45 results on '"López-Vicente, Mónica"'
Search Results
2. Residential ambient air pollution exposure and the development of white matter microstructure throughout adolescence
- Author
-
Kusters, Michelle S.W., López-Vicente, Mónica, Muetzel, Ryan L., Binter, Anne-Claire, Petricola, Sami, Tiemeier, Henning, and Guxens, Mònica
- Published
- 2024
- Full Text
- View/download PDF
3. Environmental exposures in early-life and general health in childhood
- Author
-
Amine, Ines, Guillien, Alicia, Philippat, Claire, Anguita-Ruiz, Augusto, Casas, Maribel, de Castro, Montserrat, Dedele, Audrius, Garcia-Aymerich, Judith, Granum, Berit, Grazuleviciene, Regina, Heude, Barbara, Haug, Line Småstuen, Julvez, Jordi, López-Vicente, Mónica, Maitre, Léa, McEachan, Rosemary, Nieuwenhuijsen, Mark, Stratakis, Nikos, Vafeiadi, Marina, Wright, John, Yang, Tiffany, Yuan, Wen Lun, Basagaña, Xavier, Slama, Rémy, Vrijheid, Martine, and Siroux, Valérie
- Published
- 2023
- Full Text
- View/download PDF
4. Physical symptoms and brain morphology: a population neuroimaging study in 12,286 pre-adolescents
- Author
-
Estévez-López, Fernando, Kim, Hannah H., López-Vicente, Mónica, Legerstee, Jeroen S., Hillegers, Manon H. J., Tiemeier, Henning, and Muetzel, Ryan L.
- Published
- 2023
- Full Text
- View/download PDF
5. Association of exposure to mixture of chemicals during pregnancy with cognitive abilities and fine motor function of children
- Author
-
Brennan Kearns, Pavla, van den Dries, Michiel A., Julvez, Jordi, Kampouri, Mariza, López-Vicente, Mónica, Maitre, Lea, Philippat, Claire, Småstuen Haug, Line, Vafeiadi, Marina, Thomsen, Cathrine, Yang, Tiffany C, Vrijheid, Martine, Tiemeier, Henning, and Guxens, Mònica
- Published
- 2024
- Full Text
- View/download PDF
6. Association between residential exposure to road traffic noise and cognitive and motor function outcomes in children and preadolescents
- Author
-
Pérez-Crespo, Laura, López-Vicente, Mónica, Valentín, Antònia, Burgaleta, Miguel, Foraster, Maria, Tiemeier, Henning, and Guxens, Mònica
- Published
- 2024
- Full Text
- View/download PDF
7. Effect of walnut consumption on neuropsychological development in healthy adolescents: a multi-school randomised controlled trial
- Author
-
Pinar-Martí, Ariadna, Gignac, Florence, Fernández-Barrés, Silvia, Romaguera, Dora, Sala-Vila, Aleix, Lázaro, Iolanda, Ranzani, Otavio T., Persavento, Cecilia, Delgado, Anna, Carol, Albert, Torrent, Jaume, Gonzalez, Judith, Roso, Eduard, Barrera-Gómez, Jose, López-Vicente, Mónica, Boucher, Olivier, Nieuwenhuijsen, Mark, Turner, Michelle C., Burgaleta, Miguel, Canals, Josefina, Arija, Victoria, Basagaña, Xavier, Ros, Emilio, Salas-Salvadó, Jordi, Sunyer, Jordi, and Julvez, Jordi
- Published
- 2023
- Full Text
- View/download PDF
8. Exploring the longitudinal associations of functional network connectivity and psychiatric symptom changes in youth
- Author
-
Dall'Aglio, Lorenza, Estévez-López, Fernando, López-Vicente, Mónica, Xu, Bing, Agcaoglu, Oktay, Boroda, Elias, Lim, Kelvin O., Calhoun, Vince D., Tiemeier, Henning, and Muetzel, Ryan L.
- Published
- 2023
- Full Text
- View/download PDF
9. White matter microstructure correlates of age, sex, handedness and motor ability in a population-based sample of 3031 school-age children
- Author
-
López-Vicente, Mónica, Lamballais, Sander, Louwen, Suzanne, Hillegers, Manon, Tiemeier, Henning, Muetzel, Ryan L., and White, Tonya
- Published
- 2021
- Full Text
- View/download PDF
10. Examining the interaction between prenatal stress and polygenic risk for attention-deficit/hyperactivity disorder on brain growth in childhood:Findings from the DREAM BIG consortium
- Author
-
López-Vicente, Mónica, Szekely, Eszter, Lafaille-Magnan, Marie Elyse, Morton, J. Bruce, Oberlander, Tim F., Greenwood, Celia M.T., Muetzel, Ryan L., Tiemeier, Henning, Qiu, Anqi, Wazana, Ashley, White, Tonya, López-Vicente, Mónica, Szekely, Eszter, Lafaille-Magnan, Marie Elyse, Morton, J. Bruce, Oberlander, Tim F., Greenwood, Celia M.T., Muetzel, Ryan L., Tiemeier, Henning, Qiu, Anqi, Wazana, Ashley, and White, Tonya
- Abstract
This study explored the interactions among prenatal stress, child sex, and polygenic risk scores (PGS) for attention-deficit/hyperactivity disorder (ADHD) on structural developmental changes of brain regions implicated in ADHD. We used data from two population-based birth cohorts: Growing Up in Singapore Towards healthy Outcomes (GUSTO) from Singapore (n = 113) and Generation R from Rotterdam, the Netherlands (n = 433). Prenatal stress was assessed using questionnaires. We obtained latent constructs of prenatal adversity and prenatal mood problems using confirmatory factor analyses. The participants were genotyped using genome-wide single nucleotide polymorphism arrays, and ADHD PGSs were computed. Magnetic resonance imaging scans were acquired at 4.5 and 6 years (GUSTO), and at 10 and 14 years (Generation R). We estimated the age-related rate of change for brain outcomes related to ADHD and performed (1) prenatal stress by sex interaction models, (2) prenatal stress by ADHD PGS interaction models, and (3) 3-way interaction models, including prenatal stress, sex, and ADHD PGS. We observed an interaction between prenatal stress and ADHD PGS on mean cortical thickness annual rate of change in Generation R (i.e., in individuals with higher ADHD PGS, higher prenatal stress was associated with a lower rate of cortical thinning, whereas in individuals with lower ADHD PGS, higher prenatal stress was associated with a higher rate of cortical thinning). None of the other tested interactions were statistically significant. Higher prenatal stress may promote a slower brain developmental rate during adolescence in individuals with higher ADHD genetic vulnerability, whereas it may promote a faster brain developmental rate in individuals with lower ADHD genetic vulnerability.
- Published
- 2024
11. The Berlin-Brandenburg Air Study—A Methodological Study Paper of a Natural Experiment Investigating Health Effects Related to Changes in Airport-Related Exposures
- Author
-
Soppa, Vanessa, primary, Lucht, Sarah, additional, Ogurtsova, Katherine, additional, Buschka, Anna, additional, López-Vicente, Mónica, additional, Guxens, Mònica, additional, Weinhold, Kay, additional, Winkler, Ulf, additional, Wiedensohler, Alfred, additional, Held, Andreas, additional, Lüchtrath, Sabine, additional, Cyrys, Josef, additional, Kecorius, Simonas, additional, Gastmeier, Petra, additional, Wiese-Posselt, Miriam, additional, and Hoffmann, Barbara, additional
- Published
- 2023
- Full Text
- View/download PDF
12. Green spaces and cognitive development in primary schoolchildren
- Author
-
Dadvand, Payam, Nieuwenhuijsen, Mark J, Esnaola, Mikel, Forns, Joan, Basagaña, Xavier, Alvarez-Pedrerol, Mar, Rivas, Ioar, López-Vicente, Mónica, De Castro Pascual, Montserrat, Su, Jason, Jerrett, Michael, Querol, Xavier, and Sunyer, Jordi
- Subjects
Behavioral and Social Science ,Prevention ,Mental health ,Sustainable Cities and Communities ,Child ,Cognition ,Environment ,Humans ,Memory ,Spain ,neurodevelopment ,greenness ,cognition ,built environment ,school - Abstract
Exposure to green space has been associated with better physical and mental health. Although this exposure could also influence cognitive development in children, available epidemiological evidence on such an impact is scarce. This study aimed to assess the association between exposure to green space and measures of cognitive development in primary schoolchildren. This study was based on 2,593 schoolchildren in the second to fourth grades (7-10 y) of 36 primary schools in Barcelona, Spain (2012-2013). Cognitive development was assessed as 12-mo change in developmental trajectory of working memory, superior working memory, and inattentiveness by using four repeated (every 3 mo) computerized cognitive tests for each outcome. We assessed exposure to green space by characterizing outdoor surrounding greenness at home and school and during commuting by using high-resolution (5 m × 5 m) satellite data on greenness (normalized difference vegetation index). Multilevel modeling was used to estimate the associations between green spaces and cognitive development. We observed an enhanced 12-mo progress in working memory and superior working memory and a greater 12-mo reduction in inattentiveness associated with greenness within and surrounding school boundaries and with total surrounding greenness index (including greenness surrounding home, commuting route, and school). Adding a traffic-related air pollutant (elemental carbon) to models explained 20-65% of our estimated associations between school greenness and 12-mo cognitive development. Our study showed a beneficial association between exposure to green space and cognitive development among schoolchildren that was partly mediated by reduction in exposure to air pollution.
- Published
- 2015
13. Physical symptoms and brain morphology:a population neuroimaging study in 12,286 pre-adolescents
- Author
-
Estévez-López, Fernando, Kim, Hannah H., López-Vicente, Mónica, Legerstee, Jeroen S., Hillegers, Manon H.J., Tiemeier, Henning, Muetzel, Ryan L., Estévez-López, Fernando, Kim, Hannah H., López-Vicente, Mónica, Legerstee, Jeroen S., Hillegers, Manon H.J., Tiemeier, Henning, and Muetzel, Ryan L.
- Abstract
Physical symptoms, also known as somatic symptoms, are those for which medical examinations do not reveal a sufficient underlying root cause (e.g., pain and fatigue). The extant literature of the neurobiological underpinnings of physical symptoms is largely inconsistent and primarily comprises of (clinical) case-control studies with small sample sizes. In this cross-sectional study, we studied the association between dimensionally measured physical symptoms and brain morphology in pre-adolescents from two population-based cohorts; the Generation R Study (n = 2649, 10.1 ± 0.6 years old) and ABCD Study (n = 9637, 9.9 ± 0.6 years old). Physical symptoms were evaluated using continuous scores from the somatic complaints syndrome scale from the parent-reported Child Behavior Checklist (CBCL). High‐resolution structural magnetic resonance imaging (MRI) was collected using 3-Tesla MRI systems. Linear regression models were fitted for global brain metrics (cortical and subcortical grey matter and total white matter volume) and surface-based vertex-wise measures (surface area and cortical thickness). Results were meta-analysed. Symptoms of anxiety/depression were studied as a contrasting comorbidity. In the meta-analyses across cohorts, we found negative associations between physical symptoms and surface area in the (i) left hemisphere; in the lateral orbitofrontal cortex and pars triangularis and (ii) right hemisphere; in the pars triangularis, the pars orbitalis, insula, middle temporal gyrus and caudal anterior cingulate cortex. However, only a subset of regions (left lateral orbitofrontal cortex and right pars triangularis) were specifically associated with physical symptoms, while others were also related to symptoms of anxiety/depression. No significant associations were observed for cortical thickness. This study in preadolescents, the most representative and well-powered to date, showed that more physical symptoms are modestly related to less surface area of the p
- Published
- 2023
14. Maternal circulating Vitamin D3 levels during pregnancy and behaviour across childhood
- Author
-
López-Vicente, Mónica, Sunyer, Jordi, Lertxundi, Nerea, González, Llúcia, Rodríguez-Dehli, Cristina, Espada Sáenz-Torre, Mercedes, Vrijheid, Martine, Tardón, Adonina, Llop, Sabrina, Torrent, Maties, Ibarluzea, Jesús, and Guxens, Mònica
- Published
- 2019
- Full Text
- View/download PDF
15. Exposure to road traffic noise and cognitive development in schoolchildren in Barcelona, Spain: A population-based cohort study
- Author
-
Foraster, Maria, primary, Esnaola, Mikel, additional, López-Vicente, Mónica, additional, Rivas, Ioar, additional, Álvarez-Pedrerol, Mar, additional, Persavento, Cecilia, additional, Sebastian-Galles, Nuria, additional, Pujol, Jesus, additional, Dadvand, Payam, additional, and Sunyer, Jordi, additional
- Published
- 2022
- Full Text
- View/download PDF
16. Exposure to traffic-related air pollution and noise during pregnancy and childhood, and functional brain connectivity in preadolescents
- Author
-
Pérez-Crespo, Laura, primary, Kusters, Michelle S.W., additional, López-Vicente, Mónica, additional, Lubczyńska, Małgorzata J., additional, Foraster, Maria, additional, White, Tonya, additional, Hoek, Gerard, additional, Tiemeier, Henning, additional, Muetzel, Ryan L., additional, and Guxens, Mònica, additional
- Published
- 2022
- Full Text
- View/download PDF
17. Exposure to traffic-related air pollution and noise during pregnancy and childhood, and functional brain connectivity in preadolescents
- Author
-
Pérez-Crespo, Laura, Kusters, Michelle S.W., López-Vicente, Mónica, Lubczyńska, Małgorzata J., Foraster, Maria, White, Tonya, Hoek, Gerard, Tiemeier, Henning, Muetzel, Ryan L., Guxens, Mònica, Pérez-Crespo, Laura, Kusters, Michelle S.W., López-Vicente, Mónica, Lubczyńska, Małgorzata J., Foraster, Maria, White, Tonya, Hoek, Gerard, Tiemeier, Henning, Muetzel, Ryan L., and Guxens, Mònica
- Abstract
Background: The amount of people affected by traffic-related air pollution and noise is continuously increasing, but limited research has been conducted on the association between these environmental exposures and functional brain connectivity in children. Objective: This exploratory study aimed to analyze the associations between the exposure to traffic-related air pollution and noise during pregnancy and childhood, and functional brain connectivity amongst a wide-swath of brain areas in preadolescents from 9 to 12 years of age. Methods: We used data of 2,197 children from the Generation R Study. Land use regression models were applied to estimate nitrogen oxides and particulate matter levels at participant's homes for several time periods: pregnancy, birth to 3 years, 3 to 6 years, and 6 years of age to the age at magnetic resonance imaging (MRI) assessment. Existing noise maps were used to estimate road traffic noise exposure at participant's homes for the same time periods. Resting-state functional MRI was obtained at 9–12 years of age. Pair-wise correlation coefficients of the blood-oxygen-level-dependent signals between 380 brain areas were calculated. Linear regressions were run and corrected for multiple testing. Results: Preadolescents exposed to higher levels of NO2, NOx, and PM2.5 absorbance, from birth to 3 years, and from 3 to 6 years of age showed higher correlation coefficients among several brain regions (e.g. from 0.16 to 0.19 higher correlation coefficient related to PM2.5 absorbance exposure, depending on the brain connection). Overall, most identified associations were between brain regions of the task positive and task negative networks, and were mainly inter-network (20 of 26). Slightly more than half of the connections were intra-hemispheric (14 of 26), predominantly in the right hemisphere. Road traffic noise was not associated with functional brain connectivity. Conclusions: This exploratory stu
- Published
- 2022
18. Exposure to road traffic noise and cognitive development in schoolchildren in Barcelona, Spain:A population-based cohort study
- Author
-
Foraster, Maria, Esnaola, Mikel, López-Vicente, Mónica, Rivas, Ioar, Álvarez-Pedrerol, Mar, Persavento, Cecilia, Sebastian-Galles, Nuria, Pujol, Jesus, Dadvand, Payam, Sunyer, Jordi, Foraster, Maria, Esnaola, Mikel, López-Vicente, Mónica, Rivas, Ioar, Álvarez-Pedrerol, Mar, Persavento, Cecilia, Sebastian-Galles, Nuria, Pujol, Jesus, Dadvand, Payam, and Sunyer, Jordi
- Abstract
Background Road traffic noise is a prevalent and known health hazard. However, little is known yet about its effect on children’s cognition. We aimed to study the association between exposure to road traffic noise and the development of working memory and attention in primary school children, considering school-outdoor and school-indoor annual average noise levels and noise fluctuation characteristics, as well as home-outdoor noise exposure. Methods and findings We followed up a population-based sample of 2,680 children aged 7 to 10 years from 38 schools in Barcelona (Catalonia, Spain) between January 2012 to March 2013. Children underwent computerised cognitive tests 4 times (n = 10,112), for working memory (2-back task, detectability), complex working memory (3-back task, detectability), and inattentiveness (Attention Network Task, hit reaction time standard error, in milliseconds). Road traffic noise was measured indoors and outdoors at schools, at the start of the school year, using standard protocols to obtain A-weighted equivalent sound pressure levels, i.e., annual average levels scaled to human hearing, for the daytime (daytime LAeq, in dB). We also derived fluctuation indicators out of the measurements (noise intermittency ratio, %; and number of noise events) and obtained individual estimated indoor noise levels (LAeq) correcting for classroom orientation and classroom change between years. Home-outdoor noise exposure at home (Lden, i.e., EU indicator for the 24-hour annual average levels) was estimated using Barcelona’s noise map for year 2012, according to the European Noise Directive (2002). We used linear mixed models to evaluate the association between exposure to noise and cognitive development adjusting for age, sex, maternal education, socioeconomical vulnerability index at home, indoor or outdoor traffic-related air pollution (TRAP) for corresponding school models or outdoor nitrogen dioxide (NO2) for home models. Child and school we
- Published
- 2022
19. Connecting the dots:social networks in the classroom and white matter connections in the brain
- Author
-
Mulder, Rosa H., López-Vicente, Mónica, Cortes Hidalgo, Andrea P., Steenkamp, Lisa R., Güroğlu, Berna, Tiemeier, Henning, Muetzel, Ryan L., Mulder, Rosa H., López-Vicente, Mónica, Cortes Hidalgo, Andrea P., Steenkamp, Lisa R., Güroğlu, Berna, Tiemeier, Henning, and Muetzel, Ryan L.
- Abstract
Background: Peer connections in school classrooms play an important role in social–emotional development and mental health. However, research on the association between children's peer relationships and white matter connections in the brain is scarce. We studied associations between peer relationships in the classroom and white matter structural connectivity in a pediatric population-based sample. Methods: Bullying and victimization, as well as rejection and acceptance, were assessed in classrooms in 634 children at age 7. White matter microstructure (fractional anisotropy (FA), mean diffusivity (MD)) was measured with diffusion tensor imaging at age 10. We examined global metrics of white matter microstructure and used Tract-Based Spatial Statistics (TBSS) for voxel-wise associations. Results: Peer victimization was associated with higher global FA and lower global MD and peer rejection was associated with lower global MD; however, these associations did not remain after multiple testing correction. Voxel-wise TBSS results for peer victimization and rejection were in line with global metrics both in terms of direction and spatial extent of the associations, with associated voxels (pFWE <.05) observed throughout the brain (including corpus callosum, corona radiata, sagittal stratum and superior longitudinal fasciculi). Conclusions: Although based only on cross-sectional data, the findings could indicate accelerated white matter microstructure maturation in certain brain areas of children who are victimized or rejected more often. However, repeated measurements are essential to unravel this complex interplay of peer connections, maturation and brain development over time.
- Published
- 2022
20. Developmental Changes in Dynamic Functional Connectivity From Childhood Into Adolescence
- Author
-
López-Vicente, Mónica, primary, Agcaoglu, Oktay, additional, Pérez-Crespo, Laura, additional, Estévez-López, Fernando, additional, Heredia-Genestar, José María, additional, Mulder, Rosa H., additional, Flournoy, John C., additional, van Duijvenvoorde, Anna C. K., additional, Güroğlu, Berna, additional, White, Tonya, additional, Calhoun, Vince, additional, Tiemeier, Henning, additional, and Muetzel, Ryan L., additional
- Published
- 2021
- Full Text
- View/download PDF
21. Short-term effect of air pollution on attention function in adolescents (ATENC!Ó): A randomized controlled trial in high schools in Barcelona, Spain
- Author
-
Gignac, Florence, primary, Barrera-Gómez, Jose, additional, Persavento, Cecilia, additional, Solé, Caterina, additional, Tena, Èlia, additional, López-Vicente, Mónica, additional, Foraster, Maria, additional, Amato, Fulvio, additional, Alastuey, Andrés, additional, Querol, Xavier, additional, Llavador, Humberto, additional, Apesteguia, Jose, additional, Júlvez, Jordi, additional, Couso, Digna, additional, Sunyer, Jordi, additional, and Basagaña, Xavier, additional
- Published
- 2021
- Full Text
- View/download PDF
22. Identifying factors influencing attention in adolescents with a co‐created questionnaire
- Author
-
Gignac, Florence, Solé, Caterina, Barrera-Gómez, José, Persavento, Maria Cecilia, Tena Gallego, Èlia, López-Vicente, Mónica, Júlvez, Jordi, Sunyer, Jordi, Couso, Digna, Basagaña, X, Universitat Pompeu Fabra. Department of Experimental and Health Sciences, CIBER Epidemiología y Salud Pública, and Child and Adolescent Psychiatry / Psychology
- Subjects
medicine.medical_specialty ,Adolescent ,Health, Toxicology and Mutagenesis ,education ,Secondary education ,Citizen science ,Adolescents ,Social class ,Affect (psychology) ,Article ,Developmental psychology ,03 medical and health sciences ,0302 clinical medicine ,Consistency (negotiation) ,SDG 3 - Good Health and Well-being ,Surveys and Questionnaires ,citizen science ,secondary education ,medicine ,questionnaire design ,Humans ,Attention ,030212 general & internal medicine ,adolescents ,Students ,Public health ,Data collection ,Schools ,public health ,Public Health, Environmental and Occupational Health ,Confidence interval ,Test (assessment) ,attention ,Cross-Sectional Studies ,Spain ,Medicine ,Questionnaire design ,Psychology ,030217 neurology & neurosurgery - Abstract
Studies on factors that can influence attention in healthy adolescents are recent and focus on recurrent topics. Students’ contribution to public health research often revolves around collecting data but rarely around creating data collection instruments. The ATENC!Ó project reunited secondary students and scientists to create a questionnaire including factors that students thought could affect their attention. We conducted a cross-sectional study to assess whether the factors included in this questionnaire had an effect on attention in adolescents. A total of 1667 students (13–16 years old) from 28 schools in Barcelona performed a validated attention test and answered the questionnaire. The response speed consistency (attentiveness), expressed as hit reaction time standard error (HRT-SE, in ms), was used as the primary outcome. Analyses were conducted using conditional linear regression with school as strata, adjusted for sociodemographic characteristics and further stratified by gender and maternal social class. Some factors showed a negative influence on attention, including taking medication and not reading regularly. We found a significant 14.3% (95% confidence interval: 3.4%, 25.3%) higher median of HRT-SE (increase inattentiveness) among students who reported not having a good relationship with classmates. Students’ input into research is relevant for advancing the knowledge production in public health.
- Published
- 2021
23. Early life multiple exposures and child cognitive function: A multi-centric birth cohort study in six European countries
- Author
-
Julvez, Jordi, primary, López-Vicente, Mónica, additional, Warembourg, Charline, additional, Maitre, Lea, additional, Philippat, Claire, additional, Gützkow, Kristine B., additional, Guxens, Monica, additional, Evandt, Jorunn, additional, Andrusaityte, Sandra, additional, Burgaleta, Miguel, additional, Casas, Maribel, additional, Chatzi, Leda, additional, de Castro, Montserrat, additional, Donaire-González, David, additional, Gražulevičienė, Regina, additional, Hernandez-Ferrer, Carles, additional, Heude, Barbara, additional, Mceachan, Rosie, additional, Mon-Williams, Mark, additional, Nieuwenhuijsen, Mark, additional, Robinson, Oliver, additional, Sakhi, Amrit K., additional, Sebastian-Galles, Nuria, additional, Slama, Remy, additional, Sunyer, Jordi, additional, Tamayo-Uria, Ibon, additional, Thomsen, Cathrine, additional, Urquiza, Jose, additional, Vafeiadi, Marina, additional, Wright, John, additional, Basagaña, Xavier, additional, and Vrijheid, Martine, additional
- Published
- 2021
- Full Text
- View/download PDF
24. Corrigendum to “Television viewing duration during childhood and long-association with adolescent neuropsychological outcomes” [Prev. Med. Rep. 4 (2016) 447–452.]
- Author
-
O'Connor, Giselle, Piñero Casas, Maria, Basagaña, Xavier, López Vicente, Mònica, Davand, Payam, Torrent, Maties, Martínez-Murciano, David, García-Esteban, Raquel, Marinelli, Marcella, Sunyer, Jordi, and Julvez, Jordi
- Published
- 2021
- Full Text
- View/download PDF
25. Walnuts, Long-Chain Polyunsaturated Fatty Acids, and Adolescent Brain Development: Protocol for the Walnuts Smart Snack Dietary Intervention Trial
- Author
-
Julvez, Jordi, primary, Gignac, Florence, additional, Fernández-Barrés, Silvia, additional, Romaguera, Dora, additional, Sala-Vila, Aleix, additional, Ranzani, Otavio T., additional, Persavento, Cecilia, additional, Delgado, Anna, additional, Carol, Albert, additional, Torrent, Jaume, additional, Gonzalez, Judith, additional, Roso, Eduard, additional, Barrera-Gómez, Jose, additional, López-Vicente, Mónica, additional, Garcia-Esteban, Raquel, additional, Boucher, Olivier, additional, Forns, Joan, additional, Burgaleta, Miguel, additional, Sebastián, Nuria, additional, Canals, Josefina, additional, Arija, Victoria, additional, Basagaña, Xavier, additional, Ros, Emilio, additional, Vendrell, Joan, additional, Salas-Salvadó, Jordi, additional, and Sunyer, Jordi, additional
- Published
- 2021
- Full Text
- View/download PDF
26. Short-term effect of air pollution on attention function in adolescents (ATENC!Ó):A randomized controlled trial in high schools in Barcelona, Spain
- Author
-
Gignac, Florence, Barrera-Gómez, Jose, Persavento, Cecilia, Solé, Caterina, Tena, Èlia, López-Vicente, Mónica, Foraster, Maria, Amato, Fulvio, Alastuey, Andrés, Querol, Xavier, Llavador, Humberto, Apesteguia, Jose, Júlvez, Jordi, Couso, Digna, Sunyer, Jordi, Basagaña, Xavier, Gignac, Florence, Barrera-Gómez, Jose, Persavento, Cecilia, Solé, Caterina, Tena, Èlia, López-Vicente, Mónica, Foraster, Maria, Amato, Fulvio, Alastuey, Andrés, Querol, Xavier, Llavador, Humberto, Apesteguia, Jose, Júlvez, Jordi, Couso, Digna, Sunyer, Jordi, and Basagaña, Xavier
- Abstract
Background: The recent evidence of the short-term impact of air pollution on youth cognitive functions is based primarily on observational studies. Objectives: We conducted a randomized controlled trial to assess whether purifying the air of the classrooms produced short-term changes in attention processes of adolescents. Methods: We recruited a total of 2,123 adolescents (13–16 years old) in 33 high schools in Barcelona metropolitan area (Spain). In each school, adolescents from each class were randomly split into two equal-sized groups and assigned to two different classrooms. A set of two air cleaner devices with the same appearance (one recirculating and filtrating the air and the other only recirculating the air) was used. Each one of the devices was placed at random at one of the two classrooms. Students were masked to intervention allocation and had to complete several computerized activities for 1.5 h, including an attention test (Flanker task) to be performed at baseline and at the end of the intervention. The response speed consistency, expressed as hit reaction time standard error (HRT-SE, in ms), was measured as the primary outcome. Analyses were conducted using conditional linear regressions with classroom as strata, adjusted for variables that may differ from one class to another such as temperature, humidity and carbon dioxide concentration. Results: Average levels of PM2.5 and black carbon throughout the 1.5 h of experiment were 89% and 87%, respectively, lower in the classrooms with air cleaner than in the control classrooms. No differences were found in the median of HRT-SE between classrooms with cleaned air and normal air (percent change: 1.37%, 95% confidence interval: −2.81%, 5.56%). Sensitivity analyses with secondary attention outcomes resulted in similar findings. Conclusions: Cleaning the air of a classroom to reduce exposure to air pollutants for 1.5 h did not have an impact on the attention function of adolescents. Still, in
- Published
- 2021
27. Short-term effect of air pollution on attention function in adolescents (ATENC!Ó): A randomized controlled trial in high schools in Barcelona, Spain
- Author
-
Ministerio de Ciencia, Innovación y Universidades (España), Amato, Fulvio [0000-0003-1546-9154], Alastuey, Andrés [0000-0002-5453-5495], Querol, Xavier [0000-0002-6549-9899], Gignac, Florence, Barrera-Gómez, José, Persavento, Cecilia, Solé, Caterina, Tena, Èlia, López-Vicente, Mónica, Foraster, Maria, Amato, Fulvio, Alastuey, Andrés, Querol, Xavier, Llavador, Humberto, Apesteguia, Jose, Júlvez, Jordi, Couso, Digna, Sunyer, Jordi, Basagaña, Xavier, Ministerio de Ciencia, Innovación y Universidades (España), Amato, Fulvio [0000-0003-1546-9154], Alastuey, Andrés [0000-0002-5453-5495], Querol, Xavier [0000-0002-6549-9899], Gignac, Florence, Barrera-Gómez, José, Persavento, Cecilia, Solé, Caterina, Tena, Èlia, López-Vicente, Mónica, Foraster, Maria, Amato, Fulvio, Alastuey, Andrés, Querol, Xavier, Llavador, Humberto, Apesteguia, Jose, Júlvez, Jordi, Couso, Digna, Sunyer, Jordi, and Basagaña, Xavier
- Abstract
Background The recent evidence of the short-term impact of air pollution on youth cognitive functions is based primarily on observational studies. Objectives We conducted a randomized controlled trial to assess whether purifying the air of the classrooms produced short-term changes in attention processes of adolescents. Methods We recruited a total of 2,123 adolescents (13–16 years old) in 33 high schools in Barcelona metropolitan area (Spain). In each school, adolescents from each class were randomly split into two equal-sized groups and assigned to two different classrooms. A set of two air cleaner devices with the same appearance (one recirculating and filtrating the air and the other only recirculating the air) was used. Each one of the devices was placed at random at one of the two classrooms. Students were masked to intervention allocation and had to complete several computerized activities for 1.5 h, including an attention test (Flanker task) to be performed at baseline and at the end of the intervention. The response speed consistency, expressed as hit reaction time standard error (HRT-SE, in ms), was measured as the primary outcome. Analyses were conducted using conditional linear regressions with classroom as strata, adjusted for variables that may differ from one class to another such as temperature, humidity and carbon dioxide concentration. Results Average levels of PM2.5 and black carbon throughout the 1.5 h of experiment were 89% and 87%, respectively, lower in the classrooms with air cleaner than in the control classrooms. No differences were found in the median of HRT-SE between classrooms with cleaned air and normal air (percent change: 1.37%, 95% confidence interval: −2.81%, 5.56%). Sensitivity analyses with secondary attention outcomes resulted in similar findings. Conclusions Cleaning the air of a classroom to reduce exposure to air pollutants for 1.5 h did not have an impact on the attention function of adolescents. Still, in light of previous
- Published
- 2021
28. Developmental Changes in Dynamic Functional Connectivity From Childhood Into Adolescence
- Author
-
López-Vicente, Mónica, Agcaoglu, Oktay, Pérez-Crespo, Laura, Estévez-López, Fernando, Heredia-Genestar, José María, Mulder, Rosa H., Flournoy, John C., van Duijvenvoorde, Anna C.K., Güroğlu, Berna, White, Tonya, Calhoun, Vince, Tiemeier, Henning, Muetzel, Ryan L., López-Vicente, Mónica, Agcaoglu, Oktay, Pérez-Crespo, Laura, Estévez-López, Fernando, Heredia-Genestar, José María, Mulder, Rosa H., Flournoy, John C., van Duijvenvoorde, Anna C.K., Güroğlu, Berna, White, Tonya, Calhoun, Vince, Tiemeier, Henning, and Muetzel, Ryan L.
- Abstract
The longitudinal study of typical neurodevelopment is key for understanding deviations due to specific factors, such as psychopathology. However, research utilizing repeated measurements remains scarce. Resting-state functional magnetic resonance imaging (MRI) studies have traditionally examined connectivity as ‘static’ during the measurement period. In contrast, dynamic approaches offer a more comprehensive representation of functional connectivity by allowing for different connectivity configurations (time varying connectivity) throughout the scanning session. Our objective was to characterize the longitudinal developmental changes in dynamic functional connectivity in a population-based pediatric sample. Resting-state MRI data were acquired at the ages of 10 (range 8-to-12, n = 3,327) and 14 (range 13-to-15, n = 2,404) years old using a single, study-dedicated 3 Tesla scanner. A fully-automated spatially constrained group-independent component analysis (ICA) was applied to decompose multi-subject resting-state data into functionally homogeneous regions. Dynamic functional network connectivity (FNC) between all ICA time courses were computed using a tapered sliding window approach. We used a k-means algorithm to cluster the resulting dynamic FNC windows from each scan session into five dynamic states. We examined age and sex associations using linear mixed-effects models. First, independent from the dynamic states, we found a general increase in the temporal variability of the connections between intrinsic connectivity networks with increasing age. Second, when examining the clusters of dynamic FNC windows, we observed that the time spent in less modularized states, with low intra- and inter-network connectivity, decreased with age. Third, the number of transitions between states also decreased with age. Finally, compared to boys, girls showed a more mature pattern of dynamic brain connectivity, indicated by more time spent in a highly modularized state, less t
- Published
- 2021
29. Identifying factors influencing attention in adolescents with a co‐created questionnaire:A citizen science approach with secondary students in Barcelona, Spain
- Author
-
Gignac, Florence, Solé, Caterina, Barrera‐gómez, Jose, Persavento, Cecilia, Tena, Èlia, López‐vicente, Mónica, Júlvez, Jordi, Sunyer, Jordi, Couso, Digna, Basagaña, Xavier, Gignac, Florence, Solé, Caterina, Barrera‐gómez, Jose, Persavento, Cecilia, Tena, Èlia, López‐vicente, Mónica, Júlvez, Jordi, Sunyer, Jordi, Couso, Digna, and Basagaña, Xavier
- Abstract
Studies on factors that can influence attention in healthy adolescents are recent and focus on recurrent topics. Students’ contribution to public health research often revolves around collecting data but rarely around creating data collection instruments. The ATENC!Ó project reunited secondary students and scientists to create a questionnaire including factors that students thought could affect their attention. We conducted a cross‐sectional study to assess whether the factors included in this questionnaire had an effect on attention in adolescents. A total of 1667 students (13–16 years old) from 28 schools in Barcelona performed a validated attention test and answered the questionnaire. The response speed consistency (attentiveness), expressed as hit reaction time standard error (HRT‐SE, in ms), was used as the primary outcome. Analyses were conducted using conditional linear regression with school as strata, adjusted for sociodemographic characteristics and further stratified by gender and maternal social class. Some factors showed a negative influence on attention, including taking medication and not reading regularly. We found a significant 14.3% (95% confidence interval: 3.4%, 25.3%) higher median of HRT‐SE (increase inattentiveness) among students who reported not having a good relationship with classmates. Students’ input into research is relevant for advancing the knowledge production in public health.
- Published
- 2021
30. Prenatal exposure to a wide range of environmental chemicals and child behaviour between 3 and 7 years of age - An exposome-based approach in 5 European cohorts
- Author
-
Jedynak, Paulina, MAITRE, Léa, Guxens, Mónica, Gützkow, Kristine, Julvez, Jordi, López-Vicente, Mónica, Sunyer, Jordi, Casas, Maribel, Chatzi, Leda, Gražulevičienė, Regina, Kampouri, Mariza, McEachan, Rosie, Mon-Williams, Mark, Tamayo, Ibon, Thomsen, Cathrine, Urquiza, José, Vafeiadi, Marina, Wright, John, Basagaña, Xavier, Vrijheid, Martine, Philippat, Claire, Inserm, CNRS, University Grenoble Alpes, Institute of Advanced Biosciences, Joint Research Center (U1209), Barcelona Institute for Global Health [Barcelona, Spain] (ISGlobal), University of Barcelona-Hospital Clinic [Barcelona, Spain], CIBER Epidemiologia y Salud Pùblica [Madrid, Spain] (CIBERESP), Instituto de Salud Carlos III [Madrid] (ISC), Universitat Pompeu Fabra [Barcelona] (UPF), Instituto de Salud Global - Institute For Global Health [Barcelona] (ISGlobal), Department of Child and Adolescent Psychiatry/Psychology, Erasmus Medical Centre–Sophia Children's Hospital, Rotterdam, the Netherlands, Norwegian Institute of Public Health [Oslo, Norway] (NIPH), Institut d'Investigació Sanitària Pere Virgili (IISPV), Hospital Universitari Sant Joan de Reus, Reus, Spain, Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA, Department of Social Medicine, University of Crete, Heraklion, Greece, Department of Genetics and Cell Biology, Faculty of Health, Medicine and Life Sciences, Maastricht University, Maastricht, Netherlands, Department of Environmental Sciences, Vytautas Magnus University, Kaunas, Lithuania, and Bradford Institute for Health Research, Bradford Teaching Hospitals NHS Foundation Trust, Bradford, UK
- Subjects
Child behaviour ,Strengths and Difficulties Questionnaire ,Child Behavior ,Environmental Exposure ,Internal exposome ,Article ,Cohort Studies ,Exposome ,Pregnancy ,Prenatal Exposure Delayed Effects ,Prenatal exposure ,Humans ,[SDV.SPEE]Life Sciences [q-bio]/Santé publique et épidémiologie ,Environmental Pollutants ,Female ,Child ,ComputingMilieux_MISCELLANEOUS ,Birth cohort - Abstract
Background Studies looking at associations between environmental chemicals and child behaviour usually consider only one exposure or family of exposures. Objective This study explores associations between prenatal exposure to a wide range of environmental chemicals and child behaviour. Methods We studied 708 mother-child pairs from five European cohorts recruited in 2003–2009. We assessed 47 exposure biomarkers from eight chemical exposure families in maternal blood or urine collected during pregnancy. We used the Strengths and Difficulties Questionnaire (SDQ) to evaluate child behaviour between three and seven years of age. We assessed associations of SDQ scores with exposures using an adjusted least absolute shrinkage and selection operator (LASSO) considering all exposures simultaneously and an adjusted exposome-wide association study (ExWAS) considering each exposure independently. Results LASSO selected only copper (Cu) as associated with externalizing behaviour. In the ExWAS, bisphenol A [BPA, incidence rate ratio (IRR): 1.06, 95% confidence interval (95%CI): 1.01;1.12] and mono-n-butyl phthalate (MnBP, IRR: 1.06, 95%CI: 1.00;1.13) were associated with greater risk of externalizing behaviour problems. Cu (IRR: 0.90, 95%CI: 0.82;0.98), perfluoroundecanoate (PFUnDA, IRR: 0.92, 95%CI: 0.84;0.99) and organochlorine compounds (OCs) were associated with lower risk of externalizing behaviour problems, however the associations with OCs were mainly seen among women with insufficient weight gain during pregnancy. Internalizing score worsen in association with exposure to diethyl thiophosphate (DETP, IRR: 1.11, 95%CI: 1.00;1.24) but the effect was driven by the smallest cohort. Internalizing score improved with increased concentration of perfluorooctane sulfonate (PFOS, IRR: 0.92, 95%CI: 0.85;1.00), however the association was driven by the two smallest cohorts with the lowest PFOS concentrations. Discussion This study added evidence on deleterious effects of prenatal exposure to BPA and MnBP on child behaviour. Other associations should be interpreted cautiously since they were not consistent with previous studies or they have not been studied extensively., Graphical abstract Unlabelled Image, Highlights • We studied simultaneous effect of prenatal exposure to several compounds on child behaviour. • 47 exposure biomarkers from 8 chemical exposure families were studied in 5 European cohorts. • Bisphenol A and mono-n-butyl phthalate were associated with increased behavioural problems in children. • Copper was associated with decreased behavioural problems.
- Published
- 2020
31. Neurodevelopmental effects of low dose ionizing radiation exposure: A systematic review of the epidemiological evidence
- Author
-
Pasqual, Elisa, primary, Bosch de Basea, Magda, additional, López-Vicente, Mónica, additional, Thierry-Chef, Isabelle, additional, and Cardis, Elisabeth, additional
- Published
- 2020
- Full Text
- View/download PDF
32. Maternal circulating Vitamin D-3 levels during pregnancy and behaviour across childhood
- Author
-
Procesos psicológicos básicos y su desarrollo, Psicología Social y Metodología de las Ciencias del Comportamiento, Gizarte psikologia eta portaera zientzen metodologia, Oinarrizko psikologia prozesuak eta haien garapena, López Vicente, Mónica, Sunyer, Jordi, Lertxundi Iribar, Nerea, González, Llucia, Rodríguez Dehli, Cristina, Espada Sáenz-Torre, Mercedes, Vrijheid, Martine, Tardón, Adonina, Llop, Sabrina, Torrent, Maties, Ibarluzea Maurolagoitia, Jesús María, Guxens, Mónica, Procesos psicológicos básicos y su desarrollo, Psicología Social y Metodología de las Ciencias del Comportamiento, Gizarte psikologia eta portaera zientzen metodologia, Oinarrizko psikologia prozesuak eta haien garapena, López Vicente, Mónica, Sunyer, Jordi, Lertxundi Iribar, Nerea, González, Llucia, Rodríguez Dehli, Cristina, Espada Sáenz-Torre, Mercedes, Vrijheid, Martine, Tardón, Adonina, Llop, Sabrina, Torrent, Maties, Ibarluzea Maurolagoitia, Jesús María, and Guxens, Mónica
- Abstract
Vitamin D deficiency during critical periods of development could lead to persistent brain alterations. We aimed to assess the association between maternal vitamin D-3, the major circulatory form of vitamin D, at pregnancy and neurodevelopmental outcomes during childhood, namely: behavioural problems, Attention Deficit and Hyperactivity Disorder (ADHD) and Autism Spectrum Disorder (ASD) symptoms, and social competence. This study included 2,107 mother-child pairs of a Spanish population-based birth cohort. Maternal plasma vitamin D-3 was measured in pregnancy. The outcomes were measured through questionnaires at 5, 8, 14, and 18 years old. We ran multivariate regression models adjusted for potential confounding variables. We found that per each 10 ng/mL increment of maternal vitamin D-3, children obtained higher social competence scores (coefficient =0.77; 95% CI=0.19, 1.35) at 5 years old. However, we observed null associations between maternal vitamin D-3 and total behavioural problems and ADHD and ASD symptoms in children from 5 to 18 years old. Further studies carried out in countries where the population is exposed to lower vitamin D levels are needed.
- Published
- 2019
33. Maternal seafood consumption during pregnancy and child attention outcomes: a cohort study with gene effect modification by PUFA-related genes
- Author
-
Julvez, Jordi, primary, Fernández-Barrés, Sílvia, primary, Gignac, Florence, primary, López-Vicente, Mónica, primary, Bustamante, Mariona, primary, Garcia-Esteban, Raquel, primary, Vioque, Jesús, primary, Llop, Sabrina, primary, Ballester, Ferran, primary, Fernández-Somoano, Ana, primary, Tardón, Adonina, primary, Vrijheid, Martine, primary, Tonne, Cathryn, primary, Ibarluzea, Jesus, primary, Irazabal, Amaia, primary, Sebastian-Galles, Nuria, primary, Burgaleta, Miguel, primary, Romaguera, Dora, primary, and Sunyer, Jordi, primary
- Published
- 2019
- Full Text
- View/download PDF
34. Association between Early Life Exposure to Air Pollution and Working Memory and Attention
- Author
-
Rivas, Ioar, primary, Basagaña, Xavier, additional, Cirach, Marta, additional, López-Vicente, Mónica, additional, Suades-González, Elisabet, additional, Garcia-Esteban, Raquel, additional, Álvarez-Pedrerol, Mar, additional, Dadvand, Payam, additional, and Sunyer, Jordi, additional
- Published
- 2019
- Full Text
- View/download PDF
35. Prenatal Omega-6:Omega-3 Ratio and Attention Deficit and Hyperactivity Disorder Symptoms
- Author
-
López-Vicente, Mónica, Ribas Fitó, Núria, Vilor-Tejedor, Natalia, Garcia, Raquel, Fernández-Barrés, Sílvia, Dadvand, Payam, Murcia, Mario, Rebagliato, Marisa, Ibarluzea, Jesus, Fernández Somoano, Ana, Lertxundi, Aitana, Tardon, Adonina, López-Sabater, Maria Carmen, Romaguera, Dora, Vrijheid, Martine, Sunyer Deu, Jordi, Julvez, Jordi, and Obra Social Cajastur/Fundación Liberbank, Universidad de Oviedo, CIBERESP, Department of Health of the Basque Government, the Provincial Government of Gipuzkoa, the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), Generalitat Valenciana, Generalitat de Catalunya, Fundació La marató de TV3, and the EU Commission
- Subjects
Male ,Neurobiologia del desenvolupament ,Trastorns per dèficit d'atenció amb hiperactivitat en els infants ,Pediatrics ,medicine.medical_specialty ,children, long-chain polyunsaturated fatty acids, neurodevelopment, population-based cohort ,Offspring ,Population ,Àcids grassos ,Rate ratio ,Logistic regression ,Attention deficit disorder with hyperactivity in children ,long-chain polyunsaturated fatty acids ,03 medical and health sciences ,0302 clinical medicine ,Pregnancy ,Fatty Acids, Omega-6 ,030225 pediatrics ,Fatty Acids, Omega-3 ,medicine ,Humans ,Prospective Studies ,population-based cohort ,Developmental neurobiology ,030212 general & internal medicine ,Fatty acids ,Child ,education ,Prenatal Nutritional Physiological Phenomena ,Children ,Subclinical infection ,chemistry.chemical_classification ,education.field_of_study ,neurodevelopment ,business.industry ,Fetal Blood ,medicine.disease ,chemistry ,Attention Deficit Disorder with Hyperactivity ,Docosahexaenoic acid ,Child, Preschool ,Pediatrics, Perinatology and Child Health ,Female ,business ,Infants ,Polyunsaturated fatty acid - Abstract
Supported by the Spanish Institute of Health Carlos III (Co-funded by European Regional Development Fund “A way to make Europe”) (CP14/00108, PI16/00261, MS14/00108 [to J.J.]), the Agència de Gestió d’Ajuts Universitaris i de Recerca, Generalitat de Catalunya - Fons Social Europeu (2017 FI_B 00636 [to N.V-T.]), the Spanish Ministry of Science and Innovation (RYC-2012-10995 [to P.D.] and RYC-2011-08796 [to D.R.]), Obra Social Cajastur/Fundación Liberbank, Universidad de Oviedo, CIBERESP, Department of Health of the Basque Government, the Provincial Government of Gipuzkoa, the municipalities of the study area (Zumarraga, Urretxu, Legazpi, Azkoitia y Azpeitia y Beasain), Generalitat Valenciana, Generalitat de Catalunya, Fundació La marató de TV3, and the EU Commission. ISGlobal is a member of the CERCA Programme, Generalitat de Catalunya., López-Vicente, M., Ribas Fitó, N., Vilor-Tejedor, N., Garcia-Esteban, R., Fernández-Barrés, S., Dadvand, P., Murcia, M., Rebagliato, M., Ibarluzea, J., Lertxundi, A., Fernández-Somoano, A., Tardón, A., López-Sabater, M.C., Romaguera, D., Vrijheid, M., Sunyer, J., Julvez, J.
- Published
- 2019
36. Maternal seafood consumption during pregnancy and child attention outcomes: a cohort study with gene effect modification by PUFA-related genes.
- Author
-
Julvez, Jordi, Fernández-Barrés, Sílvia, Gignac, Florence, López-Vicente, Mónica, Bustamante, Mariona, Garcia-Esteban, Raquel, Vioque, Jesús, Llop, Sabrina, Ballester, Ferran, Fernández-Somoano, Ana, Tardón, Adonina, Vrijheid, Martine, Tonne, Cathryn, Ibarluzea, Jesus, Irazabal, Amaia, Sebastian-Galles, Nuria, Burgaleta, Miguel, Romaguera, Dora, and Sunyer, Jordi
- Subjects
SEAFOOD ,ATTENTION-deficit hyperactivity disorder ,SINGLE nucleotide polymorphisms ,UNSATURATED fatty acids ,COHORT analysis ,RESEARCH ,RESEARCH methodology ,DIET ,MEDICAL cooperation ,EVALUATION research ,PRENATAL exposure delayed effects ,COMPARATIVE studies ,QUESTIONNAIRES ,LONGITUDINAL method - Abstract
Background: There is a need to test the fetal programming theoretical framework in nutritional epidemiology. We evaluated whether maternal seafood intake during pregnancy was associated with 8-year-old attention outcomes after adjusting for previous child seafood intake and cognitive function. We also explored effect modification by several single nucleotide polymorphisms (SNPs) related with polyunsaturated fatty acid (PUFA) metabolism.Methods: Our final analyses included 1644 mother-child pairs from the prospective INMA (INfancia y Medio Ambiente) cohort study (Spain, recruitment between 2003 and 2008). We used food frequency questionnaires to assess prenatal and postnatal seafood consumption of the mother-child pairs. We evaluated attention function of the children through the computer-based Attention Network Test (ANT) and we used the number of omission errors and the hit reaction time standard error (HRT-SE). Parents reported child attention deficit hyperactivity disorder (ADHD) symptoms using the Revised Conners' Parent Rating Scale Short Form (CPRS-R: S). We measured seven candidate SNPs in a subsample of 845 children. We estimated associations using regression models, adjusting for family characteristics, child seafood intake and cognitive functions at early ages, and to explore SNP effect modifications.Results: Higher total seafood intake during early pregnancy was associated with a reduction of child ANT omission errors, 5th quintile (median = 854 g/week) vs 1st quintile (median = 195 g/week), incidence risk ratio (IRR) 0.76; 95% CI = 0.61, 0.94. Similar results were observed after adjusting the models for child seafood intake and previous cognitive status. Lean, large and small fatty fish showed similar results, and generally similar but less robust associations were observed with the other attention outcomes. Shellfish and canned tuna showed weaker associations. The association patterns were weaker in late pregnancy and null in child seafood consumption. Child rs1260326 (glucokinase regulator, GCKR) and child/maternal rs2281591 (fatty acid elongase 2, ELOVL2) polymorphisms showed nominal P-value for interactions <0.10 between total seafood intake and ANT outcomes.Conclusions: After adjusting for previous child cognitive functions and child seafood intake, high pregnancy consumption (total, lean, small and large fatty fish) was independently associated with improvements of some 8-year-old attention outcomes. Genetic effect modification analyses suggest PUFA intake from seafood as a potential biological mechanism of such association. [ABSTRACT FROM AUTHOR]- Published
- 2020
- Full Text
- View/download PDF
37. The Association between Lifelong Greenspace Exposure and 3-Dimensional Brain Magnetic Resonance Imaging in Barcelona Schoolchildren
- Author
-
Dadvand, Payam, primary, Pujol, Jesus, additional, Macià, Dídac, additional, Martínez-Vilavella, Gerard, additional, Blanco-Hinojo, Laura, additional, Mortamais, Marion, additional, Alvarez-Pedrerol, Mar, additional, Fenoll, Raquel, additional, Esnaola, Mikel, additional, Dalmau-Bueno, Albert, additional, López-Vicente, Mónica, additional, Basagaña, Xavier, additional, Jerrett, Michael, additional, Nieuwenhuijsen, Mark J., additional, and Sunyer, Jordi, additional
- Published
- 2018
- Full Text
- View/download PDF
38. Heritability and genome-wide association analyses of sleep duration in children: The EAGLE Consortium
- Author
-
Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, Sunyer, Jordi, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Child and Adolescent Psychiatry / Psychology, Research Methods and Techniques, Epidemiology, Erasmus MC other, Pediatrics, Internal Medicine, Public Health, Psychiatry, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Amsterdam Cardiovascular Sciences, Amsterdam Public Health, Other Research, Public and occupational health, Epidemiology and Data Science, and Amsterdam Reproduction & Development (AR&D)
- Subjects
Male ,0301 basic medicine ,Time Factors ,Adolescent ,Sleep Duration/Sleep Quality ,Population ,Single-nucleotide polymorphism ,Genome-wide association study ,Polymorphism, Single Nucleotide ,White People ,SNP heritability ,Cohort Studies ,03 medical and health sciences ,Quantitative Trait, Heritable ,0302 clinical medicine ,030225 pediatrics ,Physiology (medical) ,Genetic variation ,Humans ,SNP ,Medicine ,Longitudinal Studies ,Child ,education ,education.field_of_study ,business.industry ,Excessive sleep ,Heritability ,genome-wide association study (GWAS) ,medicine.disease ,3. Good health ,pathway analysis ,meta-analysis ,030104 developmental biology ,Diabetes Mellitus, Type 2 ,Child, Preschool ,Meta-analysis ,Female ,Neurology (clinical) ,Sleep ,business ,childhood sleep duration ,Snp Heritability ,Genome-wide Association Study (gwas) ,Childhood Sleep Duration ,Pathway Analysis ,Genome-Wide Association Study ,Demography - Abstract
STUDY OBJECTIVES: Low or excessive sleep duration has been associated with multiple outcomes, but the biology behind these associations remains elusive. Specifically, genetic studies in children are scarce. In this study, we aimed to: (1) estimate the proportion of genetic variance of sleep duration in children attributed to common single nucleotide polymorphisms (SNPs), (2) identify novel SNPs associated with sleep duration in children, and (3) investigate the genetic overlap of sleep duration in children and related metabolic and psychiatric traits.METHODS: We performed a population-based molecular genetic study, using data form the EArly Genetics and Life course Epidemiology (EAGLE) Consortium. 10,554 children of European ancestry were included in the discovery, and 1,250 children in the replication phase.RESULTS: We found evidence of significant but modest SNP heritability of sleep duration in children (SNP h(2) 0.14, 95% CI [0.05, 0.23]) using the LD score regression method. A novel region at chromosome 11q13.4 (top SNP: rs74506765, P = 2.27e-08) was associated with sleep duration in children, but this was not replicated in independent studies. Nominally significant genetic overlap was only found (rG = 0.23, P = 0.05) between sleep duration in children and type 2 diabetes in adults, supporting the hypothesis of a common pathogenic mechanism.CONCLUSIONS: The significant SNP heritability of sleep duration in children and the suggestive genetic overlap with type 2 diabetes support the search for genetic mechanisms linking sleep duration in children to multiple outcomes in health and disease.
- Published
- 2016
39. A Longitudinal Study on Attention Development in Primary School Children with and without Teacher-Reported Symptoms of ADHD
- Author
-
Suades-González, Elisabet, primary, Forns, Joan, additional, García-Esteban, Raquel, additional, López-Vicente, Mónica, additional, Esnaola, Mikel, additional, Álvarez-Pedrerol, Mar, additional, Julvez, Jordi, additional, Cáceres, Alejandro, additional, Basagaña, Xavier, additional, López-Sala, Anna, additional, and Sunyer, Jordi, additional
- Published
- 2017
- Full Text
- View/download PDF
40. Heritability and Genome-Wide Association Analyses of Sleep Duration in Children: The EAGLE Consortium
- Author
-
LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, Sunyer, Jordi, LS IRAS EEPI EXAS (Arb.hyg+bl.st.kar.), dIRAS RA-2, Marinelli, Marcella, Pappa, Irene, Bustamante, Mariona, Bonilla, Carolina, Suarez, Anna, Tiesler, Carla M, Vilor-Tejedor, Natalia, Zafarmand, Mohammad Hadi, Alvarez-Pedrerol, Mar, Andersson, Sture, Bakermans-Kranenburg, Marian J, Estivill, Xavier, Evans, David M, Flexeder, Claudia, Fons, Joan, Gonzalez, Juan R, Guxens, Monica, Huss, Anke, van IJzendoorn, Marinus H, Jaddoe, Vincent W V, Julvez, Jordi, Lahti, Jari, López-Vicente, Mónica, Lopez-Espinosa, Maria-Jose, Manz, Judith, Mileva-Seitz, Viara R, Perola, Markus, Pesonen, Anu-Katriina, Rivadeneira, Fernando, Salo, Perttu P, Shahand, Shayan, Schulz, Holger, Standl, Marie, Thiering, Elisabeth, Timpson, Nicholas J, Torrent, Maties, Uitterlinden, André G, Smith, George Davey, Estarlich, Marisa, Heinrich, Joachim, Räikkönen, Katri, Vrijkotte, Tanja G M, Tiemeier, Henning, and Sunyer, Jordi
- Published
- 2016
41. Developmental Trajectories in Primary Schoolchildren Using n-Back Task
- Author
-
López-Vicente, Mónica, primary, Forns, Joan, additional, Suades-González, Elisabet, additional, Esnaola, Mikel, additional, García-Esteban, Raquel, additional, Álvarez-Pedrerol, Mar, additional, Júlvez, Jordi, additional, Burgaleta, Miguel, additional, Sebastián-Gallés, Núria, additional, and Sunyer, Jordi, additional
- Published
- 2016
- Full Text
- View/download PDF
42. Association between Traffic-Related Air Pollution in Schools and Cognitive Development in Primary School Children: A Prospective Cohort Study
- Author
-
European Research Council, Viana, Mar [0000-0002-4073-3802], Moreno, Teresa [0000-0003-3235-1027], Alastuey, Andrés [0000-0002-5453-5495], Querol, Xavier [0000-0002-6549-9899], Sunyer, J., Esnaola, Mikel, Álvarez-Pedrerol, Mar, Forns, Joan, Rivas, Ioar, López-Vicente, Mónica, Suades-González, Elisabet, Foraster, Maria, Basagaña, Xavier, Viana, Mar, Cirach, Marta, Moreno, Teresa, Alastuey, Andrés, Sebastián-Gallés, Núria, Querol, Xavier, European Research Council, Viana, Mar [0000-0002-4073-3802], Moreno, Teresa [0000-0003-3235-1027], Alastuey, Andrés [0000-0002-5453-5495], Querol, Xavier [0000-0002-6549-9899], Sunyer, J., Esnaola, Mikel, Álvarez-Pedrerol, Mar, Forns, Joan, Rivas, Ioar, López-Vicente, Mónica, Suades-González, Elisabet, Foraster, Maria, Basagaña, Xavier, Viana, Mar, Cirach, Marta, Moreno, Teresa, Alastuey, Andrés, Sebastián-Gallés, Núria, and Querol, Xavier
- Abstract
Air pollution is a suspected developmental neurotoxicant. Many schools are located in close proximity to busy roads, and traffic air pollution peaks when children are at school. We aimed to assess whether exposure of children in primary school to traffic-related air pollutants is associated with impaired cognitive development. We conducted a prospective study of children (n = 2,715, aged 7 to 10 y) from 39 schools in Barcelona (Catalonia, Spain) exposed to high and low traffic-related air pollution, paired by school socioeconomic index; children were tested four times (i.e., to assess the 12-mo developmental trajectories) via computerized tests (n = 10,112). Chronic traffic air pollution (elemental carbon [EC], nitrogen dioxide [NO2], and ultrafine particle number [UFP; 10–700 nm]) was measured twice during 1-wk campaigns both in the courtyard (outdoor) and inside the classroom (indoor) simultaneously in each school pair. Cognitive development was assessed with the n-back and the attentional network tests, in particular, working memory (two-back detectability), superior working memory (three-back detectability), and inattentiveness (hit reaction time standard error). Linear mixed effects models were adjusted for age, sex, maternal education, socioeconomic status, and air pollution exposure at home. Children from highly polluted schools had a smaller growth in cognitive development than children from the paired lowly polluted schools, both in crude and adjusted models (e.g., 7.4% [95% CI 5.6%–8.8%] versus 11.5% [95% CI 8.9%–12.5%] improvement in working memory, p = 0.0024). Cogently, children attending schools with higher levels of EC, NO2, and UFP both indoors and outdoors experienced substantially smaller growth in all the cognitive measurements; for example, a change from the first to the fourth quartile in indoor EC reduced the gain in working memory by 13.0% (95% CI 4.2%–23.1%). Residual confounding for social class could not be discarded completely; however, th
- Published
- 2015
43. Green and Blue Spaces and Behavioral Development in Barcelona Schoolchildren: The BREATHE Project
- Author
-
Amoly, Elmira, primary, Dadvand, Payam, additional, Forns, Joan, additional, López-Vicente, Mónica, additional, Basagaña, Xavier, additional, Julvez, Jordi, additional, Alvarez-Pedrerol, Mar, additional, Nieuwenhuijsen, Mark J., additional, and Sunyer, Jordi, additional
- Published
- 2014
- Full Text
- View/download PDF
44. Environment and Brain Development: Challenges in the Global Context
- Author
-
Julvez, Jordi, Paus, Tomas, Bellinger, David C, Eskenazi, Brenda, Tiemeier, Henning, Pearce, Neil, Ritz, Beate, White, Tonya, Ramchandani, Paul, Gispert, Juan, Desrivières, Sylvane, Brouwer, Rachel, Boucher, Olivier, Alemany, Silvia, López-Vicente, Mónica, Suades-González, Elisabeth, Forns, Joan, Grandjean, Philippe, and Sunyer, Jordi
- Published
- 2015
- Full Text
- View/download PDF
45. Physical activity, sedentary behaviour, and childhood asthma: a European collaborative analysis.
- Author
-
Eijkemans M, Mommers M, Harskamp-van Ginkel MW, Vrijkotte TGM, Ludvigsson J, Faresjö Å, Bergström A, Ekström S, Grote V, Koletzko B, Bønnelykke K, Eliasen AU, Bager P, Melbye M, Annesi-Maesano I, Baïz N, Barros H, Santos AC, Duijts L, Mensink-Bout SM, Flexeder C, Koletzko S, Schikowski T, Eggesbø MÅ, Lenters V, Fernández-Tardón G, Subiza-Perez M, Garcia-Aymerich J, López-Vicente M, Sunyer J, Torrent M, Ballester F, Kelleher C, Mehegan J, Berg AV, Herberth G, Standl M, Kuehni CE, Pedersen ESL, Jansen M, Gehring U, Boer JMA, Devereux G, Turner S, Peltola V, Lagström H, Inskip HM, Pike KC, Dalmeijer GW, Ent CKV, and Thijs C
- Subjects
- Humans, Child, Adolescent, Male, Child, Preschool, Europe epidemiology, Female, Infant, Accelerometry, Longitudinal Studies, Surveys and Questionnaires, Forced Expiratory Volume, Spirometry, Infant, Newborn, Vital Capacity, Birth Cohort, Asthma epidemiology, Asthma physiopathology, Sedentary Behavior, Exercise
- Abstract
Objectives: To investigate the associations of physical activity (PA) and sedentary behaviour in early childhood with asthma and reduced lung function in later childhood within a large collaborative study., Design: Pooling of longitudinal data from collaborating birth cohorts using meta-analysis of separate cohort-specific estimates and analysis of individual participant data of all cohorts combined., Setting: Children aged 0-18 years from 26 European birth cohorts., Participants: 136 071 individual children from 26 cohorts, with information on PA and/or sedentary behaviour in early childhood and asthma assessment in later childhood., Main Outcome Measure: Questionnaire-based current asthma and lung function measured by spirometry (forced expiratory volume in 1 s (FEV
1 ), FEV1 /forced vital capacity) at age 6-18 years., Results: Questionnaire-based and accelerometry-based PA and sedentary behaviour at age 3-5 years was not associated with asthma at age 6-18 years (PA in hours/day adjusted OR 1.01, 95% CI 0.98 to 1.04; sedentary behaviour in hours/day adjusted OR 1.03, 95% CI 0.99 to 1.07). PA was not associated with lung function at any age. Analyses of sedentary behaviour and lung function showed inconsistent results., Conclusions: Reduced PA and increased sedentary behaviour before 6 years of age were not associated with the presence of asthma later in childhood., Competing Interests: Competing interests: None declared., (© Author(s) (or their employer(s)) 2024. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.)- Published
- 2024
- Full Text
- View/download PDF
Catalog
Discovery Service for Jio Institute Digital Library
For full access to our library's resources, please sign in.