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243 results on '"MONTAGNIER L."'

1. DNA waves and water

Author

Montagnier, L., Aissa, J., Del Giudice, E., Lavallee, C., Tedeschi, A., and Vitiello, G.

Subjects
Quantitative Biology - Other Quantitative Biology, Quantum Physics
Abstract

Some bacterial and viral DNA sequences have been found to induce low frequency electromagnetic waves in high aqueous dilutions. This phenomenon appears to be triggered by the ambient electromagnetic background of very low frequency. We discuss this phenomenon in the framework of quantum field theory. A scheme able to account for the observations is proposed. The reported phenomenon could allow to develop highly sensitive detection systems for chronic bacterial and viral infections., Comment: Invited talk at the DICE2010 Conference, Castiglioncello, Italy September 2010

Published
2010
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12. Molecular characterization of the P1-like adhesin gene from Mycoplasma pirum

Author

Tham, T.N., Ferris, S., Bahraoui, E., Canarelli, S., Montagnier, L., and Blanchard, A.

Subjects
Mycoplasma -- Genetic aspects, Polypeptides -- Analysis, Biological sciences
Abstract

Localization of a gene encoding an adhesin-like polypeptide with a 28% G+C content and selective use of A- and T-rich codons were evident from isolation of a DNA fragment from the genome of Mycoplasma pirum. A genetic probe from the conserved site inside the genes for adhesins of Mycoplasma pneuomoniae and Mycoplasma genitalium is used. The reduced polypeptide displays a 26% identity with the adhesin.

Published
1994

13. Identification of Mycoplasma pirum genes involved in the salvage pathways for nucleosides

Author

Tham, T.N., Ferris, S., Kovacic, R., Montagnier, L., and Blanchard, A.

Subjects
Mycoplasma -- Genetic aspects, Nucleosides -- Analysis, Biological sciences
Abstract

The mollicute Mycoplasma pirum is used in the cloning and sequencing of the genes which encode the enzymes involved in the salvage pathway for nucleosides. The complementation of an Escherichia coli mutant enables the identification of the encoding deoxyriboaldolase. An operon organization is caused by the clustering of the genes, which is followed by the putative gene for the triose phosphate isomerase, an enzyme used in glycolis.

Published
1993

14. Virus excretion in the cervicovaginal secretions of pregnant and nonpregnant HIV-infected women

Author

Henin, Y., Mandelbrot, L., Henrion, R., Pradinaud, R., Coulaud, J.P., and Montagnier, L.

Subjects
HIV (Viruses), Cervix mucus -- Analysis, Health
Abstract

Cell-free HIV virus and HIV-infected cells found in the cervicovaginal secretions of HIV-infected women may play a role in female-to-male and mother-to-infant transmission of HIV. Of cervicovaginal samples from 55 pregnant and nonpregnant HIV-infected women, 12 samples (21.8%) tested positive for the cell-free virus, and another five samples were positive for HIV-infected cells. Altogether, HIV was detected in 31% of the secretions. Virus excretion occurred in 38% of the pregnant women compared with only 11.8% of the nonpregnant women. Virus was as likely to be excreted from women taking zidovudine as from women who were not. The presence of HIV in cervicovaginal secretions was not linked with stage of disease, history of sexually transmitted diseases or means of original infection with HIV.

Published
1993

15. Addendum: Montagnier, L.; Aïssa, J.; Capolupo, A.; Craddock, T.J.A.; Kurian, P.; Lavallee, C.; Polcari, A.; Romano, P.; Tedeschi, A.; Vitiello, G. Water Bridging Dynamics of Polymerase Chain Reaction in the Gauge Theory Paradigm of Quantum Fields. Water 2017, 9, 339

Author

Montagnier, L., primary, Aïssa, J., additional, Capolupo, A., additional, Craddock, T., additional, Kurian, P., additional, Lavallee, C., additional, Polcari, A., additional, Romano, P., additional, Tedeschi, A., additional, and Vitiello, G., additional

Published
2017
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18. Masse in movimento

Author

Bennett, MJ, Brizhik, L, Castiglioni, I, Chiappini, E, Del Giudice, E, Finelli, F, Giasanti, A, Madera, R, Marchino, L, Montagnier, L, Sassone, R, Stefanini, P, Stupiggia, M, Tedeschi, A, Tosi, M, Zamploud, M, GIASANTI, ALBERTO, Bennett, MJ, Brizhik, L, Castiglioni, I, Chiappini, E, Del Giudice, E, Finelli, F, Giasanti, A, Madera, R, Marchino, L, Montagnier, L, Sassone, R, Stefanini, P, Stupiggia, M, Tedeschi, A, Tosi, M, Zamploud, M, and GIASANTI, ALBERTO

Abstract

Con riferimento al testo di Elia Canetti "Masse e potere" come anche ad altri "classici" della letteratura sociologica riguardanti le dinamiche sociali delle masse, si esaminano le condizioni per cui la massa diventa la condizione in cui gli individui si liberano dal fatto di subire il potere degli altri.

Published
2013

19. Lifestyle-related factors and environmental agents causing cancer : an overview

Author

Irigaray, P., Newby, J. A., Clapp, R., Hardell, Lennart, Howard, V., Montagnier, L., Epstein, S., Belpomme, D., Irigaray, P., Newby, J. A., Clapp, R., Hardell, Lennart, Howard, V., Montagnier, L., Epstein, S., and Belpomme, D.

Abstract

The increasing incidence of a variety of cancers after the Second World War confronts scientists with the question of their origin. In Western countries, expansion and ageing of the population as well as progress in cancer detection using new diagnostic and screening tests cannot fully account for the observed growing incidence of cancer. Our hypothesis is that environmental factors play a more important role in cancer genesis than it is usually agreed. (1) Over the last 2-3 decades, alcohol consumption and tobacco smoking in men have significantly decreased in Western Europe and North America. (2) Obesity is increasing in many countries, but the growing incidence of cancer also concerns cancers not related to obesity nor to other known lifestyle-related factors. (3) There is evidence that the environment has changed over the time period preceding the recent rise in cancer incidence, and that this change, still continuing, included the accumulation of many new carcinogenic factors in the environment. (4) Genetic susceptibility to cancer due to genetic polymorphism cannot have changed over one generation and actually favours the role of exogenous factors through gene-environment interactions. (5) Age is not the unique factor to be considered since the rising incidence of cancers is seen across all age categories, including children, and adolescents. (6) The fetus is specifically vulnerable to exogenous factors. A fetal exposure during a critical time window may explain why current epidemiological studies may still be negative in adults. We therefore propose that the involuntary exposure to many carcinogens in the environment, including microorganisms (viruses, bacteria and parasites), radiations (radioactivity, UV and pulsed electromagnetic fields) and many xenochemicals, may account for the recent growing incidence of cancer and therefore that the risk attributable to environmental carcinogen may be far higher than it is usually agreed. Of major concern are: outdoor

Published
2007
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22. DNA waves and water

Author

Montagnier, L, primary, Aissa, J, additional, Giudice, E Del, additional, Lavallee, C, additional, Tedeschi, A, additional, and Vitiello, G, additional

Published
2011
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23. A Plea for Justice for Jailed Medical Workers

Author

Ahuja, S. K., primary, Aiuti, F., additional, Berkhout, B., additional, Biberfeld, P., additional, Burton, D. R., additional, Colizzi, V., additional, Deeks, S. G., additional, Desrosiers, R. C., additional, Dierich, M. P., additional, Doms, R. W., additional, Emerman, M., additional, Gallo, R. C., additional, Girard, M., additional, Greene, W. C., additional, Hoxie, J. A., additional, Hunter, E., additional, Klein, G., additional, Korber, B., additional, Kuritzkes, D. R., additional, Lederman, M. M., additional, Malim, M. H., additional, Marx, P. A., additional, McCune, J. M., additional, McMichael, A., additional, Miller, C., additional, Miller, V., additional, Montagnier, L., additional, Montefiori, D. C., additional, Moore, J. P., additional, Nixon, D. F., additional, Overbaugh, J., additional, Pauza, C. D., additional, Richman, D. D., additional, Saag, M. S., additional, Sattentau, Q., additional, Schooley, R. T., additional, Shattock, R., additional, Shaw, G. M., additional, Stevenson, M., additional, Trkola, A., additional, Wainberg, M. A., additional, Weiss, R. A., additional, Wolinsky, S., additional, and Zack, J. A., additional

Published
2006
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24. Efficacy and safety of Buxus sempervirens L. preparations (SPV30) in HIV-infected asymptomatic patients: a multicentre, randomized, double-blind, placebo-controlled trial

Author

Durant, J., primary, Chantre, Ph., additional, Gonzalez, G., additional, Vandermander, J., additional, Halfon, Ph., additional, Rousse, B., additional, Guédon, D., additional, Rahelinirina, V., additional, Chamaret, S., additional, Montagnier, L., additional, and Dellamonica, P., additional

Published
1998
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42. Discussion

Author

Gougeon, M.-L., primary, Montagnier, L., additional, and Collins, F.M., additional

Published
1992
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49. Role of Mycoplasma penetrans endonuclease P40 as a potential pathogenic determinant.

Author

Bendjennat, M, Blanchard, A, Loutfi, M, Montagnier, L, and Bahraoui, E

Abstract

Recently, we reported the purification to homogeneity and characterization of Ca(2+)- and Mg(2+)-dependent endonuclease P40 produced by Mycoplasma penetrans (M. Bendjennat, A. Blanchard, M. Loutfi, L. Montagnier, and E. Bahraoui, J. Bacteriol. 179; 2210-2220, 1997), a mycoplasma which was isolated for the first time from the urine of human immunodeficiency virus-infected patients. To evaluate how this nuclease could interact with host cells, we tested its effect on CEM and Molt-4 lymphocytic cell lines and on peripheral blood mononuclear cells. We observed that 10(-7) to 10(-9) M P40 is able to mediate a cytotoxic effect. We found that 100% of cells were killed after 24 h of incubation with 10(-7) M P40 while only 40% cytotoxicity was obtained after 72 h of incubation with 10(-9) M P40. Phase-contrast microscopy observations of P40-treated cells revealed morphological changes, including pronounced blebbing of the plasma membrane and cytoplasmic shrinkage characteristic of programmed cell death, which is in agreement with the internucleosomal fragmentation of P40-treated cell DNA as shown by agarose gel electrophoresis. We showed that (125)I-radiolabeled or fluorescein isothiocyanate-labeled P40 was able to bind specifically in a dose-dependent manner to the cell membrane of CEM cells, which suggested that the cytotoxicity of P40 endonuclease was mediated by its interaction with the cell surface receptor(s). The concentration of unlabeled P40 required to inhibit by 50% the formation of (125)I-P40-CEM complexes was about 3 x 10(-9) M, indicating a high-affinity interaction. Both P40 interaction and cytotoxicity are Ca(2+) dependent. Our results suggest that the cytotoxicity of M. penetrans observed in vitro is mediated at least partially by secreted P40, which, after interaction with host cells, can induce an apoptosis-like death. These results strongly suggest a major role of mycoplasmal nucleases as potential pathogenic determinants.

Published
1999

50. Phase variations of the Mycoplasma penetrans main surface lipoprotein increase antigenic diversity.

Author

Neyrolles, O, Chambaud, I, Ferris, S, Prevost, M C, Sasaki, T, Montagnier, L, and Blanchard, A

Abstract

Mycoplasma penetrans is a recently identified mycoplasma, isolated from urine samples collected from human immunodeficiency virus (HIV)-infected patients. Its presence is significantly associated with HIV infection. The major antigen recognized during natural and experimental infections is an abundant P35 lipoprotein which, upon extraction, segregates in the Triton X-114 detergent phase and is the basis of M. penetrans-specific serological assays. We report here that the P35 antigen undergoes spontaneous and reversible phase variation at high frequency, leading to heterogeneous populations of mycoplasmas, even when derived from a clonal lineage. This variation was found to be determined at the transcription level, and although this property is not unique among the members of the class Mollicutes, the mechanism by which it occurs in M. penetrans differs from those previously described for other Mycoplasma species. Indeed, the P35 phase variation was due neither to a p35 gene rearrangement nor to point mutations within the gene itself or its promoter. The P35 phase variation in the different variants obtained was concomitant with modifications in the pattern of other expressed lipoproteins, probably due to regulated expression of selected members of a gene family which was found to potentially encode similar lipoproteins. M. penetrans variants could be selected on the basis of their lack of colony immunoreactivity with a polyclonal antiserum against a Triton X-114 extract, strongly suggesting that the mechanisms involved in altering surface antigen expression might allow evasion of the humoral immune response of the infected host.

Published
1999

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