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Additional file 1: Figure A1. Sunburst chart on most recent keywords and most cited keyword. Table A1. Keywords with the highest Total Link Strength (TLS) to the keyword ‘mobility’ in Web of Science. Table A2. Keywords with the highest TLS to the keyword ‘accessibility’ in Web of Science. Table A3. Keywords with the highest TLS to the keyword ‘spatial mobility’ in Web of Science. Table A4. Keywords with the highest TLS to ‘mobility’ in Scopus. Table A5. Keywords with the highest TLS to ‘spatial analysis’ in Scopus.

Nowadays, the population is rapidly ageing because of increasing life expectancy and decreasing birth rates. Thus, the purpose of this systematic review is to prepare a comprehensive overview which identifies the activities of daily living (ADLs) that are gradually reduced among patients with dementia, as well as explore the therapies applied in relation to dementia and how they effectively improve the quality of life (QoL) of patients and caregivers. Furthermore, we aim to summarise the ADL activities influenced by therapies and examine the treatment costs and care for patients so that recommendations for research and development (R&D) can be made to improve both the QoL of people with dementia and cost-saving measures. The research focuses on four selected neurodegenerative diseases: Alzheimer, Parkinson, vascular dementia, and amyotrophic lateral sclerosis. Therefore, the peer-reviewed English written articles from 2014 to 2019 were searched between September 1 and December 13, 2019. Twenty-seven papers were included in the analysis. The results show that essential assistance occurs in connection with activities: eating, drinking, dressing, bathing, personal hygiene, use of the toilet, and transport. By contrast, shopping or cleaning is not addressed as much. A lower ability to take care of oneself is connected with poor patient health and higher social care costs because the patient requires care from external sources, such as home aid or nurse visits. The challenge that remains is to shift new knowledge from scientific disciplines and connect it with the needs of patients to remove legitimate barriers and increase the acceptance of new solutions by popularisation. Additionally, regarding the burden on caregivers, it would be appropriate to promote this area of education and employment so that family members can use formal caregivers, ensuring them free time and much-needed rest.

Minghui Yang,1,2 Petra Maresova1 1Faculty of Informatics and Management, University of Hradec Kralove, Hradec Kralove 50003, Czech Republic; 2International Business School, Guangzhou College of South China University of Technology, Guangzhou, Guangdong 510800, People’s Republic of ChinaCorrespondence: Petra MaresovaFaculty of Informatics and Management, University of Hradec Kralove, Rokitanskeho 62, Hradec Kralove 50003, Czech RepublicTel +420 737 928 745Email petra.maresova@uhk.czBackground and Purpose: In recent years, the frequent occurrence of occupational accidents, illness, and injuries has become a major issue in China. This study aims to investigate the relationship between the adoption of Occupational Health and Safety Management System (OHSMS) standards and financial performance, with a particular focus on the pharmaceutical firms in China.Methods: The study is based on a sample consisting of 125 pharmaceutical firms listed on the Shanghai and the Shenzhen stock exchanges in China for the period 2010– 2018. Each sample firm was evaluated by whether and when it is certified by an OHSMS standard depending on secondary data collected from an independent certification database. Panel-based regression models were employed to explore whether adoption of an OHSMS standard has had an impact on financial performance.Results: The regression results reveal that the adoption of an OHSMS standard positively affects contemporaneous financial performance measured by return on assets (ROA), return on equity (ROE), and earnings per share (EPS). Mixed results were found when financial performance indicators were extended by two years, suggesting that ROE will increase in the second year after a firm is certified with the standard, but EPS will decline in the third year.Conclusion: The study findings empirically show that adoption of an OHSMS standard contributes to better financial performance for pharmaceutical firms of China in the short term. However, executives of pharmaceutical firms need to be aware of the increased costs related to certification renewal and audit in the following periods and exercise their management discretion to achieve a win–win situation between OHSMS implementation and financial benefit.Keywords: occupational health and safety management system, OHSAS 18001, ISO 45001, financial performance, pharmaceutical firm

Additional file 1: Appendix Table 10. Survey question.