9 results on '"Marques, Cintia Rodrigues"'
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2. Understanding Asthma and Allergies by the Lens of Biodiversity and Epigenetic Changes
- Author
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Fiuza, Bianca Sampaio Dotto, primary, Fonseca, Héllen Freitas, additional, Meirelles, Pedro Milet, additional, Marques, Cintia Rodrigues, additional, da Silva, Thiago Magalhães, additional, and Figueiredo, Camila Alexandrina, additional
- Published
- 2021
- Full Text
- View/download PDF
3. WSB1 and IL21R Genetic Variants Are Involved in Th2 Immune Responses to Ascaris lumbricoides
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Carneiro, Valdirene Leão, primary, da Silva, Hugo Bernardino Ferreira, additional, Queiroz, Gerson de Almeida, additional, Veiga, Rafael Valente, additional, Oliveira, Pablo Rafael Silveira, additional, Carneiro, Norma Vilany Queiroz, additional, Pires, Anaque de Oliveira, additional, da Silva, Raimon Rios, additional, Sena, Flavia, additional, Belitardo, Emilia, additional, Nascimento, Regina, additional, Silva, Milca, additional, Marques, Cintia Rodrigues, additional, Costa, Ryan dos Santos, additional, Alcantra-Neves, Neuza Maria, additional, Barreto, Mauricio L., additional, Cooper, Philip J., additional, and Figueiredo, Camila Alexandrina, additional
- Published
- 2021
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4. Avaliação da associação de polimorfismos presentes no cromossomo X com asma e atopia
- Author
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Marques, Cintia Rodrigues, Figueiredo, Camila Alexandrina, Santos, Fabrício Rios, Reis, Mitermayer Galvão dos, Trindade, Soraya Castro, and Pacheco, Luis Gustavo Carvalho
- Subjects
FOXP3 ,Polimorfismos ,X-WAS ,Imunogenética ,Atopia ,IMUNOLOGIA ,Asma - Abstract
Submitted by Pós Imunologia (ppgimicsufba@gmail.com) on 2017-02-07T18:45:00Z No. of bitstreams: 1 TESE_CINTIA MARQUES.pdf: 774112 bytes, checksum: 4eb77463eb7b53260c945d76b45ec8f9 (MD5) Approved for entry into archive by Delba Rosa (delba@ufba.br) on 2017-02-08T16:17:19Z (GMT) No. of bitstreams: 1 TESE_CINTIA MARQUES.pdf: 774112 bytes, checksum: 4eb77463eb7b53260c945d76b45ec8f9 (MD5) Made available in DSpace on 2017-02-08T16:17:19Z (GMT). No. of bitstreams: 1 TESE_CINTIA MARQUES.pdf: 774112 bytes, checksum: 4eb77463eb7b53260c945d76b45ec8f9 (MD5) CAPES Asma e atopia são condições determinadas por fatores genéticos e ambientais, que podem atuar tanto independentemente quanto em interação. Diversos estudos de associação ampla do genoma têm sido desenvolvidos para tentar compreender quais componentes genéticos influenciam na asma. No entanto, genes localizados no cromossomo X são frequentemente pouco representados. Um dos genes localizados nesse cromossomo, o FOXP3, codifica uma fator de transcrição que está diretamente relacionado à ativação e diferenciação de células T regulatórias. Tais células constituem um importante mecanismo relacionado ao controle de doenças alérgicas. Diversos polimorfismos já foram descritos nas regiões codificante e regulatória do FOXP3, o que sugere que os mesmos possam ter um impacto funcional sobre a proteína correspondente. Desta forma, fatores genéticos que afetam o gene FOXP3 podem determinar diferenças na susceptibilidade a doenças alérgicas, tais como a asma. Neste contexto, o presente trabalho teve como objetivo avaliar o impacto de polimorfismos em genes localizados no cromossomo X, a exemplo FOXP3, no desenvolvimento da asma e atopia. Para analisar a associação de polimorfismos presentes no cromossomo X e asma, foi realizado um X-WAS (Estudo da Associação Ampla do Cromossomo X). Já para verificar a associação de polimorfismos no gene FOXP3 com asma e atopia foi realizado um estudo de gene-candidato. Como resultados mais importantes destaca-se a associação do polimorfismo rs12007907 no gene IL1RAPL com sintomas de asma (P = 3.33x10-6; OR=0.49, 95% IC= 0.37 - 0.67) e níveis de produção de IL-13 (p = 0.045) no X-WAS; a associação dos polimorfismos no gene FOXP3 rs2232368 (OR = 1,95; 95% IC= 1.04 – 3,66) com sintomas de asma, rs2232368 (OR = 2,31; 95% IC= 1,16 – 4,59), rs3761549 (OR = 1,44; 95% IC= 1,028 – 2,018) e rs2280883 (OR = 0,836; 95% IC= 0,704 – 0,992) com atopia, além da interação entre o rs2280883 no FOXP3 e infecção com EBV no desenvolvimento de atopia definida por SPT (OR = 0,64; 95% IC: 0,47 – 0,87) e IgE específico para aeroalérgenos (OR = 0,62; 95% IC: 0,46 – 0,83). Estes achados sugerem que polimorfismos em genes do cromossomo X, dentre eles FOXP3 e IL1RAPL, possuem impacto no desenvolvimento de asma e alergia em nossa população. No entanto, novos estudos devem ser conduzidos na tentativa de elucidar melhor o impacto funcional destes polimorfismos aqui descritos no desenvolvimento de asma e alergia, além da replicação em outras populações. Asthma and atopy are conditions determined by genetic and environmental factors, which can act independently and in interaction. Several Genome Wide Association Studies has been conducted to try to understand which genetic components influence asthma. However, genes located on the X chromosome are often underrepresented. One of the genes located in this chromosome, the FOXP3, encodes a transcription factor that is directly related to the activation and differentiation of regulatory T cells. Such cells are an important mechanism related to the control of allergic diseases. Several polymorphisms have been described in coding and regulatory regions of the FOXP3, which suggests that they may have a functional impact on the corresponding protein. Thus, genetic factors affecting the FOXP3 gene can determine differences in susceptibility to allergic diseases such as asthma. In this context, this study aimed to assess the impact of polymorphisms in genes located on the X chromosome, such the FOXP3, in the asthma and atopy risk. To analyze the association between polymorphisms on chromosome X and asthma, it was carried out an X-WAS (Study of Wide Association of Chromosome X). To verify the association of polymorphisms in the FOXP3 gene with asthma and atopy, a gene-candidate study was conducted. The meaningful results were the association of rs12007907 polymorphism in IL1RAPL gene with asthma symptoms (p = 3.33x10-6; OR = 0.49, 95% CI = 0.37 - 0.67) and IL-13 production levels (p = 0.045) in X-WAS; furthermore we observed association of rs2232368 in the FOXP3 gene with asthma symptoms (OR = 1.95; 95% CI = 4.1 - 3.66) and a association with atopy for the rs2232368 (OR = 2.313; 95% CI = 1.16 to 4.59), the rs3761549 (OR = 1.44; 95% CI = 1.03 to 2.02) and rs2280883 (OR = 0.836, 95% CI = 0.70 to 0.99). In addition, we reported an interaction between the rs2280883 located on FOXP3 and infection with EBV in the atopy development defined by SPT (OR = 0.64; 95% CI: 0.47 - 0.87) and specifc IgE to allergens (OR = 0.62; 95% CI: 0.46 - 0.83). These findings suggest that polymorphisms in genes of the X chromosome, including FOXP3 and IL1RAPL, have potential impact on the development of asthma and allergy in our population. However, further studies should be conducted to elucidate the functional impact of these polymorphisms described in this study in the asthma and atopy, as well as replication in other populations.
- Published
- 2016
5. Suggestive association between variants in IL1RAPL and asthma symptoms in Latin American children
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Marques, Cintia Rodrigues, primary, Costa, Gustavo NO, additional, da Silva, Thiago Magalhães, additional, Oliveira, Pablo, additional, Cruz, Alvaro A, additional, Alcantara-Neves, Neuza Maria, additional, Fiaccone, Rosemeire L, additional, Horta, Bernardo L, additional, Hartwig, Fernando Pires, additional, Burchard, Esteban G, additional, Pino-Yanes, Maria, additional, Rodrigues, Laura C, additional, Lima-Costa, Maria Fernanda, additional, Pereira, Alexandre C, additional, Gouveia, Mateus H, additional, Sant Anna, Hanaisa P, additional, Tarazona-Santos, Eduardo, additional, Lima Barreto, Maurício, additional, and Figueiredo, Camila Alexandrina, additional
- Published
- 2017
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6. Genetic and epigenetic studies of FOXP3 in asthma and allergy
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Marques, Cintia Rodrigues, primary, Costa, Ryan Santos, additional, Costa, Gustavo Nunes de Oliveira, additional, da Silva, Thiago Magalhães, additional, Teixeira, Tatiane Oliveira, additional, de Andrade, Emília Maria Medeiros, additional, Galvão, Alana A., additional, Carneiro, Valdirene Leão, additional, and Figueiredo, Camila Alexandrina, additional
- Published
- 2015
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7. Association of polymorphisms of endothelial nitric oxide synthase (eNOS) gene with the risk of primary open angle glaucoma in a Brazilian population
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Magalhães da Silva, Thiago, primary, Rocha, Auta Viviane, additional, Lacchini, Riccardo, additional, Marques, Cintia Rodrigues, additional, Silva, Elias Souza, additional, Tanus-Santos, José Eduardo, additional, and Rios-Santos, Fabrício, additional
- Published
- 2012
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8. NAT2, XRCC1 and hOGG1 polymorphisms, cigarette smoking, alcohol consumption and risk of upper aerodigestive tract cancer.
- Author
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Marques CR, Da Silva TM, De Albuquerque DM, Chaves MS, Marques Filho MF, Oliveira JS, Di Pietro G, Sousa SM, Simões AL, and Rios-Santos F
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- Aged, Case-Control Studies, DNA analysis, Female, Follow-Up Studies, Humans, Male, Middle Aged, Neoplasm Staging, Polymerase Chain Reaction, Polymorphism, Restriction Fragment Length, Prognosis, Risk Factors, X-ray Repair Cross Complementing Protein 1, Alcohol Drinking epidemiology, Arylamine N-Acetyltransferase genetics, DNA Glycosylases genetics, DNA-Binding Proteins genetics, Gastrointestinal Neoplasms epidemiology, Polymorphism, Single Nucleotide, Respiratory Tract Neoplasms epidemiology, Smoking epidemiology
- Abstract
Aim: To evaluate associations between polymorphisms of the N-acetyltransferase 2 (NAT2), human 8-oxoguanine glycosylase 1 (hOGG1) and X-ray repair cross-complementing protein 1 (XRCC1) genes and risk of upper aerodigestive tract (UADT) cancer., Patients and Methods: A case-control study involving 117 cases and 224 controls was undertaken. The NAT2 gene polymorphisms were genotyped by automated sequencing and XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms were determined by Polymerase Chain Reaction followed by Restriction Fragment Length Polymorphism (PCR-RFLP) methods., Results: Slow metabolization phenotype was significantly associated as a risk factor for the development of UADT cancer (p=0.038). Furthermore, haplotype of slow metabolization was also associated with UADT cancer (p=0.014). The hOGG1 Ser326Cys polymorphism (CG or GG vs. CC genotypes) was shown as a protective factor against UADT cancer in moderate smokers (p=0.031). The XRCC1 Arg399Gln polymorphism (GA or AA vs. GG genotypes), in turn, was a protective factor against UADT cancer only among never-drinkers (p=0.048)., Conclusion: Interactions involving NAT2, XRCC1 Arg399Gln and hOGG1 Ser326Cys polymorphisms may modulate the risk of UADT cancer in this population., (Copyright© 2014 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved.)
- Published
- 2014
9. Cytokines, cytokine gene polymorphisms and Helicobacter pylori infection: friend or foe?
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Figueiredo CA, Marques CR, Costa Rdos S, da Silva HB, and Alcantara-Neves NM
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- Animals, Cytokines blood, Genetic Predisposition to Disease, Helicobacter Infections blood, Helicobacter Infections microbiology, Helicobacter pylori pathogenicity, Host-Pathogen Interactions, Humans, Phenotype, Cytokines genetics, Cytokines immunology, Helicobacter Infections genetics, Helicobacter Infections immunology, Helicobacter pylori immunology, Polymorphism, Genetic
- Abstract
Helicobacter pylori (H. pylori) is a flagellated, spiral-shaped, microaerophilic Gram-negative bacillus that colonises the gastric mucosa of more than 50% of the human population. Infection is a risk factor for gastritis, ulcer disease and stomach cancer. Immunity against H. pylori is mainly related to Th1/Th17 skewing, and the activation of regulatory T cells is the main strategy used to limit inflammatory responses, which can result in the pathogen persistence and can lead to chronic gastrointestinal diseases, including cancer. Furthermore, host genetic factors that affect cytokines may determine differences in the susceptibility to many diseases. In this review, we present the cytokine profiles and the main cytokine gene polymorphisms associated with resistance/susceptibility to H. pylori and discuss how such polymorphisms may influence infection/disease outcomes.
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- 2014
- Full Text
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