1. Human breast cancer: identification of populations with a high risk of early relapse in relation to both oestrogen receptor status and c-erbB-2 overexpression
- Author
-
J. F. Qian, P. May, Evelyne May, May-Levin F, Mouriesse H, and Delarue Jc
- Subjects
Oncology ,Cancer Research ,medicine.medical_specialty ,Receptor, ErbB-2 ,medicine.drug_class ,Mammary gland ,Population ,Gene Expression ,Breast Neoplasms ,Biology ,Lower risk ,Risk Factors ,Proto-Oncogene Proteins ,Internal medicine ,Gene expression ,Biomarkers, Tumor ,medicine ,Humans ,education ,Survival analysis ,education.field_of_study ,Age Factors ,Cancer ,Blotting, Northern ,Prognosis ,medicine.disease ,Survival Analysis ,Endocrinology ,medicine.anatomical_structure ,Receptors, Estrogen ,Estrogen ,Lymph ,Neoplasm Recurrence, Local ,Research Article - Abstract
We recently defined a new early prognostic factor, the ER+(R) status, which permits the discrimination of a group presenting a high risk of early relapse among the ER+ patients. This group was referred to as ER+(R2) in contrast to ER+(R1) which corresponded to the group of ER+ patients having a lower risk of early relapse. Taking into account the whole population including the ER- and inflammatory tumours, we have extended this view and showed that ER+(R) status is a significant predictor of disease-free survival. Determination of c-erbB-2 mRNA levels in the same series of tumours showed that high expression of c-erbB-2 mRNA is significantly correlated with ER-, inflammatory tumours and with lymph nodes involvement. Moreover, a multivariate analysis showed that c-erbB-2 mRNA overexpression was a significant predictor of early relapse (P = 0.02), as significant as ER negativity and ER+(R2). For ER+ patients a high level of c-erbB-2 mRNA constitutes a higher risk of relapse for both ER+(R1) and ER+(R2) patients. However, in the case of ER- patients, early relapses were strongly correlated with c-erbB-2 overexpression. The counterpart of this observation is that ER- patients with no overexpression of c-erbB-2 constitute a group with a relatively good prognosis. Images Figure 1
- Published
- 1990
- Full Text
- View/download PDF