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1. Deep learning-based phenotyping reclassifies combined hepatocellular-cholangiocarcinoma

Author

Calderaro, Julien, Ghaffari Laleh, Narmin, Zeng, Qinghe, Maille, Pascale, Favre, Loetitia, Pujals, Anaïs, Klein, Christophe, Bazille, Céline, Heij, Lara R., Uguen, Arnaud, Luedde, Tom, Di Tommaso, Luca, Beaufrère, Aurélie, Chatain, Augustin, Gastineau, Delphine, Nguyen, Cong Trung, Nguyen-Canh, Hiep, Thi, Khuyen Nguyen, Gnemmi, Viviane, Graham, Rondell P., Charlotte, Frédéric, Wendum, Dominique, Vij, Mukul, Allende, Daniela S., Aucejo, Federico, Diaz, Alba, Rivière, Benjamin, Herrero, Astrid, Evert, Katja, Calvisi, Diego Francesco, Augustin, Jérémy, Leow, Wei Qiang, Leung, Howard Ho Wai, Boleslawski, Emmanuel, Rela, Mohamed, François, Arnaud, Cha, Anthony Wing-Hung, Forner, Alejandro, Reig, Maria, Allaire, Manon, Scatton, Olivier, Chatelain, Denis, Boulagnon-Rombi, Camille, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A., Rhaiem, Rami, Pawlotsky, Jean-Michel, Zhang, Xuchen, Luciani, Alain, Mulé, Sébastien, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, De Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Westerhoff, Maria, Lo, Regina Cheuk-Lam, Bednarsch, Jan, Gouw, Annette, Guettier, Catherine, Lequoy, Marie, Harada, Kenichi, Sripongpun, Pimsiri, Wetwittayaklang, Poowadon, Loménie, Nicolas, Tantipisit, Jarukit, Kaewdech, Apichat, Shen, Jeanne, Paradis, Valérie, Caruso, Stefano, and Kather, Jakob Nikolas

Published
2023
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2. Impact of the first wave of COVID-19 epidemy on the surgical management of sigmoid diverticular disease in France: National French retrospective study

Author

Gil, Camille, Beyer-Bergeot, Laura, Sabbagh, Charles, Zerbib, Philippe, Bridoux, Valérie, Manceau, Gilles, Panis, Yves, Buscail, Etienne, Venara, Aurélien, Khaoudy, Iman, Gaillard, Martin, Viennet, Manon, Thobie, Alexandre, Menahem, Benjamin, Eveno, Clarisse, Bonnel, Catherine, Mabrut, Jean-Yves, Badic, Bodgan, Godet, Camille, Eid, Yassine, Duchalais, Emilie, Lakkis, Zaher, Cotte, Eddy, Laforest, Anais, Defourneaux, Véronique, Maggiori, Léon, Rebibo, Lionel, Christou, Niki, Talal, Ali, Mege, Diane, Bonnamy, Cécile, Germain, Adeline, Mauvais, François, Tresallet, Christophe, Roudie, Jean, Laurent, Alexis, Trilling, Bertrand, Bertrand, Martin, Massalou, Damien, Romain, Benoit, Tranchart, Hadrien, Giger, Urs, Alves, Arnaud, and Ouaissi, Mehdi

Published
2023
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15. Urinary Lithiasis Risk Assessment after Bariatric Surgery.

Author

Tran, Marie, Ait Said, Khelifa, Menahem, Benjamin, Morello, Rémy, and Tillou, Xavier

Subjects
BARIATRIC surgery, GASTRIC bypass, RENAL colic, KIDNEY stones, RISK assessment, FOOD habits
Abstract

Malabsorption is a consequence of gastric bypass (GB). GB increases the risk of kidney stone formation. This study aimed to evaluate the accuracy of a screening questionnaire for assessing the risk of lithiasis in this population. We performed a monocentric retrospective study to evaluate a screening questionnaire administered to patients who underwent gastric bypass surgery between 2014 and 2015. Patients were asked to answer a questionnaire that included 22 questions divided into four parts: medical history, episodes of renal colic before and after bypass surgery, and eating habits. A total of 143 patients were included in the study, and the mean age of the patients was 49.1 ± 10.8 years. The time between gastric bypass surgery and the completion of the questionnaire was 50.75 ± 4.95 months. The prevalence of kidney stones in the study population was 19.6%. We found that with a score of ≥6, the sensitivity and specificity were 92.9% and 76.5%, respectively. Positive and negative predictive values were 49.1% and 97.8%, respectively. The ROC curve showed an Area Under the Curve (AUC) of 0.932 ± 0.029 (p < 0.001). We developed a reliable and short questionnaire to identify patients at a high risk of kidney stones after gastric bypass. When the results of the questionnaire were equal to or greater than six, the patient was at a high risk of kidney stone formation. With a good predictive negative value, it could be used in daily practice to screen patients who have undergone gastric bypass and are at a high risk of renal lithiasis. [ABSTRACT FROM AUTHOR]

Published
2023
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16. Nestin as a diagnostic and prognostic marker for combined hepatocellular-cholangiocarcinoma

Author

Calderaro, Julien, Di Tommaso, Luca, Maillé, Pascale, Beaufrère, Aurélie, Nguyen, Cong Trung, Heij, Lara, Gnemmi, Viviane, Graham, Rondel P, Charlotte, Frédéric, Chartier, Suzanne, Wendum, Dominique, Vij, Mukul, Allende, Daniela, Diaz, Alba, Fuster, Carla, Rivière, Benjamin, Herrero, Astrid, Augustin, Jeremy, Evert, Katja, Calvisi, Diego Francesco, Leow, Wei Qiang, Ho Wai Leung, Howard, Bednarsch, Jan, Boleslawski, Emmanuel, Rela, Mohamed, Wing-Hung Chan, Anthony, Forner, Alejandro, Reig, Maria, Pujals, Anaïs, Favre, Loetitia, Allaire, Manon, Scatton, Olivier, Uguen, Arnaud, Trepo, Eric, Otero Sanchez, Lukas, Chatelain, Denis, Remmelink, Myriam, Boulagnon-Rombi, Camille, Bazille, Celine, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Kather, Jakob Nikolas, Gouw, Annette S.H., Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A, Rhaiem, Rami, Nault, Jean Charles, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, De Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Shinde, Jayendra, Bacchuwar, Ketan, Westerhoff, Maria, Cheuk-Lam Lo, Regina, Mylène, Sebbagh, Guettier, Catherine, Lequoy, Marie, Komuta, Mina, Ziol, Marianne, Paradis, Valérie, Shen, Jeanne, Caruso, Stefano, Calderaro, Julien, Di Tommaso, Luca, Maillé, Pascale, Beaufrère, Aurélie, Nguyen, Cong Trung, Heij, Lara, Gnemmi, Viviane, Graham, Rondel P, Charlotte, Frédéric, Chartier, Suzanne, Wendum, Dominique, Vij, Mukul, Allende, Daniela, Diaz, Alba, Fuster, Carla, Rivière, Benjamin, Herrero, Astrid, Augustin, Jeremy, Evert, Katja, Calvisi, Diego Francesco, Leow, Wei Qiang, Ho Wai Leung, Howard, Bednarsch, Jan, Boleslawski, Emmanuel, Rela, Mohamed, Wing-Hung Chan, Anthony, Forner, Alejandro, Reig, Maria, Pujals, Anaïs, Favre, Loetitia, Allaire, Manon, Scatton, Olivier, Uguen, Arnaud, Trepo, Eric, Otero Sanchez, Lukas, Chatelain, Denis, Remmelink, Myriam, Boulagnon-Rombi, Camille, Bazille, Celine, Sturm, Nathalie, Menahem, Benjamin, Frouin, Eric, Tougeron, David, Tournigand, Christophe, Kempf, Emmanuelle, Kim, Haeryoung, Ningarhari, Massih, Michalak-Provost, Sophie, Kather, Jakob Nikolas, Gouw, Annette S.H., Gopal, Purva, Brustia, Raffaele, Vibert, Eric, Schulze, Kornelius, Rüther, Darius F., Weidemann, Sören A, Rhaiem, Rami, Nault, Jean Charles, Laurent, Alexis, Amaddeo, Giuliana, Regnault, Hélène, De Martin, Eleonora, Sempoux, Christine, Navale, Pooja, Shinde, Jayendra, Bacchuwar, Ketan, Westerhoff, Maria, Cheuk-Lam Lo, Regina, Mylène, Sebbagh, Guettier, Catherine, Lequoy, Marie, Komuta, Mina, Ziol, Marianne, Paradis, Valérie, Shen, Jeanne, and Caruso, Stefano

Abstract

info:eu-repo/semantics/published

Published
2022

19. ‘French LARS score’: validation of the French version of the low anterior resection syndrome (LARS) score for measuring bowel dysfunction after sphincter-preserving surgery among rectal cancer patients: a study protocol

Author

Eid, Yassine, primary, Bouvier, Véronique, additional, Dejardin, Olivier, additional, Menahem, Benjamin, additional, Chaillot, Fabien, additional, Chene, Yannick, additional, Dutheil, Jean Jacques, additional, Juul, Therese, additional, Morello, Rémy, additional, and Alves, Arnaud, additional

Published
2020
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21. Prognosis factors of hepatocellular carcinoma : mixed epidemiological and surgical

Author

Menahem, Benjamin, Unité de recherche interdisciplinaire pour la prévention et le traitement des cancers (ANTICIPE), Université de Caen Normandie (UNICAEN), Normandie Université (NU)-Normandie Université (NU)-CHU Caen, Normandie Université (NU)-Tumorothèque de Caen Basse-Normandie (TCBN)-Tumorothèque de Caen Basse-Normandie (TCBN)-Centre Régional de Lutte contre le Cancer François Baclesse [Caen] (UNICANCER/CRLC), UNICANCER-Tumorothèque de Caen Basse-Normandie (TCBN)-Normandie Université (NU)-UNICANCER-Institut National de la Santé et de la Recherche Médicale (INSERM), Normandie Université, Guy Launoy, Arnaud Alves, and STAR, ABES

Subjects
[SDV.MHEP] Life Sciences [q-bio]/Human health and pathology, Liver transplantation, Hepatocellular carcinoma, Survival : social deprivation, Surgery, Inégalités socio-économiques, Transplantation hépatique, [SDV.MHEP]Life Sciences [q-bio]/Human health and pathology
Abstract

The objective of this work was to assess in an epidemiological and a surgical ways prognosis factors of HCC after liver transplantation or liver resection. First step was to determine in a methodological review the overall and disease free survival results of these two techniques. Second step was to use the AFP-score, selection tool for patients with HCC who need liver transplantation in France, as selection tool for a group of patients who underwent surgical resection for transplantable HCC. Final step was to study influence of social deprivation on survival of patients who underwent liver transplantation for HCC in a Nation-wide study.The meta-analysis showed that Liver Transplantation, in patients with HCC meeting the Milan criteria had no benefits before 10 years for OS, compared to Liver resection. For DFS, the benefit is obtain after 3 years.AFP-score is a useful tool for the patient’s management who are suffering from solitary HCC developed on CLD. In patients “in AFP-score”, up-front LR is not associated with a loss of chance, when compare to up-front LT, based on theoretical 5-years OS.European Deprivation Index does not impact mortality after LT for HCC. Number of HCC and time on waiting-list are independent prognostic factors of survival after liver transplantation for HCC., L’objectif de ce travail était d’évaluer, selon une approche épidémiologique et thérapeutique transversale multimodale, les facteurs pronostiques de survie du CHC dans le cadre de sa prise en charge chirurgicale après transplantation hépatique ou résection chirurgicale. La première étape a été de déterminer les données de survie de la littérature après ces deux traitements chirurgicaux. Nous avons donc réalisé une méta-analyse des données de la littérature afin de comparer les résultats de la survie globale et de la survie sans récidive chez les patients transplantés ou réséqués pour CHC. La deuxième étape a consisté à étudier le score AFP, outil utilisé pour la sélection des patients en vue d’une transplantation hépatique, et de son intérêt pronostique sur la survie dans une cohorte de patients traités par une résection chirurgicale pour CHC. Enfin, la troisième étape a été d’étudier l’impact des inégalités socio-économiques, au moyen de l’index de défavorisation développé par notre équipe, sur la survie des patients transplantés pour carcinome hépatocellulaire.La méta-analyse a montré que le bénéfice de la transplantation hépatique pour carcinome hépatocellulaire en termes de survie globale pour les patients dans les critères de Milan, n’avait pas de bénéfice avant 10 ans après la chirurgie contrairement à la survie sans récidive où il existait une différence significative dès 3 ans après la chirurgie.La deuxième étude a cherché à déterminer si le score AFP, outil de sélection des patients pour transplantation hépatique pour CHC était lui aussi un bon outil de sélection pour les patients à opérer d’une chirurgie. Nous avons pu montrer que ce score était prédictif de récidive après résection hépatique et que si les patients étaient dans le score, cette récidive pouvait bénéficier d’un traitement curateur.

Published
2018

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