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4 results on '"Mohamed Metawee"'

1. Non-pulmonary vein mediated atrial fibrillation: A novel sub-phenotype.

Author

Maureen Farrell, Zachary Yoneda, Jay Montgomery, Diane Crawford, Lauren Lee Wray, Meng Xu, Matthew J Kolek, Travis Richardson, Ricardo Lugo, Mohamed Metawee, Greg Michaud, Juan Carlos Estrada, Pablo Saavedra, Sharon Shen, Arvindh Kanagasundram, Christopher R Ellis, George Crossley, Dan Roden, and M Benjamin Shoemaker

Subjects
Medicine, Science
Abstract

BACKGROUND:Atrial fibrillation (AF) is a mechanistically heterogeneous disorder, and the ability to identify sub-phenotypes ("endophenotypes") of AF would assist in the delivery of personalized medicine. We used the clinical response to pulmonary vein isolation (PVI) to identify a sub-group of patients with non-PV mediated AF and sought to define the clinical associations. METHODS:Subjects enrolled in the Vanderbilt AF Ablation Registry who underwent a repeat AF ablation due to arrhythmia recurrence were analyzed on the basis of PV reconnection. Subjects who had no PV reconnection were defined as "non-PV mediated AF". A comparison group of subjects were identified who had AF that was treated with PVI-only and experienced no arrhythmia recurrence >12 months. They were considered a group enriched for "PV-mediated AF". Univariate and multivariable binary logistic regression analysis was performed to investigate clinical associations between the PV and non-PV mediated AF groups. RESULTS:Two hundred and twenty nine subjects underwent repeat AF ablation and thirty three (14%) had no PV reconnection. They were compared with 91 subjects identified as having PV-mediated AF. Subjects with non-PV mediated AF were older (64 years [IQR 60,71] vs. 60 [52,67], P = 0.01), more likely to have non-paroxysmal AF (82% [N = 27] vs. 35% [N = 32], P

Published
2017
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4. Non-pulmonary vein mediated atrial fibrillation: A novel sub-phenotype

Author

Sharon Shen, Travis D. Richardson, George H. Crossley, Christopher R. Ellis, Pablo Saavedra, Maureen C. Farrell, Jay A. Montgomery, Zachary T. Yoneda, Mohamed Metawee, Diane M. Crawford, Meng Xu, Greg Michaud, Matthew J. Kolek, Lauren Lee Wray, Arvindh Kanagasundram, Dan M. Roden, M. Benjamin Shoemaker, Juan Carlos Estrada, and Ricardo M. Lugo

Subjects
medicine.medical_treatment, Left atrium, lcsh:Medicine, 030204 cardiovascular system & hematology, Pulmonary vein, Mathematical and Statistical Techniques, Endocrinology, 0302 clinical medicine, Atrial Fibrillation, Medicine and Health Sciences, 030212 general & internal medicine, Cardiac Atria, lcsh:Science, Univariate analysis, Multidisciplinary, Ejection fraction, Heart, Atrial fibrillation, Middle Aged, 3. Good health, medicine.anatomical_structure, Pulmonary Veins, Physical Sciences, Catheter Ablation, Cardiology, Regression Analysis, Anatomy, Arrhythmia, Statistics (Mathematics), Research Article, Biotechnology, medicine.medical_specialty, Catheters, Endocrine Disorders, Catheter ablation, Research and Analysis Methods, Veins, 03 medical and health sciences, Diabetes mellitus, Internal medicine, Diabetes Mellitus, medicine, Humans, Binary logistic regression analysis, Statistical Methods, Aged, business.industry, lcsh:R, Biology and Life Sciences, medicine.disease, Metabolic Disorders, Multivariate Analysis, Cardiovascular Anatomy, Blood Vessels, Medical Devices and Equipment, lcsh:Q, business, Mathematics, Ejection Fraction
Abstract

Background Atrial fibrillation (AF) is a mechanistically heterogeneous disorder, and the ability to identify sub-phenotypes (“endophenotypes”) of AF would assist in the delivery of personalized medicine. We used the clinical response to pulmonary vein isolation (PVI) to identify a sub-group of patients with non-PV mediated AF and sought to define the clinical associations. Methods Subjects enrolled in the Vanderbilt AF Ablation Registry who underwent a repeat AF ablation due to arrhythmia recurrence were analyzed on the basis of PV reconnection. Subjects who had no PV reconnection were defined as “non-PV mediated AF”. A comparison group of subjects were identified who had AF that was treated with PVI-only and experienced no arrhythmia recurrence >12 months. They were considered a group enriched for “PV-mediated AF”. Univariate and multivariable binary logistic regression analysis was performed to investigate clinical associations between the PV and non-PV mediated AF groups. Results Two hundred and twenty nine subjects underwent repeat AF ablation and thirty three (14%) had no PV reconnection. They were compared with 91 subjects identified as having PV-mediated AF. Subjects with non-PV mediated AF were older (64 years [IQR 60,71] vs. 60 [52,67], P = 0.01), more likely to have non-paroxysmal AF (82% [N = 27] vs. 35% [N = 32], P

Published
2017

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