26 results on '"Laberge L"'
Search Results
2. Fatigue and daytime sleepiness rating scales in myotonic dystrophy: a study of reliability
- Author
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Laberge, L, Gagnon, C, Jean, S, and Mathieu, J
- Published
- 2005
Catalog
3. First-in-human application of the self-assembled skin substitute as permanent graft to treat burn patients: A case series of 14 patients indicating clinical effectiveness
- Author
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Germain, L., primary, Larouche, D., additional, Nedelec, B., additional, Perreault, I., additional, Duranceau, L., additional, Bortoluzzi, P., additional, Beaudoin Cloutier, C., additional, Genest, H., additional, Caouette-Laberge, L., additional, Dumas, A., additional, Bussière, A., additional, Boghossian, É., additional, Kanevsky, J., additional, Leclerc, Y., additional, Lee, J., additional, Auger, F.A., additional, and Moulin, V.J., additional more...
- Published
- 2018
- Full Text
- View/download PDF
4. Maternal smoking, genes and adolescent brain and body: The saguenay youth study
- Author
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Paus, T, Pausova, Z, Abrahamowicz, M, Almerigi, J, Arbour, N, Bernard, M, Gaudet, D, Hanzalek, P, Hamet, P, Evans, A, Kramer, M, Laberge, L, Leal, S, Leonard, G, Lerner, J, Lerner, R, Mathieu, J, Perron, M, Pike, B, Pitiot, A, Richer, L, Séguin, JR, Syme, C, Tremblay, R, and Veillette, S more...
- Published
- 2016
- Full Text
- View/download PDF
5. Detection of Tuberculosis in School Teachers in the Province of Quebec
- Author
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LABERGE, L.
- Published
- 1943
6. 338 - First-in-human application of the self-assembled skin substitute as permanent graft to treat burn patients: A case series of 14 patients indicating clinical effectiveness
- Author
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Germain, L., Larouche, D., Nedelec, B., Perreault, I., Duranceau, L., Bortoluzzi, P., Beaudoin Cloutier, C., Genest, H., Caouette-Laberge, L., Dumas, A., Bussière, A., Boghossian, É., Kanevsky, J., Leclerc, Y., Lee, J., Auger, F.A., and Moulin, V.J. more...
- Published
- 2018
- Full Text
- View/download PDF
7. Development and aetiology of body dissatisfaction in adolescent boys and girls
- Author
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Dion, J., Blackburn, M. E., Auclair, J., Laberge, L., Veillette, S., Gaudreault, M., Vachon, P., Perron, M., Touchette, E., Dion, J., Blackburn, M. E., Auclair, J., Laberge, L., Veillette, S., Gaudreault, M., Vachon, P., Perron, M., and Touchette, E. more...
- Abstract
This longitudinal study aims to describe the development of body dissatisfaction (BD), measured with the Contour Drawing Rating Scale, between the ages of 14 and 18, and to identify factors associated with BD at age 18, among 413 adolescents. Between the ages of 14 and 18, the proportion of girls wanting to be thinner increased, although it remained unchanged among boys. A ratio of 1:2 girls and 1:5 boys reported having seriously tried to lose weight. Factors associated with BD in girls at age 18 were (1) wanting to be thinner, (2) body mass index (BMI), (3) weight control behaviours and (4) negative comments about weight. Factors associated with BD in boys at age 18 were (1) wanting to be thinner or bigger, (2) BMI, (3) having experienced sexual intercourse and (4) negative comments about weight. The high prevalence of BD and weight-related concerns suggest a need for early interventions. © 2014 © 2014 The Author(s). Published by Taylor & Francis. more...
- Published
- 2015
8. Towards an integrative approach to the management of myotonic dystrophy type 1
- Author
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Gagnon, C., primary, Noreau, L., additional, Moxley, R. T, additional, Laberge, L., additional, Jean, S., additional, Richer, L., additional, Perron, M., additional, Veillette, S., additional, and Mathieu, J., additional more...
- Published
- 2007
- Full Text
- View/download PDF
9. The correlation of CTG repeat length with material and social deprivation in myotonic dystrophy
- Author
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Laberge, L, primary, Veillette, S, additional, Mathieu, J, additional, Auclair, J, additional, and Perron, M, additional
- Published
- 2006
- Full Text
- View/download PDF
10. The Destruction of Garbage
- Author
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Laberge, L.
- Subjects
Articles - Published
- 1887
11. Segmental Darier's disease: A case report.
- Author
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Pastukhova E and LaBerge L
- Abstract
Segmental Darier's disease is an uncommon subtype of Darier's genodermatosis, resulting from a mutation in the ATPase type 2 during early embryogenesis. It typically presents as a persistent, pruritic papular eruption following the lines of Blaschko. Histopathology of Darier's disease demonstrates acantholysis, dyskeratosis, and corps ronds. First-line treatment includes topical retinoids, calcineurin inhibitors, and synthetic vitamin D analogues. Severe disease may require systemic therapy with oral retinoids, immunomodulators, magnesium, and low-dose naltrexone. Segmental Darier's disease is important to recognize both clinically and histologically as it may resemble other acantholytic Blaschkolinear dermatoses and should be considered in individuals presenting with a chronic localized papular eruption in a Blaschkoid distribution. Herein, we present a case of a 48-year-old male with segmental Darier's disease who improved significantly following acitretin treatment., Competing Interests: The author(s) declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article., (© The Author(s) 2023.) more...
- Published
- 2023
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12. Autologous bilayered self-assembled skin substitutes (SASSs) as permanent grafts: a case series of 14 severely burned patients indicating clinical effectiveness.
- Author
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Germain L, Larouche D, Nedelec B, Perreault I, Duranceau L, Bortoluzzi P, Beaudoin Cloutier C, Genest H, Caouette-Laberge L, Dumas A, Bussière A, Boghossian E, Kanevsky J, Leclerc Y, Lee J, Nguyen MT, Bernier V, Knoppers BM, Moulin VJ, and Auger FA more...
- Subjects
- Adult, Burns pathology, Cell Survival, Elasticity, Epithelial Cells pathology, Female, Humans, Kaplan-Meier Estimate, Male, Transplantation, Autologous, Treatment Outcome, Burns therapy, Skin Transplantation, Skin, Artificial
- Abstract
Split-thickness skin autografts (AGs) are the standard surgical treatment for severe burn injuries. However, the treatment of patients with substantial skin loss is limited by the availability of donor sites for skin harvesting. As an alternative to skin autografts, our research group developed autologous self-assembled skin substitutes (SASSs), allowing the replacement of both dermis and epidermis in a single surgical procedure. The aim of the study was to assess the clinical outcome of the SASSs as a permanent coverage for full-thickness burn wounds. Patients were recruited through the Health Canada's Special Access Program. SASSs were grafted on debrided full-thickness wounds according to similar protocols used for AGs. The graft-take and the persistence of the SASS epithelium over time were evaluated. 14 patients received surgical care with SASSs. The mean percentage of the SASS graft-take was 98 % (standard deviation = 5) at 5 to 7 d after surgery. SASS integrity persisted over time (average follow-up time: 3.2 years), without noticeable deficiency in epidermal regeneration. Assessment of scar quality (skin elasticity, erythema, thickness) was performed on a subset of patients. Non-homogeneous pigmentation was noticed in several patients. These results indicated that the SASS allowed the successful coverage of full-thickness burns given its high graft-take, aesthetic outcome equivalent to autografting and the promotion of long-term tissue regeneration. When skin donor sites are in short supply, SASSs could be a valuable alternative to treat patients with full-thickness burns covering more than 50 % of their total body surface area. more...
- Published
- 2018
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13. Novel ELOVL4 mutation associated with erythrokeratodermia and spinocerebellar ataxia (SCA 34).
- Author
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Bourque PR, Warman-Chardon J, Lelli DA, LaBerge L, Kirshen C, Bradshaw SH, Hartley T, and Boycott KM
- Published
- 2018
- Full Text
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14. Sodium Fluorescein for Ureteral Jet Detection: A Prospective Observational Study.
- Author
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Lea D, Annie-Kim GL, Eve-Lyne L, Madeleine L, Marianne B, Sarah ML, Lucie D, and Philippe Y L
- Subjects
- Adult, Endometriosis surgery, Female, Humans, Hysterectomy methods, Intraoperative Complications etiology, Leiomyoma surgery, Middle Aged, Prospective Studies, Uterine Neoplasms surgery, Contrast Media, Cystoscopy, Fluorescein, Hysterectomy adverse effects, Intraoperative Complications diagnostic imaging, Ureter injuries
- Abstract
Background and Objectives: Laparoscopic hysterectomy poses the risk of lower urinary tract injury, and intraoperative recognition of urinary tract injury is often difficult. We sought to evaluate sodium fluorescein coloration of ureteral jets during cystoscopy after laparoscopic hysterectomy and to evaluate surgeons' satisfaction with this method of injury detection., Methods: This was an observational study, in which data were collected prospectively. A total of 30 women who underwent laparoscopic hysterectomy from August 2016 to February 2017 at the Centre Hospitalier de l'Université Laval (CHUL) de Québec. Twenty-five milligrams of 10% intravenous sodium fluorescein was administered after vaginal cuff closure. Cystoscopy was then systematically performed, and the time to visualization (time from injection to coloration of ureteral jet), the quality of coloration, and the duration of cystoscopy were recorded. Side effects were systematically recorded and rigorously analyzed., Results: Most frequent indications for hysterectomy were fibroids and endometriosis with uterine weight from 76 to 885 g. Ninety-three percent of patients (n = 28) had bilateral ureteral jet coloration, whereas 1 patient had no coloration bilaterally, and another patient had a complete unilateral obstruction immediately diagnosed and resolved intraoperatively after removal of the vaginal sutures. In 90% of cases (n = 27), surgeons were highly satisfied with the use of sodium fluorescein. The average time between visualization of both left and right ureteral jets was 1 minute. Side effects included hypotension (n = 3) and yellow coloration of urine (n = 15)., Conclusion: Our study suggests that sodium fluorescein is an effective dye for documenting ureteral patency and improving visualization of ureteral jets during cystoscopy upon completion of laparoscopic hysterectomy. more...
- Published
- 2018
- Full Text
- View/download PDF
15. Congenital malformations and medical conditions associated with orofacial clefts in children in Burkina Faso.
- Author
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Nagalo K, Ouédraogo I, Laberge JM, Caouette-Laberge L, and Turgeon J
- Subjects
- Adolescent, Burkina Faso epidemiology, Child, Child, Preschool, Female, Humans, Infant, Infant, Newborn, Male, Retrospective Studies, Syndrome, Abnormalities, Multiple epidemiology, Cleft Lip epidemiology, Cleft Palate epidemiology
- Abstract
Background: Orofacial clefts are usually isolated cases but can be associated with other congenital malformations that are either recognised or unrecognised syndromes. The reported prevalence and pattern of such associated malformations, however, vary among studies., Objectives: To assess the frequencies and aetiologies of congenital malformations and associated medical conditions in children with orofacial clefts in Burkina Faso (Western Africa)., Methods: A retrospective descriptive study was carried out at the El Fateh-Suka Clinic in Ouagadougou, Burkina Faso. All children who attended surgery for the repair of a cleft lip and/or palate were included in this study., Results: The frequency of congenital malformations associated with cleft lip and/or palate was 39/185 (21.1%). In the group with multiple congenital malformations of unknown origin (34 patients; 18.4%), 66.7% had cleft lip and palate, followed by isolated cleft lip (27.4%) and isolated cleft palate (5.9%). The digestive system (35.3%), the musculoskeletal system (19.6%), and eye, ear, face, and neck (15.7%) were the most affected systems. In the group of syndromic malformations (five patients; 2.7%), amniotic band syndrome (one patient), Van der Woode syndrome (one patient), Goltz syndrome (one patient), and holoprosencephaly (two patients) were identified. Medical conditions included anaemia (39.4%), infections (9.2%), malnutrition (7.5%), and haemoglobinopathies (4.3%)., Conclusions: Congenital malformations and medical co-morbidities were frequent in children with OFCs. Further studies and a National Malformations Registry are needed to improve the comprehension of OFCs in Burkina Faso. more...
- Published
- 2017
- Full Text
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16. Prevalence and correlates of apathy in myotonic dystrophy type 1.
- Author
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Gallais B, Montreuil M, Gargiulo M, Eymard B, Gagnon C, and Laberge L
- Subjects
- Adolescent, Adult, Aged, Anxiety epidemiology, Anxiety psychology, Case-Control Studies, Cognition, Cognition Disorders psychology, Depression epidemiology, Depression psychology, Fatigue epidemiology, Fatigue psychology, Female, France, Humans, Linear Models, Male, Middle Aged, Muscular Dystrophy, Facioscapulohumeral epidemiology, Muscular Dystrophy, Facioscapulohumeral psychology, Myotonic Dystrophy psychology, Phenotype, Prevalence, Severity of Illness Index, Young Adult, Apathy, Cognition Disorders epidemiology, Myotonic Dystrophy epidemiology
- Abstract
Background: Apathy in DM1 has long been acknowledged in clinical practice. However, a major drawback is that the concept has been only sparsely explored in previous specific studies. This study aimed to determine the prevalence of apathy in myotonic dystrophy (DM1), to compare it with facioscapulohumeral dystrophy (FSHD) patients and normal healthy controls, and explore its relationship to psychopathological features and cognitive function., Methods: Levels of apathy in 38 DM1 patients with adult phenotypes were compared with 19 patients with FSHD and 20 matched controls. Patient participants were consecutively recruited, regarding their interdisciplinary annual evaluation at the neuromuscular pathology reference center (Institute of Myology, Paris, France), within an 18-month period. Additional measurements included motor disability, fatigue, depression, anxiety, and cognitive abilities. Inter-group comparisons were performed using non-parametric Kruskal-Wallis tests and Mann-Whitney U Tests. Intra-group comparisons were carried out with the Wilcoxon Signed rank and Friedman tests. Also, Spearman's correlations were used to assess the strength of linear relationships between pairs of variables. The significance level was set at 0.05., Results: Global score of apathy was significantly higher in DM1 patients than in FSHD patients (p < 0.01) and in controls (p < 0.001). Sixteen of 38 DM1 patients (39.5 %) met the criterion for apathy, contrasting with only 4 of the 19 (21.1 %) FSHD patients. No control subject was apathetic. Moreover, apathy in DM1 patients was negatively correlated to MMSE (r = -.46, p < .05) and Stroop Word (r = -.55, p < .01) scores, but not with age, educational level, disease duration, CTG repeats, motor functional disability, fatigue, depression, and anxiety., Conclusions: Apathy is a frequent symptom in DM1 (almost 40 %). It is more prevalent than in a similarly disabled group of patients with FSHD and in controls. Results also show that apathy in DM1 is independent of the psychopathological domain, fatigue, age, and motor disability, but associated to general cognitive status. These results altogether could suggest a central cause for apathy in DM1 rather than an adjustment process to cope with the progressive and debilitating nature of the disease. Data emphasize the importance to evaluate this symptom in routine clinical management of DM1 patients. more...
- Published
- 2015
- Full Text
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17. Development and aetiology of body dissatisfaction in adolescent boys and girls.
- Author
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Dion J, Blackburn ME, Auclair J, Laberge L, Veillette S, Gaudreault M, Vachon P, Perron M, and Touchette É
- Abstract
This longitudinal study aims to describe the development of body dissatisfaction (BD), measured with the Contour Drawing Rating Scale, between the ages of 14 and 18, and to identify factors associated with BD at age 18, among 413 adolescents. Between the ages of 14 and 18, the proportion of girls wanting to be thinner increased, although it remained unchanged among boys. A ratio of 1:2 girls and 1:5 boys reported having seriously tried to lose weight. Factors associated with BD in girls at age 18 were (1) wanting to be thinner, (2) body mass index (BMI), (3) weight control behaviours and (4) negative comments about weight. Factors associated with BD in boys at age 18 were (1) wanting to be thinner or bigger, (2) BMI, (3) having experienced sexual intercourse and (4) negative comments about weight. The high prevalence of BD and weight-related concerns suggest a need for early interventions. more...
- Published
- 2015
- Full Text
- View/download PDF
18. Comparisons of intellectual capacities between mild and classic adult-onset phenotypes of myotonic dystrophy type 1 (DM1).
- Author
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Jean S, Richer L, Laberge L, and Mathieu J
- Subjects
- Adult, Aged, Aged, 80 and over, Cohort Studies, Female, Humans, Intellectual Disability epidemiology, Male, Middle Aged, Myotonic Dystrophy epidemiology, Wechsler Scales standards, Young Adult, Intellectual Disability diagnosis, Intellectual Disability psychology, Intelligence, Myotonic Dystrophy diagnosis, Myotonic Dystrophy psychology, Phenotype
- Abstract
Background: Myotonic dystrophy type 1 (DM1) is an autosomal dominant genetic multisystem disorder and the commonest adult-onset form of muscular dystrophy. DM1 results from the expansion of an unstable trinucleotide cytosine-thymine-guanine (CTG) repeat mutation. CTG repeats in DM1 patients can range from 50 to several thousands, with a tendency toward increased repeats with successive generations (anticipation). Associated findings can include involvements in almost every systems, including the brain, and cognitive abnormalities occur in the large majority of patients. The objectives are to describe and compare the intellectual abilities of a large sample of DM1 patients with mild and classic adult-onset phenotypes, to estimate the validity of the Wechsler Adult Intelligence Scale-Revised (WAIS-R) in DM1 patients with muscular weakness, and to appraise the relationship of intelligence quotient (IQ) to CTG repeat length, age at onset of symptoms, and disease duration., Methods: A seven-subtest WAIS-R was administered to 37 mild and 151 classic adult-onset DM1 patients to measure their Full-Scale (FSIQ), Verbal (VIQ) and Performance IQ (PIQ). To control for potential bias due to muscular weakness, Standard Progressive Matrices (SPM), a motor-independent test of intelligence, were also completed., Results: Total mean FSIQ was 82.6 corresponding to low average IQ, and 82% were below an average intelligence. Mild DM1 patients had a higher mean FSIQ (U=88.7 vs 81.1, p<0.001), VIQ (U=87.8 vs 82.3, p=0.001), and PIQ (U=94.8 vs 83.6, p<0.001) than classic adult-onset DM1 patients. In both mild and classic adult-onset patients, all subtests mean scaled scores were below the normative sample mean. FSIQ also strongly correlate with SPM (r s =0.67, p<0.001), indicating that low intelligence scores are not a consequence of motor impairment. FSIQ scores decreased with both the increase of (CTG)n (r s =-0.41, p<0.001) and disease duration (r s =-0.26, p=0.003)., Conclusions: Results show that intellectual impairment is an extremely common and important feature in DM1, not only among the classic adult-onset patients but also among the least severe forms of DM1, with low IQ scores compared to general reference population. Health care providers involved in the follow-up of these patients should be aware of their intellectual capacities and should adapt their interventions accordingly. more...
- Published
- 2014
- Full Text
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19. Employment and work safety among 12 to 14 year olds: listening to parents.
- Author
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Usher AM, Breslin C, MacEachen E, Koehoorn M, Laberge M, Laberge L, Ledoux É, and Wong I
- Subjects
- Adolescent, Adult, Attitude, Canada, Female, Focus Groups, Humans, Male, Middle Aged, North America, Occupational Injuries prevention & control, Parent-Child Relations, Risk, Socioeconomic Factors, Trust, Employment statistics & numerical data, Occupational Health, Parents psychology, Safety, Workplace statistics & numerical data
- Abstract
Background: Survey research indicates that a surprising number of 12 to 14 year olds in North America engage in some form of paid work, and work-related injuries for this age group are reported at rates similar to older teens. Parents exhibit significant involvement in many aspects of their teens' work and may influence perceptions of work safety, yet few studies have explored this phenomenon from a qualitative perspective with parents of working 12 to 14 year olds., Methods: This paper focuses on parental perceptions and understandings of work safety based on focus groups conducted with urban Canadian parents of young teens who work for pay. Parents discussed the types of job held by their 12 to 14 year olds, the perceived costs and benefits to working at this age, and their understanding of risk and supervision on the job. A grounded theory approach was used to thematically analyze the focus group transcripts., Results: Parents in this study held favourable attitudes towards their 12 to 14 year olds' working. Parents linked pro-social moral values and skills such as responsibility, work ethic, time management, and financial literacy with their young teen's employment experience. Risks and drawbacks were generally downplayed or discounted. Perceptions of workplace safety were mitigated by themes of trust, familiarity, sense of being in control and having discretion over their 12 to 14 year olds' work situation. Further, parental supervision and monitoring fell along a continuum, from full parental responsibility for monitoring to complete trust and delegation of supervision to the workplace., Conclusions: The findings suggest that positive parental attitudes towards working overshadow occupational health and safety concerns. Parents may discount potential hazards based on the presence of certain mitigating factors. more...
- Published
- 2014
- Full Text
- View/download PDF
20. Donor-site morbidity of the inferior gluteal artery perforator flap for breast reconstruction in teenagers.
- Author
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Godbout E, Farmer L, Bortoluzzi P, and Caouette Laberge L
- Abstract
Background/objective: Few options, apart from the buttock area, are available for autologous breast reconstruction in thin teenagers. The aim of the present study was to objectively evaluate and compare donor-site morbidity of the inferior gluteal artery perforator (IGAP) flap with that of the previously described inferior gluteal musculocutaneous flap., Method: A retrospective review of all IGAP flaps for breast reconstruction performed in teenagers between June 2006 and April 2011 at the Centre Hospitalier Universitaire Sainte-Justine, Montreal, Quebec, was performed. Patients were invited to undergo a specific physical evaluation and complete a questionnaire on aesthetic and functional outcomes., Results: Thirteen records and 11 photographic charts were reviewed. Lateral buttock flattening was noticeable in nine of 11 cases. Three patients experienced some degree of inferior displacement of the gluteal crease. All six patients available for the appointment presented with a zone of dysesthesia or hypoesthesia in the territory of the operated buttock and/or posterior thigh. No motor impairment was found. The questionnaire, completed by eight patients, revealed that six were satisfied or very satisfied with the surgery. Appearance of the operated buttock was rated 3.4 on a scale from 1 to 5 (5 = normal) compared with the normal side., Conclusions: The IGAP flap remains a suitable option for breast reconstruction in slim teenagers. Similar to the myocutaneous flap, the major donor-site morbidity of the IGAP flap remains sensory impairment involving the posterior femoral cutaneous nerve. There is, however, less visible lateral depression when it is harvested as a perforator flap. more...
- Published
- 2013
- Full Text
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21. Congenital anomalies of the breast.
- Author
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Caouette-Laberge L and Borsuk D
- Abstract
Poland syndrome is a combination of chest wall deformity and absent or hypoplastic pectoralis muscle and breast associated with shortening and brachysyndactyly of the upper limb. Clinical presentation varies widely; therefore, reconstructive procedures have to be adapted to the deformity, ranging from chest wall stabilization or augmentation, dynamic muscle transfer, nipple and areola repositioning, and breast augmentation using prosthesis or autologous tissue transfer. Other congenital breast anomalies include supernumerary nipple and areola (polythelia) and breast (polymastia), which can generally be found on the embryonic mammary ridge. Absence of the nipple, areola (athelia), or the breast tissue (amastia) is less frequent. more...
- Published
- 2013
- Full Text
- View/download PDF
22. Genes, maternal smoking, and the offspring brain and body during adolescence: design of the Saguenay Youth Study.
- Author
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Pausova Z, Paus T, Abrahamowicz M, Almerigi J, Arbour N, Bernard M, Gaudet D, Hanzalek P, Hamet P, Evans AC, Kramer M, Laberge L, Leal SM, Leonard G, Lerner J, Lerner RM, Mathieu J, Perron M, Pike B, Pitiot A, Richer L, Séguin JR, Syme C, Toro R, Tremblay RE, Veillette S, and Watkins K more...
- Subjects
- Adolescent, Blood Pressure physiology, Case-Control Studies, Child, Cross-Sectional Studies, Fatty Acids metabolism, Female, Health Surveys, Heart Rate physiology, Humans, Kidney physiology, Magnetic Resonance Imaging, Male, Neuropsychological Tests, Pregnancy, Retrospective Studies, Brain anatomy & histology, Brain physiology, Brain Mapping, Family, Human Body, Maternal Behavior psychology, Smoking physiopathology
- Abstract
The search for genes of complex traits is aided by the availability of multiple quantitative phenotypes collected in geographically isolated populations. Here we provide rationale for a large-scale study of gene-environment interactions influencing brain and behavior and cardiovascular and metabolic health in adolescence, namely the Saguenay Youth Study (SYS). The SYS is a retrospective study of long-term consequences of prenatal exposure to maternal cigarette smoking (PEMCS) in which multiple quantitative phenotypes are acquired over five sessions (telephone interview, home, hospital, laboratory, and school). To facilitate the search for genes that modify an individual's response to an in utero environment (i.e. PEMCS), the study is family-based (adolescent sibships) and is carried out in a relatively geographically isolated population of the Saguenay Lac-Saint-Jean (SLSJ) region in Quebec, Canada. DNA is acquired in both biological parents and in adolescent siblings. A genome-wide scan will be carried out with sib-pair linkage analyses, and fine mapping of identified loci will be done with family-based association analyses. Adolescent sibships (12-18 years of age; two or more siblings per family) are recruited in high schools throughout the SLSJ region; only children of French-Canadian origin are included. Based on a telephone interview, potential participants are classified as exposed or nonexposed prenatally to maternal cigarette smoking; the two groups are matched for the level of maternal education and the attended school. A total of 500 adolescent participants in each group will be recruited and phenotyped. The following types of datasets are collected in all adolescent participants: (1) magnetic resonance images of brain, abdominal fat, and kidneys, (2) standardized and computer-based neuropsychological tests, (3) hospital-based cardiovascular, body-composition and metabolic assessments, and (4) questionnaire-derived measures (e.g. life habits such as eating and physical activity; drug, alcohol use and delinquency; psychiatric symptoms; personality; home and school environment; academic and vocational attitudes). Parents complete a medical questionnaire, home-environment questionnaire, a handedness questionnaire, and a questionnaire about their current alcohol and drug use, depression, anxiety, and current and past antisocial behavior. To date, we have fully phenotyped a total of 408 adolescent participants. Here we provide the description of the SYS and, using the initial sample, we present information on ascertainment, demographics of the exposed and nonexposed adolescents and their parents, and the initial MRI-based assessment of familiality in the brain size and the volumes of grey and white matter., ((c) 2007 Wiley-Liss, Inc.) more...
- Published
- 2007
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23. Normal human Merkel cells are present in epidermal cell populations isolated and cultured from glabrous and hairy skin sites.
- Author
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Fradette J, Larouche D, Fugère C, Guignard R, Beauparlant A, Couture V, Caouette-Laberge L, Roy A, and Germain L
- Subjects
- Adult, Cell Count, Cell Separation, Cells, Cultured, Hair Follicle, Humans, In Vitro Techniques, Infant, Keratinocytes cytology, Epidermal Cells, Epidermis innervation, Merkel Cells cytology
- Abstract
The Merkel cell is a highly specialized cell that primarily acts as a slowly adapting mechanoreceptor. Merkel cells are scarce in normal skin but can be identified by the expression of distinct keratin filaments. Merkel cells constitute a very unique population and many questions still remain as to their origin, number, proliferative capacity, and functions in cutaneous biology. The dissociation of epidermal cells from skin is a widely used technique to extract and culture keratinocytes. We took advantage of a two-step extraction method to quantify keratin-20-expressing Merkel cells among total cutaneous cells obtained from either hairy or glabrous skin biopsies. Flow cytometry analysis revealed that keratin-20-labeled Merkel cells represent between 3.6% and 5.7% of freshly dissociated basal epidermal cells. No significant differences were seen between samples derived from glabrous palmar and hairy anatomic sites, from children and adult, respectively. We also report on the presence of Merkel cells in primary and first subcultures of epidermal cells indicating their capacity to remain viable after extraction from skin of various anatomic sites. To our knowledge, this is the first demonstration of nontumorigenic human Merkel cells in culture in vitro. The persistence of a small number of Merkel cells in culture suggests that, with the development of appropriate culture conditions, these cells could be amplified and further studied to unravel long-standing questions relative to their paracrine function or epithelial origin. more...
- Published
- 2003
- Full Text
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24. Imaging of hemangiomas and vascular malformations in children.
- Author
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Dubois J, Garel L, Grignon A, David M, Laberge L, Filiatrault D, and Powell J
- Subjects
- Arteriovenous Malformations diagnostic imaging, Arteriovenous Malformations therapy, Child, Diagnosis, Differential, Female, Hemangioma diagnostic imaging, Hemangioma therapy, Humans, Infant, Infant, Newborn, Lymphangioma diagnosis, Lymphangioma diagnostic imaging, Magnetic Resonance Angiography, Magnetic Resonance Imaging, Male, Tomography, X-Ray Computed, Ultrasonography, Doppler, Veins abnormalities, Arteriovenous Malformations diagnosis, Diagnostic Imaging, Hemangioma diagnosis
- Published
- 1998
- Full Text
- View/download PDF
25. The Present State of Sanitation in Montreal.
- Author
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Laberge L
- Published
- 1894
26. The Destruction of Garbage.
- Author
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Laberge L
- Published
- 1887
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