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9 results on '"McCartney, T."'

1. 1457P A UK multicentre retrospective review of metastatic renal cell carcinoma (mRCC) patients (pts) outcomes with brain metastases (BM) in the modern era

Author

Ratnayake, G., primary, Challapalli, A., additional, McGrane, J., additional, Frazer, R., additional, Gupta, S., additional, Parslow, D.S., additional, Kingdon, S.J., additional, Lydon, A., additional, Sharma, A., additional, Tuthill, M., additional, McCartney, T., additional, Jabbar, R., additional, Charnley, N., additional, Malik, J.M., additional, Abhi, D., additional, Chau, C., additional, Geldart, T.R., additional, Halstead, A., additional, Anuforom, U., additional, and Bahl, A., additional

Published
2022
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4. Effect of Oral Insulin on Prevention of Diabetes in Relatives of Patients With Type 1 Diabetes A Randomized Clinical Trial

Author

Greenbaum, C., Atkinson, M., Baidal, D., Battaglia, M., Bingley, P., Bosi, E., Buckner, J., Clements, M., Colman, P., DiMeglio, L., Evans-Molina, C., Gitelman, S., Goland, R., Gottlieb, P., Herold, K., Knip, M., Krischer, J., Lernmark, A., Moore, W., Moran, A., Muir, A., Palmer, J., Peakman, M., Philipson, L., Raskin, P., Redondo, M., Rodriguez, H., Russell, W., Spain, L., Schatz, D.A., Sosenko, J., Wherrett, D., Wilson, D., Winter, W., Ziegler, A., Anderson, M., Antinozzi, P., Benoist, C., Blum, J., Bourcier, K., Chase, P., Clare-Salzler, M., Clynes, R., Cowie, C., Eisenbarth, G., Fathman, C.G., Grave, G., Harrison, L., Hering, B., Insel, R., Jordan, S., Kaufman, F., Kay, T., Kenyon, N., Klines, R., Lachin, J., Leschek, E., Mahon, J., Marks, J.B., Monzavi, R., Nanto-Salonen, K., Nepom, G., Orban, T., Parkman, R., Pescovitz, M., Peyman, J., Pugliese, A., Ridge, J., Roep, B., Roncarolo, M., Savage, P., Simell, O., Sherwin, R., Siegelman, M., Skyler, J.S., Thomas, J., Trucco, M., Wagner, J., Greenbaum, C.J., Krischer, J.P., Rafkin, L., Foulkes, M., Krause-Steinrauf, H., Lachin, J.M., Malozowski, S., Zafonte, S.J., Kenyon, N.S., Santiago, I., Bundy, B., Abbondondolo, M., Adams, T., Asif, D.A.I., Boonstra, M., Boulware, D., Burroughs, C., Cuthbertson, D., Eberhard, C., Fiske, S., Ford, J., Garmeson, J., Guillette, H., Geyer, S., Hays, B., Henderson, C., Henry, M., Heyman, K., Hsiao, B., Karges, C., Kinderman, A., Lane, L., Leinbach, A., Liu, S., Lloyd, J., Malloy, J., Maddox, K., Martin, J., Miller, J., Moore, M., Muller, S., Nguyen, T., O'Donnell, R., Parker, M., Pereyra, M.J., Reed, N., Roberts, A., Sadler, K., Stavros, T., Tamura, R., Wood, K., Xu, P., Young, K., Alies, P., Badias, F., Baker, A., Bassi, M., Beam, C., Bounmananh, L., Bream, S., Deemer, M., Freeman, D., Gough, J., Ginem, J., Granger, M., Holloway, M., Kieffer, M., Lane, P., Law, P., Linton, C., Nallamshetty, L., Oduah, V., Parrimon, Y., Paulus, K., Pilger, J., Ramiro, J., Ritzie, A.Q.L., Sharma, A., Shor, A., Song, X.H., Terry, A., Weinberger, J., Wootten, M., Harding, M.F.P., McDonough, S., Mcgee, P.F., Hess, K.O., Phoebus, D., Quinlan, S., Raiden, E., Fradkin, J., Beck, G., Blumberg, E., Gubitosi-Klug, R., Laffel, L., Veatch, R., Wallace, D., Braun, J., Brillon, D., B. lo, Mitchell, H., Naji, A., Nerup, J., Orchard, T., Steffes, M., Tsiatis, A., Zinman, B., Loechelt, B., Baden, L., Green, M., Weinberg, A., Marcovina, S., Palmer, J.P., Yu, L.P., Shultz, A., Batts, E., Fitzpatrick, K., Ramey, M., Guerra, R., Webb, C., Caffey, F., Carr, L., Ergun-Longmire, B., Fenton, C., Giebner, D., Johnson, J., Maglionico, D., Marinelli, M., Martin, K., Minnozzi, E., Riley, W., Wilson, M., Gougeon, C., Ho, J., Huang, C., Pacaud, D., Virtanen, H., Craig, C., Ghatak, A., Henderson, T., Leyland, H., Padmore, K., Paul, P., Brickman, W., Halsey-Lyda, M., Petrie, P., Rizzo, D., Steuer, R., Suchyta, K., Torchen, L., Zimmerman, D., Bode, B., Dial, M., Gazaway, K., Hosey, R., Alkanani, A., Barker, J., Barr, M., Blau, A., Burdick, P., Burke, B., Chase, H., Drye, M., Escobar, E., Fitzgerald-Miller, L., Fouts, A., Gage, V., Gall, E., Goettle, H., Harris, S., Ketchum, K., King, M., Klingensmith, G., Lehr, D., Lehr, J., Lewis, L., Logsden-Sackett, N., Lykens, J., Maahs, D., Michels, A., Pelletier, S., Rihanek, M., Rodriguez, P., Schauwecker, A., Simmons, K., Smith, J., Steck, A., Tran, B., Tran, T., Wadwa, P., Wagner, R., Wright, H., Betancourt, J., Bui, V., DeSalvo, D., Gomez, D., Jake, K., Lynds, J., McCartney, T., McDonald, A., Pena, S., Pietropaolo, M., Greenbaum, C., Atkinson, M., Baidal, D., Battaglia, M., Becker, D., Bingley, P., Bosi, E., Buckner, J., Clements, M., Colman, P., Dimeglio, L., Evans-Molina, C., Gitelman, S., Goland, R., Gottlieb, P., Herold, K., Knip, M., Krischer, J., Lernmark, A., Moore, W., Moran, A., Muir, A., Palmer, J., Peakman, M., Philipson, L., Raskin, P., Redondo, M., Rodriguez, H., Russell, W., Spain, L., Schatz, D. A., Sosenko, J., Wherrett, D., Wilson, D., Winter, W., and Ziegler, A.

Subjects
0301 basic medicine, Male, medicine.medical_specialty, Adolescent, medicine.medical_treatment, Administration, Oral, 030209 endocrinology & metabolism, Placebo, law.invention, 03 medical and health sciences, 0302 clinical medicine, Randomized controlled trial, Interquartile range, law, Internal medicine, Diabetes mellitus, medicine, Humans, Hypoglycemic Agents, Insulin, Family, Treatment Failure, Child, Original Investigation, Autoantibodies, Type 1 diabetes, Glucose tolerance test, medicine.diagnostic_test, business.industry, General Medicine, ta3121, Glucose Tolerance Test, medicine.disease, 030104 developmental biology, Diabetes Mellitus, Type 1, Child, Preschool, Cohort, Female, business, Follow-Up Studies
Abstract

Importance Type 1 diabetes requires major lifestyle changes and carries increased morbidity and mortality. Prevention or delay of diabetes would have major clinical effect. Objective To determine whether oral insulin delays onset of type 1 diabetes in autoantibody-positive relatives of patients with type 1 diabetes. Design, Setting, and Participants Between March 2, 2007, and December 21, 2015, relatives with at least 2 autoantibodies, including insulin autoantibodies and normal glucose tolerance, were enrolled in Canada, the United States, Australia, New Zealand, the United Kingdom, Italy, Sweden, Finland, and Germany. The main study group (n = 389) had first-phase insulin release on an intravenous glucose tolerance test that was higher than the threshold. The 55 patients in the secondary stratum 1 had an identical antibody profile as the main study group except they had first-phase insulin release that was lower than the threshold. Secondary strata 2 (n = 114) and strata 3 (n = 3) had different autoantibody profiles and first-phase insulin release threshold combinations. Follow-up continued through December 31, 2016. Interventions Randomization to receive 7.5 mg/d of oral insulin (n = 283) or placebo (n = 277), including participants in the main study group who received oral insulin (n = 203) or placebo (n = 186). Main Outcome and Measures The primary outcome was time to diabetes in the main study group. Significance was based on a 1-sided threshold of .05, and 1-sided 95% CIs are reported. Results Of a total of 560 randomized participants (median enrollment age, 8.2 years; interquartile range [IQR], 5.7-12.1 years; 170 boys [60%]; 90.7% white non-Hispanic; 57.6% with a sibling with type 1 diabetes), 550 completed the trial including 389 participants (median age, 8.4 years; 245 boys [63%]), 382 (96%) in the main study group. During a median follow-up of 2.7 years (IQR, 1.5-4.6 years) in the main study group, diabetes was diagnosed in 58 participants (28.5%) in the oral insulin group and 62 (33%) in the placebo group. Time to diabetes was not significantly different between the 2 groups (hazard ratio [HR], 0.87; 95% CI, 0-1.2;P = .21). In secondary stratum 1 (n = 55), diabetes was diagnosed in 13 participants (48.1%) in the oral insulin group and in 19 participants (70.3%) in the placebo group. The time to diabetes was significantly longer with oral insulin (HR, 0.45; 95% CI, 0-0.82;P = .006). The HR for time to diabetes for the between-group comparisons for the 116 participants in the other secondary stratum was 1.03 (95% CI, 0-2.11;P = .53) and for the entire cohort of 560 participants was 0.83 (95% CI, 0-1.07;P = .11), which were not significantly different. The most common adverse event was infection (n = 254), with 134 events in the oral insulin group and 120 events in the placebo group, but no significant study-related adverse events occurred. Conclusions and Relevance Among autoantibody-positive relatives of patients with type 1 diabetes, oral insulin at a dose of 7.5 mg/d, compared with placebo, did not delay or prevent the development of type 1 diabetes over 2.7 years. These findings do not support oral insulin as used in this study for diabetes prevention. Trial Registration clinicaltrials.gov Identifier:NCT00419562

Published
2017

5. The Hominin Sites and Paleolakes Drilling Project: inferring the environmental context of human evolution from eastern African rift lake deposits

Author

Cohen, A., Campisano, C., Arrowsmith, R., Asrat, A., Behrensmeyer, A. K., Deino, A., Feibel, C., Hill, A., Johnson, R., Kingston, J., Lamb, H., Lowenstein, T., Noren, A., Olago, D., Owen, R. B., Potts, R., Reed, K., Renaut, R., Schäbitz, F., Tiercelin, J.-J., Trauth, M. H., Wynn, J., Ivory, S., Brady, K., O'Grady, R., Rodysill, J., Githiri, J., Russell, J., Foerster, V., Dommain, R., Rucina, S., Deocampo, D., Billingsley, A., Beck, C., Dorenbeck, G., Dullo, L., Feary, D., Garello, D., Gromig, R., Johnson, T., Junginger, A., Karanja, M., Kimburi, E., Mbuthia, A., Mccartney, T., Mcnulty, E., Muiruri, V., Nambiro, E., Negash, E. W., Njagi, D., Wilson, J. N., Rabideaux, N., Raub, T., Sier, M. J., Smith, P., Urban, J., Warren, M., Yadeta, M., Yost, C., Zinaye, B., Cohen, A., Campisano, C., Arrowsmith, R., Asrat, A., Behrensmeyer, A. K., Deino, A., Feibel, C., Hill, A., Johnson, R., Kingston, J., Lamb, H., Lowenstein, T., Noren, A., Olago, D., Owen, R. B., Potts, R., Reed, K., Renaut, R., Schäbitz, F., Tiercelin, J.-J., Trauth, M. H., Wynn, J., Ivory, S., Brady, K., O'Grady, R., Rodysill, J., Githiri, J., Russell, J., Foerster, V., Dommain, R., Rucina, S., Deocampo, D., Billingsley, A., Beck, C., Dorenbeck, G., Dullo, L., Feary, D., Garello, D., Gromig, R., Johnson, T., Junginger, A., Karanja, M., Kimburi, E., Mbuthia, A., Mccartney, T., Mcnulty, E., Muiruri, V., Nambiro, E., Negash, E. W., Njagi, D., Wilson, J. N., Rabideaux, N., Raub, T., Sier, M. J., Smith, P., Urban, J., Warren, M., Yadeta, M., Yost, C., and Zinaye, B.

Abstract

The role that climate and environmental history may have played in influencing human evolution has been the focus of considerable interest and controversy among paleoanthropologists for decades. Prior attempts to understand the environmental history side of this equation have centered around the study of outcrop sediments and fossils adjacent to where fossil hominins (ancestors or close relatives of modern humans) are found, or from the study of deep sea drill cores. However, outcrop sediments are often highly weathered and thus are unsuitable for some types of paleoclimatic records, and deep sea core records come from long distances away from the actual fossil and stone tool remains. The Hominin Sites and Paleolakes Drilling Project (HSPDP) was developed to address these issues. The project has focused its efforts on the eastern African Rift Valley, where much of the evidence for early hominins has been recovered. We have collected about 2 km of sediment drill core from six basins in Kenya and Ethiopia, in lake deposits immediately adjacent to important fossil hominin and archaeological sites. Collectively these cores cover in time many of the key transitions and critical intervals in human evolutionary history over the last 4 Ma, such as the earliest stone tools, the origin of our own genus Homo, and the earliest anatomically modern Homo sapiens. Here we document the initial field, physical property, and core description results of the 2012–2014 HSPDP coring campaign.

Published
2016

6. The Hominin Sites and Paleolakes Drilling Project: inferring the environmental context of human evolution from eastern African rift lake deposits

Author

Paleomagnetism, NWO-ALW Open: Climate impact on human evolution: age calibration of hominin sites and paleolakes drilling project, Cohen, A., Campisano, C., Arrowsmith, R., Asrat, A., Behrensmeyer, A. K., Deino, A., Feibel, C., Hill, A., Johnson, R., Kingston, J., Lamb, H., Lowenstein, T., Noren, A., Olago, D., Owen, R. B., Potts, R., Reed, K., Renaut, R., Schäbitz, F., Tiercelin, J.-J., Trauth, M. H., Wynn, J., Ivory, S., Brady, K., O'Grady, R., Rodysill, J., Githiri, J., Russell, J., Foerster, V., Dommain, R., Rucina, S., Deocampo, D., Billingsley, A., Beck, C., Dorenbeck, G., Dullo, L., Feary, D., Garello, D., Gromig, R., Johnson, T., Junginger, A., Karanja, M., Kimburi, E., Mbuthia, A., Mccartney, T., Mcnulty, E., Muiruri, V., Nambiro, E., Negash, E. W., Njagi, D., Wilson, J. N., Rabideaux, N., Raub, T., Sier, M. J., Smith, P., Urban, J., Warren, M., Yadeta, M., Yost, C., Zinaye, B., Paleomagnetism, NWO-ALW Open: Climate impact on human evolution: age calibration of hominin sites and paleolakes drilling project, Cohen, A., Campisano, C., Arrowsmith, R., Asrat, A., Behrensmeyer, A. K., Deino, A., Feibel, C., Hill, A., Johnson, R., Kingston, J., Lamb, H., Lowenstein, T., Noren, A., Olago, D., Owen, R. B., Potts, R., Reed, K., Renaut, R., Schäbitz, F., Tiercelin, J.-J., Trauth, M. H., Wynn, J., Ivory, S., Brady, K., O'Grady, R., Rodysill, J., Githiri, J., Russell, J., Foerster, V., Dommain, R., Rucina, S., Deocampo, D., Billingsley, A., Beck, C., Dorenbeck, G., Dullo, L., Feary, D., Garello, D., Gromig, R., Johnson, T., Junginger, A., Karanja, M., Kimburi, E., Mbuthia, A., Mccartney, T., Mcnulty, E., Muiruri, V., Nambiro, E., Negash, E. W., Njagi, D., Wilson, J. N., Rabideaux, N., Raub, T., Sier, M. J., Smith, P., Urban, J., Warren, M., Yadeta, M., Yost, C., and Zinaye, B.

Published
2016

7. The Hominin Sites and Paleolakes Drilling Project: inferring the environmental context of human evolution from eastern African rift lake deposits

Author

Cohen, A., primary, Campisano, C., additional, Arrowsmith, R., additional, Asrat, A., additional, Behrensmeyer, A. K., additional, Deino, A., additional, Feibel, C., additional, Hill, A., additional, Johnson, R., additional, Kingston, J., additional, Lamb, H., additional, Lowenstein, T., additional, Noren, A., additional, Olago, D., additional, Owen, R. B., additional, Potts, R., additional, Reed, K., additional, Renaut, R., additional, Schäbitz, F., additional, Tiercelin, J.-J., additional, Trauth, M. H., additional, Wynn, J., additional, Ivory, S., additional, Brady, K., additional, O'Grady, R., additional, Rodysill, J., additional, Githiri, J., additional, Russell, J., additional, Foerster, V., additional, Dommain, R., additional, Rucina, S., additional, Deocampo, D., additional, Billingsley, A., additional, Beck, C., additional, Dorenbeck, G., additional, Dullo, L., additional, Feary, D., additional, Garello, D., additional, Gromig, R., additional, Johnson, T., additional, Junginger, A., additional, Karanja, M., additional, Kimburi, E., additional, Mbuthia, A., additional, McCartney, T., additional, McNulty, E., additional, Muiruri, V., additional, Nambiro, E., additional, Negash, E. W., additional, Njagi, D., additional, Wilson, J. N., additional, Rabideaux, N., additional, Raub, T., additional, Sier, M. J., additional, Smith, P., additional, Urban, J., additional, Warren, M., additional, Yadeta, M., additional, Yost, C., additional, and Zinaye, B., additional

Published
2016
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8. A Six Year Experience of a National Leadership Fellowship in Northern Ireland: Achieve, Develop, Explore Programme for Trainees (ADEPT).

Author

Evans RM, Davidson S, Taylor A, Macartney M, Small S, Elbaroni W, McCartney T, McMurray P, and Steele I

Subjects
Pregnancy, Humans, Child, Female, Male, Fellowships and Scholarships, Leadership, Northern Ireland, Awards and Prizes, General Practitioners
Abstract

Introduction: The Achieve, Develop, Explore Programme for Trainees (ADEPT) Clinical Leadership Fellowship Programme was established in response to growing recommendations to underpin healthcare reconfiguration in Northern Ireland with a collective leadership strategy. The fellowship combines a leadership development programme with a project carried out within a host organisation. With the fellowship now in its sixth year, a need was identified to assess its impact on the fellows' leadership skills, career choices, achievements, and views on both the fellowship and how to develop future leaders., Methods: Demographic data for all ADEPT fellows was held centrally through Northern Ireland Medical and Dental Training Agency (NIMDTA) and assessed anonymously. A mixed-methods questionnaire was composed using Smart Survey. Likert scale questions were designed to determine the extent to which participants believed ADEPT supported their development of strong and exemplary elements of the nine dimensions of the NHS Healthcare Leadership Model. The questionnaire was distributed electronically to all ADEPT alumni in November 2021 and remained open for 4 weeks., Results: There have been 46 ADEPT fellows to date (72% female; all fellows were white). ADEPT fellows were most commonly from Psychiatry (33%), Paediatrics (17%) and Obstetrics and Gynaecology (15%). There were 19 responses from the alumni cohort of 46 (41%). 75% of respondents reported that their project resulted in publication, presentation or award. Leadership skill development was identified as best in "Evaluating Information" and "Engaging the Team", whereas skills in "Sharing the Vision" and "Developing Capability" saw less improvement. The majority felt that the fellowship had been useful in securing their position as a consultant or general practitioner and 50% went on to pursue senior leadership positions., Conclusion: The ADEPT Clinical Leadership Fellowship delivers effective leadership training as measured by the nine domains of the NHS Healthcare Leadership Model. It provides value for host organisations through the projects undertaken and by developing doctors who are more likely to engage in future formal leadership roles. ADEPT alumni saw the value in their leadership experience and felt it should be embedded in standard postgraduate training schemes to reach a wider audience., (Copyright © 2023 Ulster Medical Society.)

Published
2023

9. Effect of dietary biotin and lipid on growth, stamina, lipid metabolism and biotin-containing enzymes in brook trout (Salvelinus fontinalis).

Author

Poston HA and McCartney TH

Subjects
Animals, Body Composition, Body Weight, Deficiency Diseases metabolism, Fatty Acids biosynthesis, Linoleic Acids metabolism, Liver metabolism, Oleic Acids metabolism, Palmitic Acids metabolism, Stearic Acids metabolism, Biotin, Dietary Fats, Growth, Ligases metabolism, Lipid Metabolism, Liver enzymology, Physical Fitness, Pyruvate Carboxylase metabolism, Salmonidae
Published
1974
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