1. Pairwise Rearrangement is Fixed-Parameter Tractable in the Single Cut-and-Join Model
- Author
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Bailey, Lora, Blake, Heather Smith, Cochran, Garner, Fox, Nathan, Levet, Michael, Mahmoud, Reem, Singgih, Inne, Stadnyk, Grace, and Wiedemann, Alexander
- Subjects
Quantitative Biology - Genomics ,Computer Science - Data Structures and Algorithms ,Mathematics - Combinatorics ,92-08, 92D10, 92D20, 68Q17 ,F.2.2 - Abstract
Genome rearrangement is a common model for molecular evolution. In this paper, we consider the Pairwise Rearrangement problem, which takes as input two genomes and asks for the number of minimum-length sequences of permissible operations transforming the first genome into the second. In the Single Cut-and-Join model (Bergeron, Medvedev, & Stoye, J. Comput. Biol. 2010), Pairwise Rearrangement is $\#\textsf{P}$-complete (Bailey, et. al., COCOON 2023), which implies that exact sampling is intractable. In order to cope with this intractability, we investigate the parameterized complexity of this problem. We exhibit a fixed-parameter tractable algorithm with respect to the number of components in the adjacency graph that are not cycles of length $2$ or paths of length $1$. As a consequence, we obtain that Pairwise Rearrangement in the Single Cut-and-Join model is fixed-parameter tractable by distance. Our results suggest that the number of nontrivial components in the adjacency graph serves as the key obstacle for efficient sampling., Comment: Full version of paper that appeared in SWAT 2024; arXiv admin note: text overlap with arXiv:2305.01851
- Published
- 2024