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17 results on '"Marsh, Anna-Marie"'

1. Is atrial fibrillation in HFpEF a distinct phenotype? Insights from multiparametric MRI and circulating biomarkers

Author

Dattani, Abhishek, Brady, Emer M., Kanagala, Prathap, Stoma, Svetlana, Parke, Kelly S., Marsh, Anna-Marie, Singh, Anvesha, Arnold, Jayanth R., Moss, Alastair J., Zhao, Lei, Cvijic, Mary Ellen, Fronheiser, Matthew, Du, Shuyan, Costet, Philippe, Schafer, Peter, Carayannopoulos, Leon, Chang, Ching-Pin, Gordon, David, Ramirez-Valle, Francisco, Jerosch-Herold, Michael, Nelson, Christopher P., Squire, Iain B., Ng, Leong L., Gulsin, Gaurav S., and McCann, Gerry P.

Published
2024
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2. Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

Author

Yeo, Jian L., Gulsin, Gaurav S., Brady, Emer M., Dattani, Abhishek, Bilak, Joanna M., Marsh, Anna-Marie, Sian, Manjit, Athithan, Lavanya, Parke, Kelly S., Wormleighton, Joanne, Graham-Brown, Matthew P. M., Singh, Anvesha, Arnold, J. Ranjit, Lawson, Claire, Davies, Melanie J., Xue, Hui, Kellman, Peter, and McCann, Gerry P.

Published
2022
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4. Do Lean People with Type 2 Diabetes (T2D) Have Cardiomyopathy? Assessing the Impact of BMI on Cardiac Remodelling and Quantitative Myocardial Blood Flow in T2D

Author

Cowley, Alice, primary, Dattani, Abhishek, additional, Yeo, Jian, additional, Brady, Emer, additional, Marsh, Anna-Marie, additional, Sian, Manjit, additional, Parke, Kelly, additional, Wormleighton, Joanne, additional, Gulsin, Gaurav, additional, Singh, Anvesha, additional, Arnold, Jayanath, additional, and McCann, Gerry, additional

Published
2024
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6. Impact of the Remission of Type 2 Diabetes on Cardiovascular Structure and Function, Exercise Capacity and Risk Profile: A Propensity Matched Analysis

Author

Bilak, Joanna M., primary, Yeo, Jian L., additional, Gulsin, Gaurav S., additional, Marsh, Anna-Marie, additional, Sian, Manjit, additional, Dattani, Abhishek, additional, Ayton, Sarah L., additional, Parke, Kelly S., additional, Bain, Moira, additional, Pang, Wenjie, additional, Boulos, Sherif, additional, Pierre, Tim G. St, additional, Davies, Melanie J., additional, Yates, Thomas, additional, McCann, Gerry P., additional, and Brady, Emer M., additional

Published
2023
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7. PHACTR1 modulates vascular compliance but not endothelial function: a translational study

Author

Wood, Alice, primary, Antonopoulos, Alexios, additional, Chuaiphichai, Surawee, additional, Kyriakou, Theodosios, additional, Diaz, Rebeca, additional, Al Hussaini, Abtehale, additional, Marsh, Anna Marie, additional, Sian, Manjit, additional, Meisuria, Mitul, additional, McCann, Gerry, additional, Rashbrook, Victoria S, additional, Drydale, Edward, additional, Draycott, Sally, additional, Polkinghorne, Murray David, additional, Akoumianakis, Ioannis, additional, Antoniades, Charalambos, additional, Watkins, Hugh, additional, Channon, Keith M, additional, Adlam, David, additional, and Douglas, Gillian, additional

Published
2022
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8. PHACTR1 modulates vascular compliance but not endothelial function: a translational study.

Author

Wood, Alice, Antonopoulos, Alexios, Chuaiphichai, Surawee, Kyriakou, Theodosios, Diaz, Rebeca, Hussaini, Abtehale Al, Marsh, Anna-Marie, Sian, Manjit, Meisuria, Mitul, McCann, Gerry, Rashbrook, Victoria S, Drydale, Edward, Draycott, Sally, Polkinghorne, Murray David, Akoumianakis, Ioannis, Antoniades, Charalambos, Watkins, Hugh, Channon, Keith M, Adlam, David, and Douglas, Gillian

Subjects
SPONTANEOUS coronary artery dissection, CAROTID intima-media thickness, THORACIC aorta, VASCULAR remodeling, CELL physiology, CAROTID artery
Abstract

Aims The non-coding locus at 6p24 located in Intron 3 of PHACTR1 has consistently been implicated as a risk allele in myocardial infarction and multiple other vascular diseases. Recent murine studies have identified a role for Phactr1 in the development of atherosclerosis. However, the role of PHACTR1 in vascular tone and in vivo vascular remodelling has yet to be established. The aim of this study was to investigate the role of PHACTR1 in vascular function. Methods and results Prospectively recruited coronary artery disease (CAD) patients undergoing bypass surgery and retrospectively recruited spontaneous coronary artery dissection (SCAD) patients and matched healthy volunteers were genotyped at the PHACTR1 rs9349379 locus. We observed a significant association between the PHACTR1 loci and changes in distensibility in both the ascending aorta (AA = 0.0053 ± 0.0004, AG = 0.0041 ± 0.003, GG = 0.0034 ± 0.0009, P < 0.05, n = 58, 54, and 7, respectively) and carotid artery (AA = 12.83 ± 0.51, AG = 11.14 ± 0.38, GG = 11.69 ± 0.66, P < 0.05, n = 70, 65, and 18, respectively). This association was not observed in the descending aorta or in SCAD patients. In contrast, the PHACTR1 locus was not associated with changes in endothelial cell function with no association between the rs9349379 locus and in vivo or ex vivo vascular function observed in CAD patients. This finding was confirmed in our murine model where the loss of Phactr1 on the pro-atherosclerosis ApoE −/− background did not alter ex vivo vascular function. Conclusion In conclusion, we have shown a role for PHACTR1 in arterial compliance across multiple vascular beds. Our study suggests that PHACTR1 has a key structural role within the vasculature. [ABSTRACT FROM AUTHOR]

Published
2023
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9. Additional file 1 of Association of ambulatory blood pressure with coronary microvascular and cardiac dysfunction in asymptomatic type 2 diabetes

Author

Yeo, Jian L., Gulsin, Gaurav S., Brady, Emer M., Dattani, Abhishek, Bilak, Joanna M., Marsh, Anna-Marie, Sian, Manjit, Athithan, Lavanya, Parke, Kelly S., Wormleighton, Joanne, Graham-Brown, Matthew P. M., Singh, Anvesha, Arnold, J. Ranjit, Lawson, Claire, Davies, Melanie J., Xue, Hui, Kellman, Peter, and McCann, Gerry P.

Abstract

Additional file 1: Table S1. Percentages of successful ambulatory blood pressure recordings. Table S2. Intra- and interobserver variability for E/A and E/e'. Table S3. Univariable correlation of blood pressure with MRI and echocardiographic parameters in T2D.

Published
2022
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10. Clinical associations with stage B heart failure in adults with type 2 diabetes

Author

Gulsin, Gaurav S., primary, Brady, Emer, additional, Marsh, Anna-Marie, additional, Squire, Gareth, additional, Htike, Zin Z., additional, Wilmot, Emma G., additional, Biglands, John D., additional, Kellman, Peter, additional, Xue, Hui, additional, Webb, David R., additional, Khunti, Kamlesh, additional, Yates, Tom, additional, Davies, Melanie J., additional, and McCann, Gerry P., additional

Published
2021
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11. Cardiovascular Determinants of Aerobic Exercise Capacity in Adults With Type 2 Diabetes

Author

Gulsin, Gaurav S., primary, Henson, Joseph, additional, Brady, Emer M., additional, Sargeant, Jack A., additional, Wilmot, Emma G., additional, Athithan, Lavanya, additional, Htike, Zin Z., additional, Marsh, Anna-Marie, additional, Biglands, John D., additional, Kellman, Peter, additional, Khunti, Kamlesh, additional, Webb, David, additional, Davies, Melanie J., additional, Yates, Thomas, additional, and McCann, Gerry P., additional

Published
2020
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12. Effects of Low-Energy Diet or Exercise on Cardiovascular Function in Working-Age Adults With Type 2 Diabetes: A Prospective, Randomized, Open-Label, Blinded End Point Trial

Author

Gulsin, Gaurav S., primary, Swarbrick, Daniel J., additional, Athithan, Lavanya, additional, Brady, Emer M., additional, Henson, Joseph, additional, Baldry, Emma, additional, Argyridou, Stavroula, additional, Jaicim, Nishal B., additional, Squire, Gareth, additional, Walters, Yvette, additional, Marsh, Anna-Marie, additional, McAdam, John, additional, Parke, Kelly S., additional, Biglands, John D., additional, Yates, Thomas, additional, Khunti, Kamlesh, additional, Davies, Melanie J., additional, and McCann, Gerry P., additional

Published
2020
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13. Determinants of Exercise Capacity and Myocardial Perfusion Reserve in Asymptomatic Patients With Aortic Stenosis

Author

Singh, Anvesha, primary, Jerosch-Herold, Michael, additional, Bekele, Soliana, additional, Marsh, Anna-Marie, additional, McAdam, John, additional, Greenwood, John P., additional, Dawson, Dana K., additional, Lang, Chim C., additional, Berry, Colin, additional, Zhang, Ruiqi, additional, Pakkal, Mini, additional, and McCann, Gerry P., additional

Published
2020
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14. Rationale, design and study protocol of the randomised controlled trial: Diabetes Interventional Assessment of Slimming or Training tO Lessen Inconspicuous Cardiovascular Dysfunction (the DIASTOLIC study)

Author

Gulsin, Gaurav Singh, primary, Brady, Emer M, additional, Swarbrick, Daniel J, additional, Athithan, Lavanya, additional, Henson, Joseph, additional, Baldry, Emma, additional, McAdam, John, additional, Marsh, Anna-Marie, additional, Parke, Kelly S, additional, Wormleighton, Joanne V, additional, Levelt, Eylem, additional, Yates, Thomas, additional, Bodicoat, Danielle, additional, Khunti, Kamlesh, additional, Davies, Melanie J, additional, and McCann, Gerry P, additional

Published
2019
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17. Abstract 10122: A Randomized Trial of Exercise versus Low-energy Meal Replacement Diet to Improve Cardiac Dysfunction in Working-Age Adults With Type 2 Diabetes

Author

Gulsin, Gaurav S, Swarbrick, Daniel J, Athithan, Lavanya, Brady, Emer M, Henson, Joseph J, Baldry, Emma, Argyridou, Stavroula, Marsh, Anna-Marie, Squire, Gareth, Jaicim, Nishal B, Biglands, John, Yates, Thomas, Khunti, Kamlesh, Davies, Melanie J, and McCann, Gerry

Abstract

Introduction:Adults with type 2 diabetes (T2DM) may already have diastolic dysfunction, a precursor to heart failure. Whether weight loss or exercise improve subclinical diastolic dysfunction in T2DM is not known.Methods:Phase 1) Case-control comparison of obese adults with T2DM and no CVD, with age- and sex-matched controls. Phase 2) Prospective, randomised, open-label blinded endpoint trial. Ninety obese T2DMs (age 50?7y, 59% male, BMI 37?6 kg/m2) and 39 controls (age 49?7y, 51% male, BMI 24?2 kg/m2) were recruited for Phase 1. In Phase 2, T2DMs were randomised 1:1:1 to a 12-week intervention with either: 1) routine care; 2) a low-energy (?810 kCal/day) meal replacement diet; or 3) a supervised aerobic exercise programme. Bio-anthropometric profiling and cardiac MRI at baseline and 12-weeks were performedResults:Clinical and MRI data pre- and post-intervention are shown in Table 1. Compared to controls, T2DMs had more concentric LV remodelling (p<0.001), smaller LA volumes (p=0.021) and lower circumferential peak early diastolic strain rate (cPEDSR, p=0.02). A total of 76 T2DMs completed the interventional trial. The diet arm lost 13Kg in weight, with dramatic improvements in BP and glycometabolic indices. The exercise arm had small reductions in weight, BP and HbA1c. Participants in exercise arm had an improvement in cPEDSR vs. those in routine care (0.132, 97.5% CI 0.038 to 0.225, p=0.002), without alterations in LV remodelling. cPEDSR did not improve in subjects assigned to the diet (0.016, 97.5% CI -0.075 to 0.106, p=0.731), but LV mass decreased, and LV and LA volumes increased. Furthermore, longitudinal PEDSR worsened in the diet arm vs. routine care (-0.097, 95% CI -0.173 to -0.021, p=0.016).Conclusions:Adults with T2DM have subclinical diastolic dysfunction, which improved with an exercise programme. Despite beneficial effects on cardio-metabolic factors and cardiac remodelling, weight loss did not improve and may worsen diastolic function in T2DM.

Published
2019
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