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3. Management Strategies in Clival and Craniovertebral Junction Chordomas: A 29-Year Experience

Author

Passeri, Thibault, additional, Champagne, Pierre Olivier, additional, Giammattei, Lorenzo, additional, Abbritti, Rosaria, additional, Cartailler, Jérome, additional, Calugaru, Valentin, additional, Feuvret, Loic, additional, Guichard, Jean-Pierre, additional, Polivka, Marc, additional, Adle-Biassette, Homa, additional, Mammar, Hamid, additional, Bresson, Damien, additional, Herman, Philippe, additional, Mandonnet, Emmanuel, additional, George, Bernard, additional, and Froelich, Sébastien, additional

Published
2023
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4. The Mutational Landscape of Skull-Base and Spinal Chordomas Identifies Potential Prognostic and Theranostic Biomarkers

Author

Passeri, Thibault, additional, Gutman, Tom, additional, Hamza, Abderaouf, additional, Adle-Biassette, Homa, additional, Girard, Elodie, additional, Beaurepere, Romane, additional, Tariq, Zakia, additional, Mariani, Odette, additional, Dahmani, Ahmed, additional, Bourneix, Christine, additional, Abbritti, Rosaria, additional, Driouch, Keltouma, additional, Bohec, Mylène, additional, Servant, Nicolas, additional, Baulande, Sylvain, additional, Decaudin, Didier, additional, Polivka, Marc, additional, Guichard, Jean-Pierre, additional, Calugaru, Valentin, additional, Feuvret, Loic, additional, Guinebretière, Jean-Marc, additional, Champion, Laurence, additional, Bièche, Ivan, additional, Froelich, Sébastien, additional, Mammar, Hamid, additional, and Masliah-Planchon, Julien, additional

Published
2023
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5. In vivo efficacy assessment of the CDK4/6 inhibitor palbociclib and the PLK1 inhibitor volasertib in human chordoma xenografts

Author

Passeri, Thibault, primary, Dahmani, Ahmed, additional, Masliah-Planchon, Julien, additional, El Botty, Rania, additional, Courtois, Laura, additional, Vacher, Sophie, additional, Marangoni, Elisabetta, additional, Nemati, Fariba, additional, Roman-Roman, Sergio, additional, Adle-Biassette, Homa, additional, Mammar, Hamid, additional, Froelich, Sébastien, additional, Bièche, Ivan, additional, and Decaudin, Didier, additional

Published
2022
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6. Proton therapy for adult craniopharyngioma: Experience of a single institution in 91 consecutive patients

Author

Beddok, Arnaud, primary, Scher, Nathaniel, additional, Alapetite, Claire, additional, Baussart, Bertrand, additional, Bentahila, Ghita, additional, Bielle, Franck, additional, Bolle, Stephanie, additional, Dendale, Remi, additional, Dureau, Sylvain, additional, Goudjl, Farid, additional, Helfre, Sylvie, additional, Mammar, Hamid, additional, Nichelli, Lucia, additional, Calugaru, Valentin, additional, and Feuvret, Loïc, additional

Published
2022
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7. Abstract LB567: Dramatic in vivo efficacy of the EZH2-inhibitor tazemetostat in PBRM1-mutated human chordoma xenograft

Author

Passeri, Thibault, primary, Dahmani, Ahmed, additional, Masliah-Planchon, Julien, additional, Naguez, Adnan, additional, Michou, Marine, additional, El-Botty, Rania, additional, Vacher, Sophie, additional, Bouarich, Rachida, additional, Nicolas, André, additional, Polivka, Marc, additional, Franck, Coralie, additional, Schnitzler, Anne, additional, Némati, Fariba, additional, Roman-Roman, Sergio, additional, Bourdeaut, Franck, additional, Adle-Biassette, Homa, additional, Mammar, Hamid, additional, Froelich, Sébastien, additional, Bièche, Ivan, additional, and Decaudin, Didier, additional

Published
2022
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10. Dramatic In Vivo Efficacy of the EZH2-Inhibitor Tazemetostat in PBRM1-Mutated Human Chordoma Xenograft

Author

Passeri, Thibault, primary, Dahmani, Ahmed, additional, Masliah-Planchon, Julien, additional, Naguez, Adnan, additional, Michou, Marine, additional, El Botty, Rania, additional, Vacher, Sophie, additional, Bouarich, Rachida, additional, Nicolas, André, additional, Polivka, Marc, additional, Franck, Coralie, additional, Schnitzler, Anne, additional, Némati, Fariba, additional, Roman-Roman, Sergio, additional, Bourdeaut, Franck, additional, Adle-Biassette, Homa, additional, Mammar, Hamid, additional, Froelich, Sébastien, additional, Bièche, Ivan, additional, and Decaudin, Didier, additional

Published
2022
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11. Biological Rationale and Clinical Evidence of Carbon Ion Radiation Therapy for Adenoid Cystic Carcinoma: A Narrative Review

Author

Loap, Pierre, primary, Vischioni, Barbara, additional, Bonora, Maria, additional, Ingargiola, Rossana, additional, Ronchi, Sara, additional, Vitolo, Viviana, additional, Barcellini, Amelia, additional, Goanta, Lucia, additional, De Marzi, Ludovic, additional, Dendale, Remi, additional, Pacelli, Roberto, additional, Locati, Laura, additional, Calugaru, Valentin, additional, Mammar, Hamid, additional, Cavalieri, Stefano, additional, Kirova, Youlia, additional, and Orlandi, Ester, additional

Published
2021
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12. Small metastasizing choroidal melanomas

Author

Malclès, Ariane, Kivelä, Tero, Svetlosakova, Zuzana, Jean-Louis, Bruno, Nguyen, Anh-Minh, Sallit, Rébecca, Négrier, Sylvie, Pommier, Pascal, Rivoire, Michel, Chauvel, Pierre, Mammar, Hamid, Devouassoux-Shisheboran, Mojgan, Kodjikian, Laurent, Denis, Philippe, and Grange, Jean-Daniel

Published
2015
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13. High-dose proton therapy and tomotherapy for the treatment of sacral chordoma: a retrospective monocentric study

Author

Beddok, Arnaud, Saint-Martin, Caroline, Mammar, Hamid, Feuvret, Loïc, Helfre, Sylvie, Bolle, Stéphanie, Froelich, Sebastien, Goudjil, Farid, Zefkili, Sofia, Amessis, Malika, Peurien, Dominique, Cornet, Sophie, Dendale, Rémi, Alapetite, Claire, and Calugaru, Valentin

Abstract

Radiation therapy (RT) is used for the treatment of sacral chordoma, in combination with surgery or alone for unresected tumours, to improve local control (LC) and potentially overall survival (OS). The purpose of the present study was to evaluate efficacy and toxicity of proton therapy (PT), and/or intensity modulated radiation therapy (IMRT), particularly Tomotherapy, for sacral chordoma treatment. Material: Between November 2005 and June 2018, 41 consecutive patients who were not included in clinical trials, received sacral chordoma radiation treatment in Institut Curie with Tomotherapy alone in 13 patients, and combined PT and Tomotherapy boost (Proton – Tomo) in 28 patients. RT was delivered as the exclusive local treatment in 11 patients, and as a post-operative complementary treatment in 30 patients. After a median follow-up of 46 months (range, 0–125 months), eight local relapses were observed, and seven patients developed distant metastasis (particularly bone and lung). The 2- and 5- year local relapse rates were 11.4% CI (0.65–22.2%) and 29% (10.5–47.4%), respectively. Over the follow-up period, ten patients died (24.4%). The estimated 2- and 5-year OS rates were 91.4% CI (82.5–100%) and 74.5% (59.4–93.5%), respectively. Fibrosis, cauda equina syndrome, and pain were the most common late toxicities. The comparison between Tomotherapy alone and Proton – Tomo revealed that acute and late cystitis were significantly more frequent in the Tomotherapy group: SHR = 0.12 IC95% (0.01–0.90 [p = .04]), as well as late proctitis. A dosimetric comparison confirmed the interest of PT to spare rectum and bladder in this context. RT remains essential to improve local control in sacral chordoma. The combination of proton and photon seems to improve organ at risk sparing, resulting in a decreased rate of reported late toxicities.

Published
2020
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15. Delayed Instrumentation Following Removal of Cranio-Vertebral Junction Chordomas: A Technical Note.

Author

Champagne, Pierre-Olivier, Voormolen, Eduard H., Mammar, Hamid, Bernat, Anne-Laure, Krichen, Walid, Penet, Nicolas, and Froelich, Sébastien

Subjects
ATLANTO-occipital joint, PROTON beams, PATIENT selection, TUMOR surgery, PROTON therapy, NECK pain
Abstract

Objective  To investigate on the feasibility and safety of a new approach which consists of delaying instrumentation after destabilizing craniovertebral junction (CVJ) chordoma surgery, allowing proton beam radiotherapy to be performed in a metal-free tumoral cavity. Design  This is a retrospective series of a prospectively maintained database. Participants  Five consecutive patients operated on for a CVJ chordomas for which instrumentation after tumor resection was deferred to after radiotherapy treatment. Main Outcome Measures  The main outcome consisted of measurements of the following parameters: C0–C2 angle, atlanto-dens interval (ADI), condylar gap, and the position of the dens relative to McGregor's line and coronal inclination, performed at 3 different times for all patients: before tumor surgery (baseline), before instrumentation surgery, and after instrumentation surgery. Results  For all patients, CVJ parameters deteriorated during the delay period, but stayed within normal limits for most. Because of radiological instability, one patient necessitated instrumentation before receiving radiotherapy. All parameters except condylar gap were partially corrected after instrumentation. No new neurological symptom or evolving neck pain occurred during the delay period. Conclusion  Delayed instrumentation of CVJ chordomas can be a safe alternative that might lead to improved subsequent radiotherapeutical treatment. Patient's selection and close clinical and radiological follow-up are mandatory for the success of this approach. [ABSTRACT FROM AUTHOR]

Published
2020
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16. Small metastasizing choroidal melanomas

Author

Malclès, Ariane, primary, Kivelä, Tero, additional, Svetlosakova, Zuzana, additional, Jean-Louis, Bruno, additional, Nguyen, Anh-Minh, additional, Sallit, Rébecca, additional, Négrier, Sylvie, additional, Pommier, Pascal, additional, Rivoire, Michel, additional, Chauvel, Pierre, additional, Mammar, Hamid, additional, Devouassoux-Shisheboran, Mojgan, additional, Kodjikian, Laurent, additional, Denis, Philippe, additional, and Grange, Jean-Daniel, additional

Published
2014
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