50 results on '"Michelet, Christian"'
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2. Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia
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Chirouze, Catherine, Curlier, Elodie, Descottes-Genon, Cécile, Hoen, Bruno, Patry, Isabelle, Vettoretti, Lucie, Chavanet, Pascal, Eicher, Jean-Christophe, Gohier-Treuvelot, Sandrine, Greusard, Marie-Christine, Neuwirth, Catherine, Péchinot, André, Piroth, Lionel, Célard, Marie, Cornu, Catherine, Delahaye, François, Hadid, Malika, Rausch, Pascale, Coma, Audrey, Galtier, Florence, Géraud, Philippe, Jean-Pierre, Hélène, Le Moing, Vincent, Sportouch, Catherine, Reynes, Jacques, Aissa, Nejla, Doco-Lecompte, Thanh, Goehringer, François, Keil, Nathalie, Letranchant, Lorraine, Malela, Hepher, May, Thierry, Selton-Suty, Christine, Bedos, Nathalie, Lavigne, Jean-Philippe, Lechiche, Catherine, Sotto, Albert, Duval, Xavier, Habensus, Emila Ilic, Iung, Bernard, Leport, Catherine, Longuet, Pascale, Ruimy, Raymond, Bellissant, Eric, Donnio, Pierre-Yves, Le Gac, Fabienne, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Thebault, Elise, Alla, François, Braquet, Pierre, Erpelding, Marie-Line, Minary, Laetitia, Tubiana, Sarah, Bès, Michèle, Etienne, Jérôme, Lelekov-Boissard, Taissia, Tristan, Anne, Vandenesch, François, Van Belkum, Alex, Rivadeneira, Fernando, Vanwamel, Willem, Barbas, Sandrine, Delonca, Christine, Sussmuth, Virginie, Verchère, Anne, Siméon, S., Le Moing, V., Tubiana, S., Duval, X., Fournier, D., Lavigne, J.-P., Erpelding, M.-L., Gustave, C.-A., Desage, S., Chirouze, C., Vandenesch, F., and Tattevin, P.
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- 2019
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3. In-Depth Characterization of Full-Length Archived Viral Genomes after Nine Years of Posttreatment HIV Control
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Trémeaux, Pauline, primary, Lemoine, Frédéric, additional, Mélard, Adeline, additional, Gousset, Marine, additional, Boufassa, Faroudy, additional, Orr, Sylvie, additional, Monceaux, Valérie, additional, Gascuel, Olivier, additional, Lambotte, Olivier, additional, Hocqueloux, Laurent, additional, Saez-Cirion, Asier, additional, Rouzioux, Christine, additional, Avettand-Fenoel, Véronique, additional, Bani-Sadr, Firouzé, additional, Hentzien, Maxime, additional, Berger, Jean-Luc, additional, Kmiec, Isabelle, additional, Pichancourt, Gilles, additional, Nasri, Safa, additional, Hittinger, Gilles, additional, Lambry, Véronique, additional, Beaudrey, Anne-Cécile, additional, Pialoux, Gilles, additional, Chas, Julie, additional, Palacios, Christia, additional, Adda, Anne, additional, Viard, Jean Paul, additional, Dulucq, Marie-Josée, additional, Weiss, Laurence, additional, Karmochkine, Marina, additional, Meghadecha, Mohamed, additional, Salmon-Ceron, Dominique, additional, Piétri, Marie-Pierre, additional, Blanche, Philippe, additional, Molina, Jean-Michel, additional, Taulera, Olivier, additional, Ponscarme, Diane, additional, Delgado Bertaut, Jeannine, additional, Makhloufi, Djamila, additional, Godinot, Matthieu, additional, Artizzu, Valérie, additional, Miailhes, Patrick, additional, Cotte, Laurent, additional, Pailhes, Sophie, additional, Conrad, Anne, additional, Karkowski, Ludovic, additional, Ogoudjobi, Stanislas, additional, Yazdanpanah, Yazdan, additional, Matheron, Sophie, additional, Godard, Cindy, additional, Bernard, Louis, additional, Bastides, Frédéric, additional, Bourgault, Olivier, additional, Jacomet, Christine, additional, Goncalves, Emilie, additional, Chavanet, Pascal, additional, Piroth, Lionel, additional, Gohier, Sandrine, additional, Meybeck, Agnès, additional, Huleux, Thomas, additional, Cornavin, Pauline, additional, Debab, Yasmine, additional, Théron, David, additional, Prazuck, Thierry, additional, De Dieuleveult, Barbara, additional, Faller, Jean-Pierre, additional, Eglinger, Patricia, additional, Roblot, Pascal, additional, Plainchamp, David, additional, Aumaître, Hugues, additional, Malet, Martine, additional, Rouger, Christine, additional, Rémy, Gérard, additional, Isabelle, Melle Kmiec, additional, Delassus, Jean-Luc, additional, Devidas, Alain, additional, Froguel, Eric, additional, Tassi, Sylvie, additional, Genet, Philippe, additional, Gerbe, Juliette, additional, Patey, Olivier, additional, Laurent, Richier, additional, Drobacheff, Marie-Christine, additional, Proust, Aurélie, additional, Gil, Helder, additional, Gérard, Laurence, additional, Oksenhendler, Eric, additional, Lascoux, Caroline, additional, Parlier, Sylvie, additional, Lucht, Frédéric, additional, Ronat, Véronique, additional, Dupon, Michel, additional, Dutronc, Hervé, additional, Le Puil, Séverine, additional, Neau, Didier, additional, Mercié, Patrick, additional, Morlat, Philippe, additional, Caldato, Sabrina, additional, Schmit, Jean-Luc, additional, Decaux, Nathalie, additional, Bru, Jean-Pierre, additional, Clavere, Gaëlle, additional, Delfraissy, Jean-François, additional, Goujard, Cécile, additional, Bourdic, Katia, additional, Vittecoq, Daniel, additional, Bolliot, Claudine, additional, Lambert, Thierry, additional, Bergmann, Jean-François, additional, Parrinello, Maguy, additional, Welker, Yves, additional, Lafeuillade, Alain, additional, Philip, Gisèle, additional, Rapp, Christophe, additional, Lerondel, Melle, additional, de Truchis, Pierre, additional, Huguette, Berthe, additional, Jeantils, Vincent, additional, Mchangama, Fatouma, additional, Consigny, Paul Henri, additional, Touam, Fatima, additional, le Nagat, Sophie, additional, Bouchaud, Olivier, additional, Honoré, Patricia, additional, Boué, François, additional, Raho-Moussa, Mariem, additional, Viard, Jean-Paul, additional, Cros, Agnès, additional, Salmon-Céron, Dominique, additional, Pietri, Marie-Pierre, additional, Collias, Lio, additional, Zucman, David, additional, Blétry, Olivier, additional, Bornarel, Dominique, additional, Mortier, Emmanuel, additional, Feng, Zeng, additional, Lelièvre, Jean-Daniel, additional, Katlama, Christine, additional, Dudoit, Yasmine, additional, Simon, Anne, additional, Lupin, Catherine, additional, Girard, Pierre-Marie, additional, Pauchard, Michèle, additional, Abel, Sylvie, additional, Cabié, André, additional, Fialaire, Pascale, additional, Chennebault, Jean-Marie, additional, Rehaiem, Sami, additional, de Saint Martin, Luc, additional, Perfezou, ••••, additional, Duthe, Jean-Charles, additional, Weinbreck, Pierre, additional, Genet, Claire, additional, Garnier, Florence, additional, Poizot-Martin, Isabelle, additional, Fauche, Olivia, additional, Ivanova, Alena, additional, Philibert, Patrick, additional, Penda Sow, Mame, additional, Yeni, Patrick, additional, Godard, Cyndi, additional, Raffi, François, additional, Hüe, Hervé, additional, Perré, Philippe, additional, Roger, Pierre Marie, additional, Joulie, Aline, additional, Rosenthal, Éric, additional, Michelet, Christian, additional, Souala, Faouzi, additional, Ratajczak, Maja, additional, Partisani, Marialuisa, additional, Fischer, Patricia, additional, Nau, Pascale, additional, Delobel, Pierre, additional, Balsarin, Florence, additional, De Lavaissiere, Marc, additional, Verdon, Renaud, additional, Feret, Philippe, additional, Leclercq, Pascale, additional, Gerberon, ••••, additional, Meybeck, Agnés, additional, Biekre, Raphaël, additional, May, Thierry, additional, Bouillon, ••••, additional, Caron, François, additional, Theron, David, additional, Gatfosse, Marc, additional, Martinot, Martin, additional, Pachart, Anne, additional, Poubeau, Patrice, additional, Gaud, Catherine, additional, Uludag, Agnès, additional, Arsac, Philippe, additional, Bouaraba, Lydia, additional, de Dieulevault, Barbara, additional, De Lacroix Szmania, Isabelle, additional, Richier, Laurent, additional, Daneluzzi, Vincent, additional, Rouveix, Elisabeth, additional, Beck-Wirth, Geneviève, additional, Romand, Philippe, additional, Blum, Laurent, additional, Deschaud, Martine, additional, Michau, Christophe, additional, Bernard, Christian, additional, Salaun, Florence, additional, Muller, Philippe, additional, Poinsignon, Yves, additional, Lepretre, Annie, additional, Sotto, Albert, additional, Doncesco, ••••, additional, Perfezou, Pascale, additional, Duthe, Jean Charles, additional, Niault, Mathilde Aurore, additional, Mouton-Rioux, Virginie, additional, Talarmin, Jean-Philippe, additional, Duthé, Jean Charles, additional, Dupont, Mathilde, additional, Natur, Stéphane, additional, Hitoto, Hikombo, additional, and Ibrahim, Ali Mahamadou, additional
- Published
- 2023
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4. Preliminary favorable outcome for medically and surgically managed extensively drug-resistant tuberculosis, France, 2009-2014
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Henry, Benoit, Revest, Matthieu, Dournon, Nathalie, Epelboin, Loic, Mellon, Guillaume, Bellaud, Guillaume, Mordant, Pierre, Du, Damien Le, Veziris, Nicolas, Bernard, Christine, Morel, Sebastien, Jaureguiberry, Stephane, Michelet, Christian, Bricaire, Francois, Tattevin, Pierre, and Caumes, Eric
- Subjects
Management ,Drug therapy ,International economic relations ,Company business management ,Antitubercular agents ,Microbial drug resistance -- Drug therapy ,Tuberculosis -- Drug therapy - Abstract
Multidrug-resistant tuberculosis (TB) and extensively drug-resistant TB (XDR TB) are among the most difficult infections to treat and are major public health concerns worldwide (1). In France, the number of [...]
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- 2016
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5. Deep Brain Stimulation Hardware-Related Infections: A Report of 12 Cases and Review of the Literature
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Fily, Fabien, Haegelen, Claire, Tattevin, Pierre, Buffet-Bataillon, Sylvie, Revest, Matthieu, Cady, Anne, and Michelet, Christian
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- 2011
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6. A highly virulent variant of HIV-1 circulating in the Netherlands
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Wymant, Chris, Bezemer, Daniela, Blanquart, François, Ferretti, Luca, Gall, Astrid, Hall, Matthew, Golubchik, Tanya, Bakker, Margreet, Ong, Swee Hoe, Zhao, Lele, Bonsall, David, de Cesare, Mariateresa, MacIntyre-Cockett, George, Abeler-Dörner, Lucie, Albert, Jan, Bannert, Norbert, Fellay, Jacques, Grabowski, M Kate, Gunsenheimer-Bartmeyer, Barbara, Günthard, Huldrych F, Kivelä, Pia, Kouyos, Roger D, Laeyendecker, Oliver, Meyer, Laurence, Porter, Kholoud, Ristola, Matti, van Sighem, Ard, Berkhout, Ben, Kellam, Paul, Cornelissen, Marion, Reiss, Peter, Fraser, Christophe, Aubert, V, Battegay, M, Bernasconi, E, Böni, J, Braun, D L, Bucher, H C, Burton-Jeangros, C, Calmy, A, Cavassini, M, Dollenmaier, G, Egger, M, Elzi, L, Fehr, J, Fellay, J, Furrer, H, Fux, C A, Gorgievski, M, Günthard, H, Haerry, D, Hasse, B, Hirsch, H H, Hoffmann, M, Hösli, I, Kahlert, C, Kaiser, L, Keiser, O, Klimkait, T, Kouyos, R, Kovari, H, Ledergerber, B, Martinetti, G, de Tejada, B Martinez, Marzolini, C, Metzner, K, Müller, N, Nadal, D, Nicca, D, Pantaleo, G, Rauch, A, Regenass, S, Rudin, C, Schöni-Affolter, F, Schmid, P, Speck, R, Stöckle, M, Tarr, P, Trkola, A, Vernazza, P, Weber, R, Yerly, S, van der Valk, M, Geerlings, S E, Goorhuis, A, Hovius, J W, Lempkes, B, Nellen, F J B, van der Poll, T, Prins, J M, Reiss, P, van Vugt, M, Wiersinga, W J, Wit, F W M N, van Duinen, M, van Eden, J, Hazenberg, A, van Hes, A M H, Pijnappel, F J J, Smalhout, S Y, Weijsenfeld, A M, Jurriaans, S, Back, N K T, Zaaijer, H L, Berkhout, B, Cornelissen, M T E, Schinkel, C J, Wolthers, K C, Peters, E J G, van Agtmael, M A, Autar, R S, Bomers, M, Sigaloff, K C E, Heitmuller, M, Laan, L M, Ang, C W, van Houdt, R, Jonges, M, Kuijpers, T W, Pajkrt, D, Scherpbier, H J, de Boer, C, van der Plas, A, van den Berge, M, Stegeman, A, Baas, S, Hage de Looff, L, Buiting, A, Reuwer, A, Veenemans, J, Wintermans, B, Pronk, M J H, Ammerlaan, H S M, van den Bersselaar, D N J, de Munnik, E S, Deiman, B, Jansz, A R, Scharnhorst, V, Tjhie, J, Wegdam, M C A, van Eeden, A, Nellen, J, Brokking, W, Elsenburg, L J M, Nobel, H, van Kasteren, M E E, Berrevoets, M A H, Brouwer, A E, Adams, A, van Erve, R, de Kruijf-van de Wiel, B A F M, Keelan-Phaf, S, van der Ven, B, Buiting, A G M, Murck, J L, de Vries-Sluijs, T E M S, Bax, H I, van Gorp, E C M, de Jong-Peltenburg, N C, de Mendonç A Melo, M, van Nood, E, Nouwen, J L, Rijnders, B J A, Rokx, C, Schurink, C A M, Slobbe, L, Verbon, A, Bassant, N, van Beek, J E A, Vriesde, M, van Zonneveld, L M, de Groot, J, Boucher, C A B, Koopmans, M P G, van Kampen, J J A, Fraaij, P L A, van Rossum, A M C, Vermont, C L, van der Knaap, L C, Visser, E, Branger, J, Douma, R A, Cents-Bosma, A S, Duijf-van de Ven, C J H M, Schippers, E F, van Nieuwkoop, C, van Ijperen, J M, Geilings, J, van der Hut, G, van Burgel, N D, Leyten, E M S, Gelinck, L B S, Mollema, F, Davids-Veldhuis, S, Tearno, C, Wildenbeest, G S, Heikens, E, Groeneveld, P H P, Bouwhuis, J W, Lammers, A J J, Kraan, S, van Hulzen, A G W, Kruiper, M S M, van der Bliek, G L, Bor, P C J, Debast, S B, Wagenvoort, G H J, Kroon, F P, de Boer, M G J, Jolink, H, Lambregts, M M C, Roukens, A H E, Scheper, H, Dorama, W, van Holten, N, Claas, E C J, Wessels, E, den Hollander, J G, El Moussaoui, R, Pogany, K, Smit, J V, Struik-Kalkman, D, van Niekerk, T, Pontesilli, O, Lowe, S H, Oude Lashof, A M L, Posthouwer, D, van Wolfswinkel, M E, Ackens, R P, Burgers, K, Schippers, J, Weijenberg-Maes, B, van Loo, I H M, Havenith, T R A, van Vonderen, M G A, Kampschreur, L M, Faber, S, Steeman-Bouma, R, Al Moujahid, A, Kootstra, G J, Delsing, C E, van der Burg-van de Plas, M, Scheiberlich, L, Kortmann, W, van Twillert, G, Renckens, R, Ruiter-Pronk, D, van Truijen-Oud, F A, Cohen Stuart, J W T, Jansen, E R, Hoogewerf, M, Rozemeijer, W, van der Reijden, W A, Sinnige, J C, Brinkman, K, van den Berk, G E L, Blok, W L, Lettinga, K D, de Regt, M, Schouten, W E M, Stalenhoef, J E, Veenstra, J, Vrouenraets, S M E, Blaauw, H, Geerders, G F, Kleene, M J, Kok, M, Knapen, M, van der Meché, I B, Mulder-Seeleman, E, Toonen, A J M, Wijnands, S, Wttewaal, E, Kwa, D, van Crevel, R, van Aerde, K, Dofferhoff, A S M, Henriet, S S V, Ter Hofstede, H J M, Hoogerwerf, J, Keuter, M, Richel, O, Albers, M, Grintjes-Huisman, K J T, de Haan, M, Marneef, M, Strik-Albers, R, Rahamat-Langendoen, J, Stelma, F F, Burger, D, Gisolf, E H, Hassing, R J, Claassen, M, Ter Beest, G, van Bentum, P H M, Langebeek, N, Tiemessen, R, Swanink, C M A, van Lelyveld, S F L, Soetekouw, R, van der Prijt, L M M, van der Swaluw, J, Bermon, N, Jansen, R, Herpers, B L, Veenendaal, D, Verhagen, D W M, Lauw, F N, van Broekhuizen, M C, van Wijk, M, Bierman, W F W, Bakker, M, Kleinnijenhuis, J, Kloeze, E, Middel, A, Postma, D F, Schölvinck, E H, Stienstra, Y, Verhage, A R, Wouthuyzen-Bakker, M, Boonstra, A, de Groot-de Jonge, H, van der Meulen, P A, de Weerd, D A, Niesters, H G M, van Leer-Buter, C C, Knoester, M, Hoepelman, A I M, Arends, J E, Barth, R E, Bruns, A H W, Ellerbroek, P M, Mudrikova, T, Oosterheert, J J, Schadd, E M, van Welzen, B J, Aarsman, K, Griffioen-van Santen, B M G, de Kroon, I, van Berkel, M, van Rooijen, C S A M, Schuurman, R, Verduyn-Lunel, F, Wensing, A M J, Bont, L J, Geelen, S P M, Loeffen, Y G T, Wolfs, T F W, Nauta, N, Rooijakkers, E O W, Holtsema, H, Voigt, R, van de Wetering, D, Alberto, A, van der Meer, I, Rosingh, A, Halaby, T, Zaheri, S, Boyd, A C, Bezemer, D O, van Sighem, A I, Smit, C, Hillebregt, M, de Jong, A, Woudstra, T, Bergsma, D, Meijering, R, van de Sande, L, Rutkens, T, van der Vliet, S, de Groot, L, van den Akker, M, Bakker, Y, El Berkaoui, A, Bezemer, M, Brétin, N, Djoechro, E, Groters, M, Kruijne, E, Lelivelt, K J, Lodewijk, C, Lucas, E, Munjishvili, L, Paling, F, Peeck, B, Ree, C, Regtop, R, Ruijs, Y, Schoorl, M, Schnörr, P, Scheigrond, A, Tuijn, E, Veenenberg, L, Visser, K M, Witte, E C, Van Frankenhuijsen, Maartje, Allegre, Thierry, Makhloufi, Djamila, Livrozet, Jean-Michel, Chiarello, Pierre, Godinot, Mathieu, Brunel-Dalmas, Florence, Gibert, Sylvie, Trepo, Christian, Peyramond, Dominique, Miailhes, Patrick, Koffi, Joseph, Thoirain, Valérie, Brochier, Corinne, Baudry, Thomas, Pailhes, Sylvie, Lafeuillade, Alain, Philip, Gisèle, Hittinger, Gilles, Assi, Assi, Lambry, Véronique, Rosenthal, Eric, Naqvi, Alissa, Dunais, Brigitte, Cua, Eric, Pradier, Christian, Durant, Jacques, Joulie, Aline, Quinsat, Denis, Tempesta, Serge, Ravaux, Isabelle, Martin, Isabelle Poizot, Faucher, Olivia, Cloarec, Nicolas, Champagne, Hélène, Pichancourt, Gilles, Morlat, Philippe, Pistone, Thierry, Bonnet, Fabrice, Mercie, Patrick, Faure, Isabelle, Hessamfar, Mojgan, Malvy, Denis, Lacoste, Denis, Pertusa, Marie-Carmen, Vandenhende, Marie-Anne, Bernard, Noëlle, Paccalin, François, Martell, Cédric, Roger-Schmelz, Julien, Receveur, Marie-Catherine, Duffau, Pierre, Dondia, Denis, Ribeiro, Emmanuel, Caltado, Sabrina, Neau, Didier, Dupont, Michel, Dutronc, Hervé, Dauchy, Frédéric, Cazanave, Charles, Vareil, Marc-Olivier, Wirth, Gaétane, Le Puil, Séverine, Pellegrin, Jean-Luc, Raymond, Isabelle, Viallard, Jean-François, Chaigne de Lalande, Severin, Garipuy, Daniel, Delobel, Pierre, Obadia, Martine, Cuzin, Lise, Alvarez, Muriel, Biezunski, Noemie, Porte, Lydie, Massip, Patrice, Debard, Alexa, Balsarin, Florence, Lagarrigue, Myriam, Prevoteau du Clary, François, Aquilina, Christian, Reynes, Jacques, Baillat, Vincent, Merle, Corinne, Lemoing, Vincent, Atoui, Nadine, Makinson, Alain, Jacquet, Jean Marc, Psomas, Christina, Tramoni, Christine, Aumaitre, Hugues, Saada, Mathieu, Medus, Marie, Malet, Martine, Eden, Aurélia, Neuville, Ségolène, Ferreyra, Milagros, Sotto, Albert, Barbuat, Claudine, Rouanet, Isabelle, Leureillard, Didier, Mauboussin, Jean-Marc, Lechiche, Catherine, Donsesco, Régine, Cabie, André, Abel, Sylvie, Pierre-Francois, Sandrine, Batala, Anne-Sophie, Cerland, Christophe, Rangom, Camille, Theresine, Nadine, Hoen, Bruno, Lamaury, Isabelle, Fabre, Isabelle, Schepers, Kinda, Curlier, Elodie, Ouissa, Rachida, Gaud, Catherine, Ricaud, Carole, Rodet, Roland, Wartel, Guillaume, Sautron, Carmele, Beck-Wirth, Geneviève, Michel, Catherine, Beck, Charles, Halna, Jean-Michel, Kowalczyk, Jakub, Benomar, Meryem, Drobacheff-Thiebaut, Christine, Chirouze, Catherine, Faucher, Jean-François, Parcelier, François, Foltzer, Adeline, Haffner-Mauvais, Cécile, Hustache Mathieu, Mathieu, Proust, Aurélie, Piroth, Lionel, Chavanet, Pascal, Duong, Michel, Buisson, Marielle, Waldner, Anne, Mahy, Sophie, Gohier, Sandrine, Croisier, Delphine, May, Thierry, Delestan, Mikael, Andre, Marie, Zadeh, Mahsa Mohseni, Martinot, Martin, Rosolen, Béatrice, Pachart, Anne, Martha, Benoît, Jeunet, Noëlle, Rey, David, Cheneau, Christine, Partisani, Maria, Priester, Michèle, Bernard-Henry, Claudine, Batard, Marie-Laure, Fischer, Patricia, Berger, Jean-Luc, Kmiec, Isabelle, Robineau, Olivier, Huleux, Thomas, Ajana, Faïza, Alcaraz, Isabelle, Allienne, Christophe, Baclet, Véronique, Meybeck, Agnès, Valette, Michel, Viget, Nathalie, Aissi, Emmanuelle, Biekre, Raphael, Cornavin, Pauline, Merrien, Dominique, Seghezzi, Jean-Christophe, Machado, Moise, Diab, Georges, Raffi, François, Bonnet, Bénédicte, Allavena, Clotilde, Grossi, Olivier, Reliquet, Véronique, Billaud, Eric, Brunet, Cecile, Bouchez, Sabelline, Morineau-Le Houssine, Pascale, Sauser, Fabienne, Boutoille, David, Besnier, Michel, Hue, Hervé, Hall, Nolwenn, Brosseau, Delphine, Souala, Faouzi, Michelet, Christian, Tattevin, Pierre, Arvieux, Cédric, Revest, Matthieu, Leroy, Helene, Chapplain, Jean-Marc, Dupont, Matthieu, Fily, Fabien, Patra-Delo, Solène, Lefeuvre, Céline, Bernard, Louis, Bastides, Frédéric, Nau, Pascale, Verdon, Renaud, de la Blanchardiere, Arnaud, Martin, Anne, Feret, Philippe, Geffray, Loïk, Daniel, Corinne, Rohan, Jennifer, Fialaire, Pascale, Chennebault, Jean Marie, Rabier, Valérie, Abgueguen, Pierre, Rehaiem, Sami, Luycx, Odile, Niault, Mathilde, Moreau, Philippe, Poinsignon, Yves, Goussef, Marie, Mouton-Rioux, Virginie, Houlbert, Dominique, Alvarez-Huve, Sandrine, Barbe, Frédérique, Haret, Sophie, Perre, Philippe, Leantez-Nainville, Sophie, Esnault, Jean-Luc, Guimard, Thomas, Suaud, Isabelle, Girard, Jean-Jacques, Simonet, Véronique, Debab, Yasmine, Schmit, Jean-Luc, Jacomet, Christine, Weinberck, Pierre, Genet, Claire, Pinet, Pauline, Ducroix, Sophie, Durox, Hélène, Denes, Éric, Abraham, Bruno, Gourdon, Florence, Antoniotti, Odile, Molina, Jean-Michel, Ferret, Samuel, Lascoux-Combe, Caroline, Lafaurie, Matthieu, Colin de Verdiere, Nathalie, Ponscarme, Diane, De Castro, Nathalie, Aslan, Alexandre, Rozenbaum, Willy, Pintado, Claire, Clavel, François, Taulera, Olivier, Gatey, Caroline, Munier, Anne-Lise, Gazaigne, Sandrine, Penot, Pauline, Conort, Guillaume, Lerolle, Nathalie, Leplatois, Anne, Balausine, Stéphanie, Delgado, Jeannine, Timsit, Julie, Tabet, Magda, Gerard, Laurence, Girard, Pierre-Marie, Picard, Odile, Tredup, Jürgen, Bollens, Diane, Valin, Nadia, Campa, Pauline, Bottero, Julie, Lefebvre, Benedicte, Tourneur, Muriel, Fonquernie, Laurent, Wemmert, Charlotte, Lagneau, Jean-Luc, Yazdanpanah, Yazdan, Phung, Bao, Pinto, Adriana, Vallois, Dorothée, Cabras, Ornella, Louni, Françoise, Pialoux, Gilles, Lyavanc, Thomas, Berrebi, Valérie, Chas, Julie, Lenagat, Sophie, Rami, Agathe, Diemer, Myriam, Parrinello, Maguy, Depond, Audrey, Salmon, Dominique, Guillevin, Loïc, Tahi, Tassadit, Belarbi, Linda, Loulergue, Pierre, Zak Dit Zbar, Olivier, Launay, Odile, Silbermann, Benjamin, Leport, Catherine, Alagna, Laura, Pietri, Marie-Pierre, Simon, Anne, Bonmarchand, Manuela, Amirat, Naouel, Pichon, François, Kirstetter, Myriam, Katlama, Christine, Valantin, Marc Antoine, Tubiana, Roland, Caby, Fabienne, Schneider, Luminita, Ktorza, Nadine, Calin, Ruxandra, Merlet, Audrey, Ben Abdallah, Saadia, Weiss, Laurence, Buisson, Martin, Batisse, Dominique, Karmochine, Marina, Pavie, Juliette, Minozzi, Catherine, Jayle, Didier, Castel, Philippe, Derouineau, Jean, Kousignan, Pascale, Eliazevitch, Murielle, Pierre, Isabelle, Collias, Lio, Viard, Jean-Paul, Gilquin, Jacques, Sobel, Alain, Slama, Laurence, Ghosn, Jade, Hadacek, Blanka, Thu-Huyn, Nugyen, Nait-Ighil, Lella, Cros, Agnes, Maignan, Aline, Duvivier, Claudine, Consigny, Paul Henri, Lanternier, Fanny, Shoai-Tehrani, Michka, Touam, Fatima, Jerbi, Saadia, Bodard, Loïc, Jung, Corinne, Goujard, Cécile, Quertainmont, Yann, Duracinsky, Martin, Segeral, Olivier, Blanc, Arnaud, Peretti, Delphine, Cheret, Antoine, Chantalat, Christelle, Dulucq, Marie Josée, Levy, Yves, Lelievre, Jean Daniel, Lascaux, Anne Sophie, Dumont, Cécile, Boue, François, Chambrin, Véronique, Abgrall, Sophie, Kansau, Imad, Raho-Moussa, Mariem, De Truchis, Pierre, Dinh, Aurélien, Davido, Benjamin, Marigot, Dhiba, Berthe, Huguette, Devidas, Alain, Chevojon, Pierre, Chabrol, Amélie, Agher, Nouara, Lemercier, Yvon, Chaix, Fabrice, Turpault, Isabelle, Bouchaud, Olivier, Honore, Patricia, Rouveix, Elisabeth, Reimann, Evelyne, Belan, Alix Greder, Godin Collet, Claire, Souak, Safia, Mortier, Emmanuel, Bloch, Martine, Simonpoli, Anne-Marie, Manceron, Véronique, Cahitte, Isabelle, Hiraux, Emmanuel, Lafon, Erik, Cordonnier, François, Zeng, Ai-Feng, Zucman, David, Majerholc, Catherine, Bornarel, Dominique, Uludag, Agnès, Gellen-Dautremer, Justine, Lefort, Agnès, Bazin, Christine, Daneluzzi, Vincent, Gerbe, Juliette, Jeantils, Vincent, Coupard, Mélissa, Patey, Olivier, Bantsimba, Jonas, Delllion, Sophie, Paz, Pauline Caraux, Cazenave, Benoit, Richier, Laurent, Garrait, Valérie, Delacroix, Isabelle, Elharrar, Brigitte, Vittecoq, Daniel, Bolliot, Claudine, Lepretre, Annie, Genet, Philippe, Masse, Virginie, Perrone, Véronique, Boussard, Jean-Luc, Chardon, Patricia, Froguel, Eric, Simon, Philippe, Tassi, Sylvie, Avettand Fenoel, Véronique, Barin, Francis, Bourgeois, Christine, Cardon, Fanny, Chaix, Marie-Laure, Delfraissy, Jean François, Essat, Asma, Fischer, Hugues, Lecuroux, Camille, Petrov-Sanchez, Ventzislava, Rouzioux, Christine, Saez-Cirion, Asier, Seng, Rémonie, Kuldanek, Kristin, Mullaney, Scott, Young, Carmel, Zucchetti, Antonella, Bevan, Margaret-Ann, McKernan, Sinead, Wandolo, Emily, Richardson, Celia, Youssef, Elaney, Green, Pippa, Faulkner, Sue, Faville, Rebecca, Herman, Sandra, Care, Christine, Blackman, Helen, Bellenger, Katharine, Fairbrother, Keith, Phillips, Andrew, Babiker, Abdel, Delpech, Valerie, Fidler, S, Clarke, Mindy, Fox, Julie, Gilson, R, Goldberg, David, Hawkins, David, Johnson, Anne, Johnson, Margaret, McLean, Ken, Nastouli, Eleni, Post, Frank, Kennedy, N, Pritchard, J, Andrady, U, Rajda, N, Donnelly, C, McKernan, S, Drake, S, Gilleran, G, White, D, Ross, J, Harding, J, Faville, R, Sweeney, J, Flegg, P, Toomer, S, Wilding, H, Woodward, R, Dean, G, Richardson, C, Perry, N, Gompels, M, Jennings, L, Bansaal, D, Browing, M, Connolly, L, Stanley, B, Estreich, S, Magdy, A, O'Mahony, C, Fraser, P, Jebakumar, S P R, David, L, Mette, R, Summerfield, H, Evans, M, White, C, Robertson, R, Lean, C, Morris, S, Winter, A, Faulkner, S, Goorney, B, Howard, L, Fairley, I, Stemp, C, Short, L, Gomez, M, Young, F, Roberts, M, Green, S, Sivakumar, K, Minton, J, Siminoni, A, Calderwood, J, Greenhough, D, DeSouza, C, Muthern, Lisa, Orkin, C, Murphy, S, Truvedi, M, McLean, K, Hawkins, D, Higgs, C, Moyes, A, Antonucci, S, McCormack, S, Lynn, W, Bevan, M, Fox, J, Teague, A, Anderson, J, Mguni, S, Post, F, Campbell, L, Mazhude, C, Russell, H, Carrick, G, Ainsworth, J, Waters, A, Byrne, P, Johnson, M, Kuldanek, K, Mullaney, S, Lawlor, V, Melville, R, Sukthankar, A, Thorpe, S, Murphy, C, Wilkins, E, Ahmad, S, Green, P, Tayal, S, Ong, E, Meaden, J, Riddell, L, Loay, D, Peacock, K, Blackman, H, Harindra, V, Saeed, A M, Allen, S, Natarajan, U, Williams, O, Lacey, H, Care, C, Bowman, C, Herman, S, Devendra, S V, Wither, J, Bridgwood, A, Singh, G, Bushby, S, Kellock, D, Young, S, Rooney, G, Snart, B, Currie, J, Fitzgerald, M, Arumainayyagam, J, Chandramani, S, Rajamanoharan, S, Robinson, T, Taylor, B, Brewer, C, Mayr, Christoph, Schmidt, Wolfgang, Speidel, Andrea, Strohbach, Frank, Arastéh, Keikawus, Cordes, Christiane, Stündel, Manfred, Claus, Jörg, Baumgarten, Axel, Carganico, Andreas, Ingiliz, Patrick, Dupke, Stephan, Freiwald, Matthias, Rausch, Michael, Moll, Arend, Schleehauf, Dorothea, Hintsche, Bettina, Klausen, Gerd, Jessen, Heiko, Jessen, Arne, Köppe, Siegfried, Kreckel, Peter, Schranz, Dietmar, Fischer, Klaus, Schulbin, Hubert, Speer, Miriam, Glaunsinger, Tobias, Wicke, Thomas, Bieniek, Bernhard, Hillenbrand, Heribert, Schlote, Frank, Lauenroth-Mai, Elke, Schuler, Christoph, Schürmann, Dirk, Wesselmann, Hans, Brockmeyer, Norbert, Gehring, Peter, Schmalöer, Dirk, Hower, Martin, Spornraft-Ragaller, Petra, Häussinger, Dieter, Reuter, Stefan, Esser, Stefan, Markus, Rudolf, Kreft, Burkhard, Berzow, Dirk, Christl, Andreas, Meyer, Andreas, Plettenberg, Andreas, Stoehr, Albrecht, Graefe, Katrin, Lorenzen, Thore, Adam, Axel, Schewe, Knut, Weitner, Lutwin, Fenske, Stefan, Hansen, Stefan, Stellbrink, Hans-Jürgen, Wiemer, Dorothea, Hertling, Sandra, Schmidt, Reinhold, Arbter, Peter, Claus, Bernd, Galle, Peter, Jäger, Hans, Jä Gel-Guedes, Eva, Postel, Nils, Fröschl, Monika, Spinner, Christoph, Bogner, Johannes, Salzberger, Bernd, Schölmerich, Jürgen, Audebert, Franz, Marquardt, Ties, Schaffert, Andreas, Schnaitmann, Eiko, Trein, Andreas, Frietsch, Bernhard, Müller, Marcus, Ulmer, Albrecht, Detering-Hübner, Barbara, Kern, Peter, Schubert, Franz, Dehn, Günther, Schreiber, Maria, Güler, Cengiz, Schmidt, Daniel, Meixenberger, Karolin, Medical Microbiology & Infectious Diseases, Internal Medicine, Virology, Pediatrics, Medical Microbiology and Infection Prevention, AII - Infectious diseases, Global Health, Infectious diseases, APH - Aging & Later Life, Centre interdisciplinaire de recherche en biologie (CIRB), Labex MemoLife, École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Université Paris sciences et lettres (PSL)-Collège de France (CdF (institution))-Ecole Superieure de Physique et de Chimie Industrielles de la Ville de Paris (ESPCI Paris), Université Paris sciences et lettres (PSL)-École normale supérieure - Paris (ENS-PSL), Université Paris sciences et lettres (PSL)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Internal medicine, VU University medical center, Surgery, AMS - Rehabilitation & Development, APH - Quality of Care, Psychiatry, Pediatric surgery, Neurology, Public and occupational health, APH - Mental Health, Pathology, Cardiology, ACS - Heart failure & arrhythmias, Anesthesiology, IOO, Rehabilitation medicine, Obstetrics and gynaecology, General practice, Gastroenterology and hepatology, Pulmonary medicine, ACS - Pulmonary hypertension & thrombosis, Medical oncology laboratory, Hematology, Epidemiology and Data Science, Physiology, Microbes in Health and Disease (MHD), University of Oxford, Stichting HIV Monitoring [Amsterdam], Universiteit van Amsterdam (UvA), European Bioinformatics Institute [Hinxton] (EMBL-EBI), EMBL Heidelberg, Amsterdam UMC - Amsterdam University Medical Center, The Wellcome Trust Sanger Institute [Cambridge], Karolinska Institutet [Stockholm], Robert Koch Institute [Berlin] (RKI), Ecole Polytechnique Fédérale de Lausanne (EPFL), Johns Hopkins University (JHU), Universität Zürich [Zürich] = University of Zurich (UZH), Helsinki University Hospital [Helsinki, Finlande], Helsingin yliopisto = Helsingfors universitet = University of Helsinki, National Institute of Allergy and Infectious Diseases [Bethesda] (NIAID-NIH), National Institutes of Health [Bethesda] (NIH), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris-Saclay, University College of London [London] (UCL), Kymab Ltd, Cambridge, England, Institut Pasteur [Paris] (IP), This study was funded by ERC Advanced Grant PBDR-339251 and a Li Ka Shing Foundation grant, both awarded to C.F. The ATHENA Cohort is managed by Stichting HIV Monitoring and supported by a grant from the Dutch Ministry of Health, Welfare and Sport through the Centre for Infectious Disease Control of the National Institute for Public Health and the Environment., We thank K. Fransen and G. Vanham for help with the Belgian data, O. Ratmann for help in identifying the Dutch clusters, K. Kusejko for testing for additional VB individuals in the SHCS, B. Foley for help with genome sharing, B. Dearlove and L. Thomson for help with software, and J. Herbeck and three other reviewers for helpful suggestions., Contributors and affiliations are listed in the supplementary materials., Department of Medicine, University of Helsinki, Infektiosairauksien yksikkö, HUS Inflammation Center, and Clinicum
- Subjects
Adult ,Male ,HIV-1/genetics ,Genotype ,Anti-HIV Agents ,Evolution ,[SDV]Life Sciences [q-bio] ,lnfectious Diseases and Global Health Radboud Institute for Molecular Life Sciences [Radboudumc 4] ,HIV Infections/drug therapy ,selection ,HIV Infections ,Genome, Viral ,heritability ,epidemic ,human-immunodeficiency-virus ,Evolution, Molecular ,SDG 3 - Good Health and Well-being ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Humans ,Viral ,Phylogeny ,Netherlands ,Multidisciplinary ,Genome ,model ,Virulence ,transmission ,Molecular ,setpoint viral load ,reverse-transcriptase ,dynamics ,Viral Load ,CD4 Lymphocyte Count ,lnfectious Diseases and Global Health Radboud Institute for Health Sciences [Radboudumc 4] ,3121 General medicine, internal medicine and other clinical medicine ,Anti-HIV Agents/therapeutic use ,Mutation ,HIV-1 ,Female ,progression - Abstract
Comment in Does HIV-1 virulence matter in the ART era? Lewitus E, Rolland M. Med (N Y). 2022 Apr 8;3(4):217-219. doi: 10.1016/j.medj.2022.03.003. PMID: 35590149; International audience; We discovered a highly virulent variant of subtype-B HIV-1 in the Netherlands. One hundred nine individuals with this variant had a 0.54 to 0.74 log 10 increase (i.e., a ~3.5-fold to 5.5-fold increase) in viral load compared with, and exhibited CD4 cell decline twice as fast as, 6604 individuals with other subtype-B strains. Without treatment, advanced HIV—CD4 cell counts below 350 cells per cubic millimeter, with long-term clinical consequences—is expected to be reached, on average, 9 months after diagnosis for individuals in their thirties with this variant. Age, sex, suspected mode of transmission, and place of birth for the aforementioned 109 individuals were typical for HIV-positive people in the Netherlands, which suggests that the increased virulence is attributable to the viral strain. Genetic sequence analysis suggests that this variant arose in the 1990s from de novo mutation, not recombination, with increased transmissibility and an unfamiliar molecular mechanism of virulence.
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- 2022
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7. Predictors of Long-Term Increase in CD4⁺ Cell Counts in Human Immunodeficiency Virus-Infected Patients Receiving a Protease Inhibitor-Containing Antiretroviral Regimen
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Le Moing, Vincent, Thiébaut, Rodolphe, Chêne, Geneviève, Leport, Catherine, Cailleton, Valérie, Michelet, Christian, Fleury, Hervé, Herson, Serge, and Raffi, François
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- 2002
8. Factors associated with 12 week case-fatality in Staphylococcus aureus bacteraemia: a prospective cohort study
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Chirouze, Catherine, Curlier, Elodie, Descottes-Genon, Cécile, Hoen, Bruno, Patry, Isabelle, Vettoretti, Lucie, Chavanet, Pascal, Eicher, Jean-Christophe, Greusard, Marie-Christine, Neuwirth, Catherine, Péchinot, André, Piroth, Lionel, Célard, Marie, Cornu, Catherine, Delahaye, François, Hadid, Malika, Rausch, Pascale, Coma, Audrey, Galtier, Florence, Géraud, Philippe, Jean-Pierre, Hélène, Le Moing, Vincent, Sportouch, Catherine, Reynes, Jacques, Aissa, Nejla, Doco-Lecompte, Thanh, Goehringer, François, Keil, Nathalie, Letranchant, Lorraine, Malela, Hepher, May, Thierry, Selton-Suty, Christine, Bedos, Nathalie, Lavigne, Jean-Philippe, Lechiche, Catherine, Sotto, Albert, Duval, Xavier, Habensus, Emila Ilic, Iung, Bernard, Leport, Catherine, Longuet, Pascale, Ruimy, Raymond, Bellissant, Eric, Donnio, Pierre-Yves, Le Gac, Fabienne, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Thebault, Elise, Alla, François, Braquet, Pierre, Erpelding, Marie-Line, Minary, Laetitia, Bès, Michèle, Etienne, Jérôme, Tristan, Anne, Vandenesch, François, Van Belkum, Alex, Vanwamel, Willem, Braquet, P., Alla, F., Cornu, C., Goehringer, F., Piroth, L., Chirouze, C., Revest, M., Lechiche, C., Duval, X., and Le Moing, V.
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- 2016
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9. Infective Endocarditis in Patients on Chronic Hemodialysis
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Pericàs, Juan M., primary, Llopis, Jaume, additional, Jiménez-Exposito, Maria Jesús, additional, Kourany, Wissam M., additional, Almirante, Benito, additional, Carosi, Giampiero, additional, Durante-Mangoni, Emanuele, additional, Fortes, Claudio Querido, additional, Giannitsioti, Efthymia, additional, Lerakis, Stamatios, additional, Montagna-Mella, Rodrigo, additional, Ambrosioni, Juan, additional, Tan, Ru-San, additional, Mestres, Carlos A., additional, Wray, Dannah, additional, Pachirat, Orathai, additional, Moreno, Asuncion, additional, Chu, Vivian H., additional, de Lazzari, Elisa, additional, Fowler, Vance G., additional, Miró, Jose M., additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Oses, Pablo Fernandez, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Altclas, Javier, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Tan, Ren, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, Passos de Brito, Ana Cláudia, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Siciliano, Rinaldo Focaccia, additional, Varejao Strabelli, Tania Mara, additional, Campos Vieira, Marcelo Luiz, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Cereceda, M., additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Gonzalez, Javier, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, CHU Catherine, additional, Doco-Lecompte, Thanh, additional, Selton-Suty, Christine, additional, Casalta, Jean-Paul, additional, Fournier, Pierre-Edouard, additional, Habib, Gilbert, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Sophia Athanasia, Carl Neuerburg, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Skoutelis, Athanasios, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Wanounou, Maor, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Iossa, Domenico, additional, Orlando, Serena, additional, Ursi, Maria Paola, additional, Pafundi, Pia Clara, additional, D’Amico, Fabiana, additional, Bernardo, Mariano, additional, Cuccurullo, Susanna, additional, Dialetto, Giovanni, additional, Covino, Franco Enrico, additional, Manduca, Sabrina, additional, Della Corte, Alessandro, additional, De Feo, Marisa, additional, Tripodi, Marie Françoise, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif-Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Edathodu, Jameela, additional, Halim, Magid, additional, Liew, Yee-Yun, additional, Lejko-Zupanc, Tatjana, additional, Logar, Mateja, additional, Mueller-Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manel, additional, Azqueta, Manuel, additional, Brunet, Merce, additional, Castro, Pedro, additional, De Lazzari, Elisa, additional, Falces, Carlos, additional, Fuster, David, additional, Fita, Guillermina, additional, Garcia- de- la- Maria, Cristina, additional, Garcia-Gonzalez, Javier, additional, Gatell, Jose M., additional, Marco, Francesc, additional, Miró, José M., additional, Ortiz, José, additional, Ninot, Salvador, additional, Paré, J. Carlos, additional, Pericas, Juan M., additional, Quintana, Eduard, additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sandoval, Elena, additional, Sitges, Marta, additional, Tellez, Adrian, additional, Tolosana, José M., additional, Vidal, Barbara, additional, Vila, Jordi, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Bouza, Emilio, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez-Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez-Créixems, Marta, additional, Solis, Jorge, additional, Fernandez-Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg-Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Wang, Andrew, additional, Woods, Christopher W., additional, Cantey, Robert, additional, Steed, Lisa, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara-Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Peterson, Gail, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, and Cabell, Christopher H., additional
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- 2021
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10. Efficacy and tolerability of a nucleoside reserve transcriptase inhibitor-sparing combination of lopinavir/ritonavir and efavirenz in HIV-1-infected patients
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Allavena, Clotilde, Ferre, Virginie, Brunet-Francois, Cecile, Delfraissy, Jean-Francois, Michelet, Christian, Poizot-Martin, Isabelle, Dailly, Eric, Launay, Odile, Raffi, Francois, Lafeuillade, Alain, Valantin, Marc-Antoine, and Bentata, Michelle
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HIV patients -- Medical examination ,Reverse transcriptase inhibitors -- Research ,Antiviral agents -- Research ,Health - Abstract
Recommended antiretroviral regimens include a nucleoside reverse transcriptase inhibitor (NRTI) component and this class of antiretrovirals has problems such as class cross-resistance and mitochondrial toxicity. The lopinavir/ritonavir-efavirenz combination is associated with a high rate of virologic response and should be compared with more classic NRTI-containing regimens in randomized and controlled clinical trials.
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- 2005
11. Mitochondrial abnormalities in HIV-infected lipoatrophic patients treated with antiretroviral agents
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Chapplain, Jean-Marc, Michelet, Christian, Rochcongar, Pierre, Beillot, Jocelyne, Duvauferrier, Regis, Arvieux, Cedric, Begue, Jean-Marc, Hespel, Jean-Pierre, Tattevin, Pierre, Souala, Faouzi, Dupont, Mathieu, Boubier, Cecile, and Chapon, Francoise
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Mitochondrial diseases -- Diagnosis ,Mitochondrial diseases -- Care and treatment ,Nucleosides -- Research ,Highly active antiretroviral therapy -- Health aspects ,Health - Abstract
The relation between clinical lipoatrophy (LA) and mitochondrial abnormalities occurring in the muscle of HIV-infected patients on highly active antiretroviral therapy (HAART) is investigated. The investigation confirmed that LA in long-term nucleoside reverse transcriptase inhibitors treated patients was associated with muscular mitochondrial dysfunction as shown by rapid lactic academia increase and mitochondrial histoenzymatic abnormalities.
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- 2004
12. Introduction of SARS in France, March-April, 2003
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Desenclos, Jean-Claude, van der Werf, Sylvie, Bonmarin, Isabelle, Levy-Bruhl, Daniel, Yazdanpanah, Yazdan, Hoen, Bruno, Emmanuelli, Julien, Lesens, Olivier, Dupon, Michel, Natali, Francois, Michelet, Christian, Reynes, Jacques, Guery, Benoit, Larsen, Christine, Semaille, Caroline, Mouton, Yves, Christmann, Daniel, Andre, Michel, Escriou, Nicolas, Burguiere, Anna, Manuguerra, Jean-Claude, Coignard, Bruno, Lepoutre, Agnes, Meffre, Christine, Bitar, Dounia, Decludt, Benedicte, Capek, Isabelle, Antona, Denise, Che, Didier, Herida, Magid, Infuso, Andrea, Saura, Christine, Brucker, Gilles, Hubert, Bruno, LeGoff, Dominique, and Scheidegger, Suzanne
- Abstract
We describe severe acute respiratory syndrome (SARS) in France. Patients meeting the World Health Organization definition of a suspected case underwent a clinical, radiologic, and biologic assessment at the closest [...]
- Published
- 2004
13. Predictors of Long-Term Increase in [CD4.sup.+] Cell Counts in Human Immunodeficiency Virus-Infected Patients Receiving a Protease Inhibitor-Containing Antiretroviral Regimen
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Moing, Vincent Le, Thiebaut, Rodolphe, Chene, Genevieve, Leport, Catherine, Cailleton, Valerie, Michelet, Christian, Fleury, Herve, Herson, Serge, and Raffi, Francios
- Subjects
HIV infection -- Physiological aspects ,Health - Published
- 2002
14. Time to blood culture positivity: An independent predictor of infective endocarditis and mortality in patients with Staphylococcus aureus bacteraemia
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Siméon, S., primary, Le Moing, V., additional, Tubiana, S., additional, Duval, X., additional, Fournier, D., additional, Lavigne, J.-P., additional, Erpelding, M.-L., additional, Gustave, C.-A., additional, Desage, S., additional, Chirouze, C., additional, Vandenesch, F., additional, Tattevin, P., additional, Chirouze, Catherine, additional, Curlier, Elodie, additional, Descottes-Genon, Cécile, additional, Hoen, Bruno, additional, Patry, Isabelle, additional, Vettoretti, Lucie, additional, Chavanet, Pascal, additional, Eicher, Jean-Christophe, additional, Gohier-Treuvelot, Sandrine, additional, Greusard, Marie-Christine, additional, Neuwirth, Catherine, additional, Péchinot, André, additional, Piroth, Lionel, additional, Célard, Marie, additional, Cornu, Catherine, additional, Delahaye, François, additional, Hadid, Malika, additional, Rausch, Pascale, additional, Coma, Audrey, additional, Galtier, Florence, additional, Géraud, Philippe, additional, Jean-Pierre, Hélène, additional, Le Moing, Vincent, additional, Sportouch, Catherine, additional, Reynes, Jacques, additional, Aissa, Nejla, additional, Doco-Lecompte, Thanh, additional, Goehringer, François, additional, Keil, Nathalie, additional, Letranchant, Lorraine, additional, Malela, Hepher, additional, May, Thierry, additional, Selton-Suty, Christine, additional, Bedos, Nathalie, additional, Lavigne, Jean-Philippe, additional, Lechiche, Catherine, additional, Sotto, Albert, additional, Duval, Xavier, additional, Habensus, Emila Ilic, additional, Iung, Bernard, additional, Leport, Catherine, additional, Longuet, Pascale, additional, Ruimy, Raymond, additional, Bellissant, Eric, additional, Donnio, Pierre-Yves, additional, Le Gac, Fabienne, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Thebault, Elise, additional, Alla, François, additional, Braquet, Pierre, additional, Erpelding, Marie-Line, additional, Minary, Laetitia, additional, Tubiana, Sarah, additional, Bès, Michèle, additional, Etienne, Jérôme, additional, Lelekov-Boissard, Taissia, additional, Tristan, Anne, additional, Vandenesch, François, additional, Van Belkum, Alex, additional, Rivadeneira, Fernando, additional, Vanwamel, Willem, additional, Barbas, Sandrine, additional, Delonca, Christine, additional, Sussmuth, Virginie, additional, and Verchère, Anne, additional
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- 2019
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15. Lookback exercise with imported Crimean-Congo hemorrhagic fever, Senegal and France
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Tarantola, Arnaud, Nabeth, Pierre, Tattevin, Pierre, Michelet, Christian, and Zeller, Herve
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Diagnosis ,Research ,Health aspects ,Hemorrhagic fevers -- Research -- Diagnosis -- Health aspects ,French (European people) -- Research -- Health aspects ,Hemorrhagic fever -- Research -- Diagnosis -- Health aspects ,French -- Research -- Health aspects - Abstract
A patient with suspected malaria was hospitalized successively in 2 hospitals, first in Dakar, Senegal, then in Rennes, France, where tests diagnosed Crimean-Congo hemorrhagic fever. An international incident management group [...]
- Published
- 2006
16. Genotypic evolution of HIV-1 isolates from patients after a switch of therapy from zidovudine to didanosine
- Author
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Masquelier, Bernard, Pellegrin, Isabelle, Ruffault, Annick, Ragnaud, Jean-Marie, Morlat, Philippe, Michelet, Christian, Doignon, Francois, Biteau, Nicolas, and Fleury, Herve J.A.
- Subjects
HIV (Viruses) -- Genetic aspects ,Zidovudine -- Physiological aspects ,Didanosine -- Physiological aspects ,Drug resistance in microorganisms -- Genetic aspects ,Health - Abstract
The human immunodeficiency virus (HIV) apparently is able to mutate in multiple ways in response to the antiviral drugs zidovudine (AZT) and didanosine (ddI). Researchers studied the genetic makeup of HIV isolates from 11 patients who switched from AZT to ddI because of increasing resistance to AZT. Mutations in the reverse transcriptase (RT) gene associated with AZT resistance were noted to disappear during ddI therapy, from 24 to 72 weeks. The disappearance of these mutations was slower in patients who had received prolonged AZT therapy than in those who had been treated for a shorter period of time. Switching to ddI, however, did not prove beneficial in most cases. Nine patients progressed to AIDS-related complex or AIDS during ddI therapy. Combination drug therapy may be more effective than single-drug therapy with regard to changing patterns of drug resistance.
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- 1995
17. Les fièvres hémorragiques virales
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Tattevin, Pierre, Lagathu, Gisèle, Revest, Matthieu, Michelet, Christian, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Thérapeutiques cliniques et expérimentales des infections (EA 3826) (EA 3826), Université de Nantes - UFR de Médecine et des Techniques Médicales (UFR MEDECINE), Université de Nantes (UN)-Université de Nantes (UN), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), and Jonchère, Laurent
- Subjects
fièvre de Marburg ,[SDV.MHEP.ME] Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,[SDV.MHEP.ME]Life Sciences [q-bio]/Human health and pathology/Emerging diseases ,Marburg fever ,fièvre de la Vallée du Rift ,Fièvre de Lassa ,fièvre hémorragique Crimée-Congo ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Ebola ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Crimean-Congo haemorragic fever ,Rift valley fever ,ComputingMilieux_MISCELLANEOUS ,Lassa fever - Abstract
National audience
- Published
- 2016
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18. Ruptures d'approvisionnement en médicaments anti-infectieux: causes et conséquences [Shortages in anti-infective medicines: causes and consequences]
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Luans, Caroline, Cardiet, Isabelle, Rogé, Pauline, Baslé, Béatrice, Le Corre, Pascal, Revest, Matthieu, Michelet, Christian, Tattevin, Pierre, Service de pharmacie, CHU Pontchaillou [Rennes], COMEDIMS, Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), and Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
- Subjects
antibacterial ,anti-infectieux ,vaccins ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,vaccine ,Rupture d’approvisionnement ,drug shortages ,antibiotiques ,anti-infective - Abstract
International audience; Anti-infective drugs stock-outs are increasingly frequent, and this is unlikely to change. There are numerous causes for this, mostly related to parameters difficult to control: i) 60 to 80% of raw material or components are produced outside of Europe (compared to 20% 30 years ago), with subsequent loss of independence for their procurement; ii) the economic crisis drives the pharmaceutical companies to stop producing drugs of limited profitability (even among important drugs); iii) the enforcement of regulatory requirements and quality control procedures result in an increasing number of drugs being blocked during production. The therapeutic class most affected by drug stock-outs is that of anti-infective drugs, especially injectable ones, and many therapeutic dead ends have recently occurred. We provide an update on this issue, and suggest 2 major actions for improvement: i) to implement a group dedicated to anticipating drug stock-outs within the anti-infective committee in each health care center, with the objectives of organizing and coordinating the response whenever a drug stock-out is deemed at risk (i.e., contingency plans, substitution, communication to prescribers); ii) a national reflection lead by scientific societies, in collaboration with government agencies, upstream of the most problematic drug stock-outs, to elaborate and disseminate consensus guidelines for the management of these stock-outs.
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- 2014
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19. Intérêt diagnostic des TEP-TDM en infectiologie [Contribution of 18fluoro-deoxyglucose PET/CT for the diagnosis of infectious diseases.]
- Author
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Revest, Matthieu, Patrat-Delon, Solène, Devillers, Anne, Tattevin, Pierre, Michelet, Christian, Centre d'Investigation Clinique [Rennes] (CIC), Université de Rennes (UR)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Département de médecine nucléaire [Rennes], CRLCC Eugène Marquis (CRLCC), Fonction, structure et inactivation d'ARN bactériens, Université de Rennes (UR)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-Institut National de la Santé et de la Recherche Médicale (INSERM), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), and Lecoupe-Grainville, Marie
- Subjects
Fever of unknown origin ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,[SDV.MHEP.MI] Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,(18)FDG-PET/CT ,Osteomyelitis ,Infective endocarditis ,Vascular prosthesis infection - Abstract
International audience; The diagnosis of some infectious diseases is sometimes difficult to make and new diagnostic tools have been regularly assessed to that end. 18fluoro-deoxyglucose ((18)FDG) positron-emission tomography (PET) coupled with computed tomography (CT) is one of these new procedures. It has been evaluated for numerous infectious diseases with uneven results. A literature review allowed drawing some conclusions. First, (18)FDG-PET/CT is not currently a first-line procedure for infectious diseases. Second, it has proved useful for the evaluation of patients presenting with fever of unknown origin (FUO). Its negative predictive value is 100%: the symptoms of patients experiencing FUO with negative first-line investigations and a negative (18)FDG-PET/CT will almost always spontaneously disappear. Third, (18)FDG-PET/CT also seems to be contributive for the diagnosis of vascular prosthesis infections or osteomyelitis. Fourth, it has promising results for patients presenting with infective endocarditis, especially for secondary infectious foci, or for patients presenting with suspected infection of pacemakers or implanted defibrillator; but results are still preliminary and must be confirmed. Finally(18)FDG-PET/CT cannot be recommended yet for other infectious diseases due to lack of published data.
- Published
- 2014
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20. Factors associated with 12 week case-fatality in Staphylococcus aureus bacteraemia: a prospective cohort study
- Author
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Braquet, P., primary, Alla, F., additional, Cornu, C., additional, Goehringer, F., additional, Piroth, L., additional, Chirouze, C., additional, Revest, M., additional, Lechiche, C., additional, Duval, X., additional, Le Moing, V., additional, Chirouze, Catherine, additional, Curlier, Elodie, additional, Descottes-Genon, Cécile, additional, Hoen, Bruno, additional, Patry, Isabelle, additional, Vettoretti, Lucie, additional, Chavanet, Pascal, additional, Eicher, Jean-Christophe, additional, Greusard, Marie-Christine, additional, Neuwirth, Catherine, additional, Péchinot, André, additional, Piroth, Lionel, additional, Célard, Marie, additional, Cornu, Catherine, additional, Delahaye, François, additional, Hadid, Malika, additional, Rausch, Pascale, additional, Coma, Audrey, additional, Galtier, Florence, additional, Géraud, Philippe, additional, Jean-Pierre, Hélène, additional, Le Moing, Vincent, additional, Sportouch, Catherine, additional, Reynes, Jacques, additional, Aissa, Nejla, additional, Doco-Lecompte, Thanh, additional, Goehringer, François, additional, Keil, Nathalie, additional, Letranchant, Lorraine, additional, Malela, Hepher, additional, May, Thierry, additional, Selton-Suty, Christine, additional, Bedos, Nathalie, additional, Lavigne, Jean-Philippe, additional, Lechiche, Catherine, additional, Sotto, Albert, additional, Duval, Xavier, additional, Habensus, Emila Ilic, additional, Iung, Bernard, additional, Leport, Catherine, additional, Longuet, Pascale, additional, Ruimy, Raymond, additional, Bellissant, Eric, additional, Donnio, Pierre-Yves, additional, Le Gac, Fabienne, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Tattevin, Pierre, additional, Thebault, Elise, additional, Alla, François, additional, Braquet, Pierre, additional, Erpelding, Marie-Line, additional, Minary, Laetitia, additional, Bès, Michèle, additional, Etienne, Jérôme, additional, Tristan, Anne, additional, Vandenesch, François, additional, Van Belkum, Alex, additional, and Vanwamel, Willem, additional
- Published
- 2016
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- View/download PDF
21. Validated Risk Score for Predicting 6‐Month Mortality in Infective Endocarditis
- Author
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Park, Lawrence P., primary, Chu, Vivian H., additional, Peterson, Gail, additional, Skoutelis, Athanasios, additional, Lejko‐Zupa, Tatjana, additional, Bouza, Emilio, additional, Tattevin, Pierre, additional, Habib, Gilbert, additional, Tan, Ren, additional, Gonzalez, Javier, additional, Altclas, Javier, additional, Edathodu, Jameela, additional, Fortes, Claudio Querido, additional, Siciliano, Rinaldo Focaccia, additional, Pachirat, Orathai, additional, Kanj, Souha, additional, Wang, Andrew, additional, Clara, Liliana, additional, Sanchez, Marisa, additional, Casabé, José, additional, Cortes, Claudia, additional, Nacinovich, Francisco, additional, Fernandez Oses, Pablo, additional, Ronderos, Ricardo, additional, Sucari, Adriana, additional, Thierer, Jorge, additional, Kogan, Silvia, additional, Spelman, Denis, additional, Athan, Eugene, additional, Harris, Owen, additional, Kennedy, Karina, additional, Gordon, David, additional, Papanicolas, Lito, additional, Korman, Tony, additional, Kotsanas, Despina, additional, Dever, Robyn, additional, Jones, Phillip, additional, Konecny, Pam, additional, Lawrence, Richard, additional, Rees, David, additional, Ryan, Suzanne, additional, Feneley, Michael P., additional, Harkness, John, additional, Post, Jeffrey, additional, Reinbott, Porl, additional, Gattringer, Rainer, additional, Wiesbauer, Franz, additional, Andrade, Adriana Ribas, additional, de Brito, Ana Cláudia Passos, additional, Guimarães, Armenio Costa, additional, Grinberg, Max, additional, Mansur, Alfredo José, additional, Strabelli, Tania Mara Varejao, additional, Vieira, Marcelo Luiz Campos, additional, de Medeiros Tranchesi, Regina Aparecida, additional, Paiva, Marcelo Goulart, additional, de Oliveira Ramos, Auristela, additional, Weksler, Clara, additional, Ferraiuoli, Giovanna, additional, Golebiovski, Wilma, additional, Lamas, Cristiane, additional, Karlowsky, James A., additional, Keynan, Yoav, additional, Morris, Andrew M., additional, Rubinstein, Ethan, additional, Jones, Sandra Braun, additional, Garcia, Patricia, additional, Fica, Alberto, additional, Mella, Rodrigo Montagna, additional, Fernandez, Ricardo, additional, Franco, Liliana, additional, Jaramillo, Astrid Natalia, additional, Barsic, Bruno, additional, Bukovski, Suzana, additional, Krajinovic, Vladimir, additional, Pangercic, Ana, additional, Rudez, Igor, additional, Vincelj, Josip, additional, Freiberger, Tomas, additional, Pol, Jiri, additional, Zaloudikova, Barbora, additional, Ashour, Zainab, additional, El Kholy, Amani, additional, Mishaal, Marwa, additional, Osama, Dina, additional, Rizk, Hussien, additional, Aissa, Neijla, additional, Alauzet, Corentine, additional, Alla, Francois, additional, Campagnac, Catherine, additional, Doco‐Lecompte, Thanh, additional, Selton‐Suty, Christine, additional, Casalta, Jean‐Paul, additional, Fournier, Pierre‐Edouard, additional, Raoult, Didier, additional, Thuny, Franck, additional, Delahaye, Francois, additional, Delahaye, Armelle, additional, Vandenesch, Francois, additional, Donal, Erwan, additional, Donnio, Pierre Yves, additional, Flecher, Erwan, additional, Michelet, Christian, additional, Revest, Matthieu, additional, Chevalier, Florent, additional, Jeu, Antoine, additional, Rémadi, Jean Paul, additional, Rusinaru, Dan, additional, Tribouilloy, Christophe, additional, Bernard, Yvette, additional, Chirouze, Catherine, additional, Hoen, Bruno, additional, Leroy, Joel, additional, Plesiat, Patrick, additional, Naber, Christoph, additional, Neuerburg, Carl, additional, Mazaheri, Bahram, additional, Athanasia, Sophia, additional, Deliolanis, Ioannis, additional, Giamarellou, Helen, additional, Thomas, Tsaganos, additional, Giannitsioti, Efthymia, additional, Mylona, Elena, additional, Paniara, Olga, additional, Papanicolaou, Konstantinos, additional, Pyros, John, additional, Papanikolaou, Konstantinos, additional, Sharma, Gautam, additional, Francis, Johnson, additional, Nair, Lathi, additional, Thomas, Vinod, additional, Venugopal, Krishnan, additional, Hannan, Margaret M., additional, Hurley, John P., additional, Cahan, Amos, additional, Gilon, Dan, additional, Israel, Sarah, additional, Korem, Maya, additional, Strahilevitz, Jacob, additional, Durante‐Mangoni, Emanuele, additional, Mattucci, Irene, additional, Pinto, Daniela, additional, Agrusta, Federica, additional, Senese, Alessandra, additional, Ragone, Enrico, additional, Utili, Riccardo, additional, Cecchi, Enrico, additional, De Rosa, Francesco, additional, Forno, Davide, additional, Imazio, Massimo, additional, Trinchero, Rita, additional, Grossi, Paolo, additional, Lattanzio, Mariangela, additional, Toniolo, Antonio, additional, Goglio, Antonio, additional, Raglio, Annibale, additional, Ravasio, Veronica, additional, Rizzi, Marco, additional, Suter, Fredy, additional, Carosi, Giampiero, additional, Magri, Silvia, additional, Signorini, Liana, additional, Kanafani, Zeina, additional, Kanj, Souha S., additional, Sharif‐Yakan, Ahmad, additional, Abidin, Imran, additional, Tamin, Syahidah Syed, additional, Martínez, Eduardo Rivera, additional, Soto Nieto, Gabriel Israel, additional, van der Meer, Jan T.M., additional, Chambers, Stephen, additional, Holland, David, additional, Morris, Arthur, additional, Raymond, Nigel, additional, Read, Kerry, additional, Murdoch, David R., additional, Dragulescu, Stefan, additional, Ionac, Adina, additional, Mornos, Cristian, additional, Butkevich, O.M., additional, Chipigina, Natalia, additional, Kirill, Ozerecky, additional, Vadim, Kulichenko, additional, Vinogradova, Tatiana, additional, Halim, Magid, additional, Liew, Yee‐Yun, additional, Tan, Ru‐San, additional, Logar, Mateja, additional, Mueller‐Premru, Manica, additional, Commerford, Patrick, additional, Commerford, Anita, additional, Deetlefs, Eduan, additional, Hansa, Cass, additional, Ntsekhe, Mpiko, additional, Almela, Manuel, additional, Armero, Yolanda, additional, Azqueta, Manuel, additional, Castañeda, Ximena, additional, Cervera, Carlos, additional, Falces, Carlos, additional, Garcia‐de‐la‐Maria, Cristina, additional, Fita, Guillermina, additional, Gatell, Jose M., additional, Heras, Magda, additional, Llopis, Jaime, additional, Marco, Francesc, additional, Mestres, Carlos A., additional, Miró, José M., additional, Moreno, Asuncion, additional, Ninot, Salvador, additional, Paré, Carlos, additional, Pericas, Juan M., additional, Ramirez, Jose, additional, Rovira, Irene, additional, Sitges, Marta, additional, Anguera, Ignasi, additional, Font, Bernat, additional, Guma, Joan Raimon, additional, Bermejo, Javier, additional, Garcia Fernández, Miguel Angel, additional, Gonzalez‐Ramallo, Victor, additional, Marín, Mercedes, additional, Muñoz, Patricia, additional, Pedromingo, Miguel, additional, Roda, Jorge, additional, Rodríguez‐Créixems, Marta, additional, Solis, Jorge, additional, Almirante, Benito, additional, Fernandez‐Hidalgo, Nuria, additional, Tornos, Pilar, additional, de Alarcón, Arístides, additional, Parra, Ricardo, additional, Alestig, Eric, additional, Johansson, Magnus, additional, Olaison, Lars, additional, Snygg‐Martin, Ulrika, additional, Pachirat, Pimchitra, additional, Pussadhamma, Burabha, additional, Senthong, Vichai, additional, Casey, Anna, additional, Elliott, Tom, additional, Lambert, Peter, additional, Watkin, Richard, additional, Eyton, Christina, additional, Klein, John L., additional, Bradley, Suzanne, additional, Kauffman, Carol, additional, Bedimo, Roger, additional, Corey, G. Ralph, additional, Crowley, Anna Lisa, additional, Douglas, Pamela, additional, Drew, Laura, additional, Fowler, Vance G., additional, Holland, Thomas, additional, Lalani, Tahaniyat, additional, Mudrick, Daniel, additional, Samad, Zaniab, additional, Sexton, Daniel, additional, Stryjewski, Martin, additional, Woods, Christopher W., additional, Lerakis, Stamatios, additional, Cantey, Robert, additional, Steed, Lisa, additional, Wray, Dannah, additional, Dickerman, Stuart A., additional, Bonilla, Hector, additional, DiPersio, Joseph, additional, Salstrom, Sara‐Jane, additional, Baddley, John, additional, Patel, Mukesh, additional, Stancoven, Amy, additional, Levine, Donald, additional, Riddle, Jonathan, additional, Rybak, Michael, additional, Cabell, Christopher H., additional, Baloch, Khaula, additional, Dixon, Christy C., additional, Harding, Tina, additional, Jones‐Richmond, Marian, additional, Sanderford, Bob, additional, Stafford, Judy, additional, Anstrom, Kevin, additional, Bayer, Arnold S., additional, Karchmer, A. W., additional, Sexton, Daniel J., additional, Chu, Vivian, additional, Durack, David T., additional, Eykyn, Susannah, additional, and Moreillon, Phillipe, additional
- Published
- 2016
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22. Encephalitis due to Mycobacterium tuberculosis in France. [Encéphalites tuberculeuses en France]
- Author
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Honnorat, E., De Broucker, Thomas, Mailles, A., Stahl, J. P., Michelet, Christian, Department of Infectious Diseases, CHU Grenoble, Institut de recherche en santé, environnement et travail (Irset), Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )-Institut National de la Santé et de la Recherche Médicale (INSERM)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Université d'Angers (UA), le comité de pilotage et groupe des investigateurs, and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
- Subjects
Encéphalite ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,Tuberculose - Abstract
International audience; PURPOSE: Two hundred and fifty-three patients were included in a study on the etiology of encephalitis, carried out in France in 2007. Tuberculosis was the second most frequently identified cause, after HSV and with the same number of cases as VZV. The authors report the specific features of patients presenting with tuberculosis encephalitis (TE). METHODS: TE patients were defined as patients presenting with encephalitis, with positive culture or PCR for Mycobacterium tuberculosis, or the association of clinical, biological, imaging, and epidemiological evidence (possible cases). Clinical, microbiological, and brain imaging data was analyzed and compared to that of other included patients. RESULTS: Twenty cases of TE were identified. The M/F sex-ratio was 1.5, the mean age 53 years. Four (20%) patients had a history of tuberculosis before the encephalitis. The median delay between the onset of general and neurological symptoms was significantly longer for tuberculosis cases than for others (10 days vs. 2; P
- Published
- 2013
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23. Prevalence of HIV-1 drug resistance in treated patients with viral load >50 copies/mL in 2009: a French nationwide study
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Assoumou, Lambert, Descamps, Diane, Yerly, Sabine, dos Santos, Georges, Marcelin, Anne-Geneviève, Delaugerre, Constance, Morand-Joubert, Laurence, Ruffault, Annick, Izopet, Jacques, Plantier, Jean-Christophe, Pakianather, Sophie, Montes, Brigitte, Chaix, Marie-Laure, Wirden, Marc, Costagliola, Dominique, Masquelier, Bernard, Michelet, Christian, Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Centre d'Etudes Lasers Intenses et Applications ( CELIA ), Université de Bordeaux ( UB ) -Commissariat à l'énergie atomique et aux énergies alternatives ( CEA ) -Centre National de la Recherche Scientifique ( CNRS ), Núcleo de Bioinformática Estrutural ( NBI ), Embrapa Informática Agropecuária, Service de virologie, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Pitié-Salpêtrière [APHP], Service de microbiologie [Saint-Louis], Assistance publique - Hôpitaux de Paris (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris]-Université Paris Diderot - Paris 7 ( UPD7 ), Service de bactériologie-virologie, Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Saint-Antoine [APHP], Unité de Rétrovirologie, Hôpital Pontchaillou, Laboratoire de virologie [Rouen], Hôpital Charles Nicolle [Rouen]-CHU Rouen-Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Département de microbiologie : Bactério, Virologie, Parasito, Hygiène, Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Epidémiologie Clinique et Traitement de l'Infection à VIH, Université Pierre et Marie Curie - Paris 6 ( UPMC ) -IFR113-Institut National de la Santé et de la Recherche Médicale ( INSERM ), Microbiologie cellulaire et moléculaire et pathogénicité ( MCMP ), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique ( CNRS ), Service de virologie et d'immunologie biologique, CHU Bordeaux [Bordeaux]-Groupe hospitalier Pellegrin, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Geneva University Hospital (HUG), Génétique et Ecologie des Virus, Génétique des Virus et Pathogénèse des Maladies Virales, Université Paris Diderot - Paris 7 (UPD7)-Institut National de la Santé et de la Recherche Médicale (INSERM), CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), Laboratoire Virologie [CHU Toulouse], Institut Fédératif de Biologie (IFB), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Centre Hospitalier Universitaire de Toulouse (CHU Toulouse)-Pôle Biologie [CHU Toulouse], Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Faculté de Médecine Purpan, Hôpital Charles Nicolle [Rouen], CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-CHU Rouen, Normandie Université (NU)-Normandie Université (NU)-Université de Rouen Normandie (UNIROUEN), Normandie Université (NU), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Université Paris Descartes - Paris 5 (UPD5), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), ANRS AC11 Resistance Group, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Saint-Antoine [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU)-Sorbonne Université (SU), Laboratoire de Virologie [Purpan], CHU Toulouse [Toulouse]-Institut Fédératif de Biologie (IFB) - Hôpital Purpan, Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse]-CHU Toulouse [Toulouse]-Hôpital Purpan [Toulouse], CHU Toulouse [Toulouse], Université de Rouen Normandie (UNIROUEN), Normandie Université (NU)-Normandie Université (NU)-Département de microbiologie : Bactério, Virologie, Parasito, Hygiène-Hôpital Charles Nicolle [Rouen]-CHU Rouen, Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), Centre d'Etudes Lasers Intenses et Applications (CELIA), Centre National de la Recherche Scientifique (CNRS)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Université de Bordeaux (UB), Núcleo de Bioinformática Estrutural (NBI), Service de virologie [CHU Pitié-Salpêtrière], Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Pitié-Salpêtrière [APHP], Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-Assistance publique - Hôpitaux de Paris (AP-HP) (APHP), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Saint-Antoine [APHP], Hôpital Charles Nicolle [Rouen]-CHU Rouen, Normandie Université (NU)-Département de microbiologie : Bactério, Virologie, Parasito, Hygiène, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], Université Pierre et Marie Curie - Paris 6 (UPMC)-IFR113-Institut National de la Santé et de la Recherche Médicale (INSERM), Microbiologie cellulaire et moléculaire et pathogénicité (MCMP), Université Bordeaux Segalen - Bordeaux 2-Centre National de la Recherche Scientifique (CNRS), Université de Bordeaux (UB)-Commissariat à l'énergie atomique et aux énergies alternatives (CEA)-Centre National de la Recherche Scientifique (CNRS), CHU Pitié-Salpêtrière [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Microbiologie Fondamentale et Pathogénicité (MFP), Université Pierre et Marie Curie - Paris 6 (UPMC)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Pitié-Salpêtrière [AP-HP], Sorbonne Université (SU)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Sorbonne Université (SU), CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Laboratoire de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Université Paris Diderot - Paris 7 ( UPD7 ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ), Université de Rouen Normandie ( UNIROUEN ), Normandie Université ( NU ) -Normandie Université ( NU ) -Département de microbiologie : Bactério, Virologie, Parasito, Hygiène-Hôpital Charles Nicolle [Rouen]-CHU Rouen, Université Paris Descartes - Paris 5 ( UPD5 ), Institut de recherche, santé, environnement et travail ( Irset ), Université d'Angers ( UA ) -Université de Rennes 1 ( UR1 ), Université de Rennes ( UNIV-RENNES ) -Université de Rennes ( UNIV-RENNES ) -École des Hautes Études en Santé Publique [EHESP] ( EHESP ) -Institut National de la Santé et de la Recherche Médicale ( INSERM ) -Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ) -Université des Antilles ( UA ), Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], and Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Paris Diderot - Paris 7 (UPD7)
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Male ,Prevalence ,Integrase inhibitor ,HIV Infections ,Drug resistance ,France/epidemiology ,0302 clinical medicine ,[ SDV.MP ] Life Sciences [q-bio]/Microbiology and Parasitology ,Antiretroviral Therapy, Highly Active ,Pharmacology (medical) ,030212 general & internal medicine ,Treatment Failure ,ComputingMilieux_MISCELLANEOUS ,ddc:616 ,0303 health sciences ,virological failure ,Data Collection ,Proteolytic enzymes ,HIV Infections/epidemiology/virology ,HIV-1/drug effects/genetics ,Middle Aged ,Viral Load ,3. Good health ,Infectious Diseases ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,RNA, Viral ,Female ,epidemiology ,France ,Viral load ,Microbiology (medical) ,Genotype ,Anti-HIV Agents ,antiretroviral therapy ,Biology ,03 medical and health sciences ,multidrug resistance ,Drug Resistance, Viral ,Humans ,Amino Acid Sequence ,RNA, Viral/blood ,Genotyping ,Aged ,Pharmacology ,030306 microbiology ,plasma HIV RNA ,Virology ,Health Surveys ,Reverse transcriptase ,Multiple drug resistance ,Anti-HIV Agents/therapeutic use ,HIV-1 ,HIV-1 drug resistance - Abstract
International audience; BACKGROUND: Surveillance of HIV-1 drug resistance in treated patients with plasma viral load (VL) >50 copies/mL. METHODS: The protease and reverse transcriptase (RT) genes were systematically sequenced in samples from 756 patients with VL >50 copies/mL in 2009. The genotyping results were interpreted for each antiretroviral drug (ARV) by using the ANRS algorithm v21. Weighted analyses were used to derive representative estimates of percentages of patients. Prevalence rates were compared with those obtained in 2004 among patients with VL >1000 copies/mL. RESULTS: Sequences were obtained for 506 patients. Sequencing was successful in 45%, 80% and 96% of samples with VL of 51-500, 501-1000 and >1000 copies/mL, respectively. Resistance or possible resistance to at least one ARV was observed in 59% of samples. Overall, 0.9% of samples contained viruses resistant to all drugs belonging to at least three drug classes. All resistance prevalence rates were significantly lower in 2009 than in 2004. CONCLUSION: In France, where 86% of patients were receiving combination antiretroviral therapy in 2009, only 15.0% of patients had a VL >50 copies/mL, suggesting that only 8.9% of treated patients could potentially transmit resistant viruses. Only 0.08% of patients harboured viruses fully resistant to at least three antiretroviral drug classes. Further studies are needed to determine whether resistance continues to decline over time.
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- 2013
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24. Influence of the timing of cardiac surgery on the outcome of patients with infective endocarditis and stroke
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Barsic, Bruno, Dickerman, Stuart, Krajinovic, Vladimir, Pappas, Paul, Altclas, Javier, Carosi, Giampiero, Casabé, José H., Chu, Vivian H., Delahaye, Francois, Edathodu, Jameela, Fortes, Claudio Querido, Olaison, Lars, Pangercic, Ana, Patel, Mukesh, Rudez, Igor, Tamin, Syahidah Syed, Vincelj, Josip, Bayer, Arnold S., Wang, Andrew, Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Kogan, Silvia, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Harkness, John, Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, De Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, De Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, De Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Bukovski, Suzana, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan, Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Germa Christoph, Neuerburg, Carl, Mazaheri, Bahram, Naber, Christoph, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, D. M. Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Cahan, Amos, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, Rosa, Francesco De, Forno, Davide, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, Van Der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Holland, David, Morris, Arthur, Raymond, Nigel, Read, Kerry, Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Vinogradova, Tatiana, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Del Rio, Ana, Falces, Carlos, Garcia De La Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Bouza, Emilio, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Almirante, Benito, Fernandez Hidalgo, Nuria, Tornos, Pilar, De Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Corey, G. Ralph, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Lalani, Tahaniyat, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Woods, Christopher W., Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Wray, Dannah, Dickerman, Stuart A., Bonilla, Hector, Di Persio, Joseph, Salstrom, Sara Jane, Baddley, John, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Services de Pneumologie, Exploration Fonctionnelle Respiratoire et Cardiologie (Hôpital Louis Pradel), Hospices Civils de Lyon (HCL), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), International Collaboration on Endocarditis-Prospective Cohort Study (ICE-PCS) Investigators, Université d'Angers (UA)-Université de Rennes 1 (UR1), and Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
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Male ,MESH: Endocarditis ,Time Factors ,Medizin ,030204 cardiovascular system & hematology ,endocarditis ,valve replacement ,surgery ,Cohort Studies ,0302 clinical medicine ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,030212 general & internal medicine ,Hospital Mortality ,MESH: Inpatients ,Stroke ,MESH: Cohort Studies ,MESH: Aged ,MESH: Middle Aged ,MESH: Cardiac Surgical Procedures ,Endocarditis ,Mortality rate ,Hazard ratio ,Middle Aged ,stroke ,3. Good health ,Cardiac surgery ,Infectious Diseases ,Infective endocarditis ,Female ,Cohort study ,Adult ,Microbiology (medical) ,medicine.medical_specialty ,MESH: Stroke ,03 medical and health sciences ,medicine ,Humans ,MESH: Hospital Mortality ,Cardiac Surgical Procedures ,Aged ,Inpatients ,MESH: Humans ,Proportional hazards model ,business.industry ,MESH: Time Factors ,MESH: Adult ,Odds ratio ,medicine.disease ,MESH: Male ,Surgery ,business ,MESH: Female - Abstract
International audience; BACKGROUND: The timing of cardiac surgery after stroke in infective endocarditis (IE) remains controversial. We examined the relationship between the timing of surgery after stroke and the incidence of in-hospital and 1-year mortalities. METHODS: Data were obtained from the International Collaboration on Endocarditis-Prospective Cohort Study of 4794 patients with definite IE who were admitted to 64 centers from June 2000 through December 2006. Multivariate logistic regression and Cox regression analyses were performed to estimate the impact of early surgery on hospital and 1-year mortality after adjustments for other significant covariates. RESULTS: Of the 857 patients with IE complicated by ischemic stroke syndromes, 198 who underwent valve replacement surgery poststroke were available for analysis. Overall, 58 (29.3%) patients underwent early surgical treatment vs 140 (70.7%) patients who underwent late surgical treatment. After adjustment for other risk factors, early surgery was not significantly associated with increased in-hospital mortality rates (odds ratio, 2.308; 95% confidence interval [CI], .942-5.652). Overall, probability of death after 1-year follow-up did not differ between 2 treatment groups (27.1% in early surgery and 19.2% in late surgery group, P = .328; adjusted hazard ratio, 1.138; 95% CI, .802-1.650). CONCLUSIONS: There is no apparent survival benefit in delaying surgery when indicated in IE patients after ischemic stroke. Further observational analyses that include detailed pre- and postoperative clinical neurologic findings and advanced imaging data (eg, ischemic stroke size), may allow for more refined recommendations on the optimal timing of valvular surgery in patients with IE and recent stroke syndromes.
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25. HACEK Infective Endocarditis: Characteristics and Outcomes from a Large, Multi-National Cohort
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Chambers, Stephen T, Murdoch, David, Morris, Arthur, Holland, David, Pappas, Paul, Almela, Manel, Fernández Hidalgo, Nuria, Almirante, Benito, Bouza, Emilio, Forno, Davide, Rio, Ana del, Hannan, Margaret M., Harkness, John, Kanafani, Zeina A., Lalani, Tahaniyat, Lang, Selwyn, Raymond, Nigel, Read, Kerry, Vinogradova, Tatiana, Woods, Christopher W., Wray, Dannah, Corey, G. Ralph, Chu, Vivian H., Clara, Liliana, Sanchez, Marisa, Nacinovich, Francisco, Oses, Pablo Fernandez, Ronderos, Ricardo, Sucari, Adriana, Thierer, Jorge, Casabé, José, Cortes, Claudia, Altclas, Javier, Silvia Kogan, Sanatorio, Spelman, Denis, Athan, Eugene, Harris, Owen, Kennedy, Karina, Tan, Ren, Gordon, David, Papanicolas, Lito, Eisen, Damon, Grigg, Leeanne, Street, Alan, Korman, Tony, Kotsanas, Despina, Dever, Robyn, Jones, Phillip, Konecny, Pam, Lawrence, Richard, Rees, David, Ryan, Suzanne, Feneley, Michael P., Post, Jeffrey, Reinbott, Porl, Gattringer, Rainer, Wiesbauer, Franz, Andrade, Adriana Ribas, de Brito, Ana Cláudia Passos, Guimarães, Armenio Costa, Grinberg, Max, Mansur, Alfredo José, Siciliano, Rinaldo Focaccia, Strabelli, Tania Mara Varejao, Vieira, Marcelo Luiz Campos, de Medeiros Tranchesi, Regina Aparecida, Paiva, Marcelo Goulart, Fortes, Claudio Querido, de Oliveira Ramos, Auristela, Ferraiuoli, Giovanna, Golebiovski, Wilma, Lamas, Cristiane, Santos, Marisa, Weksler, Clara, Karlowsky, James A., Keynan, Yoav, Morris, Andrew M., Rubinstein, Ethan, Jones, Sandra Braun, Garcia, Patricia, Cereceda, M., Fica, Alberto, Mella, Rodrigo Montagna, Barsic, Bruno, Bukovski, Suzana, Krajinovic, Vladimir, Pangercic, Ana, Rudez, Igor, Vincelj, Josip, Freiberger, Tomas, Pol, Jiri, Zaloudikova, Barbora, Ashour, Zainab, Kholy, Amani El, Mishaal, Marwa, Rizk, Hussien, Aissa, Neijla, Alauzet, Corentine, Alla, Francois, Campagnac, Catherine, Doco Lecompte, Thanh, Selton Suty, Christine, Casalta, Jean Paul, Fournier, Pierre Edouard, Habib, Gilbert, Raoult, Didier, Thuny, Franck, Delahaye, Francois, Delahaye, Armelle, Vandenesch, Francois, Donal, Erwan, Donnio, Pierre Yves, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Violette, Jérémie, Chevalier, Florent, Jeu, Antoine, Rusinaru, Dan M. D., Sorel, Claire, Tribouilloy, Christophe, Bernard, Yvette, Chirouze, Catherine, Hoen, Bruno, Leroy, Joel, Plesiat, Patrick, Naber, Christoph, Neuerburg, Carl, Mazaheri, Bahram, Athanasia, Sofia, Giannitsioti, Efthymia, Mylona, Elena, Paniara, Olga, Papanicolaou, Konstantinos, Pyros, John, Skoutelis, Athanasios, Sharma, Gautam, Francis, Johnson, Nair, Lathi, Thomas, Vinod, Venugopal, Krishnan, Hannan, Margaret, Hurley, John, Gilon, Dan, Israel, Sarah, Korem, Maya, Strahilevitz, Jacob, Tripodi, Marie Françoise, Casillo, Roberta, Cuccurullo, Susanna, Dialetto, Giovanni, Durante Mangoni, Emanuele, Irene, Mattucci, Ragone, Enrico, Utili, Riccardo, Cecchi, Enrico, De Rosa, Francesco, Imazio, Massimo, Trinchero, Rita, Tebini, Alessandro, Grossi, PAOLO ANTONIO, Lattanzio, Mariangela, Toniolo, Antonio, Goglio, Antonio, Raglio, Annibale, Ravasio, Veronica, Rizzi, Marco, Suter, Fredy, Carosi, Giampiero, Magri, Silvia, Signorini, Liana, Baban, Tania, Kanafani, Zeina, Kanj, Souha S., Sfeir, Jad, Yasmine, Mohamad, Abidin, Imran, Tamin, Syahidah Syed, Martínez, Eduardo Rivera, Nieto, Gabriel Israel Soto, van der Meer, Jan T. M., Chambers, Stephen, Murdoch, David R., Dragulescu, Stefan, Ionac, Adina, Mornos, Cristian, Butkevich, O. M., Chipigina, Natalia, Kirill, Ozerecky, Vadim, Kulichenko, Edathodu, Jameela, Halim, Magid, Lum, Luh Nah, Tan, Ru San, Lejko Zupanc, Tatjana, Logar, Mateja, Mueller Premru, Manica, Commerford, Patrick, Commerford, Anita, Deetlefs, Eduan, Hansa, Cass, Ntsekhe, Mpiko, Almela, Manuel, Armero, Yolanda, Azqueta, Manuel, Castañeda, Ximena, Cervera, Carlos, Falces, Carlos, Garcia de la Maria, Cristina, Fita, Guillermina, Gatell, Jose M., Marco, Francesc, Mestres, Carlos A., Miró, José M., Moreno, Asuncion, Ninot, Salvador, Paré, Carlos, Pericas, Joan, Ramirez, Jose, Rovira, Irene, Sitges, Marta, Anguera, Ignasi, Font, Bernat, Guma, Joan Raimon, Bermejo, Javier, Fernández, Miguel Angel Garcia, Gonzalez Ramallo, Victor, Marín, Mercedes, Muñoz, Patricia, Pedromingo, Miguel, Roda, Jorge, Rodríguez Créixems, Marta, Solis, Jorge, Fernandez Hidalgo, Nuria, Tornos, Pilar, de Alarcón, Arístides, Parra, Ricardo, Alestig, Eric, Johansson, Magnus, Olaison, Lars, Snygg Martin, Ulrika, Pachirat, Orathai, Pachirat, Pimchitra, Pussadhamma, Burabha, Senthong, Vichai, Casey, Anna, Elliott, Tom, Lambert, Peter, Watkin, Richard, Eyton, Christina, Klein, John L., Bradley, Suzanne, Kauffman, Carol, Bedimo, Roger, Crowley, Anna Lisa, Douglas, Pamela, Drew, Laura, Fowler, Vance G., Holland, Thomas, Mudrick, Daniel, Samad, Zaniab, Sexton, Daniel, Stryjewski, Martin, Wang, Andrew, Lerakis, Stamatios, Cantey, Robert, Steed, Lisa, Dickerman, Stuart A., Bonilla, Hector, Dipersio, Joseph, Salstrom, Sara Jane, Baddley, John, Patel, Mukesh, Peterson, Gail, Stancoven, Amy, Afonso, Luis, Kulman, Theresa, Levine, Donald, Rybak, Michael, Cabell, Christopher H., Baloch, Khaula, Dixon, Christy C., Vance G., Fowler J. r., Harding, Tina, Jones Richmond, Marian, Park, Lawrence P., Redick, Thomas, Stafford, Judy, Anstrom, Kevin, Bayer, Arnold S., Karchmer, A. W., Sexton, Daniel J., Cabell, Christopher H, Chu, Vivian, Durack, David T., Eykyn, Susannah, Moreillon, Phillipe, Universitat de Barcelona, University of Otago [Dunedin, Nouvelle-Zélande], Auckland City Hospital, Microbiology Laboratory, Middlemore Hospital, Duke University Medical Center, Clinical and experimental neuroimmunology [IDIBAPS], Institut d'Investigacions Biomèdiques August Pi i Sunyer, Vall d'Hebron University Hospital [Barcelona], Hospital Universitario Gregorio Maranon, Hospital Universitario Gregorio Marañón, Cardiologie, Maria Vittoria Hospital [Turin], Mater Hospitals, University of New South Wales [Sydney] (UNSW), American University of Beirut [Beyrouth] (AUB), Uniformed Services University of the Health Sciences (USUHS), Wellington Hospital Private, Royal North Shore Hospital (RNSH), Russian State Medical University, Durham VA Medical Center, and University of South Carolina [Columbia]
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Aortic valve ,Bacterial Diseases ,Genetics and Molecular Biology (all) ,Valvular Disease ,Medizin ,Eikenella corrodens ,Cardiobacterium ,Infection control ,Cardiovascular ,American-heart-association ,Biochemistry ,Antimicrobial therapy ,Cohort Studies ,0302 clinical medicine ,Control d'infeccions ,Diagnosis ,Odds Ratio ,Prevalence ,030212 general & internal medicine ,Prospective cohort study ,Haemophilus Influenzae ,0303 health sciences ,Multidisciplinary ,biology ,Endocarditis ,Medicine (all) ,Statistics ,Congenital Heart Disease ,Age Factors ,Bacterial ,3. Good health ,Management ,Stroke ,medicine.anatomical_structure ,Infectious Diseases ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Treatment Outcome ,Infective endocarditis ,Cohort ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Medicine ,Profile ,Health-care professionals ,Kingella ,Cardiobacterium-hominis ,Cohort study ,Research Article ,medicine.medical_specialty ,Drugs and Devices ,Science ,Haemophilus ,Referral bias ,Statistics, Nonparametric ,Medical Devices ,03 medical and health sciences ,Internal medicine ,Kingella Kingae Infection ,medicine ,Humans ,Nonparametric ,Aggregatibacter ,Endocarditis, Bacterial ,Biochemistry, Genetics and Molecular Biology (all) ,Agricultural and Biological Sciences (all) ,Staphylococcus-aureus ,Heart Failure ,030306 microbiology ,business.industry ,Acute Cardiovascular Problems ,Bloodstream Infections ,medicine.disease ,biology.organism_classification ,Surgery ,Valve endocarditis ,Cardiobacterium hominis ,business - Abstract
International audience; The HACEK organisms (Haemophilus species, Aggregatibacter species, Cardiobacterium hominis, Eikenella corrodens, and Kingella species) are rare causes of infective endocarditis (IE). The objective of this study is to describe the clinical characteristics and outcomes of patients with HACEK endocarditis (HE) in a large multi-national cohort. Patients hospitalized with definite or possible infective endocarditis by the International Collaboration on Endocarditis Prospective Cohort Study in 64 hospitals from 28 countries were included and characteristics of HE patients compared with IE due to other pathogens. Of 5591 patients enrolled, 77 (1.4%) had HE. HE was associated with a younger age (47 vs. 61 years; p < 0.001), a higher prevalence of immunologic/vascular manifestations (32% vs. 20%; p < 0.008) and stroke (25% vs. 17% p = 0.05) but a lower prevalence of congestive heart failure (15% vs. 30%; p = 0.004), death in-hospital (4% vs. 18%; p = 0.001) or after 1 year follow-up (6% vs. 20%; p = 0.01) than IE due to other pathogens (n = 5514). On multivariable analysis, stroke was associated with mitral valve vegetations (OR 3.60; CI 1.34-9.65; p < 0.01) and younger age (OR 0.62; CI 0.49-0.90; p < 0.01). The overall outcome of HE was excellent with the in-hospital mortality (4%) significantly better than for non-HE (18%; p < 0.001). Prosthetic valve endocarditis was more common in HE (35%) than non-HE (24%). The outcome of prosthetic valve and native valve HE was excellent whether treated medically or with surgery. Current treatment is very successful for the management of both native valve prosthetic valve HE but further studies are needed to determine why HE has a predilection for younger people and to cause stroke. The small number of patients and observational design limit inferences on treatment strategies. Self selection of study sites limits epidemiological inferences.
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- 2013
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26. Long-term efficacy and safety of raltegravir, etravirine, and darunavir/ritonavir in treatment-experienced patients: week 96 results from the ANRS 139 TRIO trial
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Fagard, Catherine, Colin, Céline, Charpentier, Charlotte, Rami, Agathe, Jacomet, Christine, Yeni, Patrick, Vittecoq, Daniel, Katlama, Christine, Molina, Jean-Michel, Descamps, Diane, Chêne, Geneviève, Yazdanpanah, Yazdan, Michelet, Christian, Epidémiologie et Biostatistique [Bordeaux], Université Bordeaux Segalen - Bordeaux 2-Institut de Santé Publique, d'Épidémiologie et de Développement (ISPED)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Impacts de la puissance antivirale des antirétroviraux et de la résistance virale sur les stratégies thérapeutiques des infections par les virus de l'immunodéficience humaine, Université Paris Diderot - Paris 7 (UPD7), Service des Maladies Infectieuses et Tropicales, AP-HP, Hôpital Paul Brousse, Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Service des Maladies Infectieuses et Tropicales, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7), Modélisation, Aide à la Décision, et Coût-Efficacité en Maladies Infectieuses (ATIP-Avenir Inserm), Institut National de la Santé et de la Recherche Médicale (INSERM), Institut de recherche en santé, environnement et travail (Irset), Université d'Angers (UA)-Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique ), French National Agency for Research on AIDS and Viral Hepatitis (ANRS), ANRS 139 TRIO Trial Group, Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Université Paris Diderot - Paris 7 (UPD7)-Groupe Hospitalier Saint Louis - Lariboisière - Fernand Widal [Paris], and Université d'Angers (UA)-Université de Rennes (UR)-École des Hautes Études en Santé Publique [EHESP] (EHESP)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Structure Fédérative de Recherche en Biologie et Santé de Rennes ( Biosit : Biologie - Santé - Innovation Technologique )
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Male ,Enfuvirtide ,MESH: Sulfonamides ,Etravirine ,HIV Infections ,Pharmacology ,Raltegravir Potassium ,0302 clinical medicine ,MESH: Drug Resistance, Multiple, Viral ,Pharmacology (medical) ,030212 general & internal medicine ,Darunavir ,0303 health sciences ,Sulfonamides ,MESH: Middle Aged ,biology ,MESH: Follow-Up Studies ,MESH: HIV Infections ,Middle Aged ,Pyrrolidinones ,3. Good health ,Pyridazines ,Infectious Diseases ,MESH: RNA, Viral ,Lentivirus ,RNA, Viral ,[SDV.IMM]Life Sciences [q-bio]/Immunology ,Female ,raltegravir ,medicine.drug ,Adult ,medicine.medical_specialty ,MESH: Pyrrolidinones ,03 medical and health sciences ,Drug Resistance, Multiple, Viral ,Internal medicine ,MESH: Pyridazines ,Nitriles ,medicine ,Humans ,darunavir/ritonavir ,etravirine ,MESH: HIV Protease Inhibitors ,Ritonavir ,MESH: Humans ,030306 microbiology ,business.industry ,multidrug resistant ,HIV ,MESH: Adult ,HIV Protease Inhibitors ,Raltegravir ,biology.organism_classification ,MESH: Male ,Regimen ,Pyrimidines ,MESH: Ritonavir ,business ,MESH: Female ,Follow-Up Studies - Abstract
International audience; Among 103 patients with multidrug-resistant HIV who initiated raltegravir, etravirine, and darunavir/ritonavir-containing regimen in the ANRS 139 TRIO trial, 100 participated in extended follow-up and continued study treatment until week 96. Among them, 87 (87%) received an optimized background therapy including either nucleoside reverse transcriptase inhibitors or enfuvirtide, they were 78 (78%) at week 96. At week 96, 88% achieved durable virologic response (
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- 2012
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27. Heart transplantation as salvage treatment of intractable infective endocarditis
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Aymami, Marie, primary, Revest, Matthieu, additional, Piau, Caroline, additional, Chabanne, Céline, additional, Le Gall, François, additional, Lelong, Bernard, additional, Verhoye, Jean-Philippe, additional, Michelet, Christian, additional, Tattevin, Pierre, additional, and Flécher, Erwan, additional
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- 2015
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28. Short report: Incidence of yellow fever vaccine-associated neurotropic disease
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Guimard, Thomas, Minjolle, Sophie, Polard, Elisabeth, Fily, Fabien, Zeller, Hervé, Michelet, Christian, Tattevin, Pierre, Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC), Université de Rennes (UR), Biologie des Infections Virales Émergentes - Biology of Emerging Viral Infections (UBIVE), Centre International de Recherche en Infectiologie (CIRI), École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-École normale supérieure de Lyon (ENS de Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Université Jean Monnet - Saint-Étienne (UJM)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris] (IP), Centre collaborateur de l'OMS Arbovirus et Fièvres Hémorragiques virales - Stratégies antivirales (CC-OMS), Institut Pasteur [Paris] (IP), Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Centre International de Recherche en Infectiologie - UMR (CIRI), Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut National de la Santé et de la Recherche Médicale (INSERM)-École normale supérieure - Lyon (ENS Lyon)-Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Centre National de la Recherche Scientifique (CNRS)-Institut Pasteur [Paris], and Institut Pasteur [Paris]
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Adult ,Male ,MESH: Humans ,MESH: Middle Aged ,Incidence ,Yellow Fever Vaccine ,MESH: Adult ,Middle Aged ,MESH: Male ,MESH: Yellow Fever Vaccine ,Young Adult ,[SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology ,Meningoencephalitis ,MESH: Meningitis ,MESH: Young Adult ,Humans ,Female ,Meningitis ,MESH: Incidence ,MESH: Meningoencephalitis ,MESH: Female - Abstract
International audience; Although the yellow fever 17D strain live-attenuated vaccine has been widely used over the past seven decades with a long history of safe records, recent reports of serious, sometimes fatal, adverse events, raised concerns about its tolerance. We extracted all cases of serious neurologic adverse events that occurred within 30 days of yellow fever vaccination in our institution during 2000-2008. Four cases (meningitis, n = 2 and meningo-encephalitis, n = 2) were identified. The male:female ratio was 3:1, and ages ranged from 21 to 55 years. Cerebrospinal fluid examination showed pleocytosis (10-82 cells/mm(3), 64-84% lymphocytes), with slightly elevated protein levels (0.4-0.68 g/L). All symptoms resolved in three patients, but attention disorder and cerebellar syndrome persisted in one patient (at six months follow-up). The incidence of yellow fever vaccine-associated serious neurologic events was estimated to be 9.9/100,000 vaccine doses (95% confidence interval = 2.7-25.4/100,000) in this study, which was 10 times higher than previous estimates that did not include acute meningitis.
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- 2009
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29. Fièvre recurrente à tiques: un diagnostic non rare au décours d'un séjour touristique au Sénégal [Recurrent tick-borne fever: a possible diagnosis in patients returning from Senegal]
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Patrat-Delon, Solène, Drogoul, Anne Sophie, Le Ho, Hélène, Biziraguzenyuka, Jérémie, Rabier, Valérie, Arvieux, Cédric, Michelet, Christian, Chevrier, Sylviane, Tattevin, Pierre, Service des maladies infectieuses et réanimation médicale [Rennes] = Infectious Disease and Intensive Care [Rennes], CHU Pontchaillou [Rennes], Institut Pasteur de la Guyane, Réseau International des Instituts Pasteur (RIIP), Service de Parasitologie-Mycologie [Rennes], Université de Rennes 1 (UR1), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], Signalisation et Réponses aux Agents Infectieux et Chimiques (SeRAIC), Université de Rennes (UNIV-RENNES)-Université de Rennes (UNIV-RENNES), Université de Rennes (UR)-Hôpital Pontchaillou-CHU Pontchaillou [Rennes], and Université de Rennes (UR)
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MESH: Humans ,MESH: Plasmodium ,MESH: Adult ,MESH: Amoxicillin ,MESH: Injections, Intravenous ,Borréliose ,MESH: Recurrence ,MESH: Tick-Borne Diseases ,Sénégal ,MESH: Senegal ,[SDV.MHEP.MI]Life Sciences [q-bio]/Human health and pathology/Infectious diseases ,MESH: Anti-Bacterial Agents ,MESH: Borrelia Infections ,MESH: Animals ,Fièvre récurrente à tiques ,MESH: Travel ,MESH: Female ,MESH: Treatment Outcome ,MESH: Ticks - Abstract
International audience; In Senegal, tick-borne relapsing fever caused by the spirochetes Borrelia crucidurae is the most common cause of fever after malaria in rural areas. However, this is only rarely diagnosed in France, probably because: i) the diagnosis relies on investigations that are not routinely done; ii) even undiagnosed, borreliosis may be cured with empirical antibiotic treatment. We report four observations of tick-borne relapsing fever in patients returning from Senegal: In two patients, the diagnosis relied on the observation of spirochetes in blood smears; in the other two, the diagnosis relied on typical clinico-biological signs, borreliosis serology and exposure. These four cases diagnosed over a four year period in one institution suggest that relapsing fever is not rare in patients returning from West Africa. Patients who return form Senegal with unexplained fever should be investigated with careful examination of blood smears and PCR on blood samples.
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- 2008
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30. Granulomatous lymphadenitis as a manifestation of Q fever. (Letters)
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Tattevin, Pierre, Arvieux, Cedric, Dupont, Mathieu, Guggenbuhl, Pascal, Lemeur, Alexandre, and Michelet, Christian
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Diagnosis ,Research ,Causes of ,Granuloma -- Research -- Diagnosis ,Q fever -- Diagnosis -- Research ,Lymphadenitis -- Causes of -- Research -- Diagnosis - Abstract
To the Editor: Q fever is a worldwide zoonosis caused by the obligate intracellular pathogen Coxiella burnetii (1). Human infection is usually the result of exposure to infected cattle, sheep [...]
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- 2003
31. Simultaneous Determination of 12 β-Lactam Antibiotics in Human Plasma by High-Performance Liquid Chromatography with UV Detection: Application to Therapeutic Drug Monitoring
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Verdier, Marie-Clémence, primary, Tribut, Olivier, additional, Tattevin, Pierre, additional, Le Tulzo, Yves, additional, Michelet, Christian, additional, and Bentué-Ferrer, Danièle, additional
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- 2011
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32. Risk factors for total joint arthroplasty infection in patients receiving tumor necrosis factor α-blockers: a case-control study
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Gilson, Mélanie, primary, Gossec, Laure, additional, Mariette, Xavier, additional, Gherissi, Dalenda, additional, Guyot, Marie-Hélène, additional, Berthelot, Jean-Marie, additional, Wendling, Daniel, additional, Michelet, Christian, additional, Dellamonica, Pierre, additional, Tubach, Florence, additional, Dougados, Maxime, additional, and Salmon, Dominique, additional
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- 2010
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33. Incidence of Yellow Fever Vaccine-Associated Neurotropic Disease
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Guimard, Thomas, primary, Fily, Fabien, additional, Michelet, Christian, additional, Minjolle, Sophie, additional, Polard, Elisabeth, additional, Zeller, Hervé, additional, and Tattevin, Pierre, additional
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- 2009
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34. Prevalence and Predictors of Deterioration of a Trustful Patient-Provider Relationship Among HIV-Infected Persons Treated With Antiretroviral Therapy
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Préau, Marie, primary, Leport, Catherine, additional, Villes, Virginie, additional, Michelet, Christian, additional, Collin, Fidéline, additional, Carrieri, Maria-Patrizia, additional, Ragnaud, Jean-Marie, additional, Taieb, Audrey, additional, Raffi, François, additional, and Spire, Bruno, additional
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- 2008
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35. Increasing Incidence of Severe Epstein-Barr Virus-Related Infectious Mononucleosis: Surveillance Study
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Tattevin, Pierre, primary, Le Tulzo, Yves, additional, Minjolle, Sophie, additional, Person, Arnaud, additional, Chapplain, Jean Marc, additional, Arvieux, Cedric, additional, Thomas, Remi, additional, and Michelet, Christian, additional
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- 2006
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36. Imported Crimean-Congo Hemorrhagic Fever
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Jauréguiberry, Stéphane, primary, Tattevin, Pierre, additional, Tarantola, Arnaud, additional, Legay, François, additional, Tall, Adama, additional, Nabeth, Pierre, additional, Zeller, Hervé, additional, and Michelet, Christian, additional
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- 2005
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37. A Regimen Containing Rifabutin for the Treatment of Tuberculosis in Patients Intolerant to Rifampin
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Tattevin, Pierre, primary, Revest, Mathieu, additional, Dupont, Mathieu, additional, Arvieux, Cedric, additional, and Michelet, Christian, additional
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- 2003
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38. Indications for Surgery for Elderly Patients with Infective Endocarditis
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Tattevin, Pierre, primary, Volatron, Anne‐Claire, additional, Jouneau, Stéphane, additional, Arvieux, Cédric, additional, and Michelet, Christian, additional
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- 2002
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39. Ritonavir-Saquinavir Dual Protease Inhibitor Compared to Ritonavir Alone in Human Immunodeficiency Virus-Infected Patients
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Michelet, Christian, primary, Ruffault, Annick, additional, Sébille, Véronique, additional, Arvieux, Cedric, additional, Jaccard, Philippe, additional, Raffi, François, additional, Bazin, Claude, additional, Chapplain, Jean-Marc, additional, Chauvin, Jean-Pierre, additional, Dohin, Elisabeth, additional, Cartier, François, additional, and Bellissant, Eric, additional
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- 2001
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40. Comparative Efficacies of Antibiotics in a Rat Model of Meningoencephalitis Due to Listeria monocytogenes
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Michelet, Christian, primary, Leib, Stephen L., additional, Bentue-Ferrer, Daniele, additional, and Täuber, Martin G., additional
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- 1999
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41. Endocarditis Due to Fusarium dimerum Four Years After Coronary Artery Bypass Grafting
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Camin, Anne‐Marie, primary, Michelet, Christian, additional, Langanay, Thierry, additional, de Place, Christian, additional, Chevrier, Sylviane, additional, Guého, Eveline, additional, and Guiguen, Claude, additional
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- 1999
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42. Prevalence and Predictors of Deterioration of a Trustful Patient-Provider Relationship Among HIV-lnfected Persons Treated With Antiretroviral Therapy.
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Préau, Marie, Leport, Catherine, Villes, Virginie, Michelet, Christian, Collin, Fidéline, Carrieri, Maria-Patrizia, Ragnaud, Jean-Marie, Thieb, Audrey, Raffi, François, and Spire, Bruno
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- 2008
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43. Predictors of Long-Term Increase in CD4+ Cell Counts in Human Immunodeficiency Virus-Infected Patients Receiving a Protease Inhibitor-Containing Antiretroviral Regimen.
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Le Moing, Vincent, Thiebaut, Rodolphe, Chene, Genevieve, Leport, Catherine, Cailleton, Valerie, Michelet, Christian, Fleury, Herve, and Herson, Serge
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HIV-positive persons ,PROTEASE inhibitors - Abstract
The temporal relationships between plasma human immunodeficiency virus (HIV) RNA levels and evolution of CD4+ cell counts was studied, using a 2-slope longitudinal mixed model, in 988 patients prospectively enrolled at the initiation of a protease inhibitor-containing regimen of antiretroviral therapy. The short-term slope (baseline through month 4) for mean change in CD4+ cell count was +21.2 cells/mm³/month, and the long-term slope (month 4 through month 24) was +5.5 cells/mm³/month. Compared with results from patients without viral response, the long-term slope was 2.5 cells/mm³/month higher in patients who had plasma HIV RNA levels of <500 copies/mL at month 4 (P < .001). It was significantly lower after a rebound in plasma HIV RNA level to ≥500 copies/mL (P < .0001), varied according to plasma HIV RNA level at the time of rebound, and was negative only when the plasma HIV RNA level at rebound was ≥10,000 copies/mL. If CD4+ cell counts can remain elevated despite virologic treatment failure, such a discrepant response may be transient in patients who have a high plasma HIV RNA level at the time of treatment failure. [ABSTRACT FROM AUTHOR]
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- 2002
44. Sustained Bacteremia in 26 Patients with a Permanent Endocardial Pacemaker: Assessment of Wire Removal.
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Camus, Christophe, Leport, Catherine, Raffi, Francois, Michelet, Christian, Cartier, Francois, and Vilde, Jean Louis
- Abstract
We reviewed the data on 26 patients with permanent endocardial pacemakers who had 28 episodes of bacteremia to determine whether removal of the wire is required. Patients recovered completely from the first episode in seven of 20 cases of staphylococcal bacteremia and in six of six cases of nonstaphylococcal bacteremia (P = .015). Definitive cure was not achieved during the first episode in seven cases of staphylococcal bacteremia related to the pacing system when the wire was not withdrawn; however, cure was achieved in five of six cases when the whole pacemaker was removed (P < .01). The duration of treatment was longer for the patients from whom the wire was not removed during the first episode (P < .01). Whether cases of staphylococcal bacteremia were related to the pacing system or not, the rate of recovery of the responsible microorganism from the wires was similar for both groups of patients (six [82%] of seven and three [75%] of four, respectively). Nonstaphylococcal bacteremia was unrelated to the pacing system in five of six cases; these patients were all cured without removal of the wire. [ABSTRACT FROM PUBLISHER]
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- 1993
45. Staphylococcus aureus infective endocarditis versus bacteremia strains: Subtle genetic differences at stake
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Bouchiat, Coralie, Moreau, Karen, Devillard, Sébastien, Rasigade, Jean-Philippe, Mosnier, Amandine, Geissmann, Tom, Bes, Michèle, Tristan, Anne, Lina, Gérard, Laurent, Frédéric, Piroth, Lionel, Aissa, Nejla, Duval, Xavier, Le Moing, Vincent, Vandenesch, François, Chirouze, Catherine, Curlier, Elodie, Descottes-Genon, Cécile, Hoen, Bruno, Patry, Isabelle, Vettoretti, Lucie, Chavanet, Pascal, Eicher, Jean-Christophe, Gohier-Treuvelot, Sandrine, Greusard, Marie-Christine, Neuwirth, Catherine, Péchinot, André, Célard, Marie, Cornu, Catherine, Delahaye, François, Hadid, Malika, Rausch, Pascale, Coma, Audrey, Galtier, Florence, Géraud, Philippe, Jean-Pierre, Hélène, Sportouch, Catherine, Reynes, Jacques, Doco-Lecompte, Thanh, Goehringer, François, Keil, Nathalie, Letranchant, Lorraine, Malela, Hepher, May, Thierry, Selton-Suty, Christine, Bedos, Nathalie, Lavigne, Jean-Philippe, Lechiche, Catherine, Sotto, Albert, Habensus, Emila Ilic, Iung, Bernard, Leport, Catherine, Longuet, Pascale, Ruimy, Raymond, Bellissant, Eric, Donnio, Pierre-Yves, Le Gac, Fabienne, Michelet, Christian, Revest, Matthieu, Tattevin, Pierre, Thebault, Elise, Alla, François, Braquet, Pierre, Erpelding, Marie-Line, Minary, Laetitia, Tubiana, Sarah, Bès, Michèle, Etienne, Jérôme, Barbas, Sandrine, Delonca, Christine, Sussmuth, Virginie, and Verchère, Anne
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Staphylococcus aureus ,DAPC ,Genetic distinction ,Bacteremia ,Infective endocarditis - Abstract
Infective endocarditis (IE)(1) is a severe condition complicating 10–25% of Staphylococcus aureus bacteremia. Although host-related IE risk factors have been identified, the involvement of bacterial features in IE complication is still unclear. We characterized strictly defined IE and bacteremia isolates and searched for discriminant features. S. aureus isolates causing community-acquired, definite native-valve IE (n=72) and bacteremia (n=54) were collected prospectively as part of a French multicenter cohort. Phenotypic traits previously reported or hypothesized to be involved in staphylococcal IE pathogenesis were tested. In parallel, the genotypic profiles of all isolates, obtained by microarray, were analyzed by discriminant analysis of principal components (DAPC)(2). No significant difference was observed between IE and bacteremia strains, regarding either phenotypic or genotypic univariate analyses. However, the multivariate statistical tool DAPC, applied on microarray data, segregated IE and bacteremia isolates: IE isolates were correctly reassigned as such in 80.6% of the cases (C-statistic 0.83, P
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46. Imported Crimean-Congo Hemorrhagic Fever
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Jaure´guiberry, Ste´phane, Tattevin, Pierre, Tarantola, Arnaud, Legay, Franc¸ois, Tall, Adama, Nabeth, Pierre, Zeller, Herve´, and Michelet, Christian
- Abstract
ABSTRACTCrimean-Congo hemorrhagic fever (CCHF) is a tick-borne disease that may also be transmitted through person-to-person transmission by exposure to infected body fluids. Despite its wide geographic distribution in animals, CCHF virus is rarely associated with recognized human diseases. We report the first case of imported CCHF in France.
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- 2005
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47. Multiple Organ Failure during Primary HIV Infection.
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Tattevin, Pierre, Camus, Christophe, Arvieux, Cédric, Ruffault, Annick, and Michelet, Christian
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HIV infections ,MONONUCLEOSIS ,MULTIPLE organ failure ,CANDIDIASIS ,CYTOMEGALOVIRUS diseases ,PNEUMONIA - Abstract
The appearance of primary HIV infection ranges from an asymptomatic presentation to a symptomatic illness resembling infectious mononucleosis. Severe unusual presentations include acute myopericarditis, renal failure, and opportunistic infections such as esophageal candidiasis, cytomegalovirus infection, and Pneumocystis jirovecii pneumonia. We report a case of multiple organ failure during primary HIV infection. [ABSTRACT FROM AUTHOR]
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- 2007
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48. Simultaneous determination of 12 beta-lactam antibiotics in human plasma by high-performance liquid chromatography with UV detection: application to therapeutic drug monitoring.
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Verdier MC, Tribut O, Tattevin P, Le Tulzo Y, Michelet C, and Bentué-Ferrer D
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- Humans, Sensitivity and Specificity, Spectrophotometry, Ultraviolet, Anti-Bacterial Agents blood, Chromatography, High Pressure Liquid methods, Drug Monitoring methods, beta-Lactams blood
- Abstract
A rapid and specific high-performance liquid chromatography method with UV detection (HPLC-UV) for the simultaneous determination of 12 beta-lactam antibiotics (amoxicillin, cefepime, cefotaxime, ceftazidime, ceftriaxone, cloxacillin, imipenem, meropenem, oxacillin, penicillin G, piperacillin, and ticarcillin) in small samples of human plasma is described. Extraction consisted of protein precipitation by acetonitrile. An Atlantis T3 analytical column with a linear gradient of acetonitrile and a pH 2 phosphoric acid solution was used for separation. Wavelength photodiode array detection was set either at 210 nm, 230 nm, or 298 nm according to the compound. This method is accurate and reproducible (coefficient of variation [CV] < 8%), allowing quantification of beta-lactam plasma levels from 5 to 250 μg/ml without interference with other common drugs. This technique is easy to use in routine therapeutic drug monitoring of beta-lactam antibiotics.
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- 2011
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49. Short report: Incidence of yellow fever vaccine-associated neurotropic disease.
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Guimard T, Minjolle S, Polard E, Fily F, Zeller H, Michelet C, and Tattevin P
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- Adult, Female, Humans, Incidence, Male, Middle Aged, Young Adult, Meningitis chemically induced, Meningoencephalitis chemically induced, Yellow Fever Vaccine adverse effects
- Abstract
Although the yellow fever 17D strain live-attenuated vaccine has been widely used over the past seven decades with a long history of safe records, recent reports of serious, sometimes fatal, adverse events, raised concerns about its tolerance. We extracted all cases of serious neurologic adverse events that occurred within 30 days of yellow fever vaccination in our institution during 2000-2008. Four cases (meningitis, n = 2 and meningo-encephalitis, n = 2) were identified. The male:female ratio was 3:1, and ages ranged from 21 to 55 years. Cerebrospinal fluid examination showed pleocytosis (10-82 cells/mm(3), 64-84% lymphocytes), with slightly elevated protein levels (0.4-0.68 g/L). All symptoms resolved in three patients, but attention disorder and cerebellar syndrome persisted in one patient (at six months follow-up). The incidence of yellow fever vaccine-associated serious neurologic events was estimated to be 9.9/100,000 vaccine doses (95% confidence interval = 2.7-25.4/100,000) in this study, which was 10 times higher than previous estimates that did not include acute meningitis.
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- 2009
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50. Prevalence and predictors of deterioration of a trustful patient-provider relationship among HIV-infected persons treated with antiretroviral therapy.
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Préau M, Leport C, Villes V, Michelet C, Collin F, Carrieri MP, Ragnaud JM, Taieb A, Raffi F, and Spire B
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- Adult, Female, France epidemiology, HIV Infections epidemiology, Humans, Male, Middle Aged, Multivariate Analysis, Prevalence, Time Factors, Antiretroviral Therapy, Highly Active, HIV Infections drug therapy, HIV Infections psychology, Physician-Patient Relations
- Abstract
Objectives: We studied the evolution of the patient-provider relationship (PPR) in HIV-infected patients who reported trustful relationships at highly active antiretroviral therapy (HAART) treatment initiation., Methods: Psychosocial and clinical data were obtained from the French ANRS CO-8 cohort. Break of trust was defined using the question "How much do you trust the provider who usually treats you at this clinic?" Predictors of a possible break of trust during the 5 years after initiating treatment for those patients reporting a trustful PPR at month 0 were identified using a Cox model., Results: During a total follow-up of 3,044 person-years, 68 (7%) patients reported having at least 1 break of trust in their PPR. Break of trust is independently associated with younger age, dissatisfaction with medical staff's explanations, cigarette smoking, and self-reported side effects and is independently inversely associated with severe HIV-related events and changes of treatment., Conclusions: A patient's break of trust in his provider is relatively infrequent. Accounting for the influence of immunologic status and psychosocial factors, self-reported side effects are shown to be detrimental to the PPR. Interestingly, clinical events and changes of treatment prevent a possible break of trust by reinforcing the provider's role. These results underline the importance of recognizing a patient's perceived secondary effects and developing appropriate care.
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- 2008
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