31 results on '"McLaughlin, Bryan"'
Search Results
2. Exonic Short Interspersed Nuclear Element Insertion in FAM161A Is Associated with Autosomal Recessive Progressive Retinal Atrophy in the English Shepherd.
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Stanbury, Katherine, Schofield, Ellen C., McLaughlin, Bryan, Forman, Oliver P., and Mellersh, Cathryn S.
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WHOLE genome sequencing ,GENETIC disorders ,EYE diseases ,DOG genetics ,RETINITIS pigmentosa - Abstract
Progressive retinal atrophies (PRAs) are a genetically heterogeneous group of inherited eye diseases that affect over 100 breeds of dog. The initial clinical sign is visual impairment in scotopic conditions, as a consequence of rod photoreceptor cell degeneration. Photopic vision degeneration then follows, due to progression of the disease to the cone photoreceptors, and ultimately results in complete blindness. Two full-sibling English Shepherds were diagnosed with PRA at approximately 5 years old and tested clear of all published PRA genetic variants. This study sought to identify the novel PRA-associated variant segregating in the breed. We utilised a combined approach of whole genome sequencing of the probands and homozygosity mapping of four cases and 22 controls and identified a short interspersed nuclear element within an alternatively spliced exon in FAM161A. The XP_005626197.1 c.17929_ins210 variant was homozygous in six PRA cases and heterozygous or absent in control dogs, consistent with a recessive mode of inheritance. The insertion is predicted to extend exon 4 by 39 aberrant amino acids followed by an early termination stop codon. PRA is intractable to treatment, so the development of a genetic screening test, based on the associated variant, is significant, because it provides dog breeders/owners with a means of reducing the frequency of the disease variant within this breed as well as minimising the risk of breeding puppies that will develop this blinding disease. [ABSTRACT FROM AUTHOR]
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- 2024
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3. Multiocular defect in the Old English Sheepdog: A canine form of Stickler syndrome type II associated with a missense variant in the collagen-type gene COL11A1
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Stanbury, Katherine, primary, Stavinohova, Renata, additional, Pettitt, Louise, additional, Dixon, Chris, additional, Schofield, Ellen C., additional, Mclaughlin, Bryan, additional, Pettinen, Inka, additional, Lohi, Hannes, additional, Ricketts, Sally L., additional, Oliver, James A., additional, and Mellersh, Cathryn S., additional
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- 2023
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4. Biological materials characterisation using microwave and optical dielectric spectroscopy
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McLaughlin, Bryan L.
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620 - Published
- 2008
5. Investigation of the Intraoperative Cortical Responses to Spinal Motor Mapping in a Patient with Chronic Pain
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Berwal, Deepak, primary, Telkes, Ilknur, additional, Agarwal, Shruti, additional, Paniccioli, Steven, additional, McCarthy, Kevin, additional, DiMarzio, Marisa, additional, McLaughlin, Bryan, additional, and Pilitsis, Julie G., additional
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- 2023
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6. Deliberating alone: deliberative bias and giving up on political talk
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McLaughlin, Bryan, primary, Wilkinson, Kenton T, additional, Rendon, Hector, additional, and Martinez, T J, additional
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- 2022
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7. High-Density, Actively Multiplexed µECoG Array on Reinforced Silicone Substrate
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Rachinskiy, Iakov, primary, Wong, Liane, additional, Chiang, Chia-Han, additional, Wang, Charles, additional, Trumpis, Michael, additional, Ogren, John I., additional, Hu, Zhe, additional, McLaughlin, Bryan, additional, and Viventi, Jonathan, additional
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- 2022
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8. Surgical placement of customized abdominal vagus nerve stimulating and gastrointestinal serosal surface recording electrodes
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Horn, Charles C, Wong, Liane, Shepard, Brook S, Gourash, William F, McLaughlin, Bryan L, Fisher, Lee E, and Ahmed, Bestoun H
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AcademicSubjects/MED00910 ,Case Report ,jscrep/0160 - Abstract
Bioelectronic medical approaches to control vagus nerve-to-organ signaling have the potential to treat cardiac, respiratory, gastrointestinal (GI) and metabolic diseases, such as obesity. Unlike cervical vagus nerve stimulation (VNS), abdominal VNS could provide specific therapeutic control of the GI tract without off-target effects on thoracic organs; however, surgical approaches for abdominal VNS electrode placement are not well established. Moreover, optimal device configurations and additional placement of GI recording electrodes for closed-loop control are largely unknown. We designed VNS cuff and GI planar serosal electrodes and tested placement of these devices in laparoscopic surgery in two cadavers. We determined that electrode positioning on the ventral abdominal vagus nerve and gastric antrum was feasible but other sites, such as the duodenum and proximal stomach, were more difficult. The current investigation can guide potential placement and design of VNS cuff and GI electrodes for development of closed-loop GI therapeutic devices.
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- 2021
9. Mutation in HSF4 Associated with Early but Not Late-Onset Hereditary Cataract in the Boston Terrier
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Mellersh, Cathryn S., Graves, Kathryn T., McLaughlin, Bryan, Ennis, Rosalyn B., Pettitt, Louise, Vaudin, Mark, and Barnett, Keith C.
- Published
- 2007
10. Machine learning prediction of emesis and gastrointestinal state in ferrets
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Nanivadekar, Ameya C., primary, Miller, Derek M., additional, Fulton, Stephanie, additional, Wong, Liane, additional, Ogren, John, additional, Chitnis, Girish, additional, McLaughlin, Bryan, additional, Zhai, Shuyan, additional, Fisher, Lee E., additional, Yates, Bill J., additional, and Horn, Charles C., additional
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- 2019
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11. Winning on Social Media: Candidate Social-Mediated Communication and Voting During the 2016 US Presidential Election
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Macafee, Timothy, primary, McLaughlin, Bryan, additional, and Rodriguez, Nathian Shae, additional
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- 2019
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12. An intronic LINE-1 insertion in MERTK is strongly associated with retinopathy in Swedish Vallhund dogs
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Everson, Richard, primary, Pettitt, Louise, additional, Forman, Oliver P., additional, Dower-Tylee, Olivia, additional, McLaughlin, Bryan, additional, Ahonen, Saija, additional, Kaukonen, Maria, additional, Komáromy, András M., additional, Lohi, Hannes, additional, Mellersh, Cathryn S., additional, Sansom, Jane, additional, and Ricketts, Sally L., additional
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- 2017
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13. It’s Out of My Hands: How Deferring Control to God Can Decrease Quality of Life for Breast Cancer Patients
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McLaughlin, Bryan, Yoo, Woohyun, D’Angelo, Jonathan, Tsang, Stephanie, Shaw, Bret, Shah, Dhavan, Baker, Timothy, and Gustafson, David
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Adult ,Religion and Psychology ,Internet ,Social Support ,Breast Neoplasms ,Middle Aged ,Models, Psychological ,Article ,Cohort Studies ,Self-Help Groups ,Adaptation, Psychological ,Quality of Life ,Humans ,Female ,Internal-External Control - Abstract
This paper seeks to contribute to the understanding of how and why religion affects psychosocial health outcomes. We propose a theoretical model predicting that when women with breast cancer defer control to God they will experience fewer breast cancer related concerns. Deferring control to God, however, should also reduce the likelihood that they take a proactive coping approach, which will be exacerbated by lowered breast cancer concerns. We therefore predict that this passive coping style will ultimately result in lower levels of quality of life.Data were collected as part of a randomized clinical trial funded by the National Cancer Institute. A total of 192 women with breast cancer participated in a computer-mediated social support group. Deferring control to God statements were captured by using computer-aided content analysis of discussion posts. Psychosocial outcomes were measured using longitudinal survey data. Analysis was performed using structural equation modeling.The results of our analysis largely confirm our mediation model for which we find significant model fit. As predicted, deferring control to God leads to lower levels of breast cancer concerns but also to more passive coping styles. Ultimately, deferring control to God can lead to lower levels of quality of life.Our study demonstrates how and why religious coping can lead to both positive and negative psychosocial health outcomes. Health care practitioners should encourage patients who are relying on religion to keep their end of the bargain and maintain an active coping style.
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- 2013
14. Optogenetic control of nerve growth
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Massachusetts Institute of Technology. Department of Materials Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Massachusetts Institute of Technology. Research Laboratory of Electronics, Simons Center for the Social Brain (Massachusetts Institute of Technology), Park, Seongjun, Koppes, Ryan, Froriep, Ulrich Paul, Jia, Xiaoting, Anikeeva, Polina Olegovna, Achyuta, Anil Kumar H., McLaughlin, Bryan L., Massachusetts Institute of Technology. Department of Materials Science and Engineering, Massachusetts Institute of Technology. Department of Mechanical Engineering, Massachusetts Institute of Technology. Research Laboratory of Electronics, Simons Center for the Social Brain (Massachusetts Institute of Technology), Park, Seongjun, Koppes, Ryan, Froriep, Ulrich Paul, Jia, Xiaoting, Anikeeva, Polina Olegovna, Achyuta, Anil Kumar H., and McLaughlin, Bryan L.
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Due to the limited regenerative ability of neural tissue, a diverse set of biochemical and biophysical cues for increasing nerve growth has been investigated, including neurotrophic factors, topography, and electrical stimulation. In this report, we explore optogenetic control of neurite growth as a cell-specific alternative to electrical stimulation. By investigating a broad range of optical stimulation parameters on dorsal root ganglia (DRGs) expressing channelrhodopsin 2 (ChR2), we identified conditions that enhance neurite outgrowth by three-fold as compared to unstimulated or wild-type (WT) controls. Furthermore, optogenetic stimulation of ChR2 expressing DRGs induces directional outgrowth in WT DRGs co-cultured within a 10 mm vicinity of the optically sensitive ganglia. This observed enhancement and polarization of neurite growth was accompanied by an increased expression of neural growth and brain derived neurotrophic factors (NGF, BDNF). This work highlights the potential for implementing optogenetics to drive nerve growth in specific cell populations., Charles Stark Draper Laboratory (University Research and Development Grant), National Science Foundation (U.S.). Materials Research Science and Engineering Centers (Program) (Award DMR-0819762), National Science Foundation (U.S.) (CAREER Award CBET-1253890), Simons Foundation, Korean Government Scholarship Program for Study Overseas
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- 2015
15. Optogenetic control of nerve growth
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Park, Seongjun, primary, Koppes, Ryan A., additional, Froriep, Ulrich P., additional, Jia, Xiaoting, additional, Achyuta, Anil Kumar H., additional, McLaughlin, Bryan L., additional, and Anikeeva, Polina, additional
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- 2015
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16. Navigational Structures and Information Selection Goals: A Closer Look at Online Selectivity
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Edgerly, Stephanie, primary, Vraga, Emily K., additional, McLaughlin, Bryan, additional, Alvarez, German, additional, Yang, JungHwan, additional, and Kim, Young Mie, additional
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- 2014
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17. The Effects of Expression: How Providing Emotional Support Online Improves Cancer Patients’ Coping Strategies
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Namkoong, Kang, primary, McLaughlin, Bryan, additional, Yoo, Woohyun, additional, Hull, Shawnika J., additional, Shah, Dhavan V., additional, Kim, Sojung C., additional, Moon, Tae Joon, additional, Johnson, Courtney N., additional, Hawkins, Robert P., additional, McTavish, Fiona M., additional, and Gustafson, David H., additional
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- 2013
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18. Burning Down the (White) House: Partisan Attempts to Undermine American Exceptionalism.
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MCLAUGHLIN, BRYAN and KRAUSE, AMBER
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AMERICAN politicians ,AMERICAN exceptionalism ,PARTISANSHIP ,UNITED States political parties ,PESSIMISM - Abstract
Although it is well established that U.S. politicians tend to promote American exceptionalism, we argue that partisans often attempt to undermine American exceptionalism when doing so improves the standing of their party. Results of three studies provide support for this expectation. Study 1, using American National Election Studies cumulative data, finds that evaluations of the United States' global standing are linked to evaluations of the political parties. Further, which party currently holds the White House affects partisans' appraisals of the nation's global standing. Study 2 employs an experiment where partisans are exposed to a news story proclaiming American exceptionalism to either be intact or in jeopardy. Results provide additional evidence that appraisals of the United States' global standing are more pessimistic when the president is from the opposing party. Study 3 uses a content analysis of presidential convention speeches and demonstrates that presidential candidates attempt to undermine American exceptionalism when the other party holds the White House. [ABSTRACT FROM AUTHOR]
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- 2017
19. AnADAMTS17Splice Donor Site Mutation in Dogs with Primary Lens Luxation
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Farias, Fabiana H. G., primary, Johnson, Gary S., additional, Taylor, Jeremy F., additional, Giuliano, Elizabeth, additional, Katz, Martin L., additional, Sanders, Douglas N., additional, Schnabel, Robert D., additional, McKay, Stephanie D., additional, Khan, Shahnawaz, additional, Gharahkhani, Puya, additional, O'Leary, Caroline A., additional, Pettitt, Louise, additional, Forman, Oliver P., additional, Boursnell, Mike, additional, McLaughlin, Bryan, additional, Ahonen, Saija, additional, Lohi, Hannes, additional, Hernandez-Merino, Elena, additional, Gould, David J., additional, Sargan, David R., additional, and Mellersh, Cathryn, additional
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- 2010
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20. Submillimeter Coaxial Probes for Dielectric Spectroscopy of Liquids and Biological Materials.
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McLaughlin, Bryan L. and Robertson, Paul A.
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COAXIAL cables , *BROADBAND dielectric spectroscopy , *CALIBRATION , *MONTE Carlo method , *MICROWAVE antenna design & construction , *EQUIPMENT & supplies - Abstract
In this study, 0.2-mm radius open-ended coaxial probes were constructed and simulated, to measure reference materials and biological media from 1 to 40 GHz. A novel full-wave 3-D model using CST Microwave's frequency-domain solver is demonstrated and the CST example model is provided online to accompany this paper. With this model, design parameters such as the minimum allowable flange radius, short circuit conductivity, and mechanical tolerances were investigated. In terms of measurements, a short-circuit across a tiny aperture was found to be unrepeatable; hence, a calibration technique using only reference liquids is demonstrated. At increasingly smaller radial dimensions, the aperture fields are absorbed by a proportionally smaller volume of material, resulting in microwave hyperthermia of the material. A 3-D and 1-D steady-state heat simulation is utilized to approximate the induced temperature change. Finally, a Monte Carlo technique is used to quantify the errors associated with the aperture models, calibration, and probe imperfections. [ABSTRACT FROM AUTHOR]
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- 2009
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21. Transporting, identifying and expanding: Superheroes in series television and film
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Moya, Jeanette D'Ann, Peaslee, Robert M., Oviedo, Marilda J., and McLaughlin, Bryan
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Expansion ,Identification ,Positive media effects ,Transportation ,Television ,Superheroes ,Film - Abstract
For many years, individuals have been intrigued by superheroes, more recently in film and television where it has become prevalent in today’s society. This study explores how identifying with superheroes in television shows and film may help viewers improve their self-esteem and well-being. This analysis used three theories to explore the relationship between individual fans and these superhero narratives: transportation, where one is transported through narrative to a different reality; identification, where viewers identify with specific characters; and TEBOTS (temporarily expanding boundaries of the self), where media viewers experience temporary relief from everyday life while they are engaged in a narrative. This study interviewed fifteen participants to gain a deeper understanding of how empowered feelings might translate into the physical world.
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- 2019
22. The role of social identity in niche online dating websites
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Manley, Terri, McLaughlin, Bryan, Cummins, R. Glenn, Lindquist, Carol S., and Sarge, Melanie
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Outgroup ,Romantic trust ,Self-categorization ,Social identity ,Online dating ,Romantic relationships ,Ingroup ,Romantic satisfaction - Abstract
Previous research has suggested individuals take a homogenous approach in selecting romantic partners. Specifically some researchers have suggested political partisanship could contribute to homogenous dating behaviors. However, little research has explored why individuals employ homogenous (or political homophily) dating behaviors and their role in initiating, developing, and sustaining romantic relationships. This is especially important to explore because researchers have indicated that political homogeneity can lead to political enclaves, increased polarization, and decreased political tolerance. Based on these prior findings, the current study proposed that social identity theory (SIT) and self-categorization theory (SCT) could explain how ingroup and outgroup social identification can lead to biased evaluations of others and the self, which ultimately contributes to homogenous dating behaviors. Specifically, the current study examined this relationship within an online dating context. It was purposed that when one’s social identity is made salient (i.e., niche dating websites) and ingroup prototypes are easily accessible (i.e., matched online profiles), this social identity becomes the dominant factor by which we evaluate and categorize potential partners. In order to examine this relationship, the researcher conducted an online survey experiment with a generalized convenience sample, where participants viewed a political affiliation designed dating website and a user’s profile, then reported on perceptions of trustworthiness, expectations of romantic satisfaction, self-esteem, willingness to date, and political attitudes. Results of this study suggested the salient social identity influenced biased evaluations of potential partners. Specifically, ingroup favoritism skewed perceptions of trustworthiness of potential romantic partners, which indirectly influenced expectations of relationship satisfaction and willingness to date. However, outgroup derogation did not influence perceptions of self-esteem or indirectly strengthen political attitudes, as prior research has indicated. The results of this study find support for homogenous dating behaviors, which are caused by ingroup-biased perceptions and might be limiting possible exposure to and socialization with people who hold other ideologies.
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- 2018
23. A tale of two worlds: Examining identity, media, and faith among Evangelical Christian women
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Huemmer, Jennifer, Sternadori, Miglena, McLaughlin, Bryan, Koerber, Amy, Zhang, Weiwu, and Peaslee, Robert M.
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Christian women ,Evangelical ,Symbolic interaction - Abstract
Scholars, over decades, have examined the complex and dynamic intersection between religion and society in the United States. Church attendance measurements reveal a decrease in church participation, indicating to some that a “secularization” of society may be occurring. Regardless of church attendance records, religion continues to be influential in the meaning-making and identification processes of individuals in the United States. This implies that scholars should continue to explore how and in what ways religion is incorporated in processes of identification, meaning-making, and communication. The purpose of this study is to examine how media and identity processes are constructed, negotiated, and revised over time among evangelical Christian women. Broadly, I attempted to answer three overarching questions, (a) how do Evangelical Protestant women negotiate their identities both individually and collectively?; (b) how do media processes inform, and how are they informed by this identity negotiation?; and (c) how are media and identity processes incorporated in the routine communications and lived experiences of Evangelical Protestant women? To answer these questions, I employed qualitative methods, including participant-observation, group interviews, and one-on-one interviews. These methods were chosen specifically to allow me to investigate issues of identity, religion, and media from the position of Evangelical Christian women. The results of the study support the claim of symbolic interactionism that individuals in a collective are positioned differently, and therefore interpret and interact with the objects in their environment differently. For the women who spatially, temporally, and relationally are positioned closer to the center of church power, their presentation of self more closely aligned with the norms and values of the church institution than for the women at the periphery. Furthermore, the women’s interpretation of and talk about media varied in relation to their position to the center of power within the institution. These results indicate a complex relationship between identity, media, and religion.
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- 2017
24. #SororityGirl: The sorority socialization process through the construction and maintenance of the individual and chapter sorority identity
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Thompson, Bailey Airs, McLaughlin, Bryan, Chambers, Barbara, Sternadori, Miglena, Bichard, Shannon, and Ortiz, Rebecca
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Identity ,Sorority ,Greek life - Abstract
Research on fraternity and sorority life has primarily consisted of quantitative reports by those outside the fraternity and sorority (collectively referred to as “Greek” or “Greek life”) community to evaluate negative behaviors associated with membership (chiefly fraternity membership), such as binge drinking, sexual assault, drug use, and strict adherence to traditional gender roles. This dissertation sought to break this tradition by using the researcher’s experiences as a member of Greek life to inform the research, and using qualitative in-depth interviews to allow sorority women some agency over their identity. These in-depth interviews allow the women to share their lived experiences with the academic community, so that academic research may be more representative of the true nature of sorority women’s experiences. The main purpose of this dissertation was to understand the ways in which sorority women use media, chiefly, social media, to construct and maintain their identities as individual sorority women and their collective chapter-specific identity. Forty-four interviews with active, currently-initiated sorority women, from a large Southwestern university were conducted by the researcher, a sorority alumnus herself, to understand and explain the lived experiences of sorority women, and the ways in which media reinforces and maintains these women’s identities. Additionally, this dissertation sought to understand the influence prior exposure to Greek life had on sorority women, the impact of the recruitment process of sorority women, and the extent to which stereotypes about sororities impact sorority women and their perceptions of themselves and of their chapter. Social identity theory, self-categorization theory, and media systems dependency theory were the primary theoretical lenses through which the analysis was informed. A secondary theory of presentation of self was also utilized to inform analysis. Formal recruitment, taking place in August a week before formal classes begin, was found to serve as the most important aspect of and representation of sorority life. Recruitment was experienced in one of two ways, as either a) a potential new member or b) an active, creating two paths for sorority women depending on their membership status. Media intertwined itself at every level, and each stage, of the experience for both actives and potential new members, yet in different ways. Media serves as a way to aid in the sorority socialization process, and in the construction of both the individual “sorority girl” identity, and the assimilation into larger chapter identity. There were five different stages in the journey to joining and/or continuing membership in a sorority, all revolving in some way around formal recruitment. For potential new members the five stages included: (a) pre-recruitment; (b) formal recruitment; (c) new member period; (d) initiation; and (e) chapter integration and recruitment preparation. For active sorority members, the five stages included: (a) pre-recruitment; (b) formal recruitment; (c) the training and indoctrination of new members; (d) initiation and assimilation of new sisters and the process of chapter identity maintenance and; (e) continued recruitment preparation. There were also four primary ways sorority women use media to construct and maintain their identity through: (a) the transition from an outgroup PNM to ingroup new member; (b) the ways in which new members display their newly-earned membership; (c) chapter identity maintenance through presentation of self online; and (d) the ways in which sorority women who do not construct or adhere to the “ideal” sorority identity. Overall, sorority women use media to construct and maintain their identities by cultivating an image, primarily on social media, that they want others to see and believe is true- even if this is not necessarily the case behind closed doors. They do this in order to achieve or maintain status within the Greek community, and those who do not risk a loss in status and reputation.
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- 2017
25. Power of a tweet: How does social media interaction affect social identity and university satisfaction
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Matherly, Allison A, Ortiz, Rebecca, Gotlieb, Melissa, and McLaughlin, Bryan
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Social media, Social identity theory, Twitter, Undergraduate students, College, Retention, Interaction, Organizational identification, College satisfaction - Abstract
The more undergraduate college students report satisfaction with their university, the more likely they are to remain enrolled and graduate. College student satisfaction is strongly influenced by students’ social identification with their university (e.g., they demonstrate pride as and strongly identify with being a student of the university). Students can interact with their university directly and its associated "brand" on social media platforms, using platforms such as Twitter (e.g., by posting tweets directed at a university's Twitter account or posting tweets about the university). Universities often expend substantial effort to produce content through such channels to engage students. Interacting with the university through social media may strengthen students’ social identity with the university and lead to increased student retention. This study thus examined how social media interactions with and about a college student's university may play a role in their social identity with the university and overall university satisfaction. Online questionnaires were completed by participants before and after their Twitter data was collected by the researcher to assess changes in the social identity and university satisfaction of 198 undergraduate students at a large public four-year university over a period of approximately 30 days. Data from the students’ Twitter accounts were collected during this interim time period, and a content analysis of the tweets was conducted to identify interactions with the university's Twitter account and tweets about the university in general. Results indicated that, in both the pre- and post-collection questionnaires, the more students reported social identification as a university student, the more likely they were to report overall satisfaction with the university. The more students directly interacted with the university's Twitter account, the more likely they were to report higher levels of social identification as a student; however, general interaction with the university "brand" (i.e., tweeting about the university in general) did not reveal the same significant relationship. More Twitter interaction of either kind also did not result in greater university satisfaction, despite the significant association with social identification, and therefore, future research is necessary to better understand the relationship between social identification and satisfaction. Results from this study suggest that, based upon social identity theory, when trying to build stronger identification among undergraduate students with their university, universities should focus their efforts on creating opportunities that encourage direct engagement with the university's account.
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- 2016
26. The role of communication in the identification of gay refugees and asylees throughout migration
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Rodriguez, Nathian Shae, Wilkinson, Kenton T, Peaslee, Robert M., Trejos-Castillo, Elizabeth, McLaughlin, Bryan, and Oviedo, Marilda J.
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Asylee ,Identification ,Media ,Refugee ,LGBTQ ,Communication ,Asylum ,Mediated communication ,NGO ,International communication ,LGBTI ,Interpersonal communication ,Diaspora ,Middle East ,Gay ,Globalism ,Identity ,English ,Computer literacy ,Human rights ,San Francisco ,Migration - Abstract
In recent years, millions of refugees have migrated across the globe fleeing persecution, in search of better lives. Among these refugees are lesbian, gay, bisexual, transgender, and intersex (LGBTI) individuals who are escaping maltreatment for their sexual orientation. At the time of writing, there were 76 countries with laws imposing harsh sanctions against same sex intimacy, varying from fines, imprisonment, violence, and even death. Because of their unique situations, these refugees and asylum seekers are doubly marginalized as forced migrants and sexual minorities. This study investigates how LGBTI refugees, asylum seekers, and asylees navigate their identity through the interactions throughout the migration process. Identity is produced and reproduced through social interaction. This study’s main goal was to investigate how social interactions, embedded in the lived experiences of LGBTI refugees/asylees during their migration process, created and shaped meaning specific to their identity. More specifically, the current study looked at social interactions using communication, mediated and interpersonal, to negotiate identity. In order to answer the overall research question of identity negotiation, interviews and a focused ethnography were conducted. Six self-identifying gay refugees/asylees from the Middle East North Africa (MENA) region, now residing in California’s Bay Area, were interviewed. Additionally, a focused ethnography was conducted in the queer diaspora of San Francisco’s Castro neighborhood. The LGBTIs use of media was influenced by English and computer literacy. In a pre-asylum context, media were used for asylum seeking, to find information on gay culture, and to build relationships with other queers living in secret. Whereas interpersonal communication was used to find and initiate escape routes. In a post-asylum context, media were used to find other LGBTIs in the queer diaspora, however not used to build relationships. Interpersonal communication was utilized more in the queer diaspora to foster relationships, acculturate, and shape identity. Intersectionality, marginalization, and power come together to shape the identities of the LGBTI refugees/asylees. For most of the participants, being a ‘refugee’ was substantially part of who they were. It defined their past and situated their present. For others, however, ‘refugee’ was an identity they wanted to shed. They wanted to create a new life and leave their pasts behind them. In both scenarios, being gay was still the most salient attribute of their identities. In sum, the media they consumed pre-asylum helped the refugees realize “what they were,” while the media post-asylum helped them negotiate “who they are.” The LGBTIs interviewed communicated that little aid was received from NGOs in the migration process; however, the NGOs positioned themselves as LGBTI refuge-focused. To further understand the communication endeavors seven LGBTI refugee-focused NGO employees, each charged with communication tasks, were interviewed. Specific to identity, the niche NGOs strive to create counter-narratives that help foster positive and nurturing categorizations of LGBTI refugees and asylees. They, and other LGBTIs in similar areas, have been socialized in with pejorative categorizations of gay and LGBTI. The goal of the NGOs is to change these meanings and instigate a more positive categorization for the LGBTIs and in the process save lives. The NGOs also focused on creating a more encouraging and supportive environment for the LGBTIs in their new home post-asylum. By fostering a sense of tolerance coupled with volunteers and staff who are LGBTI-friendly, the NGO introduces a social institution where more advantageous interactions can take place. These interactions help shape and reshape meaning for the LGBTIs, ultimately helping them create a social identity that cultivates happiness and a sense of self-worth.
- Published
- 2016
27. Examining Teachers' Intentions to Intervene: Developing a Contextual Resource for Cyberbullying Intervention in India
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Nadkarni, Arti Atish, McLaughlin, Bryan, Callison, Coy, Cummins, R. Glenn, and Sarge, Melanie
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Cyberbullying, India, Theory of planned behavior, Interventions - Abstract
This study examined the intention of teachers to intervene in cyberbullying situation when they encounter it at school by utilizing the theory of planned behavior (TPB). It investigated how attitudes, subjective norms, perceived behavioral control and perceived responsibility affects the teachers' intention to intervene. Questionnaire in a paper pencil format was used to collect the data from teachers in Indian schools during January-March 2016. Hierarchical regression was conducted to assess the proposed independent variables predicting the teachers’ intention to intervene. The results found that the theory of planned behavior (TPB) proves to be a strong and appropriate model to predict the teacher’s intention to intervene in cyberbullying at schools in India. All the main TPB predictor variables - attitude, subjective norm, and perceived behavioral control significantly influenced the teachers’ intention to intervene. All the variables collectively explained 40.9 % of the variance in the intention to intervene. Perceived responsibility also added a small but significant variance to the TPB model, 2.7%. Of all the predictor variables, attitude was the strongest predictor of the teachers’ intention. Moreover, the study has identified the specific underlying cognitive beliefs, determining the attitude, subjective norm and perceived behavioral control, which indirectly influences the teachers’ intention to intervene. This formative research provides a good resource to design future school-based interventions with an aim to prepare teachers to mediate the impact of cyberbullying on students in India. Overall, the results produced important insights about teachers’ attitudes, perceptions and beliefs towards intervening in cyberbullying in India.
- Published
- 2016
28. A TTPA deletion is associated with Retinopathy with Vitamin E Deficiency (RVED) in the English Cocker Spaniel Dog.
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Oliver JAC, Stanbury K, Schofield E, McLaughlin B, and Mellersh CS
- Abstract
Retinopathy with Vitamin E Deficiency (RVED) is a familial disease in the English Cocker Spaniel (ECS) dog breed. Ophthalmic abnormalities observed in RVED-affected ECS include lipofuscin granule deposition within the tapetal fundus and subsequent retinal degeneration resulting in visual deficits. Affected dogs may also exhibit neurological signs that include ataxia and hindlimb proprioceptive deficit. In all cases, circulating plasma concentrations of α-tocopherol are low. This study sought to investigate the genetic basis of RVED in the ECS breed. We undertook a genome-wide association study comprising 30 ECS with normal fundic examinations aged 6 years or older (controls) and 20 diagnosed with RVED (cases) and identified a statistically associated signal on chromosome 29 (Praw = 1.909×10-17). Whole genome sequencing (WGS) of two cases identified a 102bp deletion in exon 1 of the Alpha Tocopherol Transfer Protein gene (TTPA), truncating the protein by 34 amino acids. The c.23_124del variant segregated with RVED in a total of 30 cases and 43 controls. Variants in TTPA are causal for Ataxia with Vitamin E Deficiency (AVED) in humans which is a phenotypically similar disease to RVED. The identification of the canine variant is extremely significant as the availability of a DNA test will allow for identification of presymptomatic dogs and early therapeutic intervention which may prevent development of retinopathy and improve neurological signs. Breeders can also use the DNA test to efficiently eradicate the disease from this breed., (© The Author(s) 2025. Published by Oxford University Press on behalf of The Genetics Society of America.)
- Published
- 2025
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- View/download PDF
29. An active electronic, high-density epidural paddle array for chronic spinal cord neuromodulation.
- Author
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Parker SR, Calvert JS, Darie R, Jang J, Govindarajan LN, Angelino K, Chitnis G, Iyassu Y, Shaaya E, Fridley JS, Serre T, Borton DA, and McLaughlin BL
- Abstract
Objective: Epidural electrical stimulation (EES) has shown promise as both a clinical therapy and research tool for studying nervous system function. However, available clinical EES paddles are limited to using a small number of contacts due to the burden of wires necessary to connect each contact to the therapeutic delivery device, limiting the treatment area or density of epidural electrode arrays. We aimed to eliminate this burden using advanced on-paddle electronics. Approach: We developed a smart EES paddle with a 60-electrode programmable array, addressable using an active electronic multiplexer embedded within the electrode paddle body. The electronics are sealed in novel, ultra-low profile hermetic packaging. We conducted extensive reliability testing on the novel array, including a battery of ISO 10993-1 biocompatibility tests and determination of the hermetic package leak rate. We then evaluated the EES device in vivo, placed on the epidural surface of the ovine lumbosacral spinal cord for 15 months. Main results: The active paddle array performed nominally when implanted in sheep for over 15 months and no device-related malfunctions were observed. The onboard multiplexer enabled bespoke electrode arrangements across, and within, experimental sessions. We identified stereotyped responses to stimulation in lower extremity musculature, and examined local field potential responses to EES using high-density recording bipoles. Finally, spatial electrode encoding enabled machine learning models to accurately perform EES parameter inference for unseen stimulation electrodes, reducing the need for extensive training data in future deep models. Significance: We report the development and chronic large animal in vivo evaluation of a high-density EES paddle array containing active electronics. Our results provide a foundation for more advanced computation and processing to be integrated directly into devices implanted at the neural interface, opening new avenues for the study of nervous system function and new therapies to treat neural injury and dysfunction.
- Published
- 2024
- Full Text
- View/download PDF
30. The effects of expression: how providing emotional support online improves cancer patients' coping strategies.
- Author
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Namkoong K, McLaughlin B, Yoo W, Hull SJ, Shah DV, Kim SC, Moon TJ, Johnson CN, Hawkins RP, McTavish FM, and Gustafson DH
- Subjects
- Female, Humans, Self-Help Groups, Breast Neoplasms psychology, Social Media, Social Support
- Abstract
Background: Emotional support has traditionally been conceived as something a breast cancer patient receives. However, this framework may obscure a more complex process, facilitated by the emerging social media environment, which includes the effects of composing and sending messages to others. Accordingly, this study explores the effects of expression and reception of emotional support messages in online groups and the importance of bonding as a mediator influencing the coping strategies of breast cancer patients., Methods: Data were collected as part of two National Cancer Institute-funded randomized clinical trials. Eligible subjects were within 2 months of diagnosis of primary breast cancer or recurrence. Expression and reception of emotionally supportive messages were tracked and coded for 237 breast cancer patients. Analysis resulted from merging 1) computer-aided content analysis of discussion posts, 2) action log analysis of system use, and 3) longitudinal survey data., Results: As expected, perceived bonding was positively related to all four coping strategies (active coping: β = 0.251, P = .000; positive reframing: β = 0.288, P = .000; planning: β = 0.213, P = .006; humor: β = 0.159, P = .009). More importantly, expression (γ = 0.138, P = .027), but not reception (γ = -0.018, P = .741), of emotional support increases perceived bonding, which in turn mediates the effects on patients' positive coping strategies., Conclusions: There is increasing importance for scholars to distinguish the effects of expression from reception to understand the processes involved in producing psychosocial benefits. This study shows that emotional support is more than something cancer patients receive; it is part of an active, complex process that can be facilitated by social media.
- Published
- 2013
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31. An ADAMTS17 splice donor site mutation in dogs with primary lens luxation.
- Author
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Farias FH, Johnson GS, Taylor JF, Giuliano E, Katz ML, Sanders DN, Schnabel RD, McKay SD, Khan S, Gharahkhani P, O'Leary CA, Pettitt L, Forman OP, Boursnell M, McLaughlin B, Ahonen S, Lohi H, Hernandez-Merino E, Gould DJ, Sargan DR, and Mellersh C
- Subjects
- Animals, Chromosome Mapping, Dogs, Genome-Wide Association Study, Genotype, Humans, Phenotype, Polymorphism, Single Nucleotide, RNA Splice Sites genetics, ADAM Proteins genetics, Dog Diseases genetics, Lens Subluxation genetics, Lens Subluxation veterinary, Weill-Marchesani Syndrome genetics
- Abstract
Purpose: To identify the genetic cause of isolated canine ectopia lentis, a well-characterized veterinary disease commonly referred to as primary lens luxation (PLL) and to compare the canine disease with a newly described human Weill-Marchesani syndrome (WMS)-like disease of similar genetic etiology., Methods: Genomewide association analysis and fine mapping by homozygosity were used to identify the chromosomal segment harboring the PLL locus. The resequencing of a regional candidate gene was used to discover a mutation in a splice donor site predicted to cause exon skipping. Exon skipping was confirmed by reverse transcription-polymerase chain reaction amplification of RNA isolated from PLL-affected eyes and from skin fibroblast cultures from PLL-affected dogs. An allelic discrimination assay was used to genotype individual dogs at the splice donor site mutation., Results: The PLL locus was mapped to a 664-kb region of canine chromosome 3 containing regional candidate gene ADAMTS17. Resequencing ADAMTS17 revealed a GT-->AT splice-donor-site mutation at the 5' end of intron 10. The predicted exon 10 skipping and resultant frame shift were confirmed with RNA derived from PLL-affected dogs. The ADAMTS17 mutation was significantly associated with clinical PLL in three different dog breeds., Conclusions: A truncating mutation in canine ADAMTS17 causes PLL, a well-characterized veterinary disease, which can now be compared to a recently described rare WMS-like disease caused by truncating mutations of the human ADAMTS17 ortholog.
- Published
- 2010
- Full Text
- View/download PDF
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