Search

Background: Vasospasm occurs in up to 70% of aneurysmal subarachnoid hemorrhage (aSAH), but only half becomes symptomatic. It is unclear whether asymptomatic vasospasm (AV) detected by noninvasive testing affects outcome. Prophylactic hemodilutional, hypertensive, and hypervolemic (HHH) therapy is widely used but the benefit remains unproven. We aim to determine whether AV increases the risk of poor outcome and whether HHH is safe., Methods: A total of 175 consecutive patients with aSAH without clinical vasospasm were included. Patients with sonographic (transcranial doppler) or radiologic (computed tomography [CT] Angiography) vasospasm were assigned to AV group, while those without were assigned to no vasospasm (NV) group. Logistic regression was used to determine the association between AV and HHH on poor outcome, defined as modified Rankin scale (mRS) >3 at discharge or 3 to 6 months' follow-up., Results: In all, 106 patients had NV and 25 received HHH. A total of 69 patients had AV and 54 received HHH. Asymptomatic vasospasm compared to NV was not associated with poor outcome (odds ratio [OR] 2.6, 95% confidence interval [CI]: 0.75-8.9; P = .1). Hemodilutional, hypertensive, and hypervolemic use in patients with AV did not improve the outcome (OR 0.16, 95%CI: 0.009-2.84; P = .2). In patients with NV, HHH use showed trend toward poor outcome after multivariable adjustment (OR 12.6, 95%CI: 1.08-146.5 P = .04)., Conclusion: Asymptomatic vasospasm does not appear to be associated with poor outcome in aSAH. Hemodilutional, hypertensive, and hypervolemic therapy in AV was not associated with improved outcome and may be harmful to patients who do not have vasospasm. Further research is needed to validate this finding.

Background: Stent-assisted coiling of intracranial aneurysms is performed either as a single-stage or a multi-staged procedure. The objective of our study is to compare the complications between the in single-stage versus the multi-staged stent-assisted coiling of intracranial aneurysm., Methods: From January 2003 to January 2010, consecutive patients treated with intracranial stent for aneurysms were prospectively enrolled. Patients' demographics including cerebrovascular risk factors, aneurysms size and locations were collected. Technical and clinical complications as well as outcomes were measured. Data were analyzed retrospectively using SPSS software version 11.5., Results: 87 patients (87 aneurysms) with a mean of 51.2 ± 13.6 years were treated with 90 intracranial (Neuroform 74, Enterprise 16) stents, single-stage 37 (42.5%) and multi-staged 50 (57.5%). Eight adverse events were observed without any mortality, 6 of which were in the single-stage group-rupture of aneurysm in 2, and thrombo-embolic events in 4. Both rupture occurred in basilar artery bifurcation aneurysms, required ventriculostomy and resuscitations. In single-stage, asymptomatic intra-operative stent thrombosis developed in one, symptomatic stent thrombosis in one on day 14, transient ischemic attack on day 6 and immediate post operative stroke in one. Only two minor strokes were observed in the multi-staged group, one on post-procedure day 7 and other on day 60. Majority of the patients had good outcomes including those with events., Conclusion: Our study revealed that single-stage stent-coiling technique is associated with a higher rate of complications than multistaged procedure. Therefore, staging the procedure may be an option whenever possible.