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Your search keyword '"Mildner, Karina"' showing total 13 results
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13 results on '"Mildner, Karina"'

4. Ronin governs the metabolic capacity of the embryonic lineage for post-implantation development

Author

Salewskij, Kirill, Gross-Thebing, Theresa, Ing-Simmons, Elizabeth, Duethorn, Binyamin, Rieger, Bettina, Fan, Rui, Chen, Rui, Govindasamy, Niraimathi, Brinkmann, Heike, Kremer, Ludmila, Kuempel-Rink, Nannette, Mildner, Karina, Zeuschner, Dagmar, Stehling, Martin, Dejosez, Marion, Zwaka, Thomas P, Schöler, Hans R, Busch, Karin B, Vaquerizas, Juan M, and Bedzhov, Ivan

Published
2021
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8. Lima1 mediates the pluripotency control of membrane dynamics and cellular metabolism

Author

Duethorn, Binyamin, Groll, Fabian, Rieger, Bettina, Drexler, Hannes CA, Brinkmann, Heike, Kremer, Ludmila, Stehling, Martin, Borowski, Marie-Theres, Mildner, Karina, Zeuschner, Dagmar, Zernicka-Goetz, Magdalena, Stemmler, Marc P, Busch, Karin B, Vaquerizas, Juan M, Bedzhov, Ivan, Drexler, Hannes CA [0000-0002-8285-0644], Borowski, Marie-Theres [0000-0003-3648-7757], Zeuschner, Dagmar [0000-0002-6712-0192], Zernicka-Goetz, Magdalena [0000-0002-7004-2471], Stemmler, Marc P [0000-0002-7866-3686], Vaquerizas, Juan M [0000-0002-6583-6541], Bedzhov, Ivan [0000-0002-2122-6485], and Apollo - University of Cambridge Repository

Subjects
Male, Pluripotent Stem Cells, Science, 631/136/2086, General Physics and Astronomy, 631/532/2064, Embryonic Development, 631/80/642/333/1465, 13/109, Membrane trafficking, 13, 14, 96/31, General Biochemistry, Genetics and Molecular Biology, Article, 38, Mice, 13/100, Animals, 96/2, Embryonic Stem Cells, Cell Proliferation, 42, 64, Multidisciplinary, 631/80/313, 631/136/532/2064, 82/58, General Chemistry, Energy metabolism, Cytoskeletal Proteins, Blastocyst, 14/63, Embryogenesis, 38/77, 38/39, 64/60, Female
Abstract

Lima1 is an extensively studied prognostic marker of malignancy and is also considered to be a tumour suppressor, but its role in a developmental context of non-transformed cells is poorly understood. Here, we characterise the expression pattern and examined the function of Lima1 in mouse embryos and pluripotent stem cell lines. We identify that Lima1 expression is controlled by the naïve pluripotency circuit and is required for the suppression of membrane blebbing, as well as for proper mitochondrial energetics in embryonic stem cells. Moreover, forcing Lima1 expression enables primed mouse and human pluripotent stem cells to be incorporated into murine pre-implantation embryos. Thus, Lima1 is a key effector molecule that mediates the pluripotency control of membrane dynamics and cellular metabolism., How pluripotency transcription factors regulate the cellular architecture and energetics has remained largely unknown. Here the authors identify Lima1 as a key effector that mediates the pluripotency control of membrane dynamics and cellular metabolism.

Published
2021

13. Deciphering epiblast lumenogenesis reveals proamniotic cavity control of embryo growth and patterning.

Author

Yung Su Kim, Rui Fan, Kremer, Ludmila, Kuempel-Rink, Nannette, Mildner, Karina, Zeuschner, Dagmar, Hekking, Liesbeth, Stehling, Martin, and Bedzhov, Ivan

Subjects
*STREPTAVIDIN
Abstract

The article presents a study which aimed to decipher the mechanisms of lumenogenesis and the role of the proamniotic cavity using the 3D ES model of epiblast development in combination with direct analyses in early mouse embyros. Topics discussed include the changes in the mouse embryo during the peri-implantation stages, findings on the cavity formation, and the function of the proamniotic cavity.

Published
2021
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