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8. Abstract 12367: Sex-Specific Differences in Quality of Life and Atrial Fibrillation Recurrence Following Ablation of Persistent Atrial Fibrillation: Insights From the DECAAF II Trial

Author

Younes, Hadi, Feng, Han, Sohns, Christian, Forkmann, Mathias, Noujaim, Charbel, Mekhael, Mario, Assaf, Alaʼ, Chouman, Nour, Kreidieh, Omar, huang, chao, Lim, Chanho, El Hajjar, Abdel Hadi, donnellan, eoin, Pandey, Amitabh C, Marrouche, Nassir, and mahnkopf, christian

Published
2023
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9. Abstract 12357: Investigating Sex-Specific Factors Influencing Atrial Fibrillation Burden in Patients With Persistent Atrial Fibrillation: A DECAAF II Subanalysis

Author

Younes, Hadi, Feng, Han, Sohns, Christian, Forkmann, Mathias, Mekhael, Mario, Noujaim, Charbel, Chouman, Nour, Assaf, Alaʼ, Lim, Chanho, Dagher, Lilas, huang, chao, El Hajjar, Abdel Hadi, donnellan, eoin, Kreidieh, Omar, Pandey, Amitabh C, Marrouche, Nassir, and mahnkopf, christian

Published
2023
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12. Impact of Left Ventricular Function and Heart Failure Symptoms on Outcomes Post Ablation of Atrial Fibrillation in Heart Failure: CASTLE-AF Trial

Author

Sohns, Christian, Zintl, Konstantin, Zhao, Yan, Dagher, Lilas, Andresen, Dietrich, Siebels, Jürgen, Wegscheider, Karl, Sehner, Susanne, Boersma, Luca, Merkely, Béla, Pokushalov, Evgeny, Sanders, Prashanthan, Schunkert, Heribert, Bänsch, Dietmar, Mahnkopf, Christian, Brachmann, Johannes, and Marrouche, Nassir F.

Published
2020
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13. Feasibility and Efficacy of Transcatheter Tricuspid Valve Repair in Patients with Cardiac Implanted Electrical Devices and Trans-Tricuspid Leads

Author

Alachkar, Mhd Nawar, primary, Schnupp, Steffen, additional, Eichelsdoerfer, Astrid, additional, Milzi, Andrea, additional, Mady, Hesham, additional, Salloum, Basem, additional, Bisht, Osama, additional, Cheikh-Ibrahim, Mohammed, additional, Forkmann, Mathias, additional, Krygier, Lukas, additional, and Mahnkopf, Christian, additional

Published
2023
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16. Atrial Fibrosis, Ischaemic Stroke and Atrial Fibrillation

Author

Mahnkopf, Christian, Kwon, Younghoon, and Akoum, Nazem

Subjects
Physiology (medical), RC666-701, cardiovascular system, Clinical Arrhythmias, Diseases of the circulatory (Cardiovascular) system, embolic stroke of undetermined source, cardiovascular diseases, Atrial fibrosis, AF, Cardiology and Cardiovascular Medicine
Abstract

Atrial fibrosis is an important component of the arrhythmic substrate in AF. Evidence suggests that atrial fibrosis also plays a role in increasing the risk of stroke in patients with the arrhythmia. Patients with embolic stroke of undetermined source (ESUS), who are suspected to have AF but are rarely shown to have it, frequently demonstrate evidence of atrial fibrosis; measured using late-gadolinium enhancement MRI, this manifests as atrial remodelling encompassing structural, functional and electrical properties. In this review, the authors discuss the available evidence linking atrial disease, including fibrosis, with the risk of ischaemic stroke in AF, as well as in the ESUS population, in whom it has been linked to recurrent stroke and new-onset AF. They also discuss the implications of this association on future research that may elucidate the mechanism of stroke and stroke prevention strategies in the AF and ESUS populations.

Published
2021

23. Computational modeling identifies embolic stroke of undetermined source patients with potential arrhythmic substrate

Author

Bifulco, Savannah F, primary, Scott, Griffin D, additional, Sarairah, Sakher, additional, Birjandian, Zeinab, additional, Roney, Caroline H, additional, Niederer, Steven A, additional, Mahnkopf, Christian, additional, Kuhnlein, Peter, additional, Mitlacher, Marcel, additional, Tirschwell, David, additional, Longstreth, WT, additional, Akoum, Nazem, additional, and Boyle, Patrick M, additional

Published
2021
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24. Effects of Environmental Factors on Severity and Mortality of COVID-19

Author

Kifer, Domagoj, primary, Bugada, Dario, additional, Villar-Garcia, Judit, additional, Gudelj, Ivan, additional, Menni, Cristina, additional, Sudre, Carole, additional, Vučković, Frano, additional, Ugrina, Ivo, additional, Lorini, Luca F., additional, Posso, Margarita, additional, Bettinelli, Silvia, additional, Ughi, Nicola, additional, Maloberti, Alessandro, additional, Epis, Oscar, additional, Giannattasio, Cristina, additional, Rossetti, Claudio, additional, Kalogjera, Livije, additional, Peršec, Jasminka, additional, Ollivere, Luke, additional, Ollivere, Benjamin J., additional, Yan, Huadong, additional, Cai, Ting, additional, Aithal, Guruprasad P., additional, Steves, Claire J., additional, Kantele, Anu, additional, Kajova, Mikael, additional, Vapalahti, Olli, additional, Sajantila, Antti, additional, Wojtowicz, Rafal, additional, Wierzba, Waldemar, additional, Krol, Zbigniew, additional, Zaczynski, Artur, additional, Zycinska, Katarina, additional, Postula, Marek, additional, Lukšić, Ivica, additional, Čivljak, Rok, additional, Markotić, Alemka, additional, Brachmann, Johannes, additional, Markl, Andreas, additional, Mahnkopf, Christian, additional, Murray, Benjamin, additional, Ourselin, Sebastien, additional, Valdes, Ana M., additional, Horcajada, Juan P., additional, Castells, Xavier, additional, Pascual, Julio, additional, Allegri, Massimo, additional, Primorac, Dragan, additional, Spector, Tim D., additional, Barrios, Clara, additional, and Lauc, Gordan, additional

Published
2021
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26. How to remove an embolized TriClip from the femoral vein? A case report.

Author

Ajmi, Issameddine, Schnupp, Steffen, Mady, Hesham, and Mahnkopf, Christian

Subjects
FEMORAL vein, DUPLEX ultrasonography, TRICUSPID valve, HOSPITAL admission & discharge, TRICUSPID valve insufficiency, ECHOCARDIOGRAPHY
Abstract

Background and case summary We report a case of a 76-year-old female who was admitted to our hospital because of dyspnoea caused by a known high-grade tricuspid valve regurgitation (TR). The patient received an edge-to-edge reparation of the tricuspid valve 1 month before the current admission using the TriClip XTR (Clip) system. The post-interventional echocardiographic results were satisfying, and the patient was discharged with TR grade I. At this new admission, the echocardiographic control showed a missing Clip on the tricuspid valve with a recurrent high-grade regurgitation. Fluoroscopy showed the dislocated Clip at the level of the femoral vein. This was also confirmed using Duplex sonography with no signs of thrombosis or embolization. The challenge was how to extract the Clip using endovascular methods as the patient refused any kind of surgical removal. We managed to remove the 20 × 10 mm big clip using transfemoral access and an endovascular snare system. No post-interventional complications were registered. The patient was discharged after the intervention with a new scheduled Clip procedure. Discussion This case shows a possible safe and challenging alternative to removing dislocated Clip from the femoral vein. Experienced operators are required to have the knowledge and skills to manage these possible procedural complications using the appropriate apparatus. A surgical technique would be, in this case, common practice, however as the patient declined surgical intervention, the endovascular approach was the alternative option. [ABSTRACT FROM AUTHOR]

Published
2021
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36. Age and sex differences in atrial fibrosis among patients with atrial fibrillation.

Author

Akoum, Nazem, Mahnkopf, Christian, Kholmovski, Eugene G, Brachmann, Johannes, and Marrouche, Nassir F

Abstract

Aim: Age and female sex are associated with a higher risk of stroke in atrial fibrillation (AF). We sought to determine whether advancing age and female sex are associated with higher atrial fibrosis.Methods and results: We conducted an observational cohort study of patients with AF enrolled in the University of Utah AF Database and a non-AF control group who underwent late-gadolinium enhancement magnetic resonance imaging (LGE-MRI) for atrial fibrosis quantification. Participants with contra-indications for contrast MRI scanning were excluded. Nine hundred and eight consecutive men and women with AF and 15 non-AF controls were included in this study. Left atrial fibrosis increased with age in both men and women with AF. Women with AF (n = 316) were older than men (n = 592): mean age 68.7±11.6 vs. 64.9±11.7 years; P < 0.01, and had higher left atrial fibrosis compared with men 17.5 ± 10.1% vs. 15.3 ± 8.9%; P < 0.001. Women also had a higher prevalence of prior stroke compared with men (15.8% vs. 6.5%; P < 0.001). Age and sex relationships with atrial fibrosis remained significant in multivariate analysis. Compared with the non-AF control group, patients with AF had significantly higher atrial fibrosis: 16.0 ± 9.4 vs. 5.5 ± 5.8%; P < 0.001.Conclusions: Advancing age and female sex are associated with a higher burden of atrial fibrosis in patients with AF. Women with a prior history of stroke also have higher fibrosis compared with both women and men without history of stroke. Advanced fibrosis may explain the female and age association with stroke in AF. [ABSTRACT FROM AUTHOR]

Published
2018
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39. 'Denervation' of autonomous nervous system in idiopathic pulmonary arterial hypertension by low-dose radiation : a case report with an unexpected outcome

Author

Hohenforst-Schmidt, Wolfgang, Zarogoulidis, Paul, Özkan, Filiz, Mahnkopf, Christian, Grabenbauer, Gerhard, Kreczy, Alfons, Bartunek, Rudolf, Darwiche, Kaid, Freitag, Lutz, Li, Qiang, Huang, Haidong, Vogl, Thomas J., LePilvert, Patrick, Tsiouda, Theodora, Tsakiridis, Kosmas, Zarogoulidis, Konstantinos, Brachmann, Johannes, Hohenforst-Schmidt, Wolfgang, Zarogoulidis, Paul, Özkan, Filiz, Mahnkopf, Christian, Grabenbauer, Gerhard, Kreczy, Alfons, Bartunek, Rudolf, Darwiche, Kaid, Freitag, Lutz, Li, Qiang, Huang, Haidong, Vogl, Thomas J., LePilvert, Patrick, Tsiouda, Theodora, Tsakiridis, Kosmas, Zarogoulidis, Konstantinos, and Brachmann, Johannes

Abstract

Vasointestinal peptide metabolism plays a key physiological role in multimodular levels of vasodilatory, smooth muscle cell proliferative, parenchymal, and inflammatory lung reactions. In animal studies, vasointestinal peptide relaxes isolated pulmonary arterial segments from several mammalian species in vitro and neutralizes the pulmonary vasoconstrictor effect of endothelin. In some animal models, it reduces pulmonary vascular resistance in vivo and in monocrotaline-induced pulmonary hypertension. A 58-year-old woman presented with dyspnea and mild edema of the lower extremities. A bronchoscopy was performed without any suspicious findings suggesting a central tumor or other infiltrative disease. Endobronchial ultrasound revealed enlarged pulmonary arteries containing thrombi, a few enlarged lymph nodes, and enlarged mediastinal tissue anatomy with suspicion for mediastinal infiltration of a malignant process. We estimated that less than 10% of the peripheral vascular bed of the lung was involved in direct consolidated fibrosis as demonstrated in the left upper lobe apex. Further, direct involvement of fibrosis around the main stems of the pulmonary arteries was assumed to be low from positron emission tomography and magnetic resonance imaging scans. Assuming a positive influence of low-dose radiation, it was not expected that this could have reduced pulmonary vascular resistance by over two thirds of the initial result. However; it was noted that this patient had idiopathic pulmonary arterial hypertension mixed with "acute" (mediastinal) fibrosis which could have contributed to the unexpected success of reduction of pulmonary vascular resistance. To the best of our knowledge, this is the first report of successful treatment of idiopathic pulmonary arterial hypertension, probably as a result of low-dose radiation to the pulmonary arterial main stems. The patient continues to have no specific complaints concerning her idiopathic pulmonary arterial hypertension.

Published
2014

40. “Denervation” of autonomous nervous system in idiopathic pulmonary arterial hypertension by low-dose radiation: a case report with an unexpected outcome

Author

Hohenforst-Schmidt,Wolfgang, Zarogoulidis,Paul, Oezkan,Filiz, Mahnkopf,Christian, Grabenbauer,Gerhard, Kreczy,Alfons, Bartunek,Rudolf, Darwiche,Kaid, Freitag,Lutz, Li,Qiang, Huang,Haidong, Vogl,Thomas, LePilvert,Patrick, Tsiouda,Theodora, Tsakiridis,Kosmas, Zarogoulidis,Konstantinos, Brachmann,Johannes, Hohenforst-Schmidt,Wolfgang, Zarogoulidis,Paul, Oezkan,Filiz, Mahnkopf,Christian, Grabenbauer,Gerhard, Kreczy,Alfons, Bartunek,Rudolf, Darwiche,Kaid, Freitag,Lutz, Li,Qiang, Huang,Haidong, Vogl,Thomas, LePilvert,Patrick, Tsiouda,Theodora, Tsakiridis,Kosmas, Zarogoulidis,Konstantinos, and Brachmann,Johannes

Abstract

Wolfgang Hohenforst-Schmidt,1 Paul Zarogoulidis,2 Filiz Oezkan,3 Christian Mahnkopf,4 Gerhard Grabenbauer,5 Alfons Kreczy,6 Rolf Bartunek,7 Kaid Darwiche,3 Lutz Freitag,3 Qiang Li,8 Haidong Huang,8 Thomas Vogl,9 Patrick LePilvert,10 Theodora Tsiouda,11 Kosmas Tsakiridis,12 Konstantinos Zarogoulidis,2 Johannes Brachmann11II Medical Clinic, Coburg Clinic, University of Würzburg, Coburg, Germany; 2Pulmonary Department-Oncology Unit, G Papanikolaou General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece; 3Department of Interventional Pneumology, Ruhrlandklinik, West German Lung Center, University Hospital, University of Duisburg-Essen, Essen, Germany; 4II Medizinische Klinik, Klinik für Kardiologie, Angiologie, Pneumologie, Klinikum Coburg, 5Department of Radiotherapy, 6Department of Pathology, Cytology and Molecular Diagnostics, 7Institute of Diagnostic and Interventional Radiology, Coburg Clinic, University of Wüerzburg, Coburg, Germany; 8Department of Respiratory Diseases, Changhai Hospital/First Affiliated Hospital of the Second Military Medical University, Shanghai, People’s Republic of China; 9Department of Diagnostic and Interventional Radiology, Goethe University of Frankfurt, Frankfurt, Germany; 10Interventional Drug Delivery Systems and Strategies (ID2S2), Medical Cryogenics, Lakeland Court Jupiter, FL, USA; 11Internal Medicine Unit, Theagenio Cancer Hospital, Thessaloniki, 12Cardiothoracic Surgery Department, Saint Luke Private Hospital, Thessaloniki, GreeceAbstract: Vasointestinal peptide metabolism plays a key physiological role in multimodular levels of vasodilatory, smooth muscle cell proliferative, parenchymal, and inflammatory lung reactions. In animal studies, vasointestinal peptide relaxes isolated pulmonary arterial segments from several mammalian species in vitro and neutralizes the pulmonary vasoconstrictor effect of endothelin. In some animal models, it reduces pulmonary vascular resistance

Published
2014

41. “Denervation” of autonomous nervous system in idiopathic pulmonary arterial hypertension by low-dose radiation: a case report with an unexpected outcome

Author

Zarogoulidis, Paul, primary, Hohenforst-Schmidt, Wolfgang, additional, Zarogoulidis, Konstantinos, additional, Brachmann, Johannes, additional, Darwiche, Kaid, additional, Tsiouda, Theodora, additional, Tsakiridis, Kosmas, additional, Freitag, Lutz, additional, Oezkan, Filiz, additional, Mahnkopf, Christian, additional, Le Pivert, Patrick, additional, Vogl, Thomas, additional, Huang, Haidong, additional, Li, Qiang, additional, Kreczy, Alfons, additional, Barthunek, Rolf, additional, and Grabenbauer, Gerhard, additional

Published
2014
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48. Association of Left Atrial Fibrosis Detected by Delayed-Enhancement Magnetic Resonance Imaging and the Risk of Stroke in Patients With Atrial Fibrillation

Author

Daccarett, Marcos, primary, Badger, Troy J., additional, Akoum, Nazem, additional, Burgon, Nathan S., additional, Mahnkopf, Christian, additional, Vergara, Gaston, additional, Kholmovski, Eugene, additional, McGann, Christopher J., additional, Parker, Dennis, additional, Brachmann, Johannes, additional, MacLeod, Rob S., additional, and Marrouche, Nassir F., additional

Published
2011
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49. Magnetic resonance imaging allows acute and long-term identification of myocardial injury in patients receiving pulmonary vein isolation

Author

Sinha, Anil-Martin, primary, Burgon, Nathan, additional, Mahnkopf, Christian, additional, Ritscher, Guido, additional, Haslam, Thom, additional, Kunzelmann, Maximilian, additional, Schmidt, Martin, additional, Marschang, Harald, additional, Marrouche, Nassir F, additional, and Brachmann, Johannes, additional

Published
2010
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