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1. DNA methylation changes are a late event in acute promyelocytic leukemia and coincide with loss of transcription factor binding

Author

Schoofs, Till, Rohde, Christian, Hebestreit, Katja, Klein, Hans-Ulrich, Göllner, Stefanie, Schulze, Isabell, Lerdrup, Mads, Dietrich, Nikolaj, Agrawal-Singh, Shuchi, Witten, Anika, Stoll, Monika, Lengfelder, Eva, Hofmann, Wolf-Karsten, Schlenke, Peter, Büchner, Thomas, Hansen, Klaus, Berdel, Wolfgang E., Rosenbauer, Frank, Dugas, Martin, and Müller-Tidow, Carsten

Published
2013
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5. Rituximab Maintenance Versus Observation After Immunochemotherapy (R-CHOP, R-MCP, and R-FCM) in Untreated Follicular Lymphoma Patients: A Randomized Trial of the Ostdeutsche Studiengruppe Hämatologie und Onkologie and the German Low-Grade Lymphoma Study Group

Author

Hirt, Carsten, primary, Hoster, Eva, additional, Unterhalt, Michael, additional, Hänel, Mathias, additional, Prange-Krex, Gabriele, additional, Forstpointner, Roswitha, additional, Florschütz, Axel, additional, Graeven, Ullrich, additional, Frickhofen, Norbert, additional, Wulf, Gerald, additional, Lengfelder, Eva, additional, Lerchenmüller, Christian, additional, Schlag, Rudolf, additional, Dierlamm, Judith, additional, Fischer von Weikersthal, Ludwig, additional, Ahmed, Asima, additional, Harich, Hanns-Detlev, additional, Rosenwald, Andreas, additional, Klapper, Wolfram, additional, Dreyling, Martin, additional, Hiddemann, Wolfgang, additional, and Herold, Michael, additional

Published
2021
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6. Publisher Correction : Outcome of older (≥70 years) APL patients frontline treated with or without arsenic trioxide-an International Collaborative Study

Author

Kayser, Sabine, Rahmé, Ramy, Martínez-Cuadrón, David, Ghiaur, Gabriel, Thomas, Xavier, Guerci-Bresler, Agnes, Garrido, Ana, Pigneux, Arnaud, Gil, Cristina, Raffoux, Emmanuel, Tormo, Mar, Vey, Norbert, de la Serna, Javier, Salamero, Olga, Lengfelder, Eva, Levis, Mark, Fenaux, Pierre, Sanz, Miguel A., Platzbecker, Uwe, Schlenk, Richard F., Adès, Lionel, Montesinos, Pau, Universitat Autònoma de Barcelona, Kayser, Sabine, Rahmé, Ramy, Martínez-Cuadrón, David, Ghiaur, Gabriel, Thomas, Xavier, Guerci-Bresler, Agnes, Garrido, Ana, Pigneux, Arnaud, Gil, Cristina, Raffoux, Emmanuel, Tormo, Mar, Vey, Norbert, de la Serna, Javier, Salamero, Olga, Lengfelder, Eva, Levis, Mark, Fenaux, Pierre, Sanz, Miguel A., Platzbecker, Uwe, Schlenk, Richard F., Adès, Lionel, Montesinos, Pau, and Universitat Autònoma de Barcelona

Published
2021

7. Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide: an international collaborative study

Author

Kayser, Sabine, primary, Schlenk, Richard F., additional, Lebon, Delphine, additional, Carre, Martin, additional, Götze, Katharina S., additional, Stölzel, Friedrich, additional, Berceanu, Ana, additional, Schäfer-Eckart, Kerstin, additional, Peterlin, Pierre, additional, Hicheri, Yosr, additional, Rahme, Ramy, additional, Raffoux, Emmanuel, additional, Chermat, Fatiha, additional, Krause, Stefan W., additional, Aulitzky, Walter E., additional, Rigaudeau, Sophie, additional, Noppeney, Richard, additional, Berthon, Celine, additional, Görner, Martin, additional, Jost, Edgar, additional, Carassou, Philippe, additional, Keller, Ulrich, additional, Orvain, Corentin, additional, Braun, Thorsten, additional, Saillard, Colombe, additional, Arar, Ali, additional, Kunzmann, Volker, additional, Wemeau, Mathieu, additional, De Wit, Maike, additional, Niemann, Dirk, additional, Bonmati, Caroline, additional, Schwänen, Carsten, additional, Abraham, Julie, additional, Aljijakli, Ahmad, additional, Haiat, Stephanie, additional, Krämer, Alwin, additional, Reichle, Albrecht, additional, Gnadler, Martina, additional, Willekens, Christophe, additional, Spiekermann, Karsten, additional, Hiddemann, Wolfgang, additional, Müller-Tidow, Carsten, additional, Thiede, Christian, additional, Röllig, Christoph, additional, Serve, Hubert, additional, Bornhäuser, Martin, additional, Baldus, Claudia D., additional, Lengfelder, Eva, additional, Fenaux, Pierre, additional, Platzbecker, Uwe, additional, and Adès, Lionel, additional

Published
2021
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8. Characteristics and outcome of patients with low-/intermediate-risk acute promyelocytic leukemia treated with arsenic trioxide - an international collaborative study

Author

Kayser, Sabine, Schlenk, Richard F., Lebon, Delphine, Carre, Martin, Götze, Katharina S., Stölzel, Friedrich, Berceanu, Ana, Schäfer-Eckart, Kerstin, Peterlin, Pierre, Hicheri, Yosr, Rahme, Ramy, Raffoux, Emmanuel, Chermat, Fatiha, Krause, Stefan W., Aulitzky, Walter E., Rigaudeau, Sophie, Noppeney, Richard, Berthon, Celine, Görner, Martin, Jost, Edgar, Carassou, Philippe, Keller, Ulrich, Orvain, Corentin, Braun, Thorsten, Saillard, Colombe, Arar, Ali, Kunzmann, Volker, Wemeau, Mathieu, De Wit, Maike, Niemann, Dirk, Bonmati, Caroline, Schwänen, Carsten, Abraham, Julie, Aljijakli, Ahmad, Haiat, Stephanie, Krämer, Alwin, Reichle, Albrecht, Gnadler, Martina, Willekens, Christophe, Spiekermann, Karsten, Hiddemann, Wolfgang, Müller-Tidow, Carsten, Thiede, Christian, Röllig, Christoph, Serve, Hubert, Bornhäuser, Martin, Baldus, Claudia D., Lengfelder, Eva, Fenaux, Pierre, Platzbecker, Uwe, and Adès, Lionel

Subjects
ddc
Published
2020

9. Four versus six cycles of CHOP chemotherapy in combination with six applications of rituximab in patients with aggressive B-cell lymphoma with favourable prognosis (FLYER): a randomised, phase 3, non-inferiority trial

Author

Poeschel, Viola, Held, Gerhard, Ziepert, Marita, Witzens-Harig, Mathias, Holte, Harald, Thurner, Lorenz, Borchmann, Peter, Viardot, Andreas, Soekler, Martin, Keller, Ulrich, Schmidt, Christian, Truemper, Lorenz, Mahlberg, Rolf, Marks, Reinhard, Hoeffkes, Heinz-Gert, Metzner, Bernd, Dierlamm, Judith, Frickhofen, Norbert, Haenel, Mathias, Neubauer, Andreas, Kneba, Michael, Merli, Francesco, Tucci, Alessandra, Brown, Peter de Nully, Federico, Massimo, Lengfelder, Eva, di Rocco, Alice, Trappe, Ralf, Rosenwald, Andreas, Berdel, Christian, Maisenhoelder, Martin, Shpilberg, Ofer, Amam, Josif, Christofyllakis, Konstantinos, Hartmann, Frank, Murawski, Niels, Stilgenbauer, Stephan, Nickelsen, Maike, Wulf, Gerald, Glass, Bertram, Schmitz, Norbert, Altmann, Bettina, Loeffler, Markus, Pfreundschuh, Michael, Poeschel, Viola, Held, Gerhard, Ziepert, Marita, Witzens-Harig, Mathias, Holte, Harald, Thurner, Lorenz, Borchmann, Peter, Viardot, Andreas, Soekler, Martin, Keller, Ulrich, Schmidt, Christian, Truemper, Lorenz, Mahlberg, Rolf, Marks, Reinhard, Hoeffkes, Heinz-Gert, Metzner, Bernd, Dierlamm, Judith, Frickhofen, Norbert, Haenel, Mathias, Neubauer, Andreas, Kneba, Michael, Merli, Francesco, Tucci, Alessandra, Brown, Peter de Nully, Federico, Massimo, Lengfelder, Eva, di Rocco, Alice, Trappe, Ralf, Rosenwald, Andreas, Berdel, Christian, Maisenhoelder, Martin, Shpilberg, Ofer, Amam, Josif, Christofyllakis, Konstantinos, Hartmann, Frank, Murawski, Niels, Stilgenbauer, Stephan, Nickelsen, Maike, Wulf, Gerald, Glass, Bertram, Schmitz, Norbert, Altmann, Bettina, Loeffler, Markus, and Pfreundschuh, Michael

Abstract

Background Six cycles of R-CHOP (rituximab plus cyclophosphamide, doxorubicin, vincristine, and prednisone) are the standard treatment for aggressive B-cell non-Hodgkin lymphoma. In the FLYER trial, we assessed whether four cycles of CHOP plus six applications of rituximab are non-inferior to six cycles of R-CHOP in a population of patients with B-cell non-Hodgkin lymphoma with favourable prognosis. Methods This two-arm, open-label, international, multicentre, prospective, randomised phase 3 non-inferiority trial was done at 138 clinical sites in Denmark, Israel, Italy, Norway, and Germany. We enrolled patients aged 18-60 years, with stage I-II disease, normal serum lactate dehydrogenase concentration, ECOG performance status 0-1, and without bulky disease (maximal tumour diameter <7.5 cm). Randomisation was computer-based and done centrally in a 1:1 ratio using the Pocock minimisation algorithm after stratification for centres, stage (I vs II), and extralymphatic sites (no vs yes). Patients were assigned to receive either six cycles of R-CHOP or four cycles of R-CHOP plus two doses of rituximab. CHOP comprised cyclophosphamide (750 mg/m(2)), doxorubicin (50 mg/m(2)), and vincristine (1.4 mg/m(2), with a maximum total dose of 2 mg), all administered intravenously on day 1, plus oral prednisone or prednisolone at the discretion of the investigator (100 mg) administered on days 1-5. Rituximab was given at a dose of 375 mg/m(2) of body surface area. Cycles were repeated every 21 days. No radiotherapy was planned except for testicular lymphoma treatment. The primary endpoint was progression-free survival after 3 years. The primary analysis was done in the intention-to-treat population. Safety was assessed in all patients who received at least one dose of assigned treatment. A non-inferiority margin of -5.5% was chosen. The trial, which is completed, was prospectively registered at ClinicalTrials.gov, NCT00278421. Findings Between Dec 2, 2005, and Oct 7, 2016, 592 patien

Published
2019

10. Management of acute promyelocytic leukemia: updated recommendations from an expert panel of the European LeukemiaNet

Author

Sanz, Miguel A., primary, Fenaux, Pierre, additional, Tallman, Martin S., additional, Estey, Elihu H., additional, Löwenberg, Bob, additional, Naoe, Tomoki, additional, Lengfelder, Eva, additional, Döhner, Hartmut, additional, Burnett, Alan K., additional, Chen, Sai-Juan, additional, Mathews, Vikram, additional, Iland, Harry, additional, Rego, Eduardo, additional, Kantarjian, Hagop, additional, Adès, Lionel, additional, Avvisati, Giuseppe, additional, Montesinos, Pau, additional, Platzbecker, Uwe, additional, Ravandi, Farhad, additional, Russell, Nigel H., additional, and Lo-Coco, Francesco, additional

Published
2019
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11. Frontline therapy of acute promyelocytic leukemia: Randomized comparison of ATRA and intensified chemotherapy versus ATRA and anthracyclines

Author

Lengfelder, Eva, Goerlich, Dennis, Nowak, Daniel, Spiekermann, Karsten, Haferlach, Claudia, Krug, Utz, Kreuzer, Karl-Anton, Braess, Jan, Schliemann, Christoph, Lindemann, Hans-Walter, Horst, Heinz A., Schiel, Xaver, Flasshove, Michael, Hecht, Anna, Schnittger, Susanne, Schneider, Stephanie, Woermann, Bernhard, Hofmann, Wolf-Karsten, Berdel, Wolfgang E., Bormann, Eike, Sauerland, Cristina, Buechner, Thomas, Hiddemann, Wolfgang, Lengfelder, Eva, Goerlich, Dennis, Nowak, Daniel, Spiekermann, Karsten, Haferlach, Claudia, Krug, Utz, Kreuzer, Karl-Anton, Braess, Jan, Schliemann, Christoph, Lindemann, Hans-Walter, Horst, Heinz A., Schiel, Xaver, Flasshove, Michael, Hecht, Anna, Schnittger, Susanne, Schneider, Stephanie, Woermann, Bernhard, Hofmann, Wolf-Karsten, Berdel, Wolfgang E., Bormann, Eike, Sauerland, Cristina, Buechner, Thomas, and Hiddemann, Wolfgang

Abstract

Objectives: Randomized comparison of two treatment strategies in frontline therapy of acute promyelocytic leukemia (APL): all-trans retinoic acid (ATRA) and double induction intensified by high-dose cytosine arabinoside (HD ara-C) (German AMLCG) and therapy with ATRA and anthracyclines (Spanish PETHEMA, LPA99). Patients and results: Eighty of 87 adult patients with genetically confirmed APL of all risk groups were eligible. The outcome of both arms was similar: AMLCG vs PETHEMA: hematological complete remission 87% vs 83%, early death 13% vs 17% (P = .76), overall survival, event-free survival, leukemia-free survival, cumulative incidence of relapse at 6 years 75% vs 78% (P = .92); 75% vs 68% (P = .29); 86% vs 81% (P = .28); and 0% vs 12% (P = .04, no relapse vs four relapses), respectively. The median time to achieve molecular remission (RT-PCR negativity of PML-RARA) was 60 days in both arms (P = .12). The AMLCG regimen was associated with a longer duration of neutropenia (P = .02) and a higher rate of WHO grade >= 3 infections. Conclusions: The small number of patients limits the reliability of conclusions. With these restrictions, the outcomes of both approaches were similar and show the limitations of ATRA and chemotherapy. The HD ara-C-containing regimen was associated with a lower relapse rate in high-risk APL.

Published
2018

12. Radiotherapy (RT) to bulky (B) and extralymphatic (E) disease in combination with 6xR-CHOP-14 or R-CHOP-21 in young good-prognosis DLBCL patients: Results of the 2x2 randomized UNFOLDER trial of the DSHNHL/GLA.

Author

Pfreundschuh, Michael, Murawski, Niels, Ziepert, Marita, Altmann, Bettina, Dreyling, Martin H., Borchmann, Peter, Luminari, Stefano, Witzens-Harig, Mathias, Dierlamm, Judith, Haenel, Mathias, Truemper, Lorenz, Metzner, Bernd, Lengfelder, Eva, Keller, Ulrich B., Ruebe, Christian, Berdel, Christian, Schmitz, Norbert, Held, Gerhard, Poeschel, Viola, Pfreundschuh, Michael, Murawski, Niels, Ziepert, Marita, Altmann, Bettina, Dreyling, Martin H., Borchmann, Peter, Luminari, Stefano, Witzens-Harig, Mathias, Dierlamm, Judith, Haenel, Mathias, Truemper, Lorenz, Metzner, Bernd, Lengfelder, Eva, Keller, Ulrich B., Ruebe, Christian, Berdel, Christian, Schmitz, Norbert, Held, Gerhard, and Poeschel, Viola

Published
2018

13. Sequential high-dose cytarabine and mitoxantrone (S-HAM) versus standard double induction in acute myeloid leukemia-a phase 3 study

Author

Braess, Jan, Amler, Susanne, Kreuzer, Karl-Anton, Spiekermann, Karsten, Lindemann, Hans Walter, Lengfelder, Eva, Graeven, Ullrich, Staib, Peter, Ludwig, Wolf-Dieter, Biersack, Harald, Ko, Yon-Dschun, Uppenkamp, Michael J., De Wit, Maike, Korsten, Stefan, Peceny, Rudolf, Gaska, Tobias, Schiel, Xaver, Behringer, Dirk M., Kiehl, Michael G., Zinngrebe, Bettina, Meckenstock, Gerald, Roemer, Eva, Medgenberg, Dirk, Spaeth-Schwalbe, Ernst, Massenkeil, Gero, Hindahl, Heidrun, Schwerdtfeger, Rainer, Trenn, Guido, Sauerland, Cristina, Koch, Raphael, Lablans, Martin, Faldum, Andreas, Goerlich, Dennis, Bohlander, Stefan K., Schneider, Stephanie, Dufour, Annika, Buske, Christian, Fiegl, Michael, Subklewe, Marion, Braess, Birgit, Unterhalt, Michael, Baumgartner, Anja, Woermann, Bernhard, Beelen, Dietrich, Hiddemann, Wolfgang, Braess, Jan, Amler, Susanne, Kreuzer, Karl-Anton, Spiekermann, Karsten, Lindemann, Hans Walter, Lengfelder, Eva, Graeven, Ullrich, Staib, Peter, Ludwig, Wolf-Dieter, Biersack, Harald, Ko, Yon-Dschun, Uppenkamp, Michael J., De Wit, Maike, Korsten, Stefan, Peceny, Rudolf, Gaska, Tobias, Schiel, Xaver, Behringer, Dirk M., Kiehl, Michael G., Zinngrebe, Bettina, Meckenstock, Gerald, Roemer, Eva, Medgenberg, Dirk, Spaeth-Schwalbe, Ernst, Massenkeil, Gero, Hindahl, Heidrun, Schwerdtfeger, Rainer, Trenn, Guido, Sauerland, Cristina, Koch, Raphael, Lablans, Martin, Faldum, Andreas, Goerlich, Dennis, Bohlander, Stefan K., Schneider, Stephanie, Dufour, Annika, Buske, Christian, Fiegl, Michael, Subklewe, Marion, Braess, Birgit, Unterhalt, Michael, Baumgartner, Anja, Woermann, Bernhard, Beelen, Dietrich, and Hiddemann, Wolfgang

Abstract

Dose-dense induction with the S-HAM regimen was compared to standard double induction therapy in adult patients with newly diagnosed acute myeloid leukemia. Patients were centrally randomized (1:1) between S-HAM (2nd chemotherapy cycle starting on day 8 - dose-dense) and double induction with TAD-HAM or HAM(-HAM) (2nd cycle starting on day 21 - standard). 387 evaluable patients were randomly assigned to S-HAM (N - 203) and to standard double induction (N - 184). The primary endpoint overall response rate (ORR) consisting of complete remission (CR) and incomplete remission (CRi) was not significantly different (P = 0.202) between S-HAM (77%) and double induction (72%). The median overall survival was 35 months after S-HAM and 25 months after double induction (P = 0.323). Duration of critical leukopenia was significantly reduced after S-HAM (median 29 days) versus double induction (median 44 days)-P < 0.001. This translated into a significantly shortened duration of hospitalization after S-HAM (median 37 days) as compared to standard induction (median 49 days)-P < 0.001. In conclusion, dose-dense induction therapy with the S-HAM regimen shows favorable trends but no significant differences in ORR and OS compared to standard double induction. S-HAM significantly shortens critical leukopenia and the duration of hospitalization by 2 weeks.

Published
2018

14. Characteristics and Outcome of Older Patients with Acute Promyelocytic Leukemia Front-Line Treated with or without Arsenic Trioxide — an International Collaborative Study

Author

Kayser, Sabine, primary, Rahmé, Ramy, additional, Martínez-Cuadron, David, additional, Ghiaur, Gabriel, additional, Thomas, Xavier, additional, Sobas, Marta, additional, Guerci Bresler, Agnes, additional, Brunet, Salut, additional, Pigneux, Arnaud, additional, Gil, Cristina, additional, Raffoux, Emmanuel, additional, Tormo, Mar, additional, Vey, Norbert, additional, de la Serna, Javier, additional, Salamero, Olga, additional, Lengfelder, Eva, additional, Levis, Mark J., additional, Fenaux, Pierre, additional, Sanz, Miguel A., additional, Schlenk, Richard F., additional, Platzbecker, Uwe, additional, Ades, Lionel, additional, and Montesinos, Pau, additional

Published
2018
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15. Double Induction Strategy for Acute Myeloid Leukemia: The Effect of High-Dose Cytarabine With Mitoxantrone Instead of Standard-Dose Cytarabine With Daunorubicin and 6-Thioguanine: A Randomized Trial by the German AML Cooperative Group

Author

Büchner, Thomas, Hiddemann, Wolfgang, Wörmann, Bernhard, Löffler, Helmut, Gassmann, Winfried, Haferlach, Torsten, Fonatsch, Christa, Haase, Detlef, Schoch, Claudia, Hossfeld, Dieter, Lengfelder, Eva, Aul, Carlo, Heyll, Axel, Maschmeyer, Georg, Ludwig, Wolf-Dieter, Sauerland, Maria-Cristina, and Heinecke, Achim

Published
1999
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16. Validation of a Molecular Risk Score for Prognosis of Patients with Acute Promyelocytic Leukemia

Author

Hecht, Anna, primary, Doll, Seraphina, additional, Schaarschmidt, Heidi, additional, Nowak, Daniel, additional, Nowak, Verena, additional, Obländer, Julia, additional, Xanthopoulos, Christina, additional, Lengfelder, Eva, additional, Röllig, Christoph, additional, Ehninger, Gerhard, additional, Hofmann, Wolf-Karsten, additional, and Platzbecker, Uwe, additional

Published
2016
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17. Real Life Experience with ATRA-Arsenic Trioxide Based Regimen in Acute Promyelocytic Leukemia - Updated Results of the Prospective German Intergroup Napoleon Registry

Author

Platzbecker, Uwe, primary, Lengfelder, Eva, additional, Goetze, Katharina S, additional, Röllig, Christoph, additional, Kramer, Michael, additional, Sauer, Michaela, additional, Albers, Nadine, additional, Heuser, Michael, additional, Link, Hartmut, additional, Schäfer-Eckart, Kerstin, additional, Martin, Sonja, additional, Krause, Stefan W., additional, Hänel, Mathias, additional, Bochtler, Tilmann, additional, Jakob, Andreas, additional, Reichle, Albrecht, additional, Biersack, Harald, additional, Baldus, Claudia D., additional, Goerner, Martin, additional, Basara, Nadezda, additional, Mezger, Joerg, additional, Naumann, Ralph, additional, Kuerschner, Dorit, additional, de Wit, Maike, additional, Nolte, Florian, additional, Ringhoffer, Mark, additional, Tischler, Hans-Joachim, additional, Greiner, Jochen, additional, Kremers, Stephan, additional, Machherndl-Spandl, Sigrid, additional, Koller, Elisabeth, additional, Wattad, Mohammad Amen, additional, Aschauer, Gregor, additional, Radsak, Markus, additional, Kubin, Thomas, additional, Salih, Helmut, additional, Heits, Frank, additional, Wolf, Dominik, additional, Thiede, Christian, additional, Serve, Hubert, additional, Duehrsen, Ulrich, additional, Hochhaus, Andreas, additional, Brümmendorf, Tim H., additional, Bornhäuser, Martin, additional, Döhner, Hartmut, additional, Ehninger, Gerhard, additional, and Schlenk, Richard F., additional

Published
2016
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18. Comparison of Treatment Strategies in Patients over 60 Years with AML: Final Analysis of a Prospective Randomized German AML Intergroup Study

Author

Niederwieser, Dietger, primary, Hoffmann, Verena Sophia, additional, Pfirrmann, Markus, additional, Al-Ali, Haifa Kathrin, additional, Schwind, Sebastian, additional, Vucinic, Vladan, additional, Krahl, Rainer, additional, Kahl, Christoph, additional, Wolf, Hans-Heinrich, additional, Kreibich, Ute, additional, Hähling, Detlef, additional, Hegenbart, Ute, additional, Hirt, Carsten, additional, Peter, Norma, additional, Florschuetz, Axel, additional, Reifenrath, Kolja, additional, Schulze, Antje, additional, Zojer, Niklas, additional, Scholl, Sebastian, additional, Junghanss, Christian, additional, Pönisch, Wolfram, additional, Heyn, Simone, additional, Sayer, Herbert G., additional, Hochhaus, Andreas, additional, Heinicke, Thomas, additional, Fischer, Thomas, additional, Krämer, Alwin, additional, Dreger, Peter, additional, Maschmeyer, Georg, additional, Krug, Utz, additional, Sauerland, Maria Christina, additional, Heinecke, Achim, additional, Hehlmann, Rüdiger, additional, Lengfelder, Eva, additional, Hiddemann, Wolfgang, additional, Serve, Hubert, additional, Müller-Tidow, Carsten, additional, Berdel, Wolfgang E, additional, and Büchner, Thomas, additional

Published
2016
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19. Revised response criteria for polycythemia vera and essential thrombocythemia: an ELN and IWG-MRT consensus project

Author

Barosi, Giovanni, Mesa, Ruben, Finazzi, Guido, Harrison, Claire, Kiladjian, Jean-Jacques, Lengfelder, Eva, McMullin, Mary F., Passamonti, Francesco, Vannucchi, Alessandro M., Besses, Carlos, Gisslinger, Heinz, Samuelsson, Jan, Verstovsek, Srdan, Hoffman, Ronald, Pardanani, Animesh, Cervantes, Francisco, Tefferi, Ayalew, and Barbui, Tiziano

Published
2013
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21. Radiation and Dose‐densification of R‐CHOP in Aggressive B‐cell Lymphoma With Intermediate Prognosis: The UNFOLDER Study.

Author

Thurner, Lorenz, Ziepert, Marita, Berdel, Christian, Schmidt, Christian, Borchmann, Peter, Kaddu‐Mulindwa, Dominic, Viardot, Andreas, Witzens‐Harig, Mathias, Dierlamm, Judith, Haenel, Mathias, Metzner, Bernd, Wulf, Gerald, Lengfelder, Eva, Keller, Ulrich B., Frickhofen, Norbert, Nickelsen, Maike, Gaska, Tobias, Griesinger, Frank, Mahlberg, Rolf, and Marks, Reinhard

Published
2023
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22. Real Life Experience with ATRA-Arsenic Trioxide Based Regimen in Acute Promyelocytic Leukemia - Updated Results of the Prospective German Intergroup Napoleon Registry

Author

Platzbecker, Uwe, Lengfelder, Eva, Schäfer-Eckart, Kerstin, Götze, Katharina S, Heuser, Michael, Thol, Felicitas, Salih, Helmut R., Hänel, Mathias, Spiekermann, Karsten, Martin, Sonja, Machherndl-Spandl, Sigrid, Kunzmann, Volker, Jakob, Andreas, Tischler, Hans-Joachim, Niemann, Dirk, Mezger, Joerg, Bochtler, Tilmann, Krause, Stefan, Wit, Maike de, Baldus, Claudia D., Greil, Richard, Greiner, Jochen, Ringhoffer, Mark, Radsak, Markus, Wattad, Mohammed Amen, Schmiegel, Wolff, Koller, Elisabeth, Heits, Frank, Reichle, Albrecht, Kremers, Stephan, Hochhaus, Andreas, Basara, Nadezda, Wolf, Dominik, Goerner, Martin, Schaich, Markus, Biersack, Harald, Kirchen, Heinz, Kubin, Thomas, Aschauer, Gregor, Hesse, Tanja, Link, Hartmut, Duerk, Heinz, Kuerschner, Dorit, Fiedler, Walter, Hertenstein, Bernd, Puttrich, Martin, Kramer, Michael, Sauer, Michaela, Hiddemann, Wolfgang, Duehrsen, Ulrich, Serve, Hubert, Thiede, Christian, Ganser, Arnold, Brummendorf, Tim H., Dohner, Konstanze, Bornhäuser, Martin, Schlenk, Richard F., Rollig, Christoph, Döhner, Hartmut, Ehninger, Gerhard, and Paschka, Peter

Published
2017
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23. Next Generation RNA Sequencing of Acute Promyelocytic Leukemia (APL) Identifies Novel Long Non Coding RNAs Including New Variants of MIR181A1HG That Are Differentially Expressed during Myeloid Differentiation

Author

Lammer, Frederic, Klaumuenzer, Marion, Mossner, Maximilian, Jann, Johann Christoph, Hecht, Anna, Nowak, Verena, Fey, Stephanie, Oblaender, Julia, Pressler, Jovita, Lengfelder, Eva, Hofmann, Wolf-Karsten, Nowak, Daniel, Lammer, Frederic, Klaumuenzer, Marion, Mossner, Maximilian, Jann, Johann Christoph, Hecht, Anna, Nowak, Verena, Fey, Stephanie, Oblaender, Julia, Pressler, Jovita, Lengfelder, Eva, Hofmann, Wolf-Karsten, and Nowak, Daniel

Published
2014

24. An Optimized Risk Stratification Model in Acute Promyelocytic Leukemia Identifies Patients with an Exceptionally Good Prognosis Regarding the Incidence of Relapse

Author

Hecht, Anna, primary, Nowak, Daniel, additional, Nowak, Verena, additional, Hanfstein, Benjamin, additional, Büchner, Thomas, additional, Spiekermann, Karsten, additional, Weiss, Christel, additional, Hofmann, Wolf-Karsten, additional, Lengfelder, Eva, additional, and Nolte, Florian, additional

Published
2014
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25. Next Generation RNA Sequencing of Acute Promyelocytic Leukemia (APL) Identifies Novel Long Non Coding RNAs Including New Variants of MIR181A1HG That Are Differentially Expressed during Myeloid Differentiation

Author

Lammer, Frederic, primary, Klaumuenzer, Marion, additional, Mossner, Maximilian, additional, Jann, Johann Christoph, additional, Hecht, Anna, additional, Nowak, Verena, additional, Fey, Stephanie, additional, Oblaender, Julia, additional, Pressler, Jovita, additional, Lengfelder, Eva, additional, Hofmann, Wolf-Karsten, additional, and Nowak, Daniel, additional

Published
2014
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26. A unified definition of clinical resistance and intolerance to hydroxycarbamide in polycythaemia vera and primary myelofibrosis : results of a European LeukemiaNet (ELN) consensus process

Author

Barosi, Giovanni, Birgegård, Gunnar, Finazzi, Guido, Griesshammer, Martin, Harrison, Claire, Hasselbalch, Hans, Kiladijan, Jean-Jacques, Lengfelder, Eva, Mesa, Ruben, Mc Mullin, Mary F., Passamonti, Francesco, Reilly, John T., Vannucchi, Alessandro M., Barbui, Tiziano, Barosi, Giovanni, Birgegård, Gunnar, Finazzi, Guido, Griesshammer, Martin, Harrison, Claire, Hasselbalch, Hans, Kiladijan, Jean-Jacques, Lengfelder, Eva, Mesa, Ruben, Mc Mullin, Mary F., Passamonti, Francesco, Reilly, John T., Vannucchi, Alessandro M., and Barbui, Tiziano

Published
2010
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27. High Efficacy and Significantly Shortened Neutropenia Of Dose-Dense S-HAM As Compared To Standard Double Induction: First Results Of a Prospective Randomized Trial (AML-CG 2008)

Author

Braess, Jan, primary, Kreuzer, Karl-Anton, additional, Spiekermann, Karsten, additional, Lindemann, Hans Walter, additional, Lengfelder, Eva, additional, Graeven, Ullrich, additional, Staib, Peter, additional, Ludwig, Wolf-Dieter, additional, Biersack, Harald, additional, Ko, Yon-Dschun, additional, Uppenkamp, Michael J., additional, Korsten, Stefan, additional, De Wit, Maike, additional, Peceny, Rudolf, additional, Gaska, Tobias, additional, Schiel, Xaver, additional, Behringer, Dirk M, additional, Kiehl, Michael G., additional, Zinngrebe, Bettina, additional, Meckenstock, Gerald, additional, Roemer, Eva, additional, Medgenberg, Dirk, additional, Spaeth-Schwalbe, Ernst, additional, Braess, Birgit, additional, Massenkeil, Gero, additional, Hindahl, Heidrun, additional, Trenn, Guido, additional, Schwerdtfeger, Rainer, additional, Amler, Susanne, additional, Sauerland, Cristina, additional, Faldum, Andreas, additional, Unterhalt, Michael, additional, Bohlander, Stefan K., additional, Schneider, Stephanie, additional, Dufour, Annika, additional, Buske, Christian, additional, Fiegl, Michael, additional, Subklewe, Marion, additional, Baumgartner, Anja, additional, Woermann, Bernhard J., additional, Beelen, Dietrich, additional, and Hiddemann, Wolfgang, additional

Published
2013
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28. Arsenic Trioxide-Based Therapy Of Relapsed Acute Promyelocytic Leukemia: Updated Results Of The European Registry Of Relapsed APL (PROMYSE)

Author

Lengfelder, Eva, primary, Lo-Coco, Francesco, additional, Ades, Lionel, additional, Montesinos, Pau, additional, Grimwade, David, additional, Kishore, Bhuvan, additional, Ramadan, Safaa, additional, Pagoni, Maria, additional, Breccia, Massimo, additional, Rivas, Concha, additional, Gonzáles-Sanmiguel, José, additional, Schmidt, Anne, additional, Lambert, Jean-Francois, additional, Hofmann, Wolf-Karsten, additional, Sauerland, Maria Cristina, additional, Fenaux, Pierre, additional, and Sanz, Miguel, additional

Published
2013
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29. Acute Myeloid Leukemia: The Outcome Is Determined By Age, Genetic Group, White Blood Cell Count, Lactate Dehydrogenase, Rather Than By Chemotherapy Intensity

Author

Buchner, Thomas, primary, Berdel, Wolfgang E., additional, Krug, Utz, additional, Haferlach, Claudia, additional, Schnittger, Susanne, additional, Haferlach, Torsten, additional, Mueller-Tidow, Carsten, additional, Stelljes, Matthias, additional, Mesters, Rolf M., additional, Serve, Hubert, additional, Braess, Jan, additional, Spiekermann, Karsten, additional, Staib, Peter, additional, Grueneisen, Andreas, additional, Reichle, Albrecht, additional, Balleisen, Leopold, additional, Eimermacher, Hartmut, additional, Giagounidis, Aristoteles, additional, Rasche, Herbert, additional, Lengfelder, Eva, additional, Faldum, Andreas, additional, Sauerland, Maria Cristina, additional, Heinecke, Achim, additional, Hehlmann, Rüdiger, additional, Woermann, Bernhard J., additional, and Hiddemann, Wolfgang, additional

Published
2013
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30. Evaluation Of Myeloablative Therapy Followed By Autologous Stem Cell Transplantation In First Remission In Patients With Advanced Stage Follicular Lymphoma After Initial Immuno-Chemotherapy (R-CHOP) Or Chemotherapy Alone: Analysis Of 940 Patients Treated In Prospective Randomized Trials Of The German Low Grade Lymphoma Study Group (GLSG)

Author

Hiddemann, Wolfgang, primary, Dreyling, Martin H., additional, Metzner, Bernd, additional, Pfreundschuh, Michael, additional, Wilhelm, Martin, additional, Lengfelder, Eva, additional, Hess, Georg, additional, Hallek, Michael, additional, Schmitz, Norbert, additional, Pott, Christiane, additional, Fischer, Thomas, additional, Forstpointner, Roswitha, additional, Hoster, Eva, additional, and Unterhalt, Michael, additional

Published
2013
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32. Acute Myeloid Leukemia: Longterm Outcome Predicted by Age and Genetic Groups

Author

Buchner, Thomas, primary, Berdel, Wolfgang E., additional, Krug, Utz, additional, Haferlach, Claudia, additional, Schnittger, Susanne, additional, Stelljes, Matthias, additional, Silling, Gerda, additional, Staib, Peter, additional, Grueneisen, Andreas, additional, Reichle, Albrecht, additional, Balleisen, Leopold, additional, Eimermacher, Hartmut, additional, Giagounidis, Aristoteles, additional, Rasche, Herbert, additional, Lengfelder, Eva, additional, Sauerland, Cristina, additional, Heinecke, Achim, additional, Woermann, Bernhard Josef, additional, and Hiddemann, Wolfgang, additional

Published
2012
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33. Genome Wide DNA Methylation Analysis Identifies a Characteristic Methylation Profile for Patients with Acute Promyelocytic Leukemia and FLT3-Internal Tandem Duplication

Author

Reinwald, Mark, primary, Haag, Anjulie, additional, Lengfelder, Eva, additional, Mossner, Maximilian, additional, Hanfstein, Benjamin, additional, Nowak, Verena, additional, Klaumuenzer, Marion, additional, Nolte, Florian, additional, Oblaender, Julia, additional, Fey, Stephanie, additional, Büchner, Thomas, additional, Spiekermann, Karsten, additional, Hofmann, Wolf-Karsten, additional, and Nowak, Daniel, additional

Published
2012
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34. Inferior Outcome in Patients with Acute Promyelocytic Leukemia and High Expression of the Ets Related Gene: Role in Leukemogenesis and Potential Implications for Future Therapeutic Approaches?,

Author

Hecht, Anna, primary, Nolte, Florian, additional, Nowak, Daniel, additional, Nowak, Verena, additional, Hanfstein, Benjamin, additional, Faldum, Andreas, additional, Buchner, Thomas, additional, Spiekermann, Karsten, additional, Sauerland, Cristina, additional, Lengfelder, Eva, additional, and Hofmann, Wolf-Karsten, additional

Published
2011
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35. Outcome of Myelodysplastic Syndrome Treated with Intensive Chemotherapy within the AMLCG99 Trial

Author

Krug, Utz, primary, Muller-Tidow, Carsten, additional, Stelljes, Matthias, additional, Sauerland, Maria Cristina, additional, Heinecke, Achim, additional, Haferlach, Claudia, additional, Schnittger, Susanne, additional, Haferlach, Torsten, additional, Braess, Jan, additional, Spiekermann, Karsten, additional, Volpert, Sarah, additional, Staib, Peter, additional, Grüneisen, Andreas, additional, Kern, Wolfgang, additional, Reichle, Albrecht, additional, Ludwig, Wolf-Dieter, additional, Balleisen, Leopold, additional, Eimermacher, Hartmut, additional, Aul, Carlo, additional, Rasche, Herbert, additional, Lengfelder, Eva, additional, Thiel, Eckhard, additional, Kienast, Joachim, additional, Serve, Hubert, additional, Woermann, Bernhard Josef, additional, Hiddemann, Wolfgang, additional, Berdel, Wolfgang E., additional, and Buchner, Thomas, additional

Published
2011
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36. Identification of Recurrent Submicroscopic Deletions of chromosome1q31.3 As Possible Molecular Prognostic Markers in Acute Promyelocytic Leukemia (APL)

Author

Nowak, Daniel, primary, Klaumuenzer, Marion, additional, Hanfstein, Benjamin, additional, Mossner, Maximilian, additional, Nolte, Florian, additional, Nowak, Verena, additional, Oblaender, Julia, additional, Hecht, Anna, additional, Hütter, Gero, additional, Ogawa, Seishi, additional, Kohlmann, Alexander, additional, Haferlach, Claudia, additional, Schlegelberger, Brigitte, additional, Braess, Jan, additional, Seifarth, Wolfgang, additional, Fabarius, Alice, additional, Erben, Philipp, additional, Saussele, Susanne, additional, Müller, Martin C., additional, Buechner, Thomas, additional, Weiss, Christel, additional, Hofmann, Wolf-Karsten, additional, and Lengfelder, Eva, additional

Published
2011
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38. Front Line Treatment of Elderly Patients with Acute Promyelocytic Leukemia: Long-Term Results of the German AML Cooperative Group

Author

Lengfelder, Eva, primary, Hanfstein, Benjamin, additional, Haferlach, Claudia, additional, Braess, Jan, additional, Krug, Utz, additional, Spiekermann, Karsten, additional, Haferlach, Torsten, additional, Kreuzer, Karl-Anton, additional, Serve, Hubert, additional, Horst, Heinz A., additional, Schnittger, Susanne, additional, Erben, Philipp, additional, Woermann, Bernhard J, additional, Berdel, Wolfgang E., additional, Sauerland, Maria-Christina, additional, Heinecke, Achim, additional, Hofmann, Wolf-Karsten, additional, Hehlmann, Rüdiger, additional, Hiddemann, Wolfgang, additional, and Buchner, Thomas, additional

Published
2011
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39. Identification of the PML-RARα Associated DNA Methylome Using Reduced Representation Bisulfite Sequencing in Primary Patient Samples

Author

Rohde, Christian, primary, Schoofs, Till, additional, Hebestreit, Katja, additional, Klein, Hans-Ulrich, additional, Witten, Anika, additional, Stoll, Monika, additional, Lengfelder, Eva, additional, Hofmann, Wolf-Karsten, additional, Schlenke, Peter, additional, Göllner, Stefanie, additional, Büchner, Thomas, additional, Sauerland, Maria Cristina, additional, Koschmieder, Steffen, additional, Berdel, Wolfgang E., additional, Dugas, Martin, additional, and Müller-Tidow, Carsten, additional

Published
2011
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40. In Acute Promyelocytic Leukemia (APL) Low BAALC Gene Expression Identifies a Group of Patients with Favorable Outcome in Overall Survival and Relapse Free Survival,

Author

Nolte, Florian, primary, Hecht, Anna, additional, Nowak, Daniel, additional, Nowak, Verena, additional, Hanfstein, Benjamin, additional, Faldum, Andreas, additional, Buchner, Thomas, additional, Spiekermann, Karsten, additional, Sauerland, Cristina, additional, Hofmann, Wolf-Karsten, additional, and Lengfelder, Eva, additional

Published
2011
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41. Genome Wide DNA Methylation Analysis Reveals Significant Differences Between Blasts of Patients with Acute Promyelocytic Leukemia and CD34+-Hematopoietic Stem Cells of Healthy Individuals

Author

Reinwald, Mark, primary, Haag, Anjulie, additional, Lengfelder, Eva, additional, Nowak, Verena, additional, Mossner, Maximilian, additional, Klaumuenzer, Marion, additional, Nolte, Florian, additional, Büchner, Thomas, additional, Spiekermann, Karsten, additional, Hofmann, Wolf-Karsten, additional, and Nowak, Daniel, additional

Published
2011
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42. Treatment of Molecular and Clinical Relapse of Acute Promyelocytic Leukemia (APL) with Arsenic Trioxide: Results of the European Registry of Relapsed APL

Author

Lengfelder, Eva, primary, Lo-Coco, Francesco, additional, Montesinos, Pau, additional, Grimwade, David, additional, Ades, Lionel, additional, Kishore, Bhuvan, additional, Pagoni, Maria, additional, Ramadan, Safaa M., additional, Breccia, Massimo, additional, Holowiecka, Alexandra, additional, Pradel, Anne, additional, Sauerland, Maria Cristina, additional, Fenaux, Pierre, additional, and Sanz, Miguel Angel, additional

Published
2010
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44. High Density SNP Array Analysis of Acute Promyelocytic Leukemia (APL) Detects New Common Genomic Copy Number Alterations as Possible Cooperating Lesions

Author

Nowak, Daniel, primary, Klaumuenzer, Marion, additional, Hanfstein, Benjamin, additional, Mossner, Maximilian, additional, Nolte, Florian, additional, Nowak, Verena, additional, Oblaender, Julia, additional, Ogawa, Seishi, additional, Kohlmann, Alexander, additional, Seifarth, Wolfgang, additional, Fabarius, Alice, additional, Erben, Philipp, additional, Saussele, Susanne, additional, Mueller, Martin C, additional, Lengfelder, Eva, additional, and Hofmann, Wolf Karsten, additional

Published
2010
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45. Clinical Phenotype of Myeloproliferative Neoplasms with Activating CBL-mutations Resembles Chronic Myelomonocytic Leukemia.

Author

Popa, Juliana, primary, Schnittger, Susanne, additional, Erben, Philipp, additional, Weiss, Tamara, additional, Tefferi, Ayalew, additional, Kanders, Eva M, additional, Lengfelder, Eva, additional, Müller, Martin C., additional, Haferlach, Torsten, additional, Hochhaus, Andreas, additional, Hofmann, Wolf-Karsten, additional, and Reiter, Andreas, additional

Published
2009
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46. Long-Term Results in Patients with Acute Myeloid Leukemia (AML): The Influence of High-Dose AraC, G-CSF Priming, Autologous Transplantation, Prolonged Maintenance, Age, History, Cytogenetics, and Mutation Status. Data of the AMLCG 1999 Trial.

Author

Buchner, Thomas, primary, Berdel, Wolfgang E., additional, Haferlach, Claudia, additional, Schnittger, Susanne, additional, Haferlach, Torsten, additional, Serve, Hubert, additional, Müller-Tidow, Carsten, additional, Braess, Jan, additional, Spiekermann, Karsten, additional, Kienast, Joachim, additional, Mesters, Rolf, additional, Volpert, Sarah, additional, Staib, Peter, additional, Grüneisen, Andreas, additional, Kern, Wolfgang, additional, Reichle, Albrecht, additional, Ludwig, Wolf-Dieter, additional, Maschmeyer, Georg, additional, Balleisen, Leopold, additional, Eimermacher, Hartmut, additional, Aul, Carlo, additional, Giagounidis, Aristoteles, additional, Rasche, Herbert, additional, Hehlmann, Rüdiger, additional, Lengfelder, Eva, additional, Köpcke, Wolfgang, additional, Krug, Utz O., additional, Sauerland, Maria Cristina, additional, Heinecke, Achim, additional, Woermann, Bernhard J, additional, and Hiddemann, Wolfgang, additional

Published
2009
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47. Rituximab Overcomes Sex as a Strong Adverse Prognostic Factor for Treatment Outcome in Patients with Follicular Lymphoma: Analysis of Patients Treated with Rituximab/CHOP or CHOP in Randomized Trials of the German Low Grade Lymphoma Study Group (GLSG).

Author

Buske, Christian, primary, Hoster, Eva, additional, Dreyling, Martin H., additional, Forstpointner, Roswitha, additional, Kneba, Michael, additional, Schmitz, Norbert, additional, Schmits, Rudolf, additional, Metzner, Bernd, additional, Hallek, Michael, additional, Lengfelder, Eva, additional, Hiddemann, Wolfgang, additional, and Unterhalt, Michael, additional

Published
2009
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48. Rituximab Maintenenance Therapy in CD20+ B-Cell Non-Hodgkin-Lymphoma – Final Results of a Multicenter Prospective Randomised Phase II Study.

Author

Witzens-Harig, Mathias, primary, Benner, Axel, additional, Rieger, Michael, additional, McClanahan, Fabienne, additional, Hensel, Manfred, additional, Neben, Kai, additional, Dreger, Peter, additional, Lengfelder, Eva, additional, Schmidt-Wolf, Ingo, additional, Alwin, Krämer, additional, and Ho, Anthony D., additional

Published
2009
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50. Rituximab in Combination with CHOP in Patients with Follicular Lymphoma: Analysis of Treatment Outcome of 552 Patients Treated in a Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG) after a Follow up of 58 Months

Author

Buske, Christian, primary, Hoster, Eva, primary, Dreyling, Martin, primary, Forstpointner, Roswitha, primary, Kneba, Michael, primary, Schmitz, Norbert, primary, Schmits, Rudolf, primary, Metzner, Bernd, primary, Reiser, Marcel, primary, Lengfelder, Eva, primary, Woermann, Bernhard J, primary, Harder, Harriet, primary, Hegewisch-Becker, Susanna, primary, Berdel, Wolfgang E., primary, Hess, Georg, primary, Eimermacher, Hartmut, primary, Aldaoud, Ali, primary, Planker, Manfred, primary, Unterhalt, Michael, primary, and Hiddemann, Wolfgang, primary

Published
2008
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