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1. The Placenta as a Source of Human Material for Neuronal Repair

Author

Alessia Dallatana, Linda Cremonesi, Francesco Pezzini, Gianluca Fontana, Giulio Innamorati, and Luca Giacomello

Subjects
placenta, mesenchymal stem cells, neuronal differentiation, extracellular vesicles, extracellular matrix, regenerative medicine, Biology (General), QH301-705.5
Abstract

Stem cell therapy has the potential to meet unsolved problems in tissue repair and regeneration, particularly in the neural tissues. However, an optimal source has not yet been found. Growing evidence indicates that positive effects produced in vivo by mesenchymal stem cells (MSCs) can be due not only to their plasticity but also to secreted molecules including extracellular vesicles (EVs) and the extracellular matrix (ECM). Trophic effects produced by MSCs may reveal the key to developing effective tissue-repair strategies, including approaches based on brain implants or other implantable neural electrodes. In this sense, MSCs will become increasingly valuable and needed in the future. The placenta is a temporary organ devoted to protecting and supporting the fetus. At the same time, the placenta represents an abundant and extremely convenient source of MSCs. Nonetheless, placenta-derived MSCs (P-MSCs) remain understudied as compared to MSCs isolated from other sources. This review outlines the limited literature describing the neuroregenerative effects of P-MSC-derived biomaterials and advocates for exploiting the potential of this untapped source for human regenerative therapies.

Published
2024
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2. G Protein-Coupled Receptors and the Rise of Type 2 Diabetes in Children

Author

Alessia Dallatana, Linda Cremonesi, Maddalena Trombetta, Giulio Fracasso, Riccardo Nocini, Luca Giacomello, and Giulio Innamorati

Subjects
type 2 diabetes, diabetes in youth, GPCRs, β cells, glucose homeostasis, Biology (General), QH301-705.5
Abstract

The human genome counts hundreds of GPCRs specialized to sense thousands of different extracellular cues, including light, odorants and nutrients in addition to hormones. Primordial GPCRs were likely glucose transporters that became sensors to monitor the abundance of nutrients and direct the cell to switch from aerobic metabolism to fermentation. Human β cells express multiple GPCRs that contribute to regulate glucose homeostasis, cooperating with many others expressed by a variety of cell types and tissues. These GPCRs are intensely studied as pharmacological targets to treat type 2 diabetes in adults. The dramatic rise of type 2 diabetes incidence in pediatric age is likely correlated to the rapidly evolving lifestyle of children and adolescents of the new century. Current pharmacological treatments are based on therapies designed for adults, while youth and puberty are characterized by a different hormonal balance related to glucose metabolism. This review focuses on GPCRs functional traits that are relevant for β cells function, with an emphasis on aspects that could help to differentiate new treatments specifically addressed to young type 2 diabetes patients.

Published
2023
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3. Commissioning of a High Pressure Time Projection Chamber with Optical Readout

Author

Alexander Deisting, Abigail Victoria Waldron, Edward Atkin, Gary Barker, Anastasia Basharina-Freshville, Christopher Betancourt, Steven Boyd, Dominic Brailsford, Zachary Chen-Wishart, Linda Cremonesi, Adriana Dias, Patrick Dunne, Jennifer Haigh, Philip Hamacher-Baumann, Sebastian Jones, Asher Kaboth, Alexander Korzenev, William Ma, Philippe Mermod, Maria Mironova, Jocelyn Monroe, Ryan Nichol, Toby Nonnenmacher, Jaroslaw Nowak, William Parker, Harrison Ritchie-Yates, Stefan Roth, Ruben Saakyan, Nicola Serra, Yuri Shitov, Jochen Steinmann, Adam Tarrant, Melissa Uchida, Sammy Valder, Mark Ward, and Morgan O. Wascko

Subjects
time projection chamber, optical readout, neutrino detector development, hybrid charge and optical readout, gaseous detectors, Physics, QC1-999, Nuclear and particle physics. Atomic energy. Radioactivity, QC770-798
Abstract

The measurements of proton–nucleus scattering and high resolution neutrino–nucleus interaction imaging are key in reducing neutrino oscillation systematic uncertainties in future experiments. A High Pressure Time Projection Chamber (HPTPC) prototype has been constructed and operated at the Royal Holloway University of London and CERN as a first step in the development of a HPTPC that is capable of performing these measurements as part of a future long-baseline neutrino oscillation experiment, such as the Deep Underground Neutrino Experiment. In this paper, we describe the design and operation of the prototype HPTPC with an argon based gas mixture. We report on the successful hybrid charge and optical readout using four CCD cameras of signals from 241Am sources.

Published
2021
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5. DUNE Offline Computing Conceptual Design Report

Author

Abed Abud, Adam, babak abi, Acciarri, Roberto, Mario A Acero O, Adames, Marcio, Adamov, George, Adamowski, Mark, David Adams, Adinolfi, Marco, Adriano, Cris, Aduszkiewicz, Antoni, Aguilar, Jessica, Ahmad, Zubayer, Ahmed, Jhanzeb, Aimard, Benjamin, Faiza Akbar, Allison, Kyle, Saúl Alonso-Monsalve, Alrashed, Munera, Alt, Christoph, Alton, Andrew, Alvarez, Rodrigo, Amedo, Pablo, Anderson, John, Andrade Aldana, Diego, Constantinos Andreopoulos, Andreotti, Mirco, Andrews, Michael P., Andrianala, Fenompanirina, Sofia Andringa, Nikolay Anfimov, Anicézio Campanelli, Wallison Luiz, Artur Ankowski, Antoniassi, Marcelo, Antonova, Maria, Antoshkin, Alexander, Antusch, Stefan, Alfredo Aranda, Arellano, Luciano, Arnold, Lukas, Arroyave, Manuel, Asaadi, Jonathan, Asquith, Lily, Adam Aurisano, Aushev, Vladimir, Dario Autiero, Ayala-Torres, Marco Alberto, Azfar, Farrukh, Back, Ashley, Back, Henning, John Back, Bagaturia, Iuri, Bagby, Linda, Nikita Balashov, Balasubramanian, Supraja, Baldi, Pierre, Bruce Baller, Bambah, Bindu, Barao, F., Barenboim, Gabriela, Gary Barker, Barkhouse, Wayne, Barnes, Christopher, Barr, Giles, Barranco Monarca, Juan, Barros, Adilson, Barros, N., Barrow, J. L., Basharina-Freshville, Anastasia, Bashyal, Amit, Vincent Marc Basque, Batchelor, Charlie, James Battat, Battisti, Federico, Fatih Bay, Maria Cecilia Queiroga Bazetto, Jose Luis Bazo Alba, John Beacom, Bechetoille, Edouard, Biswaranjan Behera, Belchior, Ewerton, Leo Bellantoni, Bellettini, Giorgio, Bellini, Vincenzo, Beltramello, Olga, Nektarios Benekos, Benitez Montiel, Carlos, Douglas Benjamin, Francisco Neves, Berger, Joshua, Berkman, Sophie, Paolo Bernardini, Roman Matthias Berner, Andrea Bersani, Sergio Bertolucci, Betancourt, Minerba, Betancur Rodríguez, Amalia, Bevan, Adrian, Bezawada, Yashwanth, Bezerra, Anibal, Bezerra, T. J. C., Bhambure, Jay, Akhil Bhardwaj, Vipin Bhatnagar, Bhattacharjee, M., Bhattarai, Devesh, Bhuller, Shyam, Given Names Deactivated Family Name Deactivated, Simone Biagi, Jianming Bian, Biassoni, Matteo, Kurt Biery, Bilki, Burak, Mary Bishai, Bisignani, Valeria, Alexander Bitadze, Andrew Blake, Flor de Maria Blaszczyk, Blazey, Gerald C., Blend, Dylan, Edward Blucher, Boissevain, Jan, ANDREY BOBYSHEV, Bolognesi, Sara, Tim Bolton, Bomben, Luca, Maurizio Bonesini, Cesar Bonilla, Filiberto Bonini, Alexander Booth, Boran, Fatma, Stefania Bordoni, Aran Borkum, Nilay Bostan, Bour, Petr, Boyden, Daniel, Juraj Bracinik, Braga, Davide, Brailsford, Dominic, Antonio Branca, Brandt, Andrew, johan bremer, Chris Brew, Stephen Brice, Brizzolari, Claudia, Carl Bromberg, Jim Brooke, Bross, Alan, Giulia Brunetti, Brunetti, Maria, Buchanan, Norman, Budd, Howard, Buergi, Jonas, Caceres Vera, Gian, Cagnoli, Irene, Tejin Cai, Davide Caiulo, Calabrese, Roberto, Paolo Calafiura, Calcutt, Jacob, Calin, Marius, Livio Calivers, Calvez, Steven, Enrique Calvo Alamillo, Alessio Caminata, David Caratelli, Carber, Daniel, Carceller, J. C., Carini, Gabriella, Carlus, Bruno, Carneiro, Mateus, Paolo Carniti, Caro Terrazas, Ivan, Carranza, Hector, Carrara, Nicholas, Carroll, Lauren, Carroll, Thomas, Castaño Forero, Javier, Andres Castillo, Catano Mur, E., Cattadori, Carla, Fabien Cavalier, Cavallaro, Giuseppe, Flavio Cavanna, Centro, Sandro, Giuseppe Cerati, Alberto Cervelli, Cervera Villanueva, Anselmo, Kaustav Chakraborty, Chalifour, Michel, Andrew Chappell, Chardonnet, Etienne, Charitonidis, Nikolaos, Animesh Chatterjee, Chattopadhyay, Subhasish, Hucheng Chen, Mu-Chun Chen, Chen, Yifan, Chen, Zheyang, Chen-Wishart, Zachary, Cheon, Yoolim, Daniel Cherdack, Chi, Cheng-Yi, Childress, Sam, Robert Chirco, Chiriacescu, Ana, Chitirasreemadam, Namitha, Kihyeon Cho, Choate, Sarah, Chokheli, David, Chong, P. S., Chowdhury, Barnali, Christensen, Anne, David Christian, Georgios Christodoulou, Chukanov, Artem, Chung, Moses, Eric Church, Cicero, Valentina, Clarke, Peter, Cline, Gordon, Thomas Coan, Alfredo Giuseppe Cocco, Joao Coelho, Johann Collot, Erin Conley, Janet Conrad, Convery, Mark, Simone Copello, Cova, Paolo, Cremaldi, Lucien, Linda Cremonesi, José Ignacio Crespo Anadón, Michael Crisler, Cristaldo, Esteban, Crnkovic, Jason, Cross, Ryan, Cudd, Andrew, Clara Cuesta, Cui, Yanou, Cussans, David, Dalager, Olivia, Dallavalle, Ricardo, Da Motta, Helio, Dar, Zubair, Da Silva Peres, Leonardo, Claire David, David, Quentin, Gavin Davies, Stefano Davini, Dawson, Jaime, De, Kaushik, De, Shruti, Debbins, Paul, Bonis, Isabelle, Michal Patrick Decowski, Andre de Gouvea, Holanda, Pedro, Icaza Astiz, I. L., Deisting, Alexander, Paul de Jong, La Torre, Andres, Delbart, Alain, Leo, Veronica, David Delepine, Delgado, Maritza, Andrea Dell’Acqua, Nicola Delmonte, Lurgio, Patrick, Philip DeMar, Mello Neto, J. R. T., David DeMuth, Dennis, Steve, Densham, Chris, Grzegorz Deptuch, Albert De Roeck, Romeri, Valentina, Souza, Greg, Detje, J. P., Devi, Ritu, Ranjan Dharmapalan, Dias, Marco, Diaz, Jorge S., Félix Napoleón Díaz Desposorio, Francesco Di Capua, Antonio Di Domenico, Sergio Di Domizio, Di Giulio, Letizia, Pengfei Ding, Di Noto, Lea, Carla Distefano, Richard Diurba, Milind Diwan, Djurcic, Zelimir, Doering, Dionisio, Dolan, Stephen, furkan dolek, Michelle Dolinski, Domine, Laura, simone donati, Donon, Yann, Doran, Steven, Daniel Douglas, Angelo Dragone, Drielsma, Francois, Laura, Dominique Duchesneau, Duffy, K. E., Dugas, Katherine, Patrick Dunne, Bhaskar Dutta, Duyang, Hongyue, Olexiy Dvornikov, Dwyer, Daniel A., Dyshkant, Alexandre S., Eads, Michael, Earle, Antony, Edmunds, Daniel, Jonathan Eisch, Emberger, Lorenz, Englezos, Panagiotis, Antonio Ereditato, Erjavec, Tyler, CARLOS ESCOBAR, Evans, J. J., Erin Ewart, Ezeribe, A. C., Fahey, Kevin, Fajt, Lukas, Falcone, Andrea, Fani, Mattia, Farnese, Christian, Yasaman Farzan, Fedoseev, Dmitry, Julian Felix, Feng, Yue, Enrique Fernandez-Martinez, Federico Ferraro, Laura Fields, Filip, Peter, Amy Filkins, Frank Filthaut, Robert Fine, Giuliana Fiorillo, Fiorini, Massimiliano, Fischer, Vincent, Rory Fitzpatrick, Flanagan, Will, Fleming, Bonnie, Flight, Robert, Fogarty, Sam, William Foreman, Fowler, Jack, Jiří Franc, Domenico Franco, John Freeman, Freestone, Julian, Fried, Jack, Alexander Friedland, Stuart Fuess, Furic, I. K., Furman, Krzysztof, Andrew Furmanski, Alessandro Gabrielli, Alberto Martín Gago Medina, Gallagher, Hugh, Gallas, Alexandre, Gallego-Ros, Ana, Niccolò Gallice, Galymov, Vyacheslav, Enrico Gamberini, Gamble, Trevor, Ganacim, Francisco, Gandhi, Raj, Ganguly, Sudeshna, Gao, Fan, Gao, Shanshan, Diego Garcia Gamez, García-Peris, Miguel, Gardiner, Steven, Gastler, Dan, Gauch, Anja, Gauvreau, Jean-Luc, Paolo Gauzzi, Ge, Guanqun, Geffroy, Nicolas, Gelli, Bruno, Gendotti, Adamo, Gent, Stephen, Zahra Ghorbani moghaddam, Giammaria, Paola, Giammaria, Tommaso, Giangiacomi, Nico, Daniele Gibin, Gil-Botella, Ines, Gilligan, Sean, Gioiosa, Antonio, Girerd, Claude, Anjan Giri, Gnani, Dario, Olga Gogota, Gold, Michael, Gollapinni, Sowjanya, Gollwitzer, Keith, Ricardo Gomes, Gomez Bermeo, Laura Vanessa, Luz Stella Gomez Fajardo, Francesco Gonnella, Gonzalez-Diaz, Diego, Gonzalez-Lopez, Manuel, Maury Goodman, Goodwin, Owen, Goswami, Srubabati, Gotti, Claudio, Prof. Evgueni Goudzovski, Grace, Carl, Richard Gran, Granados, Everardo, Granger, Pierre, Grant, Christopher, Gratieri, Diego, Green, Patrick, Greenberg, Stephen, Greenler, Leland, Greer, Joel, Grenard, Jean-Louis, Griffith, W. C., Groetschla, Florian, Groh, Micah, Katarzyna Grzelak, Gu, Wenqiang, Elena Guardincerri, Guarino, Victor, Guarise, Marco, Guenette, Roxanne, Guerard, Eric, Marco Guerzoni, Daniele Guffanti, Alberto Guglielmi, Guo, Bing, Gupta, Aseem, Gupta, Vikas, Guthikonda, K. K., Pawel Guzowski, Guzzo, Marcelo, Gwon, Sunwoo, Chang Hyon Ha, Haaf, Kevin, Habig, A., Hadavand, Haleh, Haenni, Roger, Hagaman, Lee, Hahn, Alan, Haiston, James, Philip Hamacher-Baumann, Thomas Hamernik, Hamilton, Philip, Jiyeon Han, Deborah Harris, Hartnell, J., Hartnett, Trevor, Harton, John, Takuya Hasegawa, Hasnip, Ciaran, Robert Hatcher, Hatfield, Kaleb, Athanasios Hatzikoutelis, Hayes, Christopher, Hayrapetyan, Karen, Jonathan Hays, Hazen, Eric, He, Muyuan, Anne Heavey, Heeger, K. M., Jaret Heise, Henry, Sarah, Hernandez Morquecho, Miguel Angel, Kenneth Herner, Hewes, V., Hilgenberg, Christopher, Tony Hill, Stephen Hillier, Alexander Himmel, Hinkle, Elise, Hirsch, Luciana, Hoff, James, Holin, Anna, Hoppe, E. W., Glenn Horton-Smith, Matheus Hostert, Hourlier, Adrien, Howard, Bruce, Howell, Ryan, Hoyos Barrios, Jaime, Hristova, Ivana, Hronek, Maxine, Huang, Junying, Huang, Roger, Hulcher, Zachary, Iles, Gregory, Ilic, Nikolina, Mihail Antoniu Iliescu, Illingworth, Robert, Ingratta, Gianfranco, Ara Ioannisian, Irwin, Burke, Isenhower, Larry, Ismerio Oliveira, Marcelo, Ran Itay, Jackson, Christopher, Vivek Jain, James, Eric, Jang, Wooyoung, Benjamin Jargowsky, Jediny, Filip, Jena, Deepika, Yu Seon Jeong, César Jesús-Valls, Ji, Xiangpan, Jiang, Junjie, Jiang, Libo, Jipa, Alexandru, Jo, Jay Hyun, Joaquim, Filipe, Johnson, Walker, Benjamin Jones, Jones, Rhiannon, Jovancevic, Nikola, Judah, Matthew, Chang Kee Jung, Thomas Junk, Jwa, Yeon-Jae, Monireh Kabirnezhad, Kaboth, Asher, Igor Kadenko, Igor Kakorin, Kalitkina, Anastasia, Kalra, Daisy, Kamer Koseyan, Ohannes, Felipe Garcia Ken Kamiya, Daniel Kaplan, Georgia Karagiorgi, Karaman, Gurkan, Karcher, Armin, Karyotakis, Yannis, Kasai, Seiji, Kasetti, S. P., Kashur, Lane, Ioannis Katsioulas, Narine Kazarian, Edward Kearns, Pt, Keener, Kevin Kelly, Ernesto Kemp, Kemularia, Otari, Ketchum, Wes, steve kettell, Marat Khabibullin, Khotjantsev, Alexei, Khvedelidze, Arsen, Doojin Kim, King, Bonnie, Brian Kirby, Michael Kirby, Joshua Klein, Kleykamp, Jeffrey, Klustova, Anezka, Thomas Kobilarcik, Koehler, Kevin, Lisa Koerner, Koh, D. H., Samuel Kohn, Patrick Pascal Koller, Kolupaeva, Liudmila, Korablev, Denis, Michael Kordosky, Thomas Kosc, Kose, Umut, Kostelecky, V. Alan, Kunal Kothekar, Kotler, Ian, Kozhukalov, Vladimir, Kralik, Robert, Luke Kreczko, Krennrich, Frank, Igor Kreslo, William Kropp, Kroupova, Tereza, Yury Kudenko, Vitaly Kudryavtsev, Stephen Kuhlmann, Sergey Kulagin, Kumar, Jason, Kumar, Praveen, Kunze, Pablo, Kuravi, Ramachandra, Kurita, Nadine, Kuruppumullage Don Chatura Kuruppu, Václav Kůs, Kutter, Thomas, Kvasnicka, Jiri, Kwak, Donghyun, Lambert, Andrew, Benjamin Land, Charles Lane, Lang, Karol, Thomas Langford, Langstaff, Mark, Francesco Lanni, Oliver Lantwin, Larkin, Jacob, Pierre Lasorak, Last, David, Laundrie, Andy, Giuliano Laurenti, Lawrence, Andrew, Paul Laycock, Lazanu, Ionel, Massimo Lazzaroni, Le, Trung, Leardini, Sara, Learned, John, Lebrun, Patrice, Thomas LeCompte, Claire Lee, Zachary Lee, Legin, Vladyslav, Giovanna Lehmann Miotto, Lehnert, Ralf, Marcelo Augusto Leigui de Oliveira, Leitner, Matthaeus, Lepin, L. M., Shirley Li, Yichen Li, Liao, Heng-Ye, Cheng-Ju Lin, Lin, Shih-Kai, Lineros, Roberto A., Jiajie Ling, Lister, Adam, Littlejohn, Bryce, Liu, Junze, Liu, Yinrui, Sarah Lockwitz, Loew, Timothy, Milos Lokajicek, Lomidze, Irakli, Long, Ken, Lord, Tom, John LoSecco, William Louis, Xianguo Lu, Kam-Biu Luk, Lunday, Benjamin, Xiao Luo, Luppi, Eleonora, Thorsten Lux, Vitor Prestes Luzio, Maalmi, Jihane, Macfarlane, David, Machado, Ana Amelia, Pedro Machado, Christopher Macias, Macier, Jolie R., maddalena antonello, Madera, Alfonso, Peter Madigan, Magill, Steve, Kendall Mahn, Amelia Maio, Major, Adryanna, Majumdar, Krishanu, James Maloney, Igor Mandrichenko, Mandrioli, Gianni, Mandujano, Roberto, Jose Maneira, Manenti, Laura, Steven Manly, Anthony Mann, Manolopoulos, Konstantinos, Manrique Plata, Maria, Venkata Narasimha Manyam, Marchan, Miquel, Alberto Marchionni, Marciano, William, Marfatia, Danny, Camillo Mariani, Jelena Maricic, Franciole Marinho, ALYSIA MARINO, Thomas Markiewicz, Marsden, David, Marvin Marshak, Christopher Marshall, John Marshall, Marteau, Jacques, Justo Martín-Albo, Martinez, Norman, David Martinez Caicedo, Francisco Martínez López, Martínez Miravé, Pablo, Sergey Martynenko, Valerio Mascagna, Katie Mason, Andrew Mastbaum, Matichard, Fabrice, Matsuno, Shigenobu, Matthews, J., Mauger, Christopher, Nicoletta Mauri, Konstantinos Mavrokoridis, Mawby, Isobel, Mazza, Roberto, Anna Mazzacane, Mcaskill, Tracy, Mccluskey, Elaine, Mcconkey, Nicola, Kevin McFarland, Clark McGrew, Andrew McNab, Mefodiev, Alexander, Poonam Mehta, Melas, Pantelis, Mena, Olga, Mendez, Hector, Mendez, Patricia, Méndez, Diana, Alessandro Menegolli, guang meng, Mark Messier, Metcalf, William, Mewes, Matthew, Holger Meyer, Miao, Ting, Michna, Gregory, Mikola, Veera, Milincic, Radovan, Miller, Graham, Miller, William, Joshua Mills, Mineev, Oleg, Minotti, Alessandro, Omar Gustavo Miranda, Miryala, Sandeep, Mishra, C. Shekhar, Sanjib Mishra, Mislivec, Aaron, Mitchell, Mote, Mladenov, Dimitar, Mocioiu, Irina, Kristian Moffat, Andrew Mogan, Niccolo' Moggi, Rukmani Mohanta, Tanaz Mohayai, Nikolai Mokhov, Molina, Jorge, Molina Bueno, Laura, Montagna, Elisabetta, Alessandro Montanari, Claudio Montanari, Montanari, David, Daniele Montanino, Montaño Zetina, L. M., Moon, Seok Ho, Mooney, Michael, Moor, Alexandra, Deywis Moreno Lopez, Moretti, Davide, Morris, Casandra, Christopher Mossey, Mitchell Mote, Motuk, Erdem, Moura, Celio A., Mousseau, Joel, Mouster, Gwenn, Mu, Wei, Mualem, Leon, Mueller, Justin, Mathew Muether, Muheim, Franz, Muir, Alan, Mulhearn, Mike, Munford, Donnie, Muramatsu, Hajime, Murphy, Matt, Murphy, Sebastien, Musser, Jim, Nachtman, Jane, YOSHIKAZU NAGAI, Nagu, Srishti, Nalbandyan, Mikayel, Nandakumar, Raja, Naples, Donna, Shinya Narita, Atanu Nath, Navrer-Agasson, Anyssa, Nitish Nayak, Miquel Nebot Guinot, Negishi, Kentaro, Jeffrey Nelson, Nelson, Matthew, Nesbit, Jake, Marzio Nessi, David Newbold, Newcomer, F. M., Newton, Hannah, Ryan Nichol, Nicolas-Arnaldos, Francisco, Nikolica, Adrian, Nikolov, Jovana, Evan Niner, Kurtis Nishimura, Andrew Norman, Norrick, Anne, Pau Novella, Jaroslaw Andrzej Nowak, Oberling, Michael, Ochoa-Ricoux, J. P., Olivier, Andrew, Alexander Olshevskiy, Onel, Yasar, Onishchuk, Yuriy, Luis Otiniano, Ott, Jordan, Luca Pagani, Guillermo Palacio, Ornella Palamara, Sandro Palestini, Jonathan Paley, Marco Pallavicini, Palomares, Carmen, Pan, Supriya, Jose Guillermo Panduro Vazquez, Pantic, Emilija, Paolone, Vittorio, Papadimitriou, Vaia, riccardo papaleo, Antonis Papanestis, Paramesvaran, Sudarshan, Stephen Parke, Parozzi, Elisabetta, Parsa, Saba, Parsa, Zohreh, Parveen, Sabila, Mihaela Parvu, Pasciuto, Daniele, Pascoli, Silvia, Ramon Pasetes, Pasqualini, Laura, Pasternak, Jaroslaw, Pater, Joleen, Cheryl Patrick, Laura Patrizii, Ryan Patterson, Patton, Simon John, Patzak, Thomas, Paudel, Ajib, Laura Paulucci, Zarko Pavlovic, Pawloski, Greg, Payne, David, Viktor Pěč, Jm, Prof Dr Ir Simon Peeters, Pena Perez, Aldo, Pennacchio, Elisabetta, Penzo, Aldo, Orlando Peres, Pernas, Carlos, Perry, James, Pershey, Daniel, Gianluigi Ezio Pessina, Gianluca Petrillo, Petta, Catia, Petti, Roberto, Valerio Pia, Pickering, Luke, Francesco Pietropaolo, Pimentel, V. L., Pinaroli, Giovanni, Plows, Komninos-John, Robert Plunkett, Pompa, Federica, Pons, Xavier, Navaneeth Poonthottathil, Poppi, Francesco, Stephen Pordes, Porter, Joshua, Salvatore Davide Porzio, Potekhin, Maxim, Potenza, Renato, Potukuchi, B. V., Pozimski, Juergen, Michele Pozzato, Suprabh Prakash, Prakash, Tarun, Pratt, Christian, MICHELA PREST, Fernanda Psihas, Pugnere, Denis, Xin Qian, Jennifer Raaf, Radeka, Veljko, Jonas Rademacker, Radev, R., Balint Radics, Aleena Rafique, Raguzin, Eric, Rai, Mousam, Rajaoalisoa, Miriama, Rakhno, Igor, Rakotonandrasana, Andrianjafy Michaël, Rakotondravohitra, Laza, Rameika, Regina, Manuel Alejandro Ramírez Delgado, Bryan Ramson, Andrea Rappoldi, Gian Luca Raselli, Peter Neil Ratoff, Raut, Sanil, Razafinime, Herilala, Razakamiandra, Rado F., Rea, E. M., Jean-Sébastien Real, Brian Rebel, Rechenmacher, Ronald, Reggiani-Guzzo, Marina, Juergen Reichenbacher, Reitzner, S. D., Rejeb Sfar, Haifa, Andrew Renshaw, Rescia, Sergio, Resnati, Filippo, Ribas, Marlos, STEFANO RIBOLDI, Riccio, Ciro, Riccobene, Giorgio, Rice, Logan, Ricol, Jean-Stephane, Rigamonti, Alberto, Rigaut, Yann-Axel, Rincón, Edgar, Ritchie-Yates, Asher, Rivera, David, Ryan Rivera, Robert, Arnaud, Rocabado Rocha, Jose Luis, Rochester, Leon, Marco Roda, Philip Rodrigues, Manuel Jesus Rodriguez Alonso, Rodriguez Rondon, Jairo, Romeo, Emanuele, Rosauro-Alcaraz, Salvador, Rosier, Philippe, Massimo Rossella, Rossi, Marco, Mark Ross-Lonergan, Rout, Jogesh, Roy, Palash, Rubbia, Andre, Rubbia, Carlo, Brooke Russell, Ruterbories, D., Rybnikov, Arseniy, Angela Saa Hernandez, Saakyan, Ruben, sabrina sacerdoti, Narendra Sahu, paola sala, Samios, Nicholas, Oleg Samoylov, Mayly Sanchez, Sandberg, Vern, David Sanders, David Sankey, Santoro, Danilo, Saoulidou, Niki, Piera Sapienza, Sarasty, Carlos, Sarcevic, Ina, Savage, Geoffrey, Savinov, Vladimir, Giacomo Scanavini, Scaramelli, Alberto, Andrew Scarff, Scarpelli, Andrea, Schefke, Tristan, Heidi Schellman, Sebastiano Fabio Schifano, Schlabach, Philip, Schmitz, David W., Austin Schneider, Kate Scholberg, Anne Schukraft, Segreto, Ettore, Selyunin, Alexander, Carlos Senise, Jonathon Sensenig, Davide Sgalaberna, Michael Shaevitz, Shafaq, Sheeba, Shaker, Fady, Shamma, Michael, Shanahan, Peter, Sharankova, Ralitsa, Sharma, H. R., Sharma, R., Sharma, R. K., KATE SHAW, Shaw, Terri, Shchablo, Konstantin, Shepherd-Themistocleous, Claire, Sheshukov, Andrey, Wei Shi, Seodong Shin, Shoemaker, Ian M., Shooltz, Dean, Robert Shrock, Silber, Joseph, Simard, Laurent, Frank Simon, James Sinclair, Sinev, Gleb, Jaydip Singh, Singh, Jyotsna, Singh, Lakwinder, Prabhjot Singh, Venktesh Singh, SUSHIL SINGH CHAUHAN, Roland Sipos, Gabriele Sirri, Andriaseta Sitraka, Siyeon, Kim, Skarpaas, Knut, Smith, Erica, Smith, Paul, Smolik, Jan, Smy, Michael, Erica Snider, Pavel Snopok, Snowden-Ifft, Daniel, Soares Nunes, Mônica, Sobel, Henry, Mitch Soderberg, Sokolov, Sergei, Carlos Javier Solano Salinas, Stefan Soldner-Rembold, Stefano Roberto Soleti, Solomey, Nicholas, Vladimir Solovov, Sondheim, Walter, Michel Sorel, Sotnikov, A., Soto-Oton, Jose, Alexandre Sousa, Soustruznik, Karel, Fabio Spagliardi, Spanu, Maura, Spitz, Joshua, Spooner, N. J., Spurgeon, Kyle, Stalder, D. H., Stancari, Michelle, Luca Stanco, Steenis, Jacob, Stein, Raul, Steiner, Herbert M., Andre Fabiano Steklain Lisboa, Stepanova, Anna, Stewart, James, Stillwell, Ben, Jason Stock, Francesca Stocker, Stokes, Tyler, Matthew Strait, Thomas Strauss, Louis Strigari, Alexander Stuart, Suarez, J. G., Subash, Joeal, Antonio Surdo, Susic, Vasja, Louise Suter, Concetta Maria Sutera, Suvorov, Yury, Svoboda, Robert, Szczerbinska, Barbara, Andrzej Szelc, Talukdar, Nibir, Tamara, Jose, Tanaka, H. A., Shaochun Tang, Beatriz Tapia Oregui, Alexander Tapper, Salman Tariq, Tarpara, Eaglekumar, Tata, Neeraj, Tatar, E., Rex Tayloe, Abraham Teklu, Tennessen, Peter, Matteo Tenti, Kazuhiro Terao, Francesco Terranova, Gemma Testera, Thakore, Tarak, Alessandro Thea, Adrian Thompson, Thorn, Craig, Steven Timm, Vladimir Tishchenko, Natasa Todorovic, Luca Tomassetti, Alessandra Tonazzo, Torbunov, Dmitri, Torti, Marta, Mariam Tortola, Francesco Tortorici, Nicolò Tosi, Totani, Dante, Matt Toups, Christos Touramanis, Riccardo Travaglini, Trevor, Jason, Trilov, Stoyan, Wladyslaw Henryk Trzaska, Tsai, Yu-Dai, Yun-Tse Tsai, Tsamalaidze, Zviadi, Tsang, Ka Vang, Tsverava, Nikolozi, Tufanli, Serhan, Tull, Craig, Jessica Turner, Tyler, Jennifer, Tyley, E., Tzanov, Martin, Uboldi, Lorenzo, Uchida, Melissa, Urheim, Jon, Tracy Usher, Utaegbulam, Hilary, Uzunyan, Sergey, Mark Vagins, Vahle, Patricia, Sammy Valder, Valdiviesso, G. A., Edgar, R Valentim R Valentim Da Costa Lima, R. V. C. Lima, Zoya Vallari, Vallazza, Erik, Jwf, Valle, Sofia Vallecorsa, Richard Van Berg, Richard Van de Water, David Vanegas Forero, David Vannerom, Filippo Varanini, Vargas Oliva, Danaisis, Gary Varner, Svetlana Vasina, Vaughan, Noah, Vaziri, Kamran, Juan Santiago Vega Martinez, Sandro Ventura, Antonio Verdugo de Osa, Vergani, Stefano, Vermeulen, M. A., Marco Verzocchi, Matteo Vicenzi, Souza, H. V., Chiara Vignoli, Cristovao Vilela, Viren, Brett, Vrba, Tomas, Vuong, Quynh, Wachala, Tomasz, Alexander Wagner, Waldron, Abigail, Michael Wallbank, Walton, Tammy, Wang, Hanguo, Wang, Jingbo, Wang, L., Michael Wang, Wang, Xiaoran, Wang, Y., Warburton, Karl, Warner, David, Morgan Wascko, Waters, David, Alan Watson, Wawrowska, Klaudia, Weatherly, Pierce, Alfons Weber, Michele Weber, Hanyu Wei, Weinstein, Amanda, Wenman, Dan, Wetstein, Matthew, Whilhelmi, James, White, A., Brandon White, Stephen White, Leigh Whitehead, Denver Whittington, Michael Wilking, Wilkinson, Alexander, Callum Wilkinson, Williams, Zachary, Fergus Wilson, Robert Wilson, William Wisniewski, Jeremy Wolcott, Wolfs, Jean, Wongjirad, Taritree, Wood, Anthony, Wood, Kevin, Worcester, Elizabeth, Worcester, Matthew, Marianette Wospakrik, Wresilo, Karolina, Clarence Wret, Wu, Shaowei, Wanwei Wu, Wu, Wenjie, Xiao, Yiwen, Xiotidis, Ioannis, Yaeggy, Barbara, Yandel, Erin, Guang Yang, Yang, Kang, Tingjun Yang, Yankelevich, Alejandro, Yershov, Nikolai, Katsuya Yonehara, Young Soo Yoon, Young, Tim, Bo Yu, Yu, H., Jaehoon Yu, Yiding Yu, Yuan, Wenlong, Zaki, Rowan, Jaroslav Zalesak, Zambelli, Laura, Bruno Zamorano, Zani, Andrea, Zazueta, Luis, Geralyn Zeller, Zennamo, Joseph, Zeug, Kyle, Chao Zhang, Zhang, Shuaixiang, Zhang, Yuze, Zhao, Manhong, Zhivun, Elena, Zimmerman, E. D., Stefano Zucchelli, Josef Zuklin, Zutshi, Vishnu, Robert Zwaska, HEP, INSPIRE, Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), and DUNE

Subjects
Physics - Instrumentation and Detectors, DUNE, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], hep-ex, Other Fields of Physics, FOS: Physical sciences, Instrumentation and Detectors (physics.ins-det), [INFO] Computer Science [cs], programming, High Energy Physics - Experiment, physics.data-an, off-line, High Energy Physics - Experiment (hep-ex), [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Physics - Data Analysis, Statistics and Probability, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], [INFO]Computer Science [cs], [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, [PHYS.PHYS.PHYS-DATA-AN] Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an], physics.ins-det, [PHYS.PHYS.PHYS-DATA-AN]Physics [physics]/Physics [physics]/Data Analysis, Statistics and Probability [physics.data-an], Particle Physics - Experiment, Data Analysis, Statistics and Probability (physics.data-an)
Abstract

This document describes the conceptual design for the Offline Software and Computing for the Deep Underground Neutrino Experiment (DUNE). The goals of the experiment include 1) studying neutrino oscillations using a beam of neutrinos sent from Fermilab in Illinois to the Sanford Underground Research Facility (SURF) in Lead, South Dakota, 2) studying astrophysical neutrino sources and rare processes and 3) understanding the physics of neutrino interactions in matter. We describe the development of the computing infrastructure needed to achieve the physics goals of the experiment by storing, cataloging, reconstructing, simulating, and analyzing $\sim$ 30 PB of data/year from DUNE and its prototypes. Rather than prescribing particular algorithms, our goal is to provide resources that are flexible and accessible enough to support creative software solutions and advanced algorithms as HEP computing evolves. We describe the physics objectives, organization, use cases, and proposed technical solutions., Comment: 229 pages, 67 figures

6. Deep Underground Neutrino Experiment (DUNE), Far Detector Technical Design Report, Volume II: DUNE Physics

Author

babak abi, Acciarri, Roberto, Mario A Acero O, Adamov, Giorge, David Adams, Adinolfi, Marco, Ahmad, Zubayer, Ahmed, Jhanzeb, Alion, Tyler, Saúl Alonso-Monsalve, Alt, Christoph, Anderson, John, Constantinos Andreopoulos, Andrews, Michael P., Manoa Andriamirado, Andrianala, Fenompanirina, Sofia Andringa, Artur Ankowski, Anthony, Jack, Mihail Antoniu Iliescu, Antonova, Maria, Antusch, Stefan, Alfredo Aranda, Akitaka Ariga, Arnold, Lukas, Arroyave, Manuel, Asaadi, Jonathan, Adam Aurisano, Aushev, Vladimir, Dario Autiero, Azfar, Farrukh, Ashley Back, Back, Henning, John Back, Given Names Deactivated Family Name Deactivated, Baesso, Paolo, Bagby, Linda, Bajou, Raphael, Balasubramanian, Supraja, Baldi, Pierre, Bambah, Bindu, Barao, F., Barenboim, Gabriela, Gary Barker, Barkhouse, Wayne, Barnes, Christopher, Barr, Giles, Barranco Monarca, Juan, Barros, N., Barrow, J. L., Bashyal, Amit, Vincent Marc Basque, Fatih Bay, Bazo Alba, J. L., John Beacom, Bechetoille, Edouard, Biswaranjan Behera, Leo Bellantoni, Bellettini, Giorgio, Bellini V., Beltramello, Olga, Belver, D., Nektarios Benekos, Francisco Neves, Berger, Joshua, Berkman, Sophie, Paolo Bernardini, Roman Matthias Berner, Berns, Hans-Gerd, Sergio Bertolucci, Betancourt, Minerba, Bezawada, Y., Bhattacharjee, M., Simone Biagi, Jianming Bian, Biassoni, Matteo, Kurt Biery, Bilki, Burak, Mary Bishai, Alexander Bitadze, Andrew Blake, Blanco Siffert, Beatriz, Flor de Maria Blaszczyk, Blazey, Gerald C., Edward Blucher, Boissevain, Jan, Bolognesi, Sara, Tim Bolton, Maurizio Bonesini, Bongrand, Mathieu, Filiberto Bonini, Alexander Booth, Christopher Booth, Stefania Bordoni, Aran Borkum, Tommaso Boschi, Nilay Bostan, Bour, Petr, Boyd, Steve B., Boyden, Daniel, Juraj Bracinik, Braga, Davide, Brailsford, Dominic, Brandt, Andrew, johan bremer, Chris Brew, Brianne, Eldwan, Stephen Brice, Brizzolari, Claudia, Carl Bromberg, Gustaaf Brooijmans, Bross, Alan, Giulia Brunetti, Buchanan, Norman, Budd, Howard, Davide Caiulo, Paolo Calafiura, Calcutt, Jacob, Calin, Marius, Calvez, Steven, Enrique Calvo Alamillo, Camilleri, Leslie, Alessio Caminata, Mario Campanelli, David Caratelli, Carini, Gabriella, Carlus, Bruno, Paolo Carniti, Caro Terrazas, Ivan, Carranza, Hector, Andres Castillo, Cesar Manuel Castromonte Flores, Cattadori, Carla, Fabien Cavalier, Flavio Cavanna, Centro, Sandro, Giuseppe Cerati, Alberto Cervelli, Cervera Villanueva, Anselmo, Chalifour, Michel, Chang, C., Chardonnet, Etienne, Animesh Chatterjee, Chattopadhyay, Subhasish, Jorge Chaves, Hucheng Chen, Mu-Chun Chen, Chen, Yifan, Daniel Cherdack, Chi, Cheng-Yi, Childress, Sam, Chiriacescu, Ana, Kihyeon Cho, Choubey, Sandhya, Christensen, Anne, David Christian, Georgios Christodoulou, Eric Church, Clarke, Peter, Thomas Coan, Alfredo Giuseppe Cocco, Joao Coelho, Erin Conley, Janet Conrad, Convery, Mark, Luke Corwin, Cotte, Philippe, Cremaldi, Lucien, Linda Cremonesi, José Ignacio Crespo Anadón, Cristaldo, Esteban, Cross, Ryan, Clara Cuesta, Cui, Yanou, Cussans, David, Dabrowski, Mieczyslaw, Da Motta, Helio, Peres, L. Da Silva, David, Quentin, Gavin Davies, Stefano Davini, Dawson, Jaime, De, Kaushik, Almeida, Rogerio, Debbins, Paul, Bonis, Isabelle, Michal Patrick Decowski, Andre de Gouvea, Holanda, Pedro, Icaza Astiz, Iker, Deisting, Alexander, Paul de Jong, Delbart, Alain, David Delepine, Delgado, Maritza, Andrea Dell’Acqua, Lurgio, Patrick, Erin Ewart, Grant, Nick, Hernandez Morquecho, Miguel Angel, Hewes, Jeremy, Junting Huang, Huang, Junying, Marcelo Augusto Leigui de Oliveira, Li, Shaorui, Shirley Li, Manuel Alejandro Ramírez Delgado, Jaydip Singh, Singh, Jyotsna, Smith, Adryanna, Smith, Andrew, Todd, Jacob, Mello Neto, J. R. T., David DeMuth, Dennis, Steve, Densham, Chris, Gregor Recalde, Derlis, Albert De Roeck, Romeri, Valentina, Jan Vries, Joris, Ranjan Dharmapalan, Félix Napoleón Díaz Desposorio, Diaz, Jorge S., Sergio Di Domizio, Di Giulio, Letizia, Pengfei Ding, Di Noto, Lea, Carla Distefano, Richard Diurba, Milind Diwan, Djurcic, Zelimir, Dokania, Neha, Michelle Dolinski, Domine, Laura, Daniel Douglas, Drielsma, Francois, Dominique Duchesneau, Duffy, K. E., Patrick Dunne, Durkin, Tim, Duyang, Hongyue, Olexiy Dvornikov, Dwyer, Daniel A., Dyshkant, Alexandre S., Eads, Michael, Edmunds, Daniel, Jonathan Eisch, Sandrine Emery-Schrenk, Antonio Ereditato, CARLOS ESCOBAR, Lorena Escudero, Evans, J. J., Ewart, E., Ezeribe, A. C., Fahey, Kevin, Falcone, Andrea, Farnese, Christian, Yasaman Farzan, Julian Felix, Enrique Fernandez-Martinez, Pablo Fernandez, Federico Ferraro, Laura Fields, Filkins, A., Frank Filthaut, Rory Fitzpatrick, Flanagan, Will, Fleming, Bonnie, Flight, Robert, Fowler, Jack, Fox, Walt, Jiří Franc, Francis, Kurt, Domenico Franco, John Freeman, Freestone, Julian, Fried, Jack, Alexander Friedland, Stuart Fuess, Furic, Ivan, Andrew Furmanski, Gago, A., Gallagher, Hugh, Gallego-Ros, Ana, Gallice, Niccolo, Galymov, Vyacheslav, Enrico Gamberini, Gamble, Trevor, Gandhi, Raj, Reddy Pratap Gandrajula, Gao, Shanshan, Diego Garcia Gamez, García-Peris, Miguel, Gardiner, Steven, Gastler, Dan, Ge, Guanqun, Gelli, Bruno, Gendotti, Adamo, Gent, Stephen, Zahra Ghorbani moghaddam, Daniele Gibin, Gil-Botella, Ines, Girerd, Claude, Anjan Giri, Gnani, D., Olga Gogota, Gold, Michael, Gollapinni, Sowjanya, Gollwitzer, Keith, Ricardo Gomes, Gomez Bermeo, Laura Vanessa, Luz Stella Gomez Fajardo, Francesco Gonnella, Gonzalez-Cuevas, Juan Alberto, Maury Goodman, Goodwin, Owen, Goswami, Srubabati, Gotti, Claudio, Prof. Evgueni Goudzovski, Grace, Carl, Graham, Mathew, Gramellini, E., Richard Gran, Granados, Everardo, Grant, Alan, Grant, Christopher, Gratieri, Diego, Green, Patrick, Steven Green, Greenler, Leland, Greenwood, M., Greer, Joel, Griffith, W. C., Groh, Micah, Grudzinski, James, Grzelak, Katarzyna, Gu, Wenqiang, Guarino, Victor, Guenette, Roxanne, Alberto Guglielmi, Guo, Bing, Guthikonda, K. K., Gutierrez, Rafael, Pawel Guzowski, Guzzo, Marcelo, Gwon, Sunwoo, Habig, A., Hackenburg, A., Hadavand, Haleh, Haenni, Roger, Hahn, Alan, Jennifer Haigh, Haiston, James, Thomas Hamernik, Hamilton, Philip, Jiyeon Han, Harder, Kristian, Harris, Debbie, Hartnell, J., Takuya Hasegawa, Robert Hatcher, Hazen, Eric, Anne Heavey, Heeger, K. M., Hennessy, Karol, Henry, Sarah, Kenneth Herner, Hertel, Lars, Hewes, V., Higuera Pichardo, Aaron, Tony Hill, Stephen Hillier, Alexander Himmel, Hoff, James, Hohl, Christian, Holin, Anna, Hoppe, E. W., Glenn Horton-Smith, Matheus Hostert, Hourlier, Adrien, Howard, Bruce, Howell, Ryan, Hugon, Justin, Iles, Gregory, Illingworth, Robert, Ara Ioannisian, Ran Itay, Izmaylov, Alexander, James, Eric, Jargowsky, B., Jediny, Filip, César Jesús-Valls, Ji, Xiangpan, Jiang, L., Jiménez, Sergio, Jipa, Alexandru, Connor Johnson, Randy Johnson, Benjamin Jones, Sebastian Jones, Chang Kee Jung, Thomas Junk, Jwa, Yeon-Jae, Monireh Kabirnezhad, Kaboth, Asher, Kadenko, Ihor M., Felipe Garcia Ken Kamiya, Georgia Karagiorgi, Karcher, A., Karolak, Mark, Karyotakis, Yannis, Kasai, Seiji, Kasetti, Siva, Kashur, Lane, Narine Kazarian, Edward Kearns, Pt, Keener, Kevin Kelly, Kemp, Ernesto, Ketchum, Wes, steve kettell, Marat Khabibullin, Khotjantsev, Alexei, Khvedelidze, Arsen, Kim, D., King, Bonnie, Brian Kirby, Michael Kirby, Joshua Klein, Koehler, Kevin, Lisa Koerner, Samuel Kohn, Patrick Pascal Koller, Michael Kordosky, Thomas Kosc, Kose, Umut, Kostelecky, V. Alan, Kunal Kothekar, Krennrich, Frank, Igor Kreslo, Yury Kudenko, Vitaly Kudryavtsev, Sergey Kulagin, Kumar, Jason, Kumar, Rajeev, Kuruppumullage Don Chatura Kuruppu, Václav Kůs, Kutter, Thomas, Lambert, A., Lande, Kenneth, Charles Lane, Lang, Karol, Thomas Langford, Pierre Lasorak, Last, David, Lastoria, Chiara, Laundrie, Andy, Lawrence, A., Lazanu, Ionel, Ryan LaZur, Le, Trung, Learned, John, Lebrun, Patrice, Giovanna Lehmann Miotto, Lehnert, Ralf, Leitner, M., Leyton, Michael, Li, Lingge, Li, Teng, Yichen Li, Liao, Heng-Ye, Cheng-Ju Lin, Lin, Shih-Kai, Lister, Adam, Littlejohn, Bryce, Liu, J., Sarah Lockwitz, Loew, Timothy, Milos Lokajicek, Lomidze, Irakli, Long, Ken, Loo, Kai, David Lorca Galindo, Lord, Tom, John LoSecco, William Louis, Kam-Biu Luk, Xiao Luo, Nicolas Lurkin, Thorsten Lux, Vitor Prestes Luzio, Macfarlane, David, Machado, Ana Amelia, Pedro Machado, Christopher Macias, Macier, Jolie R., maddalena antonello, Peter Madigan, Magill, Steve, Kendall Mahn, Amelia Maio, James Maloney, Mandrioli, Gianni, Jose Maneira, Manenti, Laura, Manly, S., Mann, W. A., Manolopoulos, Konstantinos, Manrique Plata, Maria, Alberto Marchionni, Marciano, William, Marfatia, Danny, Camillo Mariani, Jelena Maricic, Franciole Marinho, ALYSIA MARINO, Marvin Marshak, Christopher Marshall, John Marshall, Marteau, Jacques, Justo Martín-Albo, Martinez, Norman, David Martinez Caicedo, Sergey Martynenko, Katie Mason, Andrew Mastbaum, Mehedi Masud, Matsuno, Shigenobu, Matthews, J., Mauger, Christopher, Nicoletta Mauri, Konstantinos Mavrokoridis, Mazza, Roberto, Anna Mazzacane, Mazzucato, Edoardo, Mccluskey, Elaine, Mcconkey, Nicola, Kevin McFarland, Clark McGrew, Andrew McNab, Mefodiev, Alexander, Poonam Mehta, Melas, Pantelis, Mellinato, Michele, Mena, Olga, Menary, Scott, Mendes Santos, Lucas, Mendez, Hector, Alessandro Menegolli, guang meng, Mark Messier, Metcalf, William, Mewes, Matthew, Holger Meyer, Miao, Ting, Michna, Gregory, Miedema, Thijs, Jost Migenda, Milincic, Radovan, Miller, William H., Joshua Mills, Milne, Cody, Mineev, Oleg, Omar Gustavo Miranda, Miryala, Sandeep, Mishra, C. 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W., Gabriele Sirri, Andriaseta Sitraka, Siyeon, Kim, Smargianaki, D., Smith, Erica, Smith, Paul, Smolik, Jan, Smy, Michael, Pavel Snopok, Soares Nunes, Mônica, Sobel, Henry, Mitch Soderberg, Carlos Javier Solano Salinas, Stefan Soldner-Rembold, Solomey, Nicholas, Vladimir Solovov, Sondheim, Walter, Michel Sorel, Soto-Oton, Jose, Alexandre Sousa, Soustruznik, Karel, Fabio Spagliardi, Spanu, Maura, Spitz, Joshua, Spooner, Neil Jc, Spurgeon, Kyle, Staley, Richard, Stancari, Michelle, Luca Stanco, Steiner, Herbert M., Stewart, James, Stillwell, Ben, Jason Stock, Francesca Stocker, Stokes, Tyler, Matthew Strait, Thomas Strauss, sergei striganov, Alexander Stuart, Donald Summers, Antonio Surdo, Susic, Vasja, Louise Suter, Concetta Maria Sutera, Svoboda, Robert, Szczerbinska, Barbara, Andrzej Szelc, Richard Talaga, Tanaka, H. A., Beatriz Tapia Oregui, Alexander Tapper, Salman Tariq, Tatar, E., Rex Tayloe, Abraham Teklu, Matteo Tenti, Kazuhiro Terao, Christoph Andreas Ternes, Francesco Terranova, Gemma Testera, Alessandro Thea, Joshua Thompson, Thorn, Craig, Steven Timm, Alessandra Tonazzo, Torti, Marta, Mariam Tortola, Francesco Tortorici, Totani, Dante, Matt Toups, Christos Touramanis, Trevor, Jason, Trzaska, Wladyslaw, Yun-Tse Tsai, Tsamalaidze, Zviadi, Tsang, Ka Vang, Tsverava, Nikolozi, Tufanli, Serhan, Tull, Craig, Tyley, E., Tzanov, Martin, Uchida, Melissa, Urheim, Jon, Tracy Usher, Vagins, Mark R., Vahle, Patricia, Valdiviesso, G. A., Valencia, E., Zoya Vallari, Jwf, Valle, Sofia Vallecorsa, Richard Van Berg, Richard Van de Water, David Vanegas Forero, Filippo Varanini, Vargas, Danaisis, Gary Varner, Justin Vasel, Vasseur, Georges, Vaziri, Kamran, Sandro Ventura, Antonio Verdugo de Osa, Vergani, Stefano, Vermeulen, Milo, Marco Verzocchi, Souza, H. V., Chiara Vignoli, Cristovao Vilela, Viren, Brett, Vrba, Tomas, Wachala, Tomasz, Waldron, Abigail, Michael Wallbank, Wang, Hanguo, Wang, Jingbo, Wang, Yi, Wang, Yue, Warburton, Karl, Warner, David, Morgan Wascko, Waters, David, Alan Watson, Weatherly, Pierce, Alfons Weber, Michele Weber, Hanyu Wei, Weinstein, Amanda, Wenman, Dan, Wetstein, Matthew, Yang, Shaokai, Geralyn Zeller, While, M. R., White, Andy, Leigh Whitehead, Denver Whittington, Michael Wilking, Callum Wilkinson, Williams, Zachary, Fergus Wilson, Robert Wilson, Jeremy Wolcott, Wongjirad, Taritree, Wood, Kevin, Lynn Wood, Worcester, Elizabeth, Worcester, Matthew, Clarence Wret, Wanwei Wu, Xiao, Y., Guang Yang, Tingjun Yang, Yershov, Nikolai, Katsuya Yonehara, Young, Tim, Bo Yu, Jaehoon Yu, Jaroslav Zalesak, Zambelli, Laura, Bruno Zamorano, Zani, Andrea, Zazueta, Luis, Zeller, G. P., Zennamo, Joseph, Zeug, Kyle, Chao Zhang, Zhao, Manhong, Zhivun, Elena, Guanying Zhu, Zimmerman, Eric, Zito, Marco, Stefano Zucchelli, Josef Zuklin, Zutshi, Vishnu, Robert Zwaska, Institut de Physique des 2 Infinis de Lyon (IP2I Lyon), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), AstroParticule et Cosmologie (APC (UMR_7164)), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Observatoire de Paris, Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université Paris Cité (UPCité), Institut de Recherches sur les lois Fondamentales de l'Univers (IRFU), Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université Paris-Saclay, Laboratoire de l'Accélérateur Linéaire (LAL), Université Paris-Sud - Paris 11 (UP11)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS), Laboratoire d'Annecy de Physique des Particules (LAPP), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Savoie Mont Blanc (USMB [Université de Savoie] [Université de Chambéry])-Centre National de la Recherche Scientifique (CNRS), Laboratoire de Physique Subatomique et de Cosmologie (LPSC), Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Centre National de la Recherche Scientifique (CNRS)-Université Grenoble Alpes (UGA)-Institut polytechnique de Grenoble - Grenoble Institute of Technology (Grenoble INP ), Université Grenoble Alpes (UGA), DUNE, Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Centre National de la Recherche Scientifique (CNRS)-Université de Paris (UP), Centre National de la Recherche Scientifique (CNRS)-Institut National de Physique Nucléaire et de Physique des Particules du CNRS (IN2P3)-Université Paris-Sud - Paris 11 (UP11), and HEP, INSPIRE

Subjects
Particle physics, nucleon: decay, LBNF, Physics - Instrumentation and Detectors, [PHYS.HEXP] Physics [physics]/High Energy Physics - Experiment [hep-ex], media_common.quotation_subject, far detector, FOS: Physical sciences, 01 natural sciences, High Energy Physics - Experiment, Standard Model, High Energy Physics - Experiment (hep-ex), Component (UML), 0103 physical sciences, CP: violation, antimatter, [PHYS.HEXP]Physics [physics]/High Energy Physics - Experiment [hep-ex], Deep Underground Neutrino Experiment, Grand Unified Theory, neutrino: supernova, [PHYS.PHYS.PHYS-INS-DET]Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Detectors and Experimental Techniques, capture, 010306 general physics, physics.ins-det, media_common, Physics, hep-ex, 010308 nuclear & particles physics, Instrumentation and Detectors (physics.ins-det), time projection chamber: liquid argon, deep underground detector, Universe, asymmetry: CP, neutrino: detector, grand unified theory, Neutrino detector, [PHYS.PHYS.PHYS-INS-DET] Physics [physics]/Physics [physics]/Instrumentation and Detectors [physics.ins-det], Systems engineering, CP violation, neutrino: burst, proposed experiment, Neutrino, Particle Physics - Experiment, signature
Abstract

The preponderance of matter over antimatter in the early universe, the dynamics of the supernovae that produced the heavy elements necessary for life, and whether protons eventually decay -- these mysteries at the forefront of particle physics and astrophysics are key to understanding the early evolution of our universe, its current state, and its eventual fate. DUNE is an international world-class experiment dedicated to addressing these questions as it searches for leptonic charge-parity symmetry violation, stands ready to capture supernova neutrino bursts, and seeks to observe nucleon decay as a signature of a grand unified theory underlying the standard model. The DUNE far detector technical design report (TDR) describes the DUNE physics program and the technical designs of the single- and dual-phase DUNE liquid argon TPC far detector modules. Volume II of this TDR, DUNE Physics, describes the array of identified scientific opportunities and key goals. Crucially, we also report our best current understanding of the capability of DUNE to realize these goals, along with the detailed arguments and investigations on which this understanding is based. This TDR volume documents the scientific basis underlying the conception and design of the LBNF/DUNE experimental configurations. As a result, the description of DUNE's experimental capabilities constitutes the bulk of the document. Key linkages between requirements for successful execution of the physics program and primary specifications of the experimental configurations are drawn and summarized. This document also serves a wider purpose as a statement on the scientific potential of DUNE as a central component within a global program of frontier theoretical and experimental particle physics research. Thus, the presentation also aims to serve as a resource for the particle physics community at large., 357 pages, 165 figures (updated typos in Table 6.1 and corrected errors in author list)

7. Neutrino oscillation physics potential of Hyper-Kamiokande

Author

Linda Cremonesi

Subjects
Physics, Particle physics, Physics::Instrumentation and Detectors, Proton decay, Cherenkov detector, Astrophysics::High Energy Astrophysical Phenomena, High Energy Physics::Phenomenology, Solar neutrino problem, law.invention, Nuclear physics, Neutrino detector, law, CP violation, High Energy Physics::Experiment, Neutrino, Neutrino oscillation, Cherenkov radiation
Abstract

Hyper-Kamiokande (Hyper-K) is a megaton scale water Cherenkov detector proposed to be built in Japan. Hyper-K is the logical continuation of the highly successful program of neutrino physics and proton decay searches using a water Cherenkov technique. Hyper-K will study the CP asym- metry in neutrino oscillations using the neutrino and anti-neutrino beams produced at J-PARC. With an exposure of 7.5 MW 10 7 seconds, dCP can be measured to better than 19 at all values, and CP violation can be detected with more than 3 sigma (5 sigma) significance for 76% (58%) of values of dCP.

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