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Your search keyword '"Lindsey Egan"' showing total 4 results
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4 results on '"Lindsey Egan"'

1. Diagnosis of pulmonary histoplasmosis and blastomycosis by detection of antigen in bronchoalveolar lavage fluid using an improved second-generation enzyme-linked immunoassay

Author

Michelle Durkin, Michelle Parker, Lindsey Egan, L. Joseph Wheat, Kenneth S. Knox, DeAnna Fuller, Deborah Blue-Hnidy, Ann M. LeMonte, Chadi A. Hage, Patricia Connelly, and Thomas E. Davis

Subjects
Bronchoalveolar lavage, Pulmonary and Respiratory Medicine, Pathology, medicine.medical_specialty, Antigens, Fungal, medicine.medical_treatment, Histoplasma, Enzyme-Linked Immunosorbent Assay, Liver transplantation, Statistics, Nonparametric, Histoplasmosis, Blastomycosis, Second-generation assay, Immunocompromised Host, Antigen, Humans, Medicine, Mycosis, Chi-Square Distribution, Lung Diseases, Fungal, medicine.diagnostic_test, biology, business.industry, Respiratory disease, Middle Aged, medicine.disease, biology.organism_classification, Liver Transplantation, Histoplasma antigen, Immunology, Female, business, Bronchoalveolar Lavage Fluid
Abstract

SummaryAntigen detection is a useful adjunct for the diagnosis of histoplasmosis. The purpose of this study was to evaluate antigen detection in bronchoalveolar lavage (BAL) fluid using an improved second-generation Histoplasma antigen assay. Antigen was detected in 16 of 19 (84%) cases of histoplasmosis and 5 of 6 (83.3%) blastomycosis cases using the second-generation assay vs. 13 of 19 (68%) and 4 of 6 (66.7%), respectively, in the original assay. Ten-fold concentration permitted detection of antigen in an additional case of histoplasmosis and another with blastomycosis, for an overall sensitivity of 23 of 25 (92.0%). Specificity was 98.2% in both assays in controls with other pulmonary infections. These findings support the diagnostic utility of the second-generation assay in patients with pulmonary histoplasmosis and blastomycosis.

Published
2007
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2. Histoplasmosis as a cause for a positive Fungitell™ (1→3)-β-D-glucan test

Author

D. Fuller, Kenneth S. Knox, L. Joseph Wheat, Lindsey Egan, Thomas E. Davis, Chadi A. Hage, and Patricia Connolly

Subjects
Antigens, Fungal, beta-Glucans, Lung Diseases, Fungal, biology, business.industry, Histoplasma, General Medicine, medicine.disease, biology.organism_classification, Sensitivity and Specificity, Histoplasmosis, Serology, Fungal disease, Infectious Diseases, Immunology, Humans, Medicine, Proteoglycans, Serologic Tests, business, Fungemia, 1 3 β d glucan
Abstract

We evaluated the Fungitell beta-glucan (BG) test with specimens from patients with presumed histoplasmosis. The sensitivity of the test was 87% in histoplasmosis cases and had a specificity of 68% with controls. Histoplasmosis should be considered as a possible cause for a positive BG test, but such results may be found with many other conditions that are clinically similar to this fungal disease. Therefore, there is a need to conduct confirmatory tests for histoplasmosis in the appropriate clinical setting.

Published
2008
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3. Detection of Histoplasma capsulatum Antigenuria by Ultrafiltration of Samples with False-Negative Results▿

Author

Chadi A. Hage, Patricia Connolly, D. Fuller, Kenneth S. Knox, Lindsey Egan, L. Joseph Wheat, Thomas E. Davis, and John Witt

Subjects
Microbiology (medical), Antigens, Fungal, Clinical Biochemistry, Immunology, Histoplasma, Ultrafiltration, Histoplasma capsulatum, Sensitivity and Specificity, Histoplasmosis, Antigen, medicine, Immunology and Allergy, Clinical Laboratory Immunology, Humans, False Negative Reactions, biology, business.industry, nutritional and metabolic diseases, medicine.disease, biology.organism_classification, business
Abstract

Patients with histoplasmosis may test falsely negative for Histoplasma capsulatum antigenuria. In some cases antigen is present at levels below the assay's detection limit, and ultrafiltration could improve sensitivity. Antigen was detected following ultrafiltration in 73.8% of falsely negative specimens versus 2% of controls. Ultrafiltration improved sensitivity with a small reduction in specificity.

Published
2008

4. Evaluation of the IMMY ALPHA Histoplasma Antigen Enzyme Immunoassay for Diagnosis of Histoplasmosis Marked by Antigenuria

Author

Lindsey Egan, Ann M. LeMonte, Patricia Connolly, Michelle Durkin, and L. Joseph Wheat

Subjects
Microbiology (medical), Antigens, Fungal, Histoplasma, Clinical Biochemistry, Immunology, Alpha (ethology), Urine, Sensitivity and Specificity, Histoplasmosis, Immunoenzyme Techniques, Antigen, medicine, Humans, Immunology and Allergy, In patient, Letters to the Editor, chemistry.chemical_classification, medicine.diagnostic_test, biology, business.industry, biology.organism_classification, medicine.disease, Virology, Enzyme, chemistry, Case-Control Studies, Immunoassay, Immunoenzyme techniques, business
Abstract

The sensitivity of detection of antigenuria in patients positive by the MiraVista Diagnostics Histoplasma enzyme immunoassay (MVD EIA) was 44% with the IMMY ALPHA Histoplasma antigen EIA. The specificity was 84% with the IMMY EIA versus 98% with the MVD EIA. The correlation between assays for positive cases was weak ( r 2 = 0.430).

Published
2007
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