events. Confounding and bias were adjusted by random effects and doubly robust models to calculate odds ratios and absolute treatment effects (ATE). Results: Comparing treatment of 596 with IVF to 905 with standard of care resulted in an ATE to achieve the primary outcome of 9.3% (95% CI, 4.4–14.1). IVF treatment showed a significant shift towards improved outcome across the entire range of mRS estimates, common odds ratio, 1.75 (95% CI, 1.39–2.17), reduced mortality, odds ratio, 0.47 (95% CI, 0.35–0.64), without increased adverse events, absolute difference, 1.0% (95% CI, −2.7 to 4.8). Exploratory analyses provided that early IVF treatment (≤48 hours) after symptom onset was associated with an ATE, 15.2% (95% CI, 8.6–21.8) to achieve the primary outcome. Conclusions: As compared to standard of care, the administration of IVF in patients with acute hydrocephalus caused by intracerebral and intraventricular hemorrhage was significantly associated with improved functional outcome at 6 months. The treatment effect was linked to an early time window

Published
2022

24. Hematoma Expansion and Clinical Outcomes in Patients With Factor-Xa Inhibitor–Related Atraumatic Intracerebral Hemorrhage Treated Within the ANNEXA-4 Trial Versus Real-World Usual Care

Author

Huttner, Hagen B., primary, Gerner, Stefan T., additional, Kuramatsu, Joji B., additional, Connolly, Stuart J., additional, Beyer-Westendorf, Jan, additional, Demchuk, Andrew M., additional, Middeldorp, Saskia, additional, Zotova, Elena, additional, Altevers, Julia, additional, Andersohn, Frank, additional, Christoph, Mary J., additional, Yue, Patrick, additional, Stross, Leonhard, additional, and Schwab, Stefan, additional

Published
2022
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25. Hematoma enlargement characteristics in deep versus lobar intracerebral hemorrhage

Author

Sembill, Jochen A., Kuramatsu, Joji B., Gerner, Stefan T., Sprügel, Maximilian I., Roeder, Sebastian S., Madžar, Dominik, Hagen, Manuel, Hoelter, Philip, Lücking, Hannes, Dörfler, Arnd, Schwab, Stefan, and Huttner, Hagen B.

Subjects
Aged, 80 and over, Male, Clinical Trials as Topic, Hematoma, Vitamin K, Anticoagulants, Neurosciences. Biological psychiatry. Neuropsychiatry, Middle Aged, nervous system diseases, Cohort Studies, Germany, Humans, Female, Single-Blind Method, Registries, cardiovascular diseases, Neurology. Diseases of the nervous system, RC346-429, Cerebrum, Research Articles, Research Article, Aged, Cerebral Hemorrhage, Cerebral Intraventricular Hemorrhage, RC321-571
Abstract

Objective Hematoma enlargement (HE) is associated with clinical outcomes after supratentorial intracerebral hemorrhage (ICH). This study evaluates whether HE characteristics and association with functional outcome differ in deep versus lobar ICH. Methods Pooled analysis of individual patient data between January 2006 and December 2015 from a German‐wide cohort study (RETRACE, I + II) investigating ICH related to oral anticoagulants (OAC) at 22 participating centers, and from one single‐center registry (UKER‐ICH) investigating non‐OAC‐ICH patients. Altogether, 1954 supratentorial ICH patients were eligible for outcome analyses, which were separately conducted or controlled for OAC, that is, vitamin‐K‐antagonists (VKA, n = 1186) and non‐vitamin‐K‐antagonist‐oral‐anticoagulants (NOAC, n = 107). Confounding was addressed using propensity score matching, cox regression modeling and multivariate modeling. Main outcomes were occurrence, extent, and timing of HE (>33%/>6 mL) and its association with 3‐month functional outcome. Results Occurrence of HE was not different after deep versus lobar ICH in patients with non‐OAC‐ICH (39/356 [11.0%] vs. 36/305 [11.8%], P = 0.73), VKA‐ICH (249/681 [36.6%] vs. 183/505 [36.2%], P = 0.91), and NOAC‐ICH (21/69 [30.4%] vs. 12/38 [31.6%], P = 0.90). HE extent did not differ after non‐OAC‐ICH (deep:+59% [40–122] vs. lobar:+74% [37–124], P = 0.65), but both patients with VKA‐ICH and NOAC‐ICH showed greater HE extent after deep ICH [VKA‐ICH, deep: +94% [54–199] vs. lobar: +56% [35–116], P

Published
2020

28. Stent-Assisted Coiling Using Leo+ Baby Stent

Author

Luecking, Hannes, Struffert, Tobias, Goelitz, Philipp, Engelhorn, Tobias, Brandner, Sebastian, Kuramatsu, Joji B., Lang, Stefan, Schmidt, Manuel, and Doerfler, Arnd

Subjects
ddc:610
Abstract

Background Stent-assisted coiling is well-established for treatment of cerebral aneurysms. The technique enables treatment of wide-neck, bifurcation and recurrent aneurysms with high packing rates. While described in extenso for laser cut stents, the results of patients treated with the Leo+ Baby (Balt, Montmorency, France) braided microstent are presented. Material and Methods Patients were included if treated with a Leo+ Baby and with digital subtraction angiography (DSA) follow-up available of at least 6 months. Data were evaluated for successful deployment, aneurysm occlusion according to the modified Raymond-Roy classification (MRRC), stent patency and procedure-related morbidity and mortality. Results A total of 81 patients were included and Leo+ Baby deployment was successful in all cases. Coils were used in 80 cases. In 1 case 2 stents were used stent-in-stent without additional coiling. Initial aneurysm occlusion rates were MRRCi1 51.9%, MRRCi2 11.1%, MRRCi3a 24.7% and MRRCi3b 12.3%. Occlusion rates after 6 months were MRRC6m1 78.9%, MRRC6m2 3.9%, MRRC6m3a 6.6% and MRRC6m3b 10.5%. Procedure-related morbidity was 1 case of acute stent thrombosis successfully treated with tirofiban and 1 case with transient hemiparesis due to stent thrombosis after 4 months. There was 1 case of coil-associated subarachnoid hemorrhage (SAH) which caused prolonged hospitalization. No procedure-related mortality was observed. Conclusion The results confirm that stent-assisted coiling with the Leo+ Baby stent is safe and efficient for treatment of wide neck or recurrent cerebral aneurysms. Spontaneous progressive aneurysm occlusion over 6 months supports the theory of considerable flow-modulating effects of Leo+ Baby.

Published
2021

29. Disability-Adjusted Life-Years Associated With Intracerebral Hemorrhage and Secondary Injury

Author

Haupenthal, David, primary, Kuramatsu, Joji B., additional, Volbers, Bastian, additional, Sembill, Jochen A., additional, Mrochen, Anne, additional, Balk, Stefanie, additional, Hoelter, Philip, additional, Lücking, Hannes, additional, Engelhorn, Tobias, additional, Dörfler, Arnd, additional, Schwab, Stefan, additional, Huttner, Hagen B., additional, and Sprügel, Maximilian I., additional

Published
2021
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30. Influence of Early Enteral Nutrition on Clinical Outcomes in Neurocritical Care Patients With Intracerebral Hemorrhage

Author

Peng, Jianhua, primary, Volbers, Bastian, additional, Sprügel, Maximilian I., additional, Hoelter, Philip, additional, Engelhorn, Tobias, additional, Jiang, Yong, additional, Kuramatsu, Joji B., additional, Huttner, Hagen B., additional, Dörfler, Arnd, additional, Schwab, Stefan, additional, and Gerner, Stefan T., additional

Published
2021
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32. Impact of Statins on Hematoma, Edema, Seizures, Vascular Events, and Functional Recovery After Intracerebral Hemorrhage

Author

Sprügel, Maximilian I., primary, Kuramatsu, Joji B., additional, Volbers, Bastian, additional, Saam, Justina I., additional, Sembill, Jochen A., additional, Gerner, Stefan T., additional, Balk, Stefanie, additional, Hamer, Hajo M., additional, Lücking, Hannes, additional, Hölter, Philip, additional, Nolte, Christian H., additional, Scheitz, Jan F., additional, Rocco, Andrea, additional, Endres, Matthias, additional, and Huttner, Hagen B., additional

Published
2021
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33. Bedside Catheter Hematoma Evacuation in Vitamin K Antagonist-Related Intracerebral Hemorrhage: A Safe and Feasible Approach

Author

Volbers, Bastian, primary, Niesen, Wolf-Dirk, additional, Amiri-Soltani, Samuel, additional, Staykov, Dimitre, additional, Shah, Mukesch Johannes, additional, Lang, Stefan, additional, Lücking, Hannes, additional, Kuramatsu, Joji B., additional, Huttner, Hagen B., additional, Schwab, Stefan, additional, and Bardutzky, Jürgen, additional

Published
2020
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34. Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11-13 November 2018

Author

Ahmed, Niaz Audebert, Heinrich Turc, Guillaume Cordonnier, Charlotte Christensen, Hanne Sacco, Simona Sandset, Else Charlotte Ntaios, George Charidimou, Andreas Toni, Danilo and Pristipino, Christian Koehrmann, Martin Kuramatsu, Joji B. and Thomalla, Geotz Mikulik, Robert Ford, Gary A. and Marti-Fabregas, Joan Fischer, Urs Thoren, Magnus Lundstrom, Erik Rinkel, Gabriel J. E. van der Worp, H. Bart and Matusevicius, Marius Tsivgoulis, Georgios Milionis, Haralampos and Rubiera, Marta Hart, Robert Moreira, Tiago Lantz, Maria and Sjostrand, Christina Andersen, Grethe Schellinger, Peter and Kostulas, Konstantinos Sunnerhagen, Katharina Stibrant Keselman, Boris Korompoki, Eleni Purrucker, Jan Khatri, Pooja and Whiteley, William Berge, Eivind Mazya, Michael Dippel, Diederik W. J. Mustanoja, Satu Rasmussen, Mads Soderqvist, Asa Kuntze Escudero-Martinez, Irene Steiner, Thorsten

Abstract

The purpose of the European Stroke Organisation-Karolinska Stroke Update Conference is to provide updates on recent stroke therapy research and to give an opportunity for the participants to discuss how these results may be implemented into clinical routine. The meeting started 22 years ago as Karolinska Stroke Update, but since 2014 it is a joint conference with European Stroke Organisation. Importantly, it provides a platform for discussion on the European Stroke Organisation guidelines process and on recommendations to the European Stroke Organisation guidelines committee on specific topics. By this, it adds a direct influence from stroke professionals otherwise not involved in committees and work groups on the guideline procedure. The discussions at the conference may also inspire new guidelines when motivated. The topics raised at the meeting are selected by the scientific programme committee mainly based on recent important scientific publications. This year's European Stroke Organisation-Karolinska Stroke Update Meeting was held in Stockholm on 11-13 November 2018. There were 11 scientific sessions discussed in the meeting including two short sessions. Each session except the short sessions produced a consensus statement (Full version with background, issues, conclusions and references are published as web-material and at and ) and recommendations which were prepared by a writing committee consisting of session chair(s), scientific secretary and speakers. These statements were presented to the 250 participants of the meeting. In the open meeting, general participants commented on the consensus statement and recommendations and the final document were adjusted based on the discussion from the general participants Recommendations (grade of evidence) were graded according to the 1998 Karolinska Stroke Update meeting with regard to the strength of evidence. Grade A Evidence: Strong support from randomised controlled trials and statistical reviews (at least one randomised controlled trial plus one statistical review). Grade B Evidence: Support from randomised controlled trials and statistical reviews (one randomised controlled trial or one statistical review). Grade C Evidence: No reasonable support from randomised controlled trials, recommendations based on small randomised and/or non-randomised controlled trials evidence.

Published
2019

35. Consensus statements and recommendations from the ESO-Karolinska Stroke Update Conference, Stockholm 11–13 November 2018

Author

Ahmed, Niaz, primary, Audebert, Heinrich, additional, Turc, Guillaume, additional, Cordonnier, Charlotte, additional, Christensen, Hanne, additional, Sacco, Simona, additional, Sandset, Else Charlotte, additional, Ntaios, George, additional, Charidimou, Andreas, additional, Toni, Danilo, additional, Pristipino, Christian, additional, Köhrmann, Martin, additional, Kuramatsu, Joji B, additional, Thomalla, Götz, additional, Mikulik, Robert, additional, Ford, Gary A, additional, Martí-Fàbregas, Joan, additional, Fischer, Urs, additional, Thoren, Magnus, additional, Lundström, Erik, additional, Rinkel, Gabriel JE, additional, Worp, H Bart van der, additional, Matusevicius, Marius, additional, Tsivgoulis, Georgios, additional, Milionis, Haralampos, additional, Rubiera, Marta, additional, Hart, Robert, additional, Moreira, Tiago, additional, Lantz, Maria, additional, Sjöstrand, Christina, additional, Andersen, Grethe, additional, Schellinger, Peter, additional, Kostulas, Konstantinos, additional, Sunnerhagen, Katharina Stibrant, additional, Keselman, Boris, additional, Korompoki, Eleni, additional, Purrucker, Jan, additional, Khatri, Pooja, additional, Whiteley, William, additional, Berge, Eivind, additional, Mazya, Michael, additional, Dippel, Diederik WJ, additional, Mustanoja, Satu, additional, Rasmussen, Mads, additional, Söderqvist, Åsa Kuntze, additional, Escudero-Martínez, Irene, additional, and Steiner, Thorsten, additional

Published
2019
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37. Abstract WMP102: Antiplatelet Therapy in Intracerebral Hemorrhage

Author

Sprügel, Maximilian I, primary, Kuramatsu, Joji B, additional, Gerner, Stefan T, additional, Sembill, Jochen A, additional, Beuscher, Vanessa D, additional, Hagen, Manuel, additional, Roeder, Sebastian S, additional, Lücking, Hannes, additional, Struffert, Tobias, additional, Dörfler, Arnd, additional, Schwab, Stefan, additional, and Huttner, Hagen B, additional

Published
2019
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38. Cardioembolic Stroke Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage

Author

Murphy, Meredith P., primary, Kuramatsu, Joji B., additional, Leasure, Audrey, additional, Falcone, Guido J., additional, Kamel, Hooman, additional, Sansing, Lauren H., additional, Kourkoulis, Christina, additional, Schwab, Kristin, additional, Elm, Jordan J., additional, Gurol, M. Edip, additional, Tran, Huy, additional, Greenberg, Steven M., additional, Viswanathan, Anand, additional, Anderson, Christopher D., additional, Schwab, Stefan, additional, Rosand, Jonathan, additional, Shi, Fu-Dong, additional, Kittner, Steven J., additional, Testai, Fernando D., additional, Woo, Daniel, additional, Langefeld, Carl D., additional, James, Michael L., additional, Koch, Sebastian, additional, Huttner, Hagen B., additional, Biffi, Alessandro, additional, and Sheth, Kevin N., additional

Published
2018
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39. Association of prothrombin complex concentrate administration and hematoma enlargement in non-vitamin K antagonist oral anticoagulant-related intracerebral hemorrhage

Author

Gerner, Stefan T, Kuramatsu, Joji B, Erbguth, Frank, Schellinger, Peter D, Fink, Gereon R, Stetefeld, Henning, Schneider, Hauke, Neugebauer, Hermann, Röther, Joachim, Claßen, Joseph, Michalski, Dominik, Dörfler, Arnd, Sembill, Jochen A, Schwab, Stefan, Huttner, Hagen B, II, RETRACE, Horn, Markus, Bahner, Dirk, Hagemann, Georg, Rakers, Florian, Haeusler, Karl Georg, Sobesky, Jan, Schurig, Johannes, Sprügel, Maximilian I, Zweynert, Sarah, Bauer, Miriam, Vajkoczy, Peter, Dohmen, Christian, Schwarz, Michael, Reimann, Gernot, Reichmann, Heinz, Endres, Matthias, Bogenreuther, Christina, Hagen, Manuel, Knappe, Ruben, Köhrmann, Martin, Kloska, Stephan P, Ringwald, Jürgen, Hamann, Gerhard F, Michels, Peter, Ringleb, Peter A, Purrucker, Jan, Rizos, Timolaos, Witte, Otto W, Günther, Albrecht, Wöhrle, Johannes C, Alshammari, Fahid, Grau, Armin, Palm, Frederick, Urbanek, Christian, Glahn, Jörg, Knappe, Ulrich J, Wiendl, Heinz, Fisse, Anna Lena, Minnerup, Jens, Nueckel, Martin, Bäzner, Hansjörg, Schwert, Henning, Stösser, Sebastian, Volkmann, Jens, Müllges, Wolfgang, Kraft, Peter, Schubert, Anna-Lena, and Köhrmann, Martin (Beitragende*r)

Subjects
Male, therapeutic use [Hemostatics], Medizin, epidemiology [Germany], adverse effects [Blood Coagulation Factors], Blood Pressure, Hemostatics, therapeutic use [Blood Coagulation Factors], mortality [Hematoma], Cohort Studies, Germany, Humans, ddc:610, Hospital Mortality, adverse effects [Anticoagulants], Aged, Cerebral Hemorrhage, Retrospective Studies, Aged, 80 and over, prothrombin complex concentrates, Hematoma, pathology [Cerebral Hemorrhage], pathology [Hematoma], chemically induced [Cerebral Hemorrhage], chemically induced [Hematoma], Anticoagulants, Middle Aged, Blood Coagulation Factors, Treatment Outcome, Factor Xa, Female, mortality [Cerebral Hemorrhage]
Abstract

To investigate parameters associated with hematoma enlargement in non-vitamin K antagonist oral anticoagulant (NOAC)-related intracerebral hemorrhage (ICH).This retrospective cohort study includes individual patient data for 190 patients with NOAC-associated ICH over a 5-year period (2011-2015) at 19 departments of neurology across Germany. Primary outcome was the association of prothrombin complex concentrate (PCC) administration with hematoma enlargement. Subanalyses were calculated for blood pressure management and its association with the primary outcome. Secondary outcomes include associations with in-hospital mortality and functional outcome at 3 months assessed using the modified Rankin Scale.The study population for analysis of primary and secondary outcomes consisted of 146 NOAC-ICH patients with available follow-up imaging. Hematoma enlargement occurred in 49/146 (33.6%) patients with NOAC-related ICH. Parameters associated with hematoma enlargement were blood pressure ≥ 160mmHg within 4 hours and-in the case of factor Xa inhibitor ICH-anti-Xa levels on admission. PCC administration prior to follow-up imaging was not significantly associated with a reduced rate of hematoma enlargement either in overall NOAC-related ICH or in patients with factor Xa inhibitor intake (NOAC: risk ratio [RR] = 1.150, 95% confidence interval [CI] = 0.632-2.090; factor Xa inhibitor: RR = 1.057, 95% CI = 0.565-1.977), regardless of PCC dosage given or time interval until imaging or treatment. Systolic blood pressure levels 160mmHg within 4 hours after admission were significantly associated with a reduction in the proportion of patients with hematoma enlargement (RR = 0.598, 95% CI = 0.365-0.978). PCC administration had no effect on mortality and functional outcome either at discharge or at 3 months.In contrast to blood pressure control, PCC administration was not associated with a reduced rate of hematoma enlargement in NOAC-related ICH. Our findings support the need of further investigations exploring new hemostatic reversal strategies for patients with factor Xa inhibitor-related ICH. Ann Neurol 2018;83:186-196.

Published
2017

40. Management of therapeutic anticoagulation in patients with intracerebral haemorrhage and mechanical heart valves

Author

Kuramatsu, Joji B, primary, Sembill, Jochen A, additional, Gerner, Stefan T, additional, Sprügel, Maximilian I, additional, Hagen, Manuel, additional, Roeder, Sebastian S, additional, Endres, Matthias, additional, Haeusler, Karl Georg, additional, Sobesky, Jan, additional, Schurig, Johannes, additional, Zweynert, Sarah, additional, Bauer, Miriam, additional, Vajkoczy, Peter, additional, Ringleb, Peter A, additional, Purrucker, Jan, additional, Rizos, Timolaos, additional, Volkmann, Jens, additional, Müllges, Wolfgang, additional, Kraft, Peter, additional, Schubert, Anna-Lena, additional, Erbguth, Frank, additional, Nueckel, Martin, additional, Schellinger, Peter D, additional, Glahn, Jörg, additional, Knappe, Ulrich J, additional, Fink, Gereon R, additional, Dohmen, Christian, additional, Stetefeld, Henning, additional, Fisse, Anna Lena, additional, Minnerup, Jens, additional, Hagemann, Georg, additional, Rakers, Florian, additional, Reichmann, Heinz, additional, Schneider, Hauke, additional, Wöpking, Sigrid, additional, Ludolph, Albert Christian, additional, Stösser, Sebastian, additional, Neugebauer, Hermann, additional, Röther, Joachim, additional, Michels, Peter, additional, Schwarz, Michael, additional, Reimann, Gernot, additional, Bäzner, Hansjörg, additional, Schwert, Henning, additional, Claßen, Joseph, additional, Michalski, Dominik, additional, Grau, Armin, additional, Palm, Frederick, additional, Urbanek, Christian, additional, Wöhrle, Johannes C, additional, Alshammari, Fahid, additional, Horn, Markus, additional, Bahner, Dirk, additional, Witte, Otto W, additional, Günther, Albrecht, additional, Hamann, Gerhard F, additional, Lücking, Hannes, additional, Dörfler, Arnd, additional, Achenbach, Stephan, additional, Schwab, Stefan, additional, and Huttner, Hagen B, additional

Published
2018
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41. Abstract WP347: Cardioembolic Risk and Recovery After Anticoagulation-Related Intracerebral Hemorrhage

Author

Biffi, Alessandro, primary, Murphy, Meredith P, additional, Kuramatsu, Joji B, additional, Leasure, Audrey, additional, Kamel, Hooman, additional, Kourkoulis, Christina, additional, Schwab, Kristin, additional, Ayres, Alison M, additional, Elm, Jordan, additional, Gurol, M. Edip, additional, Greenberg, Steven M, additional, Viswanathan, Anand, additional, Anderson, Christopher D, additional, Schwab, Stefan, additional, Rosand, Jonathan, additional, Testai, Fernando D, additional, Woo, Daniel, additional, Huttner, Hagen B, additional, and Sheth, Kevin N, additional

Published
2018
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43. Meningioma growth dynamics assessed by radiocarbon retrospective birth dating

Author

Huttner, Hagen B., primary, Bergmann, Olaf, additional, Salehpour, Mehran, additional, El Cheikh, Raouf, additional, Nakamura, Makoto, additional, Tortora, Angelo, additional, Heinke, Paula, additional, Coras, Roland, additional, Englund, Elisabet, additional, Eyüpoglu, Ilker Y., additional, Kuramatsu, Joji B., additional, Roeder, Sebastian S., additional, Kloska, Stephan P., additional, Muehlen, Iris, additional, Doerfler, Arnd, additional, Schwab, Stefan, additional, Possnert, Göran, additional, Bernard, Samuel, additional, and Frisén, Jonas, additional

Published
2018
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44. Effects of clobazam for treatment of refractory status epilepticus

Author

Madžar, Dominik, Geyer, Anna, Knappe, Ruben U., Gollwitzer, Stephanie, Kuramatsu, Joji B., Gerner, Stefan T., Hamer, Hajo M., and Huttner, Hagen B.

Subjects
Medizinische Fakultät, Clinical Neurology, ddc:610
Abstract

Background Clobazam (CLB) is a well characterized antiepileptic drug (AED) that differs from other benzodiazepines by its basic chemical structure and pharmacodynamic properties. Only one previous study examined the efficacy of CLB as add-on therapy in refractory status epilepticus (RSE). Methods We analyzed RSE episodes treated in our institution between 2001 and 2012. Successful treatment with CLB was scored if CLB was the last AED added to therapy before RSE termination. We assessed the differences between patients with and without CLB and correlated CLB with outcome. Among patients treated with CLB, we studied responders and non-responders and compared our CLB cohort with recently published data. Results CLB was part of the AED regimen in 24/70 (34.3 %) RSE episodes. In six of these (25.0 %) RSE resolution was attributed to CLB. Baseline characteristics of episodes with and without CLB treatment showed no significant differences and RSE termination rates were very similar (83.3 % vs. 80.4 %). CLB was administered in clinically more complex RSE with longer RSE duration and worse outcome, but CLB was not related independently to outcome. Comparison of our results with previously published data revealed that baseline characteristics as well as CLB maintenance doses and time of treatment initiation were similar in both cohorts. CLB was less frequently the last AED added to RSE therapy in our patients indicating a lower treatment success rate than previously reported. Conclusions CLB represents a reasonable AED and promising add-on agent for treatment of RSE. However, rates of successful CLB response were substantially lower than in a recently published study. Differing RSE characteristics and treatment strategies may account for the discrepancy between study results, as RSE etiologies and seizures types associated with unfavorable prognosis were more common in our cohort, while anesthetics tended to be less frequently applied to achieve seizure control.

Published
2016

47. Anemia is an independent prognostic factor in intracerebral hemorrhage: an observational cohort study

Author

Kuramatsu, Joji B, Gerner, Stefan T, Lücking, Hannes, Kloska, Stephan P, Schellinger, Peter D, Köhrmann, Martin, and Huttner, Hagen B

Subjects
Spontaneous ICH, Aged, 80 and over, Male, Research, Anemia, Middle Aged, Unfavorable outcome, Prognosis, Critical Care and Intensive Care Medicine, Cohort Studies, Intracerebral haemorrhage, Medizinische Fakultät, Humans, Female, ddc:610, On admission anemia, Outcome predictor, Aged, Cerebral Hemorrhage, Follow-Up Studies, Retrospective Studies
Abstract

Introduction To date only two studies have evaluated anemia status in acute intracerebral hemorrhage (ICH) reporting that on admission anemia (OAA) was associated with larger hematoma volume, and lower hemoglobin levels during hospital stay, which related to poorer outcome. The question remains whether anemia influences outcome through related volume-effects or itself has an independent impact? Methods This single-center investigation included 435 consecutive patients with spontaneous ICH admitted to the Department of Neurology over five years. Functional short- and long-term outcome (3 months and 1 year) were analyzed for anemia status. Multivariate logistic and graphical regression analyses were calculated for associations of anemia and to determine independent effects on functional outcome. It was decided to perform a separate analysis for patients with ICH-volume

Published
2014

50. Endovascular Thrombectomy Versus Intravenous Thrombolysis of Posterior Cerebral Artery Occlusion Stroke.

Author

Räty S, Nguyen TN, Nagel S, Strambo D, Michel P, Herweh C, Qureshi MM, Abdalkader M, Virtanen P, Olive-Gadea M, Ribo M, Psychogios M, Nguyen A, Kuramatsu JB, Haupenthal D, Köhrmann M, Deuschl C, Escolà JK, Demeestere J, Lemmens R, Vandewalle L, Yaghi S, Shu L, Puetz V, Kaiser DPO, Kaesmacher J, Mujanovic A, Marterstoc DC, Engelhorn T, Berberich A, Klein P, Haussen DC, Mohammaden MH, Abdelhamid H, Fragata I, Cunha B, Romoli M, Hu W, Song J, Fifi JT, Matsoukas S, Sheth SA, Salazar-Marioni SA, Marto JP, Ramos JN, Miszczuk M, Riegler C, Poli S, Poli K, Jadhav AP, Desai S, Maus V, Kaeder M, Siddiqui AH, Monteiro A, Kokkonen T, Diana F, Masoud HE, Suryadareva N, Mokin M, Thanki S, Ylikotila P, Alpay K, Siegler JE, Linfante I, Dabus G, Yavaghal D, Saini V, Nolte CH, Siebert E, Möhlenbruch MA, Ringleb PA, Nogueira RG, Hanning U, Meyer L, Fischer U, and Strbian D

Abstract

Background and Purpose: Posterior cerebral artery occlusion (PCAo) can cause long-term disability, yet randomized controlled trials to guide optimal reperfusion strategy are lacking. We compared the outcomes of PCAo patients treated with endovascular thrombectomy (EVT) with or without intravenous thrombolysis (IVT) to patients treated with IVT alone., Methods: From the multicenter retrospective Posterior cerebraL ArTery Occlusion (PLATO) registry, we included patients with isolated PCAo treated with reperfusion therapy within 24 hours of onset between January 2015 and August 2022. The primary outcome was the distribution of the modified Rankin Scale (mRS) at 3 months. Other outcomes comprised 3-month excellent (mRS 0-1) and independent outcome (mRS 0-2), early neurological improvement (ENI), mortality, and symptomatic intracranial hemorrhage (sICH). The treatments were compared using inverse probability weighted regression adjustment., Results: Among 724 patients, 400 received EVT+/-IVT and 324 IVT alone (median age 74 years, 57.7% men). The median National Institutes of Health Stroke Scale score on admission was 7, and the occluded segment was P1 (43.9%), P2 (48.3%), P3-P4 (6.1%), bilateral (1.0%), or fetal posterior cerebral artery (0.7%). Compared to IVT alone, EVT+/-IVT was not associated with improved functional outcome (adjusted common odds ratio [OR] 1.07, 95% confidence interval [CI] 0.79-1.43). EVT increased the odds for ENI (adjusted OR [aOR] 1.49, 95% CI 1.05-2.12), sICH (aOR 2.87, 95% CI 1.23-6.72), and mortality (aOR 1.77, 95% CI 1.07-2.95)., Conclusion: Despite higher odds for early improvement, EVT+/-IVT did not affect functional outcome compared to IVT alone after PCAo. This may be driven by the increased risk of sICH and mortality after EVT.

Published
2024
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