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3 results on '"Lara Maleyeff"'

1. Association of genetic and sulcal traits with executive function in congenital heart disease

Author

Lara Maleyeff, Jane W. Newburger, David Wypij, Nina H. Thomas, Evdokia Anagnoustou, Martina Brueckner, Wendy K. Chung, John Cleveland, Sean Cunningham, Bruce D. Gelb, Elizabeth Goldmuntz, Donald J Hagler Jr, Hao Huang, Eileen King, Patrick McQuillen, Thomas A. Miller, Ami Norris‐Brilliant, George A. Porter Jr, Amy E. Roberts, P. Ellen Grant, Kiho Im, and Sarah U. Morton

Subjects
Neurosciences. Biological psychiatry. Neuropsychiatry, RC321-571, Neurology. Diseases of the nervous system, RC346-429
Abstract

Abstract Objective Persons with congenital heart disease (CHD) are at increased risk of neurodevelopmental disabilities, including impairments to executive function. Sulcal pattern features correlate with executive function in adolescents with single‐ventricle heart disease and tetralogy of Fallot. However, the interaction of sulcal pattern features with genetic and participant factors in predicting executive dysfunction is unknown. Methods We studied sulcal pattern features, participant factors, and genetic risk for executive function impairment in a cohort with multiple CHD types using stepwise linear regression and machine learning. Results Genetic factors, including predicted damaging de novo or rare inherited variants in neurodevelopmental disabilities risk genes, apolipoprotein E genotype, and principal components of sulcal pattern features were associated with executive function measures after adjusting for age at testing, sex, mother's education, and biventricular versus single‐ventricle CHD in a linear regression model. Using regression trees and bootstrap validation, younger participant age and larger alterations in sulcal pattern features were consistently identified as important predictors of decreased cognitive flexibility with left hemisphere graph topology often selected as the most important predictor. Inclusion of both sulcal pattern and genetic factors improved model fit compared to either alone. Interpretation We conclude that sulcal measures remain important predictors of cognitive flexibility, and the model predicting executive outcomes is improved by inclusion of potential genetic sources of neurodevelopmental risk. If confirmed, measures of sulcal patterning may serve as early imaging biomarkers to identify those at heightened risk for future neurodevelopmental disabilities.

Published
2024
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2. Abnormal Right-Hemispheric Sulcal Patterns Correlate with Executive Function in Adolescents with Tetralogy of Fallot

Author

Michael J. Rivkin, Caitlin K. Rollins, Lara Maleyeff, Sarah U. Morton, David Wypij, David C. Bellinger, Jane W. Newburger, P. Ellen Grant, Amy E. Roberts, Christopher G. Watson, Hyuk Jin Yun, and Kiho Im

Subjects
Adult, Heart Defects, Congenital, Male, medicine.medical_specialty, Heart disease, Adolescent, Cognitive Neuroscience, Developmental Disabilities, Pattern analysis, 030204 cardiovascular system & hematology, Neuropsychological Tests, 03 medical and health sciences, Cellular and Molecular Neuroscience, Executive Function, Young Adult, 0302 clinical medicine, Internal medicine, medicine, Humans, In patient, Brain magnetic resonance imaging, Child, Tetralogy of Fallot, Cerebral Cortex, medicine.diagnostic_test, business.industry, Brain, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Case-Control Studies, Cardiology, Female, Original Article, Neuropsychological testing, business, 030217 neurology & neurosurgery
Abstract

Neurodevelopmental disabilities are the most common noncardiac conditions in patients with congenital heart disease (CHD). Executive function skills have been frequently observed to be decreased among children and adults with CHD compared with peers, but a neuroanatomical basis for the association is yet to be identified. In this study, we quantified sulcal pattern features from brain magnetic resonance imaging data obtained during adolescence among 41 participants with tetralogy of Fallot (ToF) and 49 control participants using a graph-based pattern analysis technique. Among patients with ToF, right-hemispheric sulcal pattern similarity to the control group was decreased (0.7514 vs. 0.7553, P = 0.01) and positively correlated with neuropsychological testing values including executive function (r = 0.48, P

Published
2020

3. Abnormal Left-Hemispheric Sulcal Patterns Correlate with Neurodevelopmental Outcomes in Subjects with Single Ventricular Congenital Heart Disease

Author

Jane W. Newburger, Michael J. Rivkin, Kiho Im, Lara Maleyeff, David Wypij, Hyuk Jin Yun, Jonathan G. Seidman, David C. Bellinger, Sarah U. Morton, P. Ellen Grant, Amy E. Roberts, and Christine E. Seidman

Subjects
Heart Defects, Congenital, Male, medicine.medical_specialty, Brain development, Heart disease, Adolescent, Cognitive Neuroscience, Neuropsychological Tests, Lateralization of brain function, Cellular and Molecular Neuroscience, Internal medicine, medicine, Humans, Exome, Cerebrum, medicine.diagnostic_test, business.industry, Working memory, Magnetic resonance imaging, medicine.disease, Magnetic Resonance Imaging, Teratology, stomatognathic diseases, medicine.anatomical_structure, Ventricle, Neurodevelopmental Disorders, Cardiology, Female, Original Article, business
Abstract

Neurodevelopmental abnormalities are the most common noncardiac complications in patients with congenital heart disease (CHD). Prenatal brain abnormalities may be due to reduced oxygenation, genetic factors, or less commonly, teratogens. Understanding the contribution of these factors is essential to improve outcomes. Because primary sulcal patterns are prenatally determined and under strong genetic control, we hypothesized that they are influenced by genetic variants in CHD. In this study, we reveal significant alterations in sulcal patterns among subjects with single ventricle CHD (n = 115, 14.7 ± 2.9 years [mean ± standard deviation]) compared with controls (n = 45, 15.5 ± 2.4 years) using a graph-based pattern-analysis technique. Among patients with CHD, the left hemisphere demonstrated decreased sulcal pattern similarity to controls in the left temporal and parietal lobes, as well as the bilateral frontal lobes. Temporal and parietal lobes demonstrated an abnormally asymmetric left–right pattern of sulcal basin area in CHD subjects. Sulcal pattern similarity to control was positively correlated with working memory, processing speed, and executive function. Exome analysis identified damaging de novo variants only in CHD subjects with more atypical sulcal patterns. Together, these findings suggest that sulcal pattern analysis may be useful in characterizing genetically influenced, atypical early brain development and neurodevelopmental risk in subjects with CHD.

Published
2018

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