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3 results on '"Li Wen Wong"'

1. Natural hollow clay nanotubes and their applications as polymer nanocomposites in tissue engineering

Author

Li Wen Wong, Calvin Bok Sun Goh, Pooria Pasbakhsh, and Joash Ban Lee Tan

Subjects
Biomaterials, Clay minerals, Halloysite nanotube, Imogolite, Nanomaterials, Scaffold design, Materials of engineering and construction. Mechanics of materials, TA401-492
Abstract

Tissue engineering has garnered considerable attention within the broader field of regenerative medicine that utilizes naturally-occurring nanomaterials as fillers in polymeric scaffolds and as carriers for sustained, targeted drug delivery. These nanomaterials act as functional constructs for the recovery of defective tissues and organs, which may aid in overcoming the current challenges of donor organ shortage. The present article looks into the properties of naturally-occurring nanomaterials, including halloysite nanotubes (Hal), imogolite, and chrysotile, and their potential to improve both the mechanical and biological aspects of polymeric scaffolds in tissue engineering applications. While Hal is natively comprised of hydrous aluminosilicate (primarily in the form of hollow tubes), imogolites are comprised of silanol tetrahedrons and Al–OH octahedrons with typically narrower and shorter dimensions than Hal. Even so, both Hal and imogolites have been found to be highly biocompatible and with negligible cytotoxicities. Conversely, the extensively fibrous and smaller dimensions of chrysotile (compared to Hal and imogolites) have been associated with bioaccumulation and asbestosis, limiting chrysotile applications. Nevertheless, the electrostatically-charged lumens of these nanomaterials enable the encapsulation and sustained release of active agents into the surrounding tissues. Furthermore, the large surface areas and high aspect ratio of both Hal and imogolites greatly enhance the crosslinking and load-bearing capacities of composite polymeric scaffolds; while also providing accessible sites that facilitate cellular attachment and proliferation. This review contributes towards a better understanding of natural nanotube utilization in tissue engineering by highlighting their potential applications to polymer nanocomposites.

Published
2022
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2. Extremely low prevalence in soil-transmitted helminth infections among a multi-ethnic community in Segamat, Malaysia

Author

Daniel D. Reidpath, Shaun Wen Huey Lee, Sadequr Rahman, Sui Mae Lee, Qasim Ayub, Kuan Shion Ong, Jacky Dwiyanto, Calvin Bok Sun Goh, and Li Wen Wong

Subjects
0301 basic medicine, Ethnic community, medicine.medical_specialty, Helminth infections, Short Communication, 030231 tropical medicine, Prevalence, Tropics, 030108 mycology & parasitology, 03 medical and health sciences, 0302 clinical medicine, Geography, Soil-transmitted helminth, Environmental health, Epidemiology, parasitic diseases, medicine, Helminths, Population study, Parasitology
Abstract

Soil-transmitted helminth infections (STHs) are recognized as a major health issue among socio-economically deprived communities. However, information is still lacking regarding the prevalence rates of STHs in the broader community across different countries in the tropics. This community study aimed to determine the prevalence and risk factors for STHs in semi-rural communities in Segamat of Johor, Malaysia. A cross-sectional study was conducted with information collected from the study population through questionnaire. A total of 224 stool samples were examined for intestinal parasites through formalin-ether concentration and Kato–Katz techniques. Overall, only 1.8% (n = 4/224) of participants were infected with soil-transmitted helminths, the extremely low prevalence may be explained by the proper housing conditions with basic amenities and the practices of hygienic habits in daily life, highlighting the importance of adopting good hygienic practices.

Published
2020

3. First reported case of Gilbertella persicaria in human stool: outcome of a community study from Segamat, Johor, Malaysia

Author

Daniel D. Reidpath, Joash Ban Lee Tan, Sadequr Rahman, Marie Andrea Laetitia Huët, Jacky Dwiyanto, Calvin Bok Sun Goh, Sui Mae Lee, Kuan Shion Ong, and Li Wen Wong

Subjects
Mucorales, Male, Veterinary medicine, Adolescent, Fungus, Microbiology, 03 medical and health sciences, Feces, Microbial ecology, Mycology, Media Technology, Food microbiology, Humans, 030304 developmental biology, 0303 health sciences, biology, Calcium Oxalate, 030306 microbiology, Hydrogen-Ion Concentration, Isolation (microbiology), biology.organism_classification, Urease, Anti-Bacterial Agents, Gastrointestinal Microbiome, Fungal and Bacterial Physiology - Short Communication, Biofilms, Carrier State, Genome, Fungal, Gilbertella persicaria
Abstract

Species of fungi belonging to the order Mucorales can be found everywhere in the environment. Gilbertella persicaria, which belongs to this order, have often been isolated from fruits and in water systems. However, there has been no report of isolation of this fungus from human samples. During a gut mycobiome study, from the Segamat community, Gilbertella persicaria was isolated from a human fecal sample and was characterized through a series of morphological assessment, biochemical tests, and molecular techniques. The isolate produced a white velvety surface that turned grayish after 24 h. Although no biofilm production was observed, the results indicated that the isolate could form calcium oxalate crystals, produced urease, and was resistant to low pH. The isolate was sensitive to amphotericin but resistant to voriconazole and itraconazole. The features of this fungus that could help in its survival in the human gut are also discussed. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s42770-020-00323-z) contains supplementary material, which is available to authorized users.

Published
2020

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